Preductal tablets are described by the manual as a drug that improves metabolism in the myocardium and neurosensory organs in ischemia. The active substance is trimetazidine hydrochloride.
Mechanism of action
Means "Preductal", indications for the use of which will be described below, contributes to the normal functioning of ion channels in membranes. The medication also provides the transfer of sodium and potassium ions, maintaining cell homeostasis. The drug reduces the size of myocardial lesions, without exerting a direct effect on hemodynamic parameters. Against the background of angina pectoris, the drug contributes to an increase in the coronary reserve, thus slowing the onset of ischemia provoked by physical overstrain. The tool provides restrictions on fluctuations in blood pressure, without a significant change in the frequency of heart contractions. In patients with ischemic dysfunction, when taking the medication, an improvement in contractile function in the left ventricle is noted.
The drug "Preductal". Application. Price
The cost of medicine in pharmacies is from 700 rubles. What pathologies are prescribed for "Preductal"? Indications for use of this medication are as follows: coronary heart disease, cochleo-vestibular disorders of ischemic nature (tinnitus, dizziness, and others). The medicine is recommended to prevent angina attacks (in combination with other drugs or as a single agent). In chorioretinal vascular disorders with an ischemic component, the drug "Preductal" is also prescribed. Indications for use, the severity of the pathology, as well as patient tolerance are the main criteria in determining the duration of medication.
Dosage regimen
The drug is drunk with food. It is advisable to take the medicine in the morning and evening hours. The recommended dose is 1 tab. 2 r / day The drug should not be chewed or crushed. The duration of therapy or prevention is determined by the specialist personally.
Side effects
Means "Preductal", the indications for use of which are given above, can provoke a number of complications. In particular, on the basis of therapy or prevention, abdominal pain, dyspepsia, constipation, vomiting, and nausea are noted. Patients may develop asthenia, dizziness, tremors, headaches. Undesirable consequences include various motor disorders (reversible, as a rule, after stopping admission), sleep disorder. A frequent side effect is an allergic reaction, manifested by skin rash, irritation, urticaria. In some cases, Quincke edema may occur. On the basis of taking the medication, extrasystole, tachycardia, palpitations, orthostatic hypotension with dizziness, general weakness, loss of balance are likely.
Contraindications
Do not prescribe medication for patients with renal failure, with hypersensitivity, Parkinson's disease, motor disorders associated with the "restless legs" syndrome. Not recommended for patients under 18 years of age. The advisability of using the drug during pregnancy or during feeding is determined by a specialist.