In the article, we consider the instructions and reviews for "Metformin Canon" 850 mg. The ability to use this medication for weight loss was first established by athletes who used this drug in order to obtain additional energy from body fat. But his main indication is diabetes treatment.
Release format
The drug is produced in different dosages, and one of them is 850 mg. Instructions for "Metformin Canon" are available in each pack. The tool is made in the form of biconvex oval tablets, which have a white color.
Pharmacological effects
The medication in question is a hypoglycemic agent, which is referred to as biguanides. It can accumulate in the liver, in the kidneys and in the salivary glands. The effectiveness of this medication is directly related to the ability to inhibit gluconeogenesis. Its effectiveness is caused by the formation of free acids and the oxidation of fats, which affects the pharmacological effect of the drug:
- Lowering sugar levels.
- Increased sensitivity of the insulin receptor along with improved sugar absorption, acid oxidation and glucose utilization.
- Reducing the absorption of thyroid-stimulating hormone and glucose from the digestive system.
- Lower cholesterol, triglyceride and low density lipoprotein.
- The process of normalizing blood coagulation along with improving its rheological properties, which reduces the risk of blood clots.
- Weight loss as part of the treatment of obesity.
special instructions
According to the instructions for Metformin Canon, 850 mg, when using this drug, glucose control after meals and on an empty stomach is very important, along with regular monitoring of creatinine concentration (with preserved kidney functions once a year, and for older people with reduced clearance four times in twelve months). If there is pain in the muscles and abdomen, vomiting and weakness in the body, against a background of malaise (symptoms of lactic acidosis), and, in addition, with signs of genitourinary tract disease or pulmonary infections, you should stop taking the pills, and then consult a doctor.
When using the drug with other hypoglycemic agents, the ability to quickly psychomotor reaction is reduced. During the period of drug therapy, one should refrain from taking alcohol to avoid the occurrence of lactic acidosis. The drug is contraindicated during pregnancy, against the background of lactation, natural feeding ceases when there is a need for the use of Metformin Canon. For weight loss, this medicine is often used.
Slimming
Getting rid of kilograms with excess weight is a rather difficult task in psychological and physiological terms, as it requires considerable effort and significant changes in the usual way of life. In this regard, not only nutritionists, but also directly those who want to lose weight, are regularly in search of the easiest ways to normalize body weight. In recent years, it has become popular to use drugs to reduce the weight of drugs that are not intended for weight loss, but show such results in the treatment of the underlying disease.
One of these drugs is Metformin Canon. These pills are prescribed by doctors to lower their glucose levels in the presence of diabetes. Athletes and bodybuilders were the first to use Metformin Canon for weight loss. Further, having received numerous positive reviews, the drug began to go far beyond sports and medical circles.
Thus, in the fight against obesity with diabetes, the drug lowers glucose levels, which eliminates excess appetite with a craving for sweets. Athletes and girls on a diet that do not have diabetes use a medicine three times a day for 500 milligrams for twenty-two days (after which you need a break for a month). When taken, physical activity is required along with the exclusion of carbohydrate and fatty foods from the diet.
Drug interaction
As indicated by the instructions of Metformin Canon, 850 mg, it is contraindicated to use these tablets two days before and after the study using a radiopaque drug. There are drugs that must be used carefully with the remedy we describe:
- First of all, it is Danazol, which increases the possibility of hyperglycemic effectiveness.
- "Chlorpromazine" in high doses (100 milligrams per day) and antihypertensive drugs increases the concentration of glucose in the blood. "Chlorpromazine" decreases the release of insulin.
- In some examples, ketosis is caused by glucocorticosteroids, glucose tolerance decreases and its concentration increases.
- Loop diuretics increase the risk of developing signs of lactic acidosis.
- Injection of adrenergic agonists reduces the hypoglycemic effect.
- Derivatives of insulin, sulfonylurea, acarbose and salicylate increase the hypoglycemic effect.
- "Nifedipine" increases the absorption of metformin.
Indications for appointment
The medicine “Metformin Canon” is prescribed for adult diabetics with the second type of disease in the event that a lifestyle modification (low-carb diet along with adequate physical activity, control of the emotional state) did not provide absolute glycemic control.
For patients who are overweight, Metformin is the best choice. This drug can be well combined with hypoglycemic drugs of other pharmacological categories, in which the mechanism of action differs from biguanides. Combined therapy with insulin is also possible.
A drug is also prescribed for the treatment of type II diabetes in children who are older than ten years. It is used as a first-line single drug or in combination with insulin. Bodybuilders use this medicine to dry muscles, and girls with weight loss are experimenting, but this use is justified only when excess weight problems are associated with insulin resistance and metabolic failure.
Side effects
According to the instructions and reviews for Metformin Canon, 850 mg, in adults and in children, the side effects of taking the medicine are the same. There is a taste of metal in the mouth along with an upset digestive system in the form of a lack of appetite, nausea, abdominal pain, diarrhea and vomiting. The liver function indicator is violated, hepatitis occurs. Reactions such as B12 hypovitaminosis with allergic manifestations (skin itching, rash, erythema, urticaria) to the drug are very rare.
Overdose
This drug must be taken only in the prescribed portion, otherwise there may be a risk of overdose. Admission of Metformin, equal to 85 grams, can lead to the development of lactic acidosis, which will be accompanied by muscle pain, and, in addition, discomfort in the abdomen, nausea and vomiting. In the event that assistance is not provided in a timely manner, then an overdose of this drug can lead to dizziness, impaired consciousness and coma are not excluded. Now we turn to contraindications and find out when patients should not take this medication for treatment.
Contraindications
In accordance with the instructions for use with Metformin Canon, 850 mg, for persons under ten years of age and after sixty, subject to heavy physical exertion, it is forbidden to take this drug. The remaining contraindications may be associated with pathologies or other drugs:
- The presence of hypersensitivity to the drug or auxiliary components.
- Compliance with a non-nutritious diet.
- The presence of chronic alcoholism along with alcohol poisoning.
- Application two days before and after performing radioisotope and radiological studies.
- The presence of extensive injuries and surgical operations when insulin is needed.
- The development of a state of hypoxia (in the form of sepsis, shock, bronchopulmonary disease, kidney infections, and so on).
- The clinical manifestation of chronic and acute pathologies leading to the development of tissue hypoxia.
- The development of diabetic ketoacidosis, coma, precoma.
- The appearance of violations in the work of the kidneys or the failure of this organ.
- The occurrence of violations in the liver and its failure.
- The presence of acute conditions in which the risk of developing impaired renal function in the form of fever, dehydration (with the appearance of diarrhea, vomiting) increases.
- The development of lactic acidosis, in history, including.
Storage and sale conditions
The drug is released only by prescription. The shelf life of this product is two years, at the end of which it is forbidden to use this medicine. The medication should be stored in a place protected from light, which should be dry, at a temperature not exceeding twenty degrees.
The price of 60 tablets of "Metformin Canon" 850 mg - about 200 rubles.
Next, we find out what people write about this medication, and, in addition, we will get acquainted with the opinions of doctors about the effectiveness of the medication in question.
First, consider reviews about the "Metformin Canon" 850 mg from patients.
Patient Comments
In the reviews, patients confirm the effectiveness of the medication in question in the treatment of diabetes and as a means to lose unwanted kilograms. According to consumer reviews, Metformin Canon is an affordable and effective medicine, especially with regard to controlling glucose levels and body weight. Among the main disadvantages, the appearance of side effects from the digestive system is very often mentioned.
Doctors reviews
In their reviews of "Metformin Canon" 850 mg, experts also confirm the capabilities of this drug. But they warn that during therapy regular monitoring of glucose concentration should be carried out.
It is better to familiarize yourself with the reviews of doctors about Metformin Canon in advance.
Doctors write that while taking this drug, severe malaise, general weakness, pain in the muscles or abdomen along with vomiting can occur. In all these cases, patients should consult a doctor, as such symptoms may indicate the development of lactic acidosis.
In addition, doctors in reviews of Metformin Canon advise caution in cases of impaired renal function, for example, at the beginning of therapy with anti-inflammatory non-steroid drugs. Specialists recommend to patients with a doctor against the background of the development of manifestations of an infectious disease of the genitourinary system or bronchopulmonary infection.
What is the difference between Metformin and Metformin Canon?
In answer to this question, it is worth noting that Metformin is the international non-proprietary name for the substance, which is the only representative of the biguanide category. Any drugs based on it have their trade name of various manufacturers. That’s the whole difference. "Metformin Canon" and "Metformin" are the same means.
It’s just that Metformin is produced by the Serbian manufacturer, and Metformin Canon is Russian. Formally, there should not be any significant differences between them. However, in practice, differences can be associated with dosage adjustment.
Metformin Long Canon
This medication acts as an oral hypoglycemic agent from the category of biguanides. The mechanism of action is associated with the ability of the drug to suppress gluconeogenesis along with the formation of free fatty acids. The drug increases peripheral receptor insulin sensitivity. It is worth noting that "Metformin Long Canon" does not affect the amount of insulin in the blood, but changes its pharmacodynamics.
The drug stimulates glycogen synthesis. The transport capacity of all types of membrane glucose transporters increases. The medication, among other things, delays the absorption of glucose within the intestines, reduces the level of triglycerides, and also improves fibrinolytic blood properties. Against the background of the use of this drug, the patient's body weight remains stable or may moderately decrease.
Indications for the use of a prolonged drug
The main indication is type 2 diabetes in adults (especially among patients with obesity), provided that exercise and diet therapy are ineffective. In these cases, the drug is prescribed as part of monotherapy and in combination with other hypoglycemic oral agents or insulin.
Contraindications
Metformin Long Canon is not used in the following situations:
- Against the background of the patient's hypersensitivity to metformin or to various auxiliary ingredients.
- With diabetic ketoacidosis, precoma or coma.
- Against the background of insufficiency or impaired renal function.
- In acute conditions with a risk of developing renal dysfunction. In case of dehydration (with severe or chronic diarrhea, repeated vomiting), severe infectious diseases (for example, infection of the respiratory canals, urinary tract).
- The presence of clinically pronounced manifestations of chronic pathologies that can lead to tissue hypoxia.
- Conducting extensive surgical operations and injuries when insulin therapy is prescribed.
- The appearance of impaired liver function.
- In chronic alcoholism and acute alcohol poisoning.
- Against the background of a hypocaloric diet.
- Children under eighteen.
Method of administration and dosage of prolonged medication
This medication should be taken by patients inside. The tablets are swallowed, not chewed and washed down with a sufficient amount of liquid. They can be drunk once after or during dinner. The doctor selects the dose of the medicine individually for a particular patient based on the result of glucose concentration measurements.
For patients who have not previously taken metformin, the recommended initial dosage of this medicine is 500 milligrams once a day after dinner. Every ten or fifteen days, it is recommended to adjust the amount of medication based on the result of measuring glucose concentration in blood plasma. A slow increase in dose favors better tolerance by the digestive system.
Thus, the medicine “Metformin Canon” considered in the article was developed for the treatment of type 2 diabetes in adult patients. But, as has already been noted many times, at the moment it is gaining widespread precisely in the role of a means to achieve accelerated weight loss and is sometimes even appointed by people as nutritionists.
We reviewed the instructions for the "Metformin Canon" 850 mg.