Tiapridal is an antipsychotic drug made on the basis of tiapride. The medication is used as a sedative, analgesic and sleeping pill. The basis of antipsychotic action is the blocking of dopamine receptors, which significantly affect the functioning of the central nervous system. In this article we will talk in detail about the drug.
Release form, the components of the drug
The medicine is available in two forms, tablets and solution can be purchased:
- One tablet, like one ampoule, includes 100 milligrams of the main component and excipients. As auxiliary ingredients in the composition used povidone, magnesium stearate, mannitol. The composition is also supplemented with aqueous colloidal dioxide, silicon and microcrystalline cellulose.
- In addition to the main component, the solution includes sodium chloride and water for injection.
One box contains 20 tablets (2 blisters of 10 tablets) or 12 ampoules (2 blisters of 6 ampoules). Instructions for use "Tiapridal" in the form of a solution for injection allows you to enter intravenously and intramuscularly. This form of the drug is suitable only for the treatment of adult patients.
Pharmacodynamics of Tiapridal
The drug has antipsychotic, analgesic and anxiolytic effects. According to the instructions for use, Tiapridal selectively blocks the functioning of D 2 receptors of central dopamine. In this case, no effect is exerted on the D 1 receptors. The drug allows you to get rid of dyskinesia, when used in old age, improves thinking.
Pharmacokinetics of Tiapridal
With intramuscular injection of the drug (200 mg), its maximum level in the body is detected after 30 minutes, when using tablets in the same dose - after 60 minutes. The bioavailability when using the drug immediately before eating increases from 75% to 95%. Due to this use of the drug, its maximum level in the body rises (by 40%).
Absorption in the body of elderly patients is slower. "Tiapridal" instructions for use include agents that penetrate the placental and blood-brain barriers. It is known that during the period of therapy, the drug is present in the composition of breast milk. In women, partial elimination of the drug occurs faster than in men (in 2.9 hours), the difference is 0.7 hours. Metabolism is characterized as moderate. The main part of the drug (70%) is removed from the body by the kidneys unchanged.
Indications for the use of the drug "Tiapridal"
For the implementation of therapy using the medicine “Tiapridal”, the readings are as follows:
- dyskinesia (late, spontaneous);
- Gilles de la Tourette syndrome;
- chorea;
- behavioral disorders (aggressive states, agitation, etc.) that occur mainly in chronic alcoholism and in elderly patients;
- negative manifestations in behavior, such as aggressive state and agitation;
- pain of an intense nature (chronic forms).
Contraindications, restrictions on the use of the drug "Tiapridal"
It is forbidden to prescribe "Tiapridal" instructions for use for children whose age is less than six years. In pediatrics, therapy is carried out only in tablets. The drug can not be treated by pregnant women and patients who are breastfeeding. The medication is not used with increased sensitivity to its components and other similar means. Contraindications include the following conditions:
- significant hepatic and renal failure;
- diagnosis of prolactin-dependent neoplasm, suspicion of its presence;
- hypertensive crisis;
- diagnosis of pheochromocytoma, suspicion of its presence.
Tablets and solution are not used together with Sultoprid and dopamine receptor agonists (the exception is the treatment of patients with Parkinson's disease), they are not combined with certain types of antipsychotics, antiarrhythmic drugs belonging to classes III and I A.
The treatment with the medicine “Tiapridal” does not allow the instructions to be performed simultaneously with the use of “Moxifloxacin”, “Sparfloxacin”, “Difemanil”, “Erythromycin”, “Bepridil”, “Misolastine”, “Levadopa”, “Cizapride” and with the intravenous administration of “Vincamine” .
If a patient (especially the elderly) is undergoing treatment with drugs that can lead to the development of hypokalemia, worsening of cardiac conduction, lengthening of the QT interval, and the occurrence of pronounced bradycardia, use Thiapridal with caution. Caution is also required in such cases:
- Parkinson's disease;
- lengthening of the QT interval is congenital in nature;
- hypokalemia;
- chronic course of renal failure;
- bradycardia;
- diseases in which the cardiovascular system is disrupted (decompensation stage);
- epilepsy.
Treatment with Tiapridal
Instructions for use “Tiapridal” first recommends using in small doses, gradually increasing them, in order to obtain the maximum effect.
Behavioral Disorders
For their relief, it is necessary to use 200 mg of the drug daily (up to 300). A positive effect is achieved on average in a month and a half. Elderly patients are prescribed a lower dose of the drug - 50 mg. A single dose should be used twice a day, while its increase is allowed in compliance with a certain interval, this action is performed gradually, taking into account the recommendations of a specialist. The daily dose may not exceed 300 mg.
Chronic intense pain
The daily dose of medication for the treatment of such conditions is from 200 mg to 400.
Chorea, Gilles de la Tourette syndrome
When treating a child, the daily dose of the drug is selected taking into account body weight and is 3-6 mg / kg. If therapy is required for an adult, first use 25 mg of the drug per day, later (after a gradual increase in dose) - 300-800 mg.
Agitation, aggression
The recommended daily dose of the drug is from 100 mg to 150.
Behavioral Disorders
The recommended dose for daily use (from 200 to 300 mg) in the case of the development of a delirious or pre-lirious state rises to 400-1200 mg. The maximum possible dose that cannot be exceeded is 1800 mg. The introduction of the drug is carried out on average with an interval of five hours. If treatment is necessary for an elderly person, 2-3 injections are made daily, between which an interval of 6 hours is observed. For the treatment of such patients per day, it is recommended to take from 200 mg of the drug to 300. At a time, no more than 100 mg of Tiapridal is allowed.
Intense chronic pain
Therapy is based on the introduction of a daily dose corresponding to 200-400 mg of the drug.
Side effects when taking the drug "Tiapridal"
In the treatment with the drug "Tiapridal" instructions for use, reviews confirm the likelihood of some adverse reactions. Violations of the genitourinary, nervous, endocrine and cardiovascular systems can occur. In addition, there is a risk of problems with the senses. Other negative effects include allergies, accompanied by skin manifestations, weight gain, orthostatic hypotension.
Overdose of Tiapridal
When using an overdose of the drug, an overdose is possible, its symptoms are impaired consciousness, the most serious of which is coma, antipsychotic syndrome (malignant, acute). In order to eliminate this condition of the body, treatment is based on anticholinergic drugs. After drug withdrawal, symptomatic treatment and plasmapheresis are necessary.
special instructions
Before using the medicine “Tiapridal”, the instructions for use recommend that you perform a correction of hypokalemia. During therapy, it is important to constantly monitor the electrolyte balance, conduct an electrocardiogram, and monitor changes in the clinical picture.
If extrapyramidal syndrome develops as a result of taking antipsychotics, anticholinergic drugs should be used instead of the dopamine receptor agonist.
At the time of treatment, it is worth abandoning activities that pose a potential danger, it is not recommended to perform work that requires special care and a quick reaction.
Interaction with other substances
The combination of some drugs with taking the medicine "Tiapridal" instructions, reviews are associated with the likelihood of unwanted reactions of the body. It is not recommended to use "Clonidine", antihistamines, anxiolytics, barbiturates and opioid analgesics during therapy, since the effect of "Tiapridal" will be more pronounced. Due to incompatibility, do not take Levodopa and alcohol. The medication can be combined with the use of neurotropic drugs, analgesics, antidepressants, antipsychotics. There is a high risk of orthostatic hypotension with the simultaneous use of antihypertensive drugs with Tiapridal.
The cost of the drug, analogues, reviews on the drug "Tiapridal"
If necessary, be treated with the “Tiapridal” agent, instructions, description allow you to find out what the drug is. The price of the drug is important when choosing a medication for therapy. A solution in ampoules can be bought for about 995 rubles, and tablets - for 1400 rubles.
Among the analogues of the drug are Eglonil, Betamax. From substitutes can be selected “Sulpiride” or “Prosulpine”. There is another analogue of the drug - “Tiaprid”, it is considered the most affordable, it is a fairly popular option, a domestic drug, produced by the company “Organika”. The composition of Tiaprid contains the same active substance that is part of the medicine Tiapridal. Instructions for use analogues are advised to select when the original cannot be used simultaneously with some drugs, causes side effects or does not provide the desired effect. To make the drug most effective, when choosing it, many points are taken into account.
During the treatment period, it is important to follow all the doctor’s advice and recommendations, which contains instructions for use. “Tiapridal”, as the reviews show, in most cases is used to eliminate conditions accompanied by nervous excitement and aggressive behavior, alcoholic psychosis. Patients and doctors are usually satisfied with the result of therapy. Basically, a second course is not required for the reason that the desired effect develops after the implementation of the first course. Reviews show that for patients, the medicine “Tiapridal” is convenient to use.