"Flexid" is a bactericidal antimicrobial drug. He has a wide range of influence. Reviews about "Flexid" are abundant.
The medication has the following dosage forms:
- Film-coated tablets, octagonal, biconvex, light pink-orange, risk either on one side (500 mg) or on two sides (250 mg) (five, seven or ten pieces in a blister, a cardboard bundle includes one, two, three or five blisters).
- Infusion solution: a clear liquid of greenish-yellow color (50 or 100 milliliters in a disposable low-density plastic bag, there is a loop for hanging, a cardboard bundle includes one, five or twenty bags).
According to reviews, Flexid 500 mg is very popular.
Structure
One tablet contains the active ingredient levofloxacin hemihydrate; excipients: sodium carboxymethyl starch, talc, lactose monohydrate, croscarmellose sodium, anhydrous colloidal silicon dioxide, glyceryl dibehenate, povidone. The film membrane contains titanium dioxide, talc, macrogol 6000, iron red oxide, hyprolose, hypromellose, iron yellow oxide.
One milliliter of solution includes: the active component of levofloxacin hemihydrate; excipients sodium hydroxide solution 0.1 M, water for injection, hydrochloric acid solution 1 M, sodium chloride.
Indications for use
The medication, in accordance with the instructions, is recommended for use in the treatment of infections that are excited by strains of microorganisms sensitive to levofloxacin:
- urinary tract infections (uncomplicated and complicated, including pyelonephritis);
- bacterial chronic prostatitis;
- infections of the lower respiratory tract (chronic and acute bronchitis, community-acquired pneumonia);
- soft tissue and skin infections;
- infections of ENT organs (acute sinusitis) - for tablets;
- for solution - pulmonary anthrax (treatment and prevention);
- drug-resistant types of tuberculosis (as part of a comprehensive treatment).
According to reviews, "Flexid" from prostatitis helps a lot.
The recommended single dose for the treatment of chronic prostatitis should be no less than 500 mg. A higher dose can be prescribed only after examination of the patient for the presence of renal failure. The course of treatment for chronic prostatitis is four weeks. If necessary, the course can be repeated, taking a break of one month.
Contraindications
The drug is prohibited in the following situations: minor age; epilepsy - the frequency of seizures increases.
Special attention should be paid to alcoholic beverages, since Flexid is one of the antibiotics, and alcohol should be discontinued during treatment.
A contraindication to the use of the drug is pregnancy. There is no information on the penetration of the active component into the milk of a woman, but with lactation, treatment should be suspended.
The correct use of Flexid is of great importance.
Instructions for use: dosage and method
Dosage and duration of treatment are determined based on the severity, nature of the infection and indications. Treatment with the drug should be continued from 48 to 72 hours after the elimination of the symptoms of inflammation. The therapeutic course is prohibited to terminate prematurely or to suspend without medical prescription.
Flexid tablets should be taken once or twice a day orally, not chewed and swallowed, washed down with plenty of water. Eating does not affect the effectiveness of the drug. If necessary, in order to facilitate the selection of the dosage, the tablet can be broken into dividing risk into parts. With oral administration of the drug, the maximum daily dosage should not be more than a thousand milligrams. The solution is administered slowly by intravenous drip infusion once or twice a day. Infusion infusion continues for at least half an hour with the introduction of a dosage of 250 milligrams and an hour - 500 according to the instructions to Flexid.
We will review reviews about the drug below.
The infusion solution can be combined with a solution of sodium chloride 0.9%, glucose solution 5% or in Ringer's solution at a concentration of 2.5%, combined solutions that are intended for parenteral nutrition (amino acids, electrolytes and carbohydrates). The solution must not be mixed with such solutions that have an alkaline reaction, or with heparin. If after 2 to 4 days of intravenous infusion an improvement in the patient's condition is achieved, it can be transferred to the oral use of an antibacterial drug. Since when administered orally, the bioavailability of the active substance reaches 100%, when the patient is transferred to the form of tablets, a dose adjustment is not required.
Side effects
According to reviews of "Flexide", the drug can cause the following side effects:
- Gastrointestinal tract: often - nausea, diarrhea, vomiting; infrequently - abdominal pain, dyspepsia, flatulence, constipation; with an unknown frequency - hepatitis, pancreatitis, diarrhea with blood impurities (in some cases, it is possible to judge the development of enterocolitis, including pseudomembranous colitis), stomatitis.
- Bile ducts and liver: often - increased activity of alkaline phosphatase, gamma-glutamyl transferase and liver transaminases; infrequently - a higher concentration of bilirubin in the plasma; unknown frequency - hepatitis, jaundice, severe liver failure, including acute failure, in some situations with a fatal outcome, mainly in patients with severe underlying disease (for example, with sepsis).
- The system of the heart and blood vessels: often for a solution of "flexid" - phlebitis; rarely - decreased pressure, sinus tachycardia, palpitations; unknown frequency - ventricular rhythm disturbances, an extended QT interval, ventricular tachycardia of the Pirouette type (most often if there is a risk of a prolonged QT period that can cause cardiac arrest).
- From the nervous system: the most common symptoms are headache, insomnia, dizziness; infrequently - anxiety, high excitability, anxiety, tremor, drowsiness, confusion; in rare cases - convulsions, nightmares, paresthesias, disorientation, agitation, psychotic disorders, depression (including hallucinations, paranoia); unknown frequency - intracranial benign hypertension, sensory peripheral neuropathy, syncope, sensory-motor peripheral neuropathy, dyskinesia, coordination disorders (including extrapyramidal defects), suicidal attempts / thoughts, mental disorders accompanied by behavioral disorders and self-harm.
- Eating disorders and metabolism: an infrequent case - anorexia; in rare situations - hypoglycemia (high sweating, trembling, increased appetite - mainly in patients with diabetes mellitus); very rarely - porphyric seizures (porphyria - a rather rare violation of material metabolism, seizures appear in patients who already suffer from this disease, in accordance with the experience of using other quinolines; the possibility of such a complication is not excluded also with levofloxacin); unknown frequency - hypoglycemic coma and hyperglycemia.
- Sense organs: violation of the sensitivity of taste (dysgeusia), vertigo; rarely - visual impairment, tinnitus; unknown frequency - loss or loss of hearing, loss or impairment of smell, transient loss of vision, loss of taste sensitivity (ageusia).
- Urinary system: infrequently hypercreatininemia occurs; in rare cases, acute kidney failure (including the result of interstitial nephritis).
- Muscular and skeletal system: arthralgia, myalgia; in rare cases, tendonitis, muscle weakness (especially important for patients with myasthenia gravis); unknown frequency - arthritis, ligament / muscle rupture, tendon rupture, for example, Achilles, rhabdomyolysis.
- Respiratory systems: shortness of breath, bronchospasm, allergic pneumonitis.
- Immune system: hypersensitive reactions, angioedema, anaphylactoid and anaphylactic shock (in some cases after the first intravenous administration of the drug).
- Soft tissue and skin: infrequently - hyperhidrosis, skin rash, urticaria, itching; leukocytoclastic vasculitis, photosensitive reactions, erythema multiforme exudative, Lyell syndrome (epidermal toxic necrolysis), Stevens-Johnson syndrome.
- Lymphatic system and blood: infrequently - eosinophilia, leukopenia; rarely - neutropenia, thrombocytopenia; unknown frequency - hemolytic anemia, agranulocytosis, pancytopenia.
- Other: reactions at the injection site (redness, pain); infrequently - fungal infections, superinfection, asthenia; pyrexia (body temperature rises); in some cases, pain, including giving away in the sternum, limbs, back.
This is confirmed by the instructions for use and reviews of Flexid 500 and 250 mg.
Overdose
Symptoms of an overdose of the drug include: nausea, erosion of the mucous membranes of the gastrointestinal tract, tremors, dizziness, hallucinations, convulsions, prolongation of the QT period, loss / impaired consciousness. In this case, ECG indicators are monitored, as well as symptomatic treatment. Hemodialysis is ineffective, specific antidote is unknown.
Impact on the ability to control complex mechanisms and vehicles
During the use of Flexid, confusion, dizziness, visual impairment, and other negative effects can be observed that lead to a decrease in concentration of attention, as well as the speed of mental / motor reactions. Patients who receive the drug should therefore be especially careful when driving vehicles and operating other complex machinery. Analogues of Flexida should be selected by a doctor.
Use during Pregnancy and Breastfeeding
When conducting experiments on animals, the reproductive toxicity of the drug was not found. Since there is no similar information on the use of the drug in humans, and also taking into account the possible negative effect of medicines of the fluoroquinolone series on the points of cartilage growth of the skeleton (in accordance with experimental information), the appointment of pregnant women is prohibited. It is not known whether the drug passes into breast milk, so if you need to use "Flexida" during the lactation period, you must stop breast-feeding.
Use in pediatrics and the elderly
At a minor age, the use of Flexid tablets of 500 and 250 mg is impossible due to the alleged threat of joint cartilage disturbance.
Elderly patients do not need to change the dosage regimen of the drug, however, it is necessary to control QC, since patients of this age category increase the likelihood of a concomitant decrease in renal function.
Drug interaction
No pharmacokinetic interaction with theophylline was found, but with the combined use of this drug with quinolones, the threshold for convulsive readiness may decrease.
With fenbufen, the concentration of the active substance increases by approximately 13%, with cyclosporine, the half-life increases by 33%. Cimetidine and probenecid - the renal clearance of the active component decreases by 24 and 34%, respectively, as a result of suppressing the secretion of tubules (such combinations are used carefully, especially if there are functional renal impairments).
Glibenclamide, digoxin, calcium carbonate, ranitidine - no clinically significant effect was found on the pharmacokinetics of the active substance. Warfarin and other vitamin K antagonists - blood coagulability indicators, that is, the prothrombin period, and / or the likelihood of bleeding in the patient increase.
Analogues of Flexida
The medication has the following analogues: Levoximed; Eleflox; “Lebel”; "Ekolevid"; "Ivacin"; Hayleflox; "Wry"; "Floratsid"; Levotek; "Tanflomed"; "Levolet R"; "Tavanic"; Levostar; Signicef; Levotek; Roflox Scan; Levoflox; "Remedia"; "Levofloxacin STADA"; Oftaquix; "OD-Levox"; Levofloxacin-Nova; Maclevo Levofloxacin-SOLOpharm "; "Lufi"; "Levofloxacin-Teva"; Lefsan; Leobeg "Lefoktsin"; Leflobact.
Also, many want to find analogues cheaper than Flexida. These include: “Ciprofloxacin”, “Leflobact”, “Levofloxacin”.
Reviews
About "Flexide" in tablet form, speak quite controversially. Some patients consider the drug effective, successfully used to treat many infectious diseases.
"Flexid", according to reviews, quickly eliminates signs of inflammation, lowers temperature, improves the condition of the body, it is also convenient to use and has an affordable cost.
Other patients consider the effect of the antibiotic not so effective, they talk about a large number of adverse reactions that occur during treatment (the most common are insomnia, dizziness, vomiting, muscle weakness, nausea, pain in the liver and stomach, heart palpitations), and in some cases, for this I had to cancel the drug. About solution for infusions; no reviews.
We reviewed the application "Flexid" instructions for use and reviews.