Assigned for the treatment of diabetes, Metformin has established a pronounced predictable effect on the endocrine system. Doctors suggested that this tool can be effectively used in the treatment of other pathologies due to hormonal problems. In particular, as observations and studies have shown, Metformin treatment of polycystic ovary (PCOS) is reasonable and effective.
What is this about?
PCOS is one of the widespread "female" diseases. On average, almost every fifth woman in the period of reproductive activity suffers from this pathological condition. Polycystic disease is classified as endocrine disease. With it, the performance of the ovaries is impaired, the reproductive function of the body and the endocrine function are affected primarily. Metformin, used during polycystic disease, makes it possible to smooth out hormonal disorders, since pathology leads to an inadequate concentration of estrogen and progesterone in the body. If PCOS is diagnosed, self-medication is not allowed. This is a serious illness that can cause infertility and diabetes. It is known that against the background of such a disease, the danger of malignant processes is higher.
About the disease in more detail
Doctors who worked on how Metformin affects the ovaries took into account the characteristics of what is happening in the human body with PCOS. However, first it is worth considering the nuances of this disease from the very beginning. In particular, information about factors that can initiate pathological processes is curious. So, if insulin is excessively generated in a woman’s body, the risk of PCOS is much higher. An increase in the content of this hormone initiates the generation of androgens - this process takes place in the ovaries. This negatively affects the development of the follicle, due to which ovulation cannot proceed normally. By identifying such a mechanics of the disease, scientists have suggested that hypoglycemic drugs can help women with PCOS. As it became known from further observations, this assumption was true. The drug stabilizes the generation of insulin, as a result, other processes associated with the hormonal background gradually come back to normal.
What is Metformin?
Metformin, used to treat polycystic ovary, belongs to the class of antidiabetic medicines. This pharmaceutical product is classified as biguanides. It is designed to eliminate insulin resistance. The effectiveness of the active compound is multifaceted. "Metformin" reduces the resistance of tissues on the periphery to the hormone insulin, and also normalizes glucose metabolism. In the process of taking a pharmaceutical product, the fat profile of the blood changes positively. If diabetes is established, the progress of the disease slows down significantly. The best ovulation is observed, the concentration of testosterone decreases. Under the influence of the drug, the menstrual cycle becomes better.
Effective, as you can conclude from the reviews of doctors, with polycystic ovary, Metformin also helps to stabilize weight and get rid of extra pounds. Usually, treatment with this medication is combined with the normalization of the nutrition program, with the exception of particularly unhealthy foods, and a review of the daily routine. It is advised to introduce regular sports in reasonable amounts into habits, taking into account the characteristics of a person's condition.
Is it worth taking?
If you refer to the instructions for the drug, it does not find recommendations for taking the product with PCOS. The possibility of prescribing a medication is indicated by specialized studies on the problems of hormonal imbalance. Based on their results, the ability to stabilize the hormonal background in the case of PCOS is proved. In addition, the drug helps to stabilize the ovulatory cycle and generally improve the organ's performance.
As you can see from the reviews, Metformin was advised for many women with polycystic. Patients who listened to the recommendations of the attending doctor were satisfied with the result. Some, however, as can be concluded from materials published in specialized sources, have tried to use this medicine arbitrarily, without first consulting a doctor. In this case, the reviews of Metformin for polycystic ovary are not so positive. Some showed poor efficacy, others suffered intolerance or side effects. Only an experienced specialist can evaluate how applicable the drug is in a particular case, whether it will be useful. PCOS is a rather severe pathology, self-medication of which is categorically not recommended.
Technical Information and Rules
Characterized by positive reviews, “Metformin”, prescribed for polycystic ovary often enough, is available in tablet form. Each instance is made in the shape of a circle, has a shell, is made in white. The active ingredient is metformin hydrochloride. The capsule contains half a gram of this compound.
"Metformin" is allowed to sell only with the provision of a prescription by the attending doctor. It is strictly forbidden to prescribe a medication for yourself, since this can lead to unpredictable malfunctions in the body. The doctor will choose the optimal dose based on the characteristics of the patient’s body condition. First, the doctor will examine the patient, collect the medical history in order to know all the pathologies characteristic of the case, limitations, individual nuances. Be sure to prescribe tests to assess the quality of blood, urine. An important preliminary study is checking the sugar content in the circulatory system.
Typical application
Although in each case the doctor prescribes the program individually, it is known that there is a classical regimen - this is suitable for a rather large percentage of patients (but remember that in each case a correction may be necessary). You can learn about such a typical scheme by reading reviews about how to take Metformin ovary for polycystic ovaries. In them, women who received treatment with this remedy indicate that most often the doctor prescribes a medication to take one capsule three times daily. Accordingly, a single dose is half a gram of the active ingredient. "Metformin" must be swallowed before a meal, with it. It is necessary to swallow each capsule completely. You can not chew, dissolve. It is important to drink plenty of water with the drug.
Understanding how to take Metformin for polycystic ovary disease, it is necessary to evaluate the maximum dose limits. The body should not receive more than 1.7 g of active ingredient per day.
The therapeutic course in PCOS is quite long. On average, Metformin is used for six months or more. From time to time check the ovulatory cycle, the quality of menstruation. Ovulation usually becomes normal after six months of therapy. After completing the first course, you need to pause. If necessary, a repeated course is indicated. The duration of each such period, the duration of the pause is determined by the attending doctor.
Sometimes you can’t
It is important not only to know how to take Metformin for polycystic ovary (and other pathologies), but also to be guided in contraindications. Such conditions of the body are known in which the drug in question is strictly prohibited. The list of restrictions is relatively large. In no case should you receive Metformin if the functionality of the liver and kidneys is severely impaired. You can not prescribe a remedy to people suffering from severely occurring infectious pathologies. Contraindications are acute conditions, against which a violation of renal performance is possible.
"Metformin" is not used for gangrene. The drug is prohibited with coma against diabetes. The instructions explaining how to take Metformin for polycystic disease specify the impossibility of treatment with this agent if the patient is 60 years old or older. It is strictly forbidden to take pills if she underwent a serious operation.
Additional restrictions
You can not use the drug for milk acidosis. The drug is prohibited for women bearing a child or breastfeeding. Do not use "Metformin" for polycystic and other diseases if pathology is detected in a minor. For girls under the age of fifteen, other means must be selected - safe and permitted for such an age group.
It is strictly forbidden to take a pharmaceutical product if the patient's body is sensitive, susceptible to the main ingredient or other components used by the manufacturer. An allergic reaction, sensitization as a response to the components of the drug - conditions that exclude the possibility of treatment for them.
Unwanted effects
Among the negative consequences of taking Metformin is anemia, a decrease in the concentration of sugars in the blood, and lactic acidosis. Some were sick and vomited.
Possible pain in the abdomen. Some were worried about increased flatulence, an unpleasant aftertaste, loss of appetite and stool disorders. Such manifestations are characteristic of the initial period of the drug program and do not require specialized correction, do not force to refuse to take the drug.
It is known that tablets are capable of provoking an allergy. Most often skin reactions - rashes, itching, redness. There is a risk of hepatic impairment.
Many or few?
Assigned with polycystic Metformin must be taken in strict accordance with the recommended dosages. Excessive intake can cause unwanted reactions of the body. An overdose can be suspected if a woman is sick and vomits, if the stomach attracts attention with sharp sharp attacks of pain. Against the background of excessive intake, the chair is disturbed, the temperature drops. Muscle cramps are possible. If a person does not receive treatment, he gradually becomes worse. Breathing is depressed, the head is spinning, consciousness is confused, broken. There is a danger of a coma.
About risks and their importance
The most negative consequence of the excessive use of Metformin prescribed for polycystic ovaries is lactic acidosis. This is a serious condition, life threatening. It is formed if the concentration of lactic acid in the body rises. Such a condition without adequate outside assistance can provoke the death of a person. If you suspect lactic acidosis, you should immediately contact a qualified doctor.
Assuming an overdose of Metformin, you need to use the help of a qualified doctor as soon as possible. The best option is to call an ambulance.
Excessive medication requires urgent treatment. "Metformin" is canceled, the doctor selects the appropriate measures for symptomatic treatment. In general, blood dialysis is needed. Shown measures to stop symptoms characteristic of a particular case. An overdose of “Metformin” is treated only in stationary conditions.
Mutual action
With polycystic ovary "Metformin" can be prescribed in combination with other drugs. This largely depends on the condition of the person and the need to treat other pathologies, if any. When prescribing the medicine, the doctor will interview the patient to find out what she is already taking, the course of which drugs she recently completed. It is extremely difficult to independently assess the potential mutual influence of pharmaceutical products. Only an experienced doctor will make a combined scheme so that the funds do not interfere with each other.
It is recommended to avoid the combination of the medicinal product in question and Dinazole, since such a combination is associated with an increased risk of impaired sugar concentration in the circulatory system. Very carefully, “Metformin” and “Cimetidine” are prescribed at the same time, because of which the main active ingredient of the drug in question is eliminated by the body somewhat more slowly. It is strictly forbidden to take "Chlorpromazine" during treatment with "Metformin" polycystic ovary. This drug can reduce the rate of insulin release, lowers its concentration in the body.
If there is a need for antipsychotics, it is necessary to reduce the dosage of the pharmaceutical product in question. Combining Metformin and medications that affect the level of blood coagulation, you need to carefully select the dose, since the effectiveness of anticoagulants is somewhat reduced under the influence of metformin.
About the nuances
For polycystic ovaries, Metformin is not prescribed for pregnant women and those who are planning on conceiving a baby in the near future. If a woman feeds her child with her own milk, you can not use the medicine in question. If there is a reasonable need for taking the medication, you will have to transfer the child to an alternative feeding format.
If Metformin is prescribed for polycystic ovaries, if the need for this drug is due to other diagnoses, the entire treatment period will have to refrain from alcohol-containing drinks. You can not take medicinal products if they contain ethanol. Alcohol (regardless of form) greatly increases the risk of lactic acidosis, which, as indicated above, in severe cases can provoke the death of the patient.
Sometimes Metformin is prescribed for women who must adhere to a very strict diet - up to a thousand calories per day. If a specific case is characterized by such restrictions, the drug is administered under regular and strict medical supervision.
The active ingredient of the drug does not affect the person’s ability to drive cars or vehicles. You can just as successfully as before perform dangerous actions that require you to concentrate.
Relevance of the issue
PCOS is diagnosed if a woman's condition includes two signs of this disease from a complete list of features identified by doctors. Among the signs distinguish excessive content of androgens in the body, polycystic, an-, oligovulation in the form of a chronicle. Among all other pathological conditions, PCOS is most often detected when trying to determine why a woman has anovulatory infertility. This is especially true in developed countries. Among the typical clinical manifestations of this condition are irregular menstrual cycles, hirsutism, acne, hair loss, indicating an increased content of androgens in the body.
A connection between PCOS and two types of metabolic disorders was revealed. In America, organized research involving young women. It was found that in the case of the second type of diabetic disease, PCOS occurs on average 10 times more often than those who do not have diabetes. Decreased glucose tolerance, the second type of diabetic disease, often develops closer to the age of thirty. In the case of PCOS and overweight, such effects by 30 years were identified in 30-50% of the studied persons.
Research and their results
Additionally analyzed the frequency of occurrence of metabolic syndrome. It was established that with PCOS it is more likely - the frequency is two or even three times higher against the background of healthy peers with a similar BMI. About one in five women under the age of twenty with PCOS suffers from metabolic syndrome.
Finally, it was found that the risk of death from a heart attack is double that of a tendency to oligomenorrhea. Scientists have suggested that most of these individuals have PCOS.
"Metformin", in turn, is effective in the second type of diabetic disease. It inhibits hepatic glucose synthesis, increases the susceptibility of tissues on the periphery. An increase in such sensitivity was detected against PCOS without metabolic syndrome. Retrospective studies were conducted to show how the active ingredient of the drug is able to slow down glucose intolerance. The results are considered significant enough to be able to say with confidence: the drug really effectively prevents the progress of the condition.