Disruption of the hormonal background can be observed at any age. The reasons for the lack of hormones can be very diverse and sometimes it is not so simple to establish them. It remains only to fight in every possible way with the consequences, which, if not taken, can be serious. With a lack of estrogens, vaginal suppositories for Ovipol Clio microflora are often prescribed. Let us consider in more detail this drug, what indications and contraindications, what are the patient reviews.
The composition of the drug and the form of release
“Ovipol Clio” - candles (we will consider the reviews a bit below), which in their composition contain the main active substance - this is estriol. Auxiliary components are the composition of semi-synthetic glycerides. They do not come into contact with the active substance, but facilitate the administration of suppositories.
Chemical and pharmaceutical plant "Akrikhin" produces the drug in the form of vaginal suppositories. They are white with a yellowish tinge. There are 15 suppositories in a cardboard package.
Exposure to Estriol
After entering the body, the active substance is rapidly released and begins to exert its therapeutic effect on the pelvic organs of a woman:
- It affects the revascularization of epithelial tissue.
- Estriol (candles with it are very effective) contributes to the densification of epithelial tissues.
- The number of surface cells is increasing.
- The synthesis of cervical secretion is stimulated.
- With atrophy, the epithelium is restored and regenerates faster.
- The acid-base balance comes back to normal.
- Vaginal suppositories for microflora are simply irreplaceable, they quickly restore it.
- Candles improve blood circulation to tissues.
- The risk of developing an inflammatory process is reduced.
Also, candles have the following effect:
- Affect the positive or negative relationship between the pituitary, hypothalamus and the female reproductive cycle.
- As a result of the use of suppositories, the amount of cholesterol that is simply necessary for the synthesis of sex hormones rises.
- Glucose metabolism improves and insulin receptors increase sensitivity.
- The function of blood coagulation comes back to normal.
- The active substance of suppositories stimulates the function of the endocrine glands.
The use of suppositories has its advantage over hormonal pills, because the growth of estrogen is carried out smoothly, which significantly reduces the risk of developing oncology.
Indications for use of the drug
“Ovipol Clio” - candles (reviews confirm this), which have proven effective in the treatment of the following pathologies:
- Atrophic processes of the epithelium of the urogenital system, which are provoked by a lack of estrogen.
- In the preparatory period before surgery or during recovery from it.
- If the smear gives mixed results, then the candles are prescribed to clarify the diagnosis and a second analysis is done in a week.
- Senile colpitis.
- To eliminate dryness of the vaginal mucosa.
- As a prophylactic for relapse of diseases of the genitourinary system.
- To normalize the microflora of the vagina.
- In the preparatory or recovery period with vaginal plastic surgery.
- Suppositories effectively eliminate vulvar itching and help get rid of kraurosis.
- Atrophic cystitis is also successfully treated with the use of this drug.
- Therapy of vaginal ulcers.
Most often, “Ovipol Clio” (candles), the reviews of which we will consider, give a positive result after the first use, but the therapy should be fully completed in order to fix it for a long time.
Who does not show therapy
Despite the good effect of therapy with the use of Ovipol Clio suppositories, the instructions for use contain a number of contraindications for treatment:
- Oncology of the mammary gland.
- Malignant neoplasms are estrogen-dependent.
- Genital bleeding.
- Endometrial hyperplasia, not amenable to drug treatment.
- Existing or a history of thrombosis and thromboembolism.
- Do not prescribe the drug in conditions preceding thrombosis: ischemic attacks, angina pectoris.
- The presence of risk factors for the development of thrombosis, these include: damage to the heart valves, atrial fibrillation, pathology of the vessels of the brain or coronary arteries, uncontrolled hypertension, smoking.
- Thrombophlebitis.
- Cholestatic jaundice.
- The presence of such a diagnosis as otosclerosis.
- Diseases of the liver in acute form or in history. The drug is not prescribed until all indicators have returned to normal.
- The presence of hereditary factors predisposing to the development of thrombosis.
- The period of bearing a baby.
- Breast-feeding.
- Excessive sensitivity to the constituent components of the drug.
The list is quite extensive, so consultation with a doctor is mandatory before therapy.
You can also name the list of diseases in which treatment with the drug is allowed, but it is necessary to strictly dose and follow the scheme of use:
- Diabetes.
- Adenoma of the liver.
- Frequent migraine.
- Epilepsy.
- Inflammatory processes in the pancreas.
- Bronchial asthma.
- Coronary heart disease.
- Swelling.
- Heart failure.
Therapy regimen and dosage
Suppositories "Ovipol Klio" (instructions for use contain this information) are used only intravaginally and most often before bedtime. Depending on the severity of the pathology and condition of the body, the dosage and duration of therapy differ:
- If atrophy of the mucous membrane of the urogenital tract occurs, the doctor prescribes 1 suppository every day for several weeks, and then the dosage is reduced, depending on the symptoms present, to 1 suppository 2 times a week.
- If pre- or postoperative therapy is carried out, it is recommended to use 1 suppository daily for 14 days.
- If it is necessary to clarify the diagnosis, the drug is prescribed at 0.5 mg every other day for 7 days.
- For the treatment of senile colpitis, one suppository is prescribed for a night for two weeks.
If the patient skips taking the drug, then it is necessary to resume it as soon as possible, but just do not use 2 suppositories on the same day, a double dosage is not allowed. It must be remembered that attempts to use the drug orally can result in severe bleeding, headache, and vomiting.
Undesirable manifestations during drug therapy
“Ovipol Klio” - candles (reviews confirm this), which are often well tolerated by the body, as a rule, the manifestation of side effects is associated with exceeding the recommended dosage. Patients may experience:
- Headache.
- Soreness in the muscles.
- Dizziness.
- Disruption of the stomach.
- Feeling of fullness in the mammary glands.
- Genital itching.
- Swelling.
- In rare cases, visual impairment was observed.
- Lack of coordination of movements.
- Cramps.
This drug is considered quite safe if you follow the dosage and use it correctly.
Interaction of Ovipol Clio with other drugs
When choosing a therapy, the doctor always finds out from the patient what medicines he is taking at the moment. This must always be taken into account, since drugs can affect each other's effects. Candles "Ovipol Clio" enhance the effect of the following medicines:
- Drugs group barbiturates.
- Medicines for the treatment of epilepsy.
- Antibacterial drugs.
- Analgesics.
- Anticonvulsants.
- Hypoglycemic drugs.
- Thyroid hormones.
- Diuretics.
- Anticoagulants.
- Male sex hormones.
When prescribing the drug in conjunction with other drugs, it is necessary to adjust the dosage.
Special instructions for treatment with the drug
If there is a long-term therapy with Ovipolom Clio, it is recommended to undergo periodic examinations. Before starting the reception and every six months to undergo an examination with a gynecologist and mammologist. It is possible to use suppositories during menopause in women if the symptomatology reduces the patient's quality of life.
Before prescribing, the doctor should always relate the benefits and harms of therapy. During treatment, a woman should regularly report all cases of vaginal bleeding, the appearance of jaundice, and engorgement of the mammary glands. If pain occurs in the legs, chest, shortness of breath, then the doctor will prescribe a thorough examination.
Treatment will have to be canceled if:
- Diagnosed with a violation of the liver.
- A sharp increase in blood pressure.
- Migraine develops.
- Phlebitis.
If long-term estrogen treatment is carried out, then the risk of developing endometrial cancer increases. The higher it is, the greater the dosage and duration of therapy. The duration of hormone replacement therapy affects the risk of developing breast cancer. Against the background of treatment, the density of the mammary gland increases, which complicates the study.
If treatment continues for more than 5 years, then the risk of developing ovarian cancer also increases. A small part of patients develop, as a side effect, a malignant tumor of the liver. It significantly increases the risk of intra-abdominal bleeding.
HRT increases the risk of thromboembolism by almost 3 times. He is especially great in the first year of treatment. During the appointment of the drug, all risk factors must be taken into account, and if therapy is performed before surgery, the prevention of VTE is important. The drug must be canceled for a while, and after surgery to resume only after the patient is on her feet.
In old age, the risk of stroke increases. If treatment is prescribed for a young patient whose relatives have thrombosis, then a study is carried out for the presence of thrombophilic disorders. If any are found, then hormone therapy is contraindicated.
With a tendency to edema, the presence of kidney pathologies, especially with renal failure, hormone therapy should be carried out only under the supervision of a doctor.
Given that the main active ingredient in suppositories (estriol) increases the lithogenicity of bile, that is, the risk of developing gallstone disease.
The consequences of prolonged estriol therapy
If there is a long-term treatment with the use of sex hormones, then the vaginal microflora normalizes, the symptoms of senile colpitis decrease, but it must be borne in mind that there is a risk of developing pathological processes.
- Often a side effect of long-term therapy is endometrial cancer. The risk depends on the dosage and duration of treatment.
- The appearance of malignant neoplasms in the mammary gland.
- Ovarian cancer
- Neoplasms in the liver.
- Elderly patients are at high risk for ischemic stroke.
- Cholelithiasis.
- The occurrence of dementia.
During long-term treatment, it is necessary to periodically visit a specialist to monitor the course of therapy and its effectiveness, as well as to monitor the slightest deterioration in the patient's condition.
Ovipol Clio (candles): analogues
Any drug has its own analogues, as a rule, they have the same active substance, but the choice should be carried out under the guidance of a doctor. If we consider Ovipol Klio (candles), their price ranges from 500 to 600 rubles per package. For a drug in pharmacies, you can find Russian analogues, for example:
But there are imported drugs:
- Ovestin.
- "Elvagin."
- "Estrokad."
It must be remembered that if you decide to replace Ovipol Clio (candles) with an imported analogue, the price can be much higher and the result is almost the same. So is it worth it to overpay for a foreign manufacturer? You should always discuss all issues related to drug replacement. The active substance may be the same, but you can not discount the presence of auxiliary components, which may also have an effect on the tolerance of the product.
Patient Reviews
If you look at the reviews of patients who have been treated with this drug, then you can find different opinions. Some respond positively, note that a few days after the start of use, the vagina was dry, the itching disappeared, and the symptoms of the menopause became less pronounced. Women note that Ovipol Klio copes no worse than Ovestin.
But some women did not help candles or caused discomfort, burning. If such symptoms appear during treatment, then it is worth telling the doctor, and then the drug will have to be replaced or the dosage adjusted. We can say that each body has its own characteristics, pathology individually proceeds, therefore there is no universal remedy that would help everyone equally.
Any hormonal disorders can now be effectively treated if you consult a doctor in a timely manner. Selection of drugs should be carried out only by a doctor. Self-medication in such situations is fraught with serious complications.