Means "Macropen" is an antibiotic that belongs to the class of macrolides. This medication is available in the form of tablets for oral use, which are coated with a film protective coating and are packaged in blisters of 8 pieces and in cardboard boxes of 2 blisters. Instructions for use with Macropen 400 mg tablets are in each pack.
The tablet of this medicine contains 0.4 g of the active active element - midecamycin, as well as a number of substances that have an auxiliary effect. They are macrogol, a copolymer of methacrylic acid, titanium dioxide and talc.
Also available on sale are orange granules for the preparation of Macropen suspension. Instructions for use indicate that they must be diluted with water. The numbers indicate the dosage - in 5 ml of the finished suspension contains 175 mg of the active substance.
Pharmacological properties
According to the instructions for use of Macropen, it is an antibacterial agent from the macrolide category, the action of which is aimed at suppressing protein synthesis in the cells of infectious pathogens. In low doses, the drug has a bacteriostatic effect (stops the reproduction and growth of pathological microbes), at higher concentrations it has a bactericidal effect (leads to the death of the pathogen).
According to the instructions for use, Macropen 400 mg has high therapeutic efficacy in relation to the following pathogenic bacteria:
- chlamydia
- mycoplasma;
- ureaplasma;
- staphylococcus;
- Helicobacter pylori;
- streptococcus;
- clostridia;
- corynebacterium diphtheria;
- listeria.
Indications for appointment
In accordance with the instructions for use, "Macropen" in tablets is prescribed for diseases that are caused by pathological microflora sensitive to the main active element. These include:
- Infectious inflammatory processes of the lower and upper respiratory tract: otitis media, tonsillitis, sinusitis, pharyngitis, frontal sinusitis, sinusitis, bronchitis (both acute and chronic), laryngotracheitis, pneumonia.
- Inflammatory infections of the urinary organs: chlamydia, cystitis, urethritis, mycoplasmosis.
- Infections of subcutaneous fatty tissue and soft tissues: carbunculosis, furunculosis, abscess, pyoderma, phlegmon.
- As part of a comprehensive treatment for gastric ulcer caused by bacteria Helicobacter pylori.
- As part of a comprehensive treatment for childhood infections: whooping cough, diphtheria.
Contraindications
This medication can be used in the treatment of the above pathologies as prescribed by a specialist after conducting a preliminary examination of the patient and determining the sensitivity of pathogens to the drug. Before starting treatment with these tablets, the patient is recommended to study in detail the attached instructions for use with Macropen 400 mg, since this pharmaceutical preparation has a number of contraindications for use:
- cases of individual intolerance of components included in its content;
- severe impairment of kidney and liver function, severe cases of hepatic or renal failure;
- first trimester of pregnancy;
- children's age - less than three years for a similar dosage form (the product is in the form of a suspension for children).
Instructions for use with Macropen confirms that with some caution, this medication is prescribed in the second and third trimester of pregnancy, during lactation and if there is a history of allergic reactions to drugs with the presence of acetylsalicylic acid.
Dosage regimen and method of application
According to the instructions for use of "Macropen", patients in adulthood are prescribed one tablet 3-4 times a day, which depends on the severity and stage of a particular disease, the presence of complications and some features of the body. The medicine should be taken orally, before meals or an hour after, if necessary, the tablet is allowed to grind or chew, drinking plenty of fluids. The duration of the therapeutic course with this drug should not exceed seven days. In the absence of the expected therapeutic effect, the patient is recommended to consult a doctor again to clarify the sensitivity of the infectious pathogen to this medication.
For children after three years, the daily dosage of the drug is calculated individually in accordance with body weight and tolerance to the medication.
Use in childhood
This medicine is also used in the form of a suspension of 175 mg of the main substance per 5 ml - a liquid form that is very convenient for babies. The medicine is produced in the form of granules from which the suspension for children "Macropen" is prepared. Instructions for use indicate that they are orange in color, they must be dissolved in water.
This antibiotic (20 g of powder) is packaged in dark glass bottles and in cardboard boxes, which also comes with a special measuring spoon and instructions for use. After diluting the medicinal powder, 100 ml of an orange liquid with a characteristic banana flavor is obtained, which, as a rule, is enough for a full therapeutic course. The drug in the form of a suspension can be given to babies older than two months.
Instructions for use with Macropen are simple and straightforward.
Each parent experiences when his child is faced with an infectious disease. Especially when his body cannot cope with it on his own, in such a case one has to resort to antibacterial medications. "Macropen" for children quickly copes not only with symptoms, but also with the main cause of pathology, it is prescribed for:
- Infectious inflammation of the respiratory tract (bacterial pharyngitis, tonsillitis, bronchitis, pneumonia).
- Inflammatory diseases of subcutaneous fat and skin.
- Infectious processes in the bladder, kidneys or ureters.
Only a doctor can prescribe this medicine to a child.
The use of antibacterial drugs is necessary when the pathogenic flora actively multiplies and poisons the children's body, causing intoxication, the symptoms of which are chills and fever.
Use during lactation and pregnancy
Instructions for use with Macropen tablets informs that in the first months of pregnancy, their use, like any other antibacterial drug from the macrolide group, is strictly contraindicated, since this can negatively affect the development of the internal organs of the unborn baby.
In the second and third trimesters, the use of this medication is possible only if there are vital indications, when the expected benefit for the woman becomes higher than the possible risk to the fetus. Therapy is carried out under the strict supervision of a specialist.
Since the active active element of the drug can be excreted in human milk, the use of Macropen during lactation is undesirable. If necessary, therapy for a nursing mother should decide on the transfer of the child to an artificial milk mixture.
Adverse reactions
According to the instructions for use and reviews of "Macropen", the following side symptoms may develop in patients with this pharmaceutical drug during the development of the following side effects:
- pain in the stomach;
- nausea;
- excessive salivation;
- the urge to vomit;
- diarrhea;
- decreased appetite;
- increased activity of liver transaminases ;
- in some cases, with an increase in recommended dosages of the drug, inhibition of liver function is possible;
- vaginal dysbiosis with prolonged therapy at high dosages in women;
- bronchospasm;
- allergic rashes;
- angioedema, urticaria.
Overdose symptoms
With a significant increase in 400 mg dosages recommended by the instructions for use with Macropen and prolonged use of the drug, patients may experience signs of an overdose, which, in most cases, are expressed in strengthening the above adverse reactions and numerous disorders of the liver and kidneys.
In the event of a similar situation, it is recommended to rinse the stomach as quickly as possible and take enterosorbents. If necessary, symptomatic therapy may be given.
If the correct doses of the drug are observed, cases of overdose are extremely rare.
Drug interaction
What else can you learn from the instructions for use? “Macropen” for adults and children should not be prescribed simultaneously with other antibacterial drugs of the macrolide class, since the risk of developing side effects and overdose is significantly increased.
The concomitant use of this drug with Warfarin and Cyclosporin slows down the process of their elimination from the body, as a result of which negative symptoms may develop in patients. It is necessary to consider and adjust the dosage if necessary, such a therapeutic interaction.
Special recommendations
The use of the drug "Macropen" for more than seven days can lead to the development of sensitivity of the infectious pathogen to the active active element of this drug. In the absence of the expected therapeutic effect, it is recommended to consult a doctor for the selection of another drug.
When severe diarrhea develops during treatment with the Macropen medication, the patient should consult a specialist to exclude pseudomembranous colitis.
It is also forbidden to independently reduce the prescribed dosage or cancel treatment with this agent when the condition improves, since this can lead to the development of pathogen resistance to the active substance and the resumption of clinical symptoms of the disease, which requires the selection of a stronger drug in high doses.
This medication does not affect the activity of the nervous system and is not able to slow down the speed of mental and motor reactions. This is confirmed by the instructions for use with Macropen 400 mg tablets.
Analogs
In order to find a full-fledged generic, you need to look for it in the same pharmacological category - macrolide antibiotics, which are classified according to structure and origin (semi-synthetic and natural).
The first generation of macrolides includes erythromycin and oleandomycin. Semi-synthetic drugs of this series:
- "Dirithromycin";
- Clarithromycin;
- Flurithromycin;
- "Roxithromycin."
The second generation of antimicrobials with a more modern molecular structure includes medicines:
- Spiramycin
- Leukomycin;
- "Josamycin";
- "Midecamycin."
Special attention should be paid to the drug "Azithromycin" - an unnatural macrolide that is between the first and second generation and forms a group of azalides, to which pathogens practically do not develop resistance.
As a full replacement for the Macropen antibiotic, experts recommend the following analogues:
- Aziklar;
- Azro
- "ZIT-250";
- Ezeklar
- Hemomycin;
- "Starket";
- "Sumamed";
- "Azithromycin";
- "Klafar";
- Clindamycin;
- Lekoklar;
- Azimed
- "Azithrom";
- "Renicin";
- Claricin;
- Azinort;
- "Azit";
- "Asiaggio";
- Klasan
- "Dazel";
- "Free Max";
- "Roxide";
- Wilprafen
- "Defense";
- Ormax
- "Roxysandosis."
Drug price
The approximate cost of Macropen in tablet form is 330 rubles. It depends on the region and the pharmacy network.
Reviews
This medication is today a very popular antibiotic of the macrolide category and is used for a wide variety of pathological conditions of an inflammatory nature.
Most of the patients who took this medicine were satisfied with the result of its therapeutic effect, and observed that upon infection with an infection of one kind or another and the subsequent development of the disease from taking these antibiotics, their general state of health significantly improved, and the symptoms of the disease quickly disappeared. In addition, patients noted that when starting therapy in the early stages of the pathology, the drug has a better effect and, in some cases, it is possible to avoid the development of the disease.
Experts are also confident that this medication very effectively helps fight the diseases listed in the indications for the use of the drug, however, they do not advise patients to use this medication on their own, since improper dosages and methods of use can adversely affect their health. They recommend that when developing a pathological condition, it is mandatory to receive medical advice in order to properly formulate treatment and quickly eliminate the pathology.
We have reviewed the instructions for use and analogues for the Macropen product.