The drug "Warfarin" instructions for use are classified as anticoagulants of indirect exposure. The medicine is able to suppress the synthesis of coagulation factors (K-vitamin dependent), as well as S and C proteins in the liver. The optimal anticoagulant effect is observed on the third or fifth day after the start of therapy and stops after three to five days from the last dose. The drug is available in tablet form.
It is recommended when taking the medicine "Warfarin" diet, which involves maintaining approximately the same amount in the diet of vitamin K.
Indications
The drug is prescribed for the prevention and treatment of thromboembolism and vascular thrombosis. The instructions for use include thromboembolism and acute venous pulmonary artery thrombosis, re-occurrence of myocardial infarction, postoperative thrombosis as indications for the drug "Warfarin". The drug is prescribed for thromboembolic or surgical elimination of thrombosis (as an additional tool), for atrial fibrillation (electric cardioversion), recurrent (repeated) venous thrombosis, and thromboembolism in the pulmonary artery. Means "Warfarin" recommends the use instructions for prosthetics of blood vessels, as well as heart valves (combined use with acetylsalicylic acid is allowed ). In addition, the drug is prescribed for thrombosis of the cerebral, coronary and peripheral arteries, as well as for the secondary prevention of thromboembolism or thrombosis with flickering in the atria or after a heart attack.
Contraindications to the drug "Warfarin" instructions for use include individual intolerance, kidney or liver diseases of severe course, acute bleeding, arterial hypertension (of a severe nature), exacerbation of an ulcer in the stomach or duodenum, hemorrhagic diathesis, lack of S and C proteins, alcoholism, cerebral hemorrhage, renal failure, acute DIC, thrombocytopenia. The drug is not prescribed during pregnancy.
The most common side effect when taking "Warfarin" is bleeding. In rare cases, there is skin necrosis, increased liver enzymes, diarrhea, eczema, hair loss, vasculitis.
Dosage
The drug is indicated for oral administration. A single use at the same time is recommended. The initial dosage is from two and a half to five milligrams per day.
The subsequent regimen of the drug "Warfarin" (INR or prothrombin time is taken into account) is determined individually. Two to four times from the original should be increased prothrombin time. In this case, INR (international normalized ratio) should reach (depending on the pathology, the likelihood of bleeding, the risk of thrombosis) 2.2-4.4.
For elderly patients or in a weakened state, low doses of the drug "Warfarin" are prescribed.
Before the approaching operation (in the case of a predisposition to the development of thromboembolic complications), therapy begins two to three days before the intervention.
In acute thrombosis, treatment is carried out in combination with the Heparin medicine until the anticoagulant effect is fully manifested (as a rule, not earlier than the third or fifth day).
The duration of therapy depends on the patient's condition.
Before starting treatment, it is necessary to determine the INR indicator (in accordance with prothrombin time, taking into account the sensitivity coefficient of thromboplastin).
According to many patients, the medicine "Warfarin" is not only effective, but also convenient, since you need to take it only once a day. In addition, the drug is well tolerated, side effects are extremely rare. However, before using the drug, you must consult a specialist and carefully read the instructions.