It contains information about Quentiax in the radar. The instructions for using this tool are quite simple, but it is important to follow it, which is why it is published in one of the oldest reference books of medicines (it has been published since 1993!). Doctors, prescribing the drug, draw the attention of patients: the effectiveness of therapy is directly determined by compliance with the requirements of the instructions for use. The drug “Quentiax”, as noted by those who use it, when taking adequate doses provokes relatively few negative effects, mainly only weak negative reactions of the body are observed. Let's try to figure out how to use the medication correctly.
It is important!
On the expanses of the World Wide Web, you can find a lot of information about the instructions for use of Quentiax. Indeed, the data is useful, they allow you to get a general idea about the medication, but they are not the basis for prescribing funds for yourself. Only a doctor can prescribe such a drug, and in a pharmacy it is sold only with a prescription.
Before use, it is necessary to carefully study the instructions for the use of Quentiax. It is likely that the manufacturer will make some adjustments to it. The most relevant and accurate data is always enclosed in the packaging of the medication and requires detailed familiarization.
general information
The first thing that can be learned from the instructions for use of Quentiax is the active component, due to which the product shows its positive result. It is called quetiapine. The medicine belongs to the group of antipsychotics and is on sale in tablets. The basic substance is present in one tablet at a concentration of 25 to 300 mg. The exact amount is indicated on the cardboard packaging in which the blisters with the drug are stored.
In addition to Quentiax, there are two more names of medicines on the basis of the same active compound:
For Quentiax analogues, the instructions for use are generally similar to the substance described: these are also tablets that must be drunk in strict accordance with the scheme recommended by the doctor. Differences are observed in the effectiveness of the reception and the features of the negative reaction of the body. Replace Quentiax with similar medicines without the recommendation of a doctor is not worth it even for the purpose of saving. If it is not possible to purchase the prescribed medicine, you need to make an appointment with the doctor and find out what you can replace it with.
Medication: what is it and why?
As can be seen from the instructions for use, Quentiax is based on quetiapine. This is an atypical antipsychotic drug. In medical practice, its use is widespread in various forms of schizophrenia, including acute course, a chronic form of the disease. You can resort to Quentiax for bipolar disorder and a number of other pathologies that are quite common in the practice of psychiatrists.
Reception of an antipsychotic influences neurotransmitter brain receptors. As indicated in the instructions for use, Quentiax is characterized by an affinity for dopamine, serotonin, histamine, and adrenergic receptors. It is noted that the drug has a strong effect on 5-HT2 receptors, especially in comparison with inhibition of dopamine D1, D2 receptors. It is noted that Quentiax does not have a pronounced effect with respect to GABA, benzodiazepine, and cholinergic muscarinic receptors.
How it works?
As can be seen from the instructions for use of Quentiax (photos of the drug are presented in the material), at the moment there is no absolutely accurate and reliable information explaining the features of the influence of the active component on the human body. Medical practice shows that extrapyramidal (rarely observed), antipsychotic results are due to the combined antagonistic effects on brain receptors. However, it is worth recognizing: Quentiax is not the only drug on the modern pharmacological market, the mechanism of action of which has no clear reason, it has yet to be studied.
But the effectiveness, as can be seen from the reviews, instructions for the use of Quentiax, is beyond doubt. This is confirmed by specific tests conducted to identify antipsychotic efficacy, and numerous responses. As noted by patients whom the doctor recommended to undergo treatment with this drug, Quentiax provokes rather mild side effects, which usually disappear at the very first time after the start of therapy. In this regard, the tool is preferable to many other antipsychotics having similar effectiveness for the human body. At the same time, it cannot be denied that Quentiax is not suitable for some.
Tested and proven
One of the key tests used to confirm the effectiveness of Quentiax is called a conditional avoidance study. The technique showed the effectiveness of the drug in a therapeutic course. During specialized clinical trials, it was also possible to identify that the active component of the drug equally copes with both negative and positive manifestations of schizophrenic disorders. As can be seen from the reviews, instructions for use, Quentiax (and this is officially confirmed) is comparable in its effect to medicines on haloperidol, chlorpromazine, but at the same time it does not show negative side effects characteristic of these compounds.
At the same time, it is known that the drug can provoke drowsiness. According to doctors, the Quentiax instructions for use contain an adequate explanation of this fact. The drug has an effect on histamine receptors, which leads to a similar effect on humans. This fact must be taken into account when passing the course by people who are forced to work with machines, machines, other equipment and tasks that require an increased reaction rate. This applies to driving.
Additional research methods
As part of the development of the drug, certain animal studies have been carried out. The main task was to identify extrapyramidal symptoms. The information received was taken into account and included in the instructions for use of Quentiax. Reviews of the drug contain the opinion that the possible reactions listed in the document are indeed observed, but very rarely, and in most patients this response of the body does not occur.
Experiments with animals have shown that the use of a dosage that allows blocking a number of dopamine receptors can be accompanied by catalepsy only in a very weak form. It is known that the active substance is distinguished by selectivity of action, especially in relation to the mesolimbic system. Confirmation of this conclusion is a selective decrease in the bit frequency of A10 neurons in comparison with A9. In a study of the efficacy of a drug in monkeys, it was found that the likelihood of dystonia is minimal.
Research and effects
As can be seen from the instructions for use, Quentiax CP does not lead to an increase in prolactin concentration. Clinical studies in which patients repeatedly used a fixed dosage of the drug showed that the amount of prolactin coincides with that observed in the placebo control group and those who used the substance in a dosage from the range of acceptable concentration.
Additionally, three studies were carried out, involving a comparison of the effectiveness of the drug against the background of placebo groups. Information about the results is also recorded in the instructions for use of Quentiax SR. A variety of dosages were used, from the minimum to 750 mg per day. The results showed that extrapyramidal symptoms are observed with equal frequency in all groups of patients. Tests did not show the dependence of the frequency of extrapyramidal symptoms in the layout of Quentiax and cholinergics. Also, in the course of studies it was revealed that the remedy shows the best effect with daily use twice a day. The effect on the receptors lasts up to 12 hours with the normal functioning of the internal systems.
What is going on in the body?
Instructions for use of the drug “Quentiax” (200 mg or any other dosage) contains a mention of the increased absorption of the active component when taken orally. There is no dependence of bioavailability on meals. In the plasma component of the blood, the active component reaches its highest concentration within half an hour after the medication is ingested.
Up to 83% of the active substance, according to the instructions for use of Quentiax (200 mg and a different dosage), quickly forms a strong bond with plasma proteins. Metabolism mainly occurs in the liver, biological transformation is due to oxidative reactions, sulfoxylation. In the course of studies, it was determined that the main metabolic enzyme is CYP3A4. Compounds produced by metabolism do not have a pharmacological effect on the human body.
The elimination half-life is seven hours. Up to five percent leave the body unchanged. 73% of metabolic reaction products are excreted by the urinary system, 21% - with feces.
Pharmacokinetics
According to reviews, Quentiax analogues (instructions for use may differ slightly) have a similar effect if they are based on the same active component, but drugs from the group of antipsychotics, which include other substances as the main compounds, differ (often) in more severe adverse reactions . This is largely due to pharmacokinetic differences. Quentiax, as studies have shown, is characterized by a linear process if the drug is used in a therapeutic dose. There are no specific reactions depending on gender or racial.
On average, the clearance of the active component is observed to be lower by a third, and sometimes by half, in the treatment of elderly people. This requires adjustment of the treatment program if the patient is over 65 years old. Plasma clearance is reduced by a quarter in severe renal failure, hepatic impairment, including cirrhosis, provoked by addiction to alcoholic beverages. At the same time, there are cases when the clearance in people with such health disorders remains at the level characteristic of a person with healthy kidneys and liver.
When to apply?
The manufacturer recommends using the tool in the following diagnoses:
- schizophrenia;
- depressive, manic pathologies due to bipolar disorder of the first, second class;
- psychotic organic disorders.
How to use?
The best effect is observed when dividing the daily dose into two doses with equal time intervals between them. The use of the product does not depend on the intake of food in the digestive system. For adults, at the beginning of the therapeutic course (4 days), it is recommended to use Quentiax according to the following scheme: 50 mg, 100 mg, 200 mg, 300 mg. The fifth day and other course - titratable dosage in the range of 300-450 mg.
As practice shows, sometimes a stable clinical effect can be achieved already 150 mg daily, but in some patients, a pronounced effect gives only the constant use of 750 mg.
In the treatment of elderly people, the medicine is allowed only under the condition of controlled, careful use and regular check of vital signs of the body. The initial dosage is 25 mg, the daily increase varies from 25 to 50. It is necessary to increase the amount of Quentiax daily until a pronounced result can be achieved. Experts note that in most cases the effective dose is significantly less than for young patients. For children and adolescents, Quentiax is not recommended for use, since there have been no official studies to establish side effects and the safety of using the medication. There is no accurate data on the effectiveness of the drug in the treatment of minors.
If a therapeutic course is prescribed to a patient with impaired liver and kidney function, the starting dose is 25 mg. Every day it is increased by 25-50 mg until a persistent positive effect of the program is observed. Typically, the patient is additionally prescribed regular studies of the body in order to prevent severe disorders associated with an overdose due to the inability of internal organs to process the received medication.
Negative effects: what to expect?
According to cardiologists, the Quentiax instructions for use, although it indicates an adverse effect on the functioning of the cardiac system, many patients do not pay due attention to this. The manufacturer draws attention to the side effects indicated in the instructions that are the conditions identified in the comparison of the control groups taking the drug and the placebo controlled. Treatment of both categories was accompanied by a number of negative reactions of the body, so only those for which the frequency was higher in comparison with the placebo group were included in the official list.
It was noted that most often patients complained of a headache - almost a fifth of the control group encountered this. Some developed febrile, asthenic conditions, abdominal pain syndrome. Up to 2% of patients experienced a sharp increase in body weight, lumbar pain, pain in the chest. It is known that the medication increases drowsiness, can contribute to the development of feelings of anxiety, and provokes dizziness. There is a likelihood of stool disorders, an increase in the activity of liver transaminases - the indicators return to normal when the therapeutic course is continued. Up to one and a half percent of patients experienced leukopenia, neutropenia. Extremely small, but there is a risk of developing eosinophilia.
As can be seen from the reviews of cardiologists, instructions for use, “Quentiax” can provoke hypotension, heart rhythm disturbance and hypertension. There is a possibility of pain in the ears, infection of the urinary tract, rhinitis, myalgia. In some patients, a rash and dry skin were observed.
When is it impossible?
As can be seen from the instructions for use, Quentiax is not allowed if the patient is characterized by hypersensitivity to any substance present in the medication. You can not use the medicine if the patient is taking a course of drugs containing cytochrome inhibitors. Such compounds include drugs for:
- erythromycin;
- nefazodone;
- clarithromycin.
Limitations are the use of antifungal drugs on azole and HIV protease inhibitors.
Special occasion: pregnancy and lactation
No specific studies have been conducted to determine the degree of danger of using Quentiax during the period of bearing a child and breastfeeding. Currently, the following approach is being practiced: if it is necessary to use antipsychotics with an effect similar to Quentiax, the doctor analyzes the possible risks for the woman and the fetus, compares it with positive effects in the case of a therapeutic course, introduces the patient to all possible negative outcomes of taking the medicine and only with it agreement and the apparent dominance of positive aspects recommends taking this drug.
It is not known whether the active ingredient of Quentiax is excreted in breast milk, in what quantity it occurs. If necessary, take a therapeutic course, it is recommended to switch to artificial feeding, avoiding breastfeeding. Experimental studies were conducted, during which it was not possible to establish the likelihood of mutations, as well as the teratogenic, clastogenic effect of the active substance.
Special experiments
Additional studies were organized to identify the effect of the drug on sexual activity. The experiments took place only on animals. As the results showed, sexual activity decreases, the length of time between estruses increases, and the likelihood of pregnancy decreases. False pregnancy was observed in some experimental individuals. , , , , , , . «».
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