"Drotaverinum" application instruction relates to the pharmacological group of antispasmodics. The main active ingredient in this drug is drotaverine, and the drug itself is available in such dosage forms as conventional tablets, capsules for internal use and an injection solution.
This myotropic antispasmodic has such pharmacological and chemical parameters that are close to the properties of Papaverine. But according to the degree of action and its duration, the properties of Drotaverin are much stronger than those of Papaverine. The medicine has the ability to reduce the entry of Ca2 + elements into cells. "Drotaverinum" instructions describe how a drug that improves overall intestinal motility, helps to dilate blood vessels. The medicine does not have any negative effect on the autonomic system and does not have the ability to penetrate into the central nervous system.
Having antispasmodic effect, the drug "Drotaverin" is effective for use in cases where there are contraindications for the use of drugs from the group of m-anticholinergics. Typically, these drugs are used by patients to treat glaucoma and prostatic hypertrophy. When taking the drug by intravenous administration, its components begin to act after about two to four hours, while the drug begins to exert the greatest effect within half an hour.
This drug is prescribed for the prevention and treatment of diseases such as muscle cramps, colic in the kidneys, intestines or gall bladder, cholecystitis. The drug is effective in the treatment of spastic constipation, colitis, gastroduodenitis, duodenal ulcers and stomach.
Drotaverinum is used in the treatment of endarteritis, cerebral arteries. The instruction also indicates the possibility of using the drug to overcome a number of gynecological problems, in particular, to prevent miscarriages and postpartum contractions.
It should be borne in mind that when taking the drug "Drotaverin", the instruction provides and warns of contraindications in which the use of this drug should be excluded or limited. Firstly, it should not be taken if the patient has been diagnosed with severe forms of liver and kidney failure, cardiogenic shock, angle-closure glaucoma. Secondly, the drug is not prescribed in cases of pregnancy and breastfeeding. And finally, Drotaverinum, a composition which includes methylene derivatives in the form of hydrochloride, can cause serious problems in those patients who have hypersensitivity to these compounds.
In addition, when taking the drug, side effects in the form of dizziness, palpitations, the occurrence of a number of allergic reactions can be observed. Particular care should be taken in the use of the drug by intravenous administration. With this technique, collapse, cardiac blockages and stops of the respiratory center can occur.
If an overdose occurs in patients, cardiac activity sharply decreases, and this can lead to its stop or paralysis of the respiratory center.
"Drotaverinum", the instruction recommends use in the doses and modes of administration strictly specified in it. Before any use of this medicine, a doctor’s consultation is required.
If the drug is prescribed as part of complex therapy, it should be borne in mind that it is able to enhance the effect of "Papaverine", but blood pressure will decrease while taking it with tricyclic antidepressants. The antispasmodic properties of the drug are enhanced by the simultaneous use of phenobarbital.