The drug "Orungamine" (tablets) is included in the category of antifungal agents with a wide spectrum of activity. The mechanism of influence of the drug is based on the ability of the active substance - itraconazole - to inhibit the synthesis process in the membrane of fungal cells. The tool is effective against yeast, yeast-like fungi, dermatophytes. Maximum bioavailability is observed when taken orally immediately after a hearty meal. The medicine reaches the highest concentration in three to four hours.
Means "Orungamine". Instructions for use. Indications
The medicine is prescribed for fungal keratitis, dermatomycosis, onychomycosis, provoked by yeast / dermatophytes and moldy fungi. The indications include systemic mycoses: candidiasis and aspergillosis, sporotrichosis, histoplasmosis, cryptococcosis ( including cryptococcal meningitis ). The drug “Orungamine” recommends the use of the drug for blastomycosis, paracoccidioidomycosis and other tropical or systemic lesions. Prescribe a remedy for pityriasis versicolor, candidiasis with spread to the mucous membranes or skin, vulvovaginal candidiasis , including with deep visceral candidiasis.
The drug "Orungamine." Instruction manual
Reviews of experts confirm the advisability of taking the medicine immediately after eating. The drug is swallowed whole. In case of impaired immunity, reduced absorption may be noted. In this regard, the need for an increase in dosage is likely. Against the background of onychomycosis, "pulse therapy" is prescribed. One course involves taking the medicine at a dose of two tablets / capsules per day twice. The duration of treatment is a week. For fungal infections of the nails of the hands, two courses are recommended, three legs. A break between weekly meals is 21 days. As the nails grow, clinical results will become apparent. Against the background of onychomycosis (in accordance with the severity of the course of the pathology), a specialist can prescribe continuous medication for three months, two capsules / tablets per day.
Side effects
When taking the drug, dyspepsia, toxic damage to the liver of a severe nature, increased activity of liver enzymes (reversible), constipation, nausea are noted. Patients may have jaundice (cholestatic), anorexia, hepatitis, peripheral neuropathy, headache. In some cases, dizziness, hypokalemia, swelling, headache, and fatigue appear. In women due to treatment, the menstrual cycle may be disrupted. The negative manifestations when taking the drug "Orungamine" application instructions include congestive heart failure, dark urine, pulmonary edema, angioedema. The drug also provokes alopecia.
The medicine "Orungamine." Instructions for use. Contraindications
Do not prescribe the drug at the same time as the drugs "Midazolam", "Triazolam", "Pimozide", "Quinidine", "Dofetilide", "Cisapride", "Lovastatin", "Simvastatin". Contraindications include intolerance. The appointment during pregnancy / lactation is performed according to vital indications.