Diseases affecting the musculoskeletal system can be manifested by muscle spasm and increased tone. Patients who are in this condition need adequate treatment based on the use of muscle relaxants. Doctors often prescribe Tolperisone. Analogs, price, instructions for using this drug will be discussed in the article.
The drug with the active substance tolperisone hydrochloride is available in tablets. Stearic acid and citric acid , as well as lactose and crospovidone, are additionally added to the drug.
pharmachologic effect
"Tolperisone", drug analogues are muscle relaxants that have a central effect. The mechanism of the effect of the drug on the body is not fully understood.
Tolperisone provides local anesthesia. It is known that the medication due to the active substance present in the composition eliminates muscle hypertonicity, as a result of which the pain disappears. The drug helps to improve peripheral blood flow, achieve antispasmodic and adrenergic blocking effects, it inhibits the work of the caudal part of the reticular formation of the brain.
“Tolperisone”, analogues, synonyms allow eliminating hypertonicity of striated muscles and eliminating its spasm in those cases when the problems arose due to obliterating vascular disease or encephalopapia.
Who is prescribed Tolperisone?
Doctors prescribe the drug Tolperisone in the presence of the following problems:
- diseases accompanied by muscle spasm, such as stroke, multiple sclerosis; among these diseases - encephalomyelitis, myelopathy;
- diseases manifested by muscular dystonia; these include cerebral palsy, other types of encephalopathy;
- processes, as a result of the development of which the musculoskeletal system is affected, pronounced muscle spasms are noted; they include arthrosis, affecting large joints, and lumbago; such a symptom manifests spondylarthrosis, spondylosis.
When used in the Tolperizon complex, analogues are used to treat acrocyanosis, arteriosclerosis, Raynaud's disease, angiopathy.
Contraindications to taking Tolperisone
The drug is not prescribed for persons under 18 years of age, patients with myasthenia gravis, women who are bearing a child and breastfeeding, patients who cannot tolerate lactose and other components of the drug.
The instruction contains some restrictions. In the treatment of patients in whom the functional state of the liver and kidneys is impaired, the medication is used with extreme caution.
Sometimes "Tolperizon" analogues are prescribed during pregnancy. But since the effect of these drugs on the body of pregnant women has not been studied, their use is possible only in cases where the benefits to the woman’s body significantly exceed the risk to the fetus. First-trimester drug treatment requires special care for the patient’s body condition. During treatment with “Tolperisone”, breast-feeding is temporarily stopped.
The use of "Tolperisone": dosage
The medication is intended for internal use after eating food (a tablet taken on an empty stomach has low bioavailability). The recommended dose at the initial stage of treatment is 50 mg of the drug 3 times every day. Over time, it is increased to 150 mg, but not sharply, but gradually. The frequency of taking the medicine remains the same. The duration of therapy for each patient is determined individually.
A medicine with an active substance called tolperisone hydrochloride, analogues in the treatment of patients who have a violation in the liver or kidneys (medium, lungs), are used very carefully and in carefully selected doses. There is a need for constant monitoring of their health. Severe violations are a contraindication to the use of Tolperisone.
Side effects
A large number of reviews indicate good tolerance by the body of the components present in the composition of the drug. The development of adverse reactions after taking the tablets is not a very common occurrence. Very rarely, muscle weakness is present, and headache and the presence of arterial hypertension are sometimes noted. There may be disturbances in the intestines, in which nausea and vomiting appear. Of allergic reactions, angioedema, pruritus, urticaria after the use of the drug "Tolperisone" may be present. Analogs also have side effects.
Overdose
No cases of overdose have been reported. As a result of taking a dose higher than recommended, arterial hypotension may develop, respiratory failure and heart function may occur. To eliminate such manifestations, gastric lavage and treatment (supportive, symptomatic) are necessary.
Drug Interactions Tolperisone
If the drug is used with niflumic acid, it enhances its effect. Tolperisone also increases the activity of Clonidine, psychotropic drugs, drugs that provide anesthesia, and peripheral muscle relaxants.
"Tolperisone" analogues can be combined with other drugs - drugs, including ethanol, sedatives, hypnotics.
When combined with other muscle relaxants of the same effect that the Tolperisone tablets have, a dose reduction of this agent is required.
A medication can affect drugs in the metabolism of which the CYP2D6 isoenzyme is involved, increasing their concentration.
Analogues, the cost of the drug
What can replace Tolperizon? A good and fairly popular medicine is "Midokalm", if necessary, it can be used as a substitute with a similar active ingredient.
Other drug options are known, for example, Tizanidine and Sirdalud. In addition to these funds, you can use Tizalud, Tizanil, Liorezal or Baklosan. There is another substitute - Tolperizon-OBL. This drug is cheaper than the often used Midokalm, which is one of the most popular analogues of the Tolperisone medication. Price, analogues - the basis for choosing the most profitable and effective substitutes.
Patients who were treated with the muscle relaxant Tolperisone are generally satisfied with the result. The highest efficiency is noted if necessary to eliminate spondylosis and spondylarthrosis, cure encephalomyelitis, multiple sclerosis. The average cost of tablets with a dosage of 50 mg is 140 rubles, with a dose of 150 mg - 190 rubles.