The history of the use of this drug begins in the middle of the 20th century. When scientists succeeded for the first time in synthesizing the predecessor of Anaprilin, he received only positive reviews. In addition, they were awarded the Nobel Prize for developing an effective drug. The publication will tell about the composition and action of Anaprilin, indications and contraindications, dosages and reviews of the drug.
Composition "Anaprilina"
"Anaprilin" is a medication that is part of the adrenergic blocking group. The main active element in the composition is propranolol. It reduces the frequency and compression power of the heart muscle. The remaining substances included in Anaprilin only complement its action and do not have the same healing properties. What are these components? Here they are:
- Calcium stearate.
- Microcrystalline cellulose.
- Colloidal silicon dioxide.
- Hypromellose.
- Milk sugar.
- Talc.
- Starch.
Forms of drug release
According to reviews, Anaprilin is available for purchase only in tablet form. They are produced by manufacturers with a dosage of 40 and 10 milligrams. There are packages of 100, 50 and 10 pieces. Tablets are placed in multi-circuit cell plates made of plastic, and then in cardboard boxes. It is worth noting that some companies pack 50 and 100 pieces in sale in jars of dark glass. They are usually also placed in a cardboard block. Manufacturers always attach an insert with instructions and a description of the drug to all Anaprilin release options.
Indications for use
As a rule, doctors prescribe this drug to treat the vascular system and heart disease. Tablets are prescribed for myocardial infarction, atrial and sinus tachycardia, arrhythmias and mitral valve prolapse. Also, the tool effectively relieves the symptoms of oncoming migraine, eliminates heart rhythm malfunctions, essential tremor and treats extrasystole.
So, the indications for the use of "Anaprilin" are the following:
- Frequent pain and discomfort in the heart.
- Unstable angina pectoris.
- Cardiomyopathy.
- Arterial hypertension.
- Tachycardia.
- Pheochromocytoma.
- Coronary heart disease.
Many patients are interested in what pressure Anaprilin helps with. Doctors recommend taking this medication to lower high rates.
pharmachologic effect
The main active substance produces a hypotensive, antiarrhythmic and antianginal effect. With regular use, Anaprilin is able to reduce the compression rate of the heart muscle and its oxygen demand. As a result, peripheral vascular resistance improves and blood pressure normalizes.
In addition, Anaprilin helps to reduce the intake of calcium ions into the cells. It also stimulates digestion, increases uterine muscle contraction, and helps to stop bleeding after surgery and childbirth.
The antihypertensive effect is fully manifested after about two weeks of taking Anaprilin. Antianginal action is provided by reducing myocardial oxygen demand. That is, due to the achievement of a negative chronotropic effect. Also, judging by the reviews, "Anaprilin" reduces the severity of ischemia and provides an antiarrhythmic effect, which reduces the risk of sudden death.
The ability of the drug to prevent the occurrence of acute headaches is provided by reducing the expansion of the arteries. It also helps reduce tremor. Propranolol in large doses is able to have a sedative effect.
It is worth noting that Anaprilin is rapidly absorbed into the blood. The half-life of the active substance can last 3-5 hours. With prolonged use, this interval increases to 12 hours. With the help of metabolites, the kidneys remove 90% of propranolol from the body, but 1% remains in a stable form. As many patients note, the positive dynamics of treatment is noticeable after about a month of taking the drug.
Contraindications to the drug
Before starting treatment, consult your doctor. Perhaps he will prohibit taking the drug for some reason. There are a number of contraindications to Anaprilin, in which its use is prohibited. These are the following cases:
- Diabetes.
- Colitis.
- Bronchial asthma.
- Bradycardia.
- Hay fever.
- Heart failure.
- Severe stage of myocardial infarction.
- Vasomotor rhinitis.
- Blocking of the atrioventricular type, which is accompanied by ventricular heart failure.
- Reception of tranquilizers.
Doctors note that Anaprilin can affect the visual organs. Therefore, it is not recommended for people who drive vehicles. Also, it should be used with caution in acute depression, renal failure, and patients in advanced or childhood.
Compatibility "Anaprilina" and alcohol
With the simultaneous use of alcohol and Anaprilin, the effectiveness of the drug approaches zero. Some side effects may occur: severely low blood pressure, fainting, chills, nausea, vomiting. In the worst case, this can lead to rapid death. Therefore, it is better not to take risks and do not check in practice the compatibility of Anaprilin and alcohol. They absolutely can not be mixed!
Anaprilin for breastfeeding and pregnancy
In general, the effect of Anaprilin on a developing child is not well understood. Doctors only suggest that intrauterine growth can slow down during pregnancy, and bradycardia and hypoglycemia can begin. Also, the substances included in Anaprilin seep into the mother’s milk, which can also adversely affect the baby during breastfeeding.
The use of propranolol during pregnancy can only be justified in one case: if the potential risk to the bearing fetus does not exceed the expected benefit to the mother. Then in this case it is necessary to carefully monitor the health of the child. The same applies to the use of propranolol during breastfeeding. Doctors also recommend that you stop taking the drug 2-3 days before giving birth.
Even if there are indications for the use of Anaprilin, in no case should you prescribe it yourself during pregnancy and lactation! In such situations, consulting a doctor is vital.
Side effects
In rare cases, side effects may occur due to taking Anaprilin. Usually they are manifested by the following symptoms:
- Muscle weakness.
- Nausea and vomiting.
- Diarrhea.
- Stomach aches.
- Inflammation of the colon.
- Focal or complete baldness.
- Itching on the skin.
- Pharyngitis.
- Trouble breathing.
- Shortness of breath (dyspnea).
- Coughing.
- Bradycardia
- Depressed or depressed.
- Insomnia.
- Decreased libido and potency.
- Leukopenia
- Vision problems.
An overdose of "Anaprilin"
Also, side effects from Anaprilin may occur in case of an overdose. It manifests itself with the following symptoms:
- Difficulty breathing.
- Bronchospasm.
- Arrhythmia.
- Muscle cramps.
- Acrocyanosis.
- Dizziness.
- Headaches.
In case of an overdose, symptomatic therapy is necessary. But before that, you should first do a gastric lavage. To avoid overdose and minimize the risk of side effects, it is important to take Anaprilin only as directed by your doctor.
Dosage and route of administration
It is worth noting once again that Anaprilin can be taken strictly after the doctor writes out the prescription. The drug is recommended to be used half an hour before a meal with a sufficient amount of water. There is no need to chew tablets, break them in half or grind them into powder. The frequency of administration, dosage and duration of treatment is determined depending on the disease and the age of the patient. Here is the information contained in the instructions for "Anaprilin":
- With arrhythmias, you need to take tablets three to four times a day for 10-30 milligrams.
- With hypertension at the beginning of the disease, 80 milligrams is prescribed twice a day. That is, the total amount of the drug should not exceed 160 milligrams. Over time, if the doctor considers it necessary, the dosage can be increased to 320 milligrams per day.
- With angina pectoris, Anaprilin should be taken four times a day for 20 milligrams. And so the first three days. In the next three days, the dosage should be increased to 40 milligrams three times a day. After taking the drug, they are again brought up to 20 milligrams. If necessary, if there is evidence, Anaprilin can be taken five to six times a day, 40 milligrams each. That is, the total daily dose should be 200-240 milligrams.
- In case of migraine, according to the instructions, Anaprilin can be taken no more than 80-160 milligrams per day.
- After a heart attack, the drug is prescribed at 40 milligrams four times a day.
- For the treatment of essential tremor, at first a portion of 40-60 milligrams is divided into two or three times a dose of 20 milligrams. Gradually, the total daily dosage should be brought to 160 milligrams.
- In a panic attack, it is recommended to take Anaprilin from 1 tablet (or even from a quarter of a tablet). Dosage must be calculated taking into account the severity of the condition. The drug in a short time will reduce the frequency of compression of the heart muscle, normalize blood pressure, eliminate anxiety attacks and help get rid of fears that arose for no apparent reason.
The action of propranolol usually appears two hours after taking the pill. The effect can last up to five hours. To speed up the action, doctors recommend not to drink the drug with water, but to put Anaprilin under the tongue. In this case, the effect will manifest itself after a maximum of half an hour, but usually it can be noticed after twenty minutes. However, with this option of using tablets, you can feel numbness of the tongue.
As a rule, the course of admission lasts three to four weeks. If necessary, it can be renewed. But here it is important to observe the interval between courses. It should be at least 1.5-2 months. The dosage, course of administration and the appropriateness of its repetition can only be determined by a doctor. Experts say that this drug should be discontinued gradually. Otherwise, there is a risk of developing myocardial ischemia. Also, with a long course, it is important to take cardiac glucosides at the same time.
Anaprilin for children
Initially, this drug was intended only for adults. Today, doctors allow his admission even by children. But experts prescribe propranolol to minors only in the most extreme cases. The instructions indicate the following dosages of Anaprilin.
The drug can be given only to those babies who have reached the age of three. Dosage is calculated depending on body weight and disease. 0.25-0.5 milligrams of propranolol three to four times a day should be given per kilogram of the child’s weight. For convenience, it is better to purchase Anaprilin tablets at 10 milligrams. They are much easier to separate to the desired dosage.
If the child is taking this drug, then you need to closely monitor his condition and the ongoing changes. It is also necessary to be observed at the attending physician and periodically visit a medical institution.
Purchase and storage of Anaprilin
The drug can only be purchased in pharmacies. Moreover, some pharmacists sell it strictly by prescription. On average, Anaprilin costs 20-80 rubles. The price depends on the volume of packaging, manufacturer and region of sale of the medicine.
Anaprilin tablets should be stored in a dark place in which the air temperature does not exceed 8-25 degrees Celsius. The total shelf life of the drug is not more than four years.
Reviews about the drug
According to reviews, Anaprilin is an effective and inexpensive drug. People consider it the most affordable and easiest way to treat arterial hypertension. It is also often used as an emergency aid for migraines, panic attacks and a rapid pulse, which is associated with psycho-emotional stress.
Patients like the fact that the pills give an almost instant effect if they are placed under the tongue. Therefore, if necessary, the tool can be used once. However, it is not addictive.
In general, the reviews of doctors and ordinary people are positive. But they urge you to carefully study the instructions and consult a specialist. After all, this drug, like many others, has certain contraindications and side effects.
Modern analogues of Anaprilin
If for some reason Anaprilin is not suitable or is currently not on sale, then it can be replaced with other similar drugs. These include the following:
- Propranolol
- "Bisoprolol".
- Carvedilol.
- Nebivolol.
- "Metoprolol".
- "Niolol".
- "Propamine."
- Stobetin.
- "Noloten."
- Lokren.
- "Observed."
- "Inderal".
- "Phenazel."
- Ganfort.
- Xonef.
These modern analogues of Anaprilin are in a wide variety of price categories. Some of them are selective, while others are non-selective beta-adrenergic blockers. Both groups are suitable for lowering blood pressure. However, buyers note that some of the above drugs are difficult to find in the Russian pharmacy chain.
Even analogues have their contraindications and side effects. Therefore, before starting treatment, it is necessary to consult a specialist. Only a doctor can choose the most suitable drug and the right dosage.