Why is a drug such as Fraxiparin prescribed? Instructions for use of the mentioned medicine, its release form and composition will be presented below. Also from the materials of this article you will learn about whether this drug has side effects and contraindications.
Form, packaging, composition
In what packaging does the drug "Fraxiparin" go on sale? Instructions for use indicate that this tool is available in a syringe, which, in turn, is placed in a blister and a cardboard bundle.
A slightly opaque preparation intended for subcutaneous injection is a colorless and clear liquid. It may contain 9500, 5700, 2850, 3800 or 7600 IU of anti-Xa nadroparin calcium. In addition, the medication also includes such additional substances as purified water, calcium hydroxide solution, hydrochloric acid.
Pharmacological and pharmacokinetic features
What is the drug "Fraxiparin"? The instructions for use attached to the medicine indicate that it is a very effective antithrombotic and anticoagulant agent.
The active substance of the drug is low molecular weight heparin. It is obtained by depolymerization and exhibits a fairly high ability to bind to plasma proteins. Such an effect leads to increased inhibition of factor Xa.
After subcutaneous injection, the maximum anti-Xa activity is observed after about five hours. The drug is absorbed by 88%.
If the medication was administered intravenously, then its highest concentration in the blood is observed after about 10 minutes. In this case, the half-life is 2 hours.
The drug in the liver is metabolized by depolymerization and desulfation.
Indications for use
Why use the drug "Fraxiparin"? Instructions for use (the photo of the medicine can be found in this article) states that such a medication is often prescribed to prevent thromboembolic complications, including after surgical and orthopedic surgeries.
The anticoagulant agent is recommended for use by persons with a high risk of thrombosis, as well as those suffering from acute or respiratory or heart failure.
Contraindications
In what conditions is the drug “Fraxiparin” not recommended for use? Instructions for use contain the following list of contraindications:
- organ damage with bleeding;
- thrombocytopenia developed in the past with the use of nadroparin;
- the age of a person under 18 years;
- bleeding or an increased risk of its development associated with worsening hemostasis;
- renal failure, especially severe;
- intracranial hemorrhage;
- acute infectious endocarditis;
- surgery or injury to the eyeballs, spinal cord, or brain;
- hypersensitivity of the patient to the drug substances.
One cannot fail to say that Fraxiparin, reviews of which are ambiguous, should be taken with extreme caution in cases of renal or hepatic insufficiency, changes in blood circulation in the retina or choroid of the eye, severe hypertension, and severe illnesses risk of bleeding, peptic ulcers in the past, as well as when combined with other anticoagulants, after surgery, and patients weighing up to 40 kg.
The drug "Fraxiparin": instructions for use
In IVF, the drug "Fraxiparin" is prescribed in order to improve the rheological parameters of the blood and facilitate implantation.
Use such a drug should only be prescribed by a doctor. It must be injected subcutaneously into the abdomen, alternating between the left and right sides. In this case, the patient should be in a prone position. In some cases, the medication is injected into the thigh.
How to inject Fraxiparin? The needle must be inserted perpendicular to the crease of the skin, which is formed by the fingers of the free hand. In this case, the pinch should be held during the entire injection. After the injection, rubbing the injection site is prohibited.
What should be the dosage of Fraxiparin? 0.3 ml is prescribed to prevent thromboembolism in surgery (2850 anti-Xa ME). The medication is administered four hours before the operation, and subsequently - once a day. Treatment can be continued for at least one week or the entire period of risk of increased thrombosis (for example, until the transition to outpatient monitoring).
Now you know for what purposes the drug “Fraxiparin” (0.3 ml) can be prescribed.
In addition to surgery, this tool is also actively used to prevent thromboembolism in orthopedics. It is administered subcutaneously at 38 anti-XA ME per kg of weight. The indicated dose can be increased by 1.5 times, but only on the fourth day after orthopedic intervention.
Fraxiparin medication is administered subcutaneously once a day to people with a high risk of thrombosis in an amount calculated depending on the weight of the patient (for less than 70 kg - 3800 anti-XA ME per day, and more than 5700 anti-XA ME).
In the treatment of thromboembolism, anticoagulants in the form of tablets should be prescribed as soon as possible. Therapy with “Fraxiparin” is not stopped until the goal of prothrombin time is reached.
Overdose symptoms
Now you know how to inject Fraxiparin. It should be noted that when using high dosages of this drug, the patient may experience bleeding of various localization. At the same time, mild bleeding does not require urgent therapy (you just need to lower the dose or postpone the next injection).
As for severe overdoses, protamine sulfate helps to neutralize the anticoagulant effect of heparin. Its use is required only in severe cases.
Side effects
What side effects can Fraxiparin cause? Reviews of patients say that such a drug promotes the development of bleeding of various localizations, thrombocytopenia, eosinophilia, an increase in the content of liver enzymes and hypersensitivity. Patients may also develop small subcutaneous hematomas at the injection site. In these cases, treatment with Fraxiparin should be discontinued.
Drug interaction
The risk of developing hyperkalemia is significantly increased with a combination of the drug in question with ACE inhibitors, potassium salts, angiotensin receptor blockers, potassium-sparing diuretics, Tacrolimus, heparins, Cyclosporin, NSAIDs, and Trimethoprim.
It should also be said that the combination with acetylsalicylic acid, NSAIDs, indirect anticoagulants, Dextran or fibrinolytics mutually reinforces the effects of drugs.
Pregnancy and lactation
Is it possible to take “Fraxiparin” during child bearing? Instructions for use during pregnancy (reviews of the drug will be presented below) states that nadroparin calcium (the active substance of the drug) penetrates the placenta quite easily. Also, this medicinal component is excreted along with breast milk.
In connection with all of the above, it should be noted that “Fraxiparin” injections are not recommended to prescribe during the bearing of a child and during breastfeeding. However, in some cases, such a drug is still prescribed to patients.
So how to use the drug "Fraxiparin"? Instructions for use during pregnancy should be developed only by an experienced specialist. In this case, a woman should be constantly monitored by her doctor.
Analogs, price
The following medicines are analogues of this drug: Heparin-Farmeks, Atenat, Enoksarin, Wessel Due F, Zibor, Heparin, Fragmin, Heparin-Biolek, Flenoks, Heparin-Darnitsa ”,“ Novoparin ”,“ Heparin-Indar ”,“ Kleksan ”,“ Heparin-Novofarm ”.
The price of the drug "Fraxiparin" is very high. For 10 syringes (0.3 ml) you will have to give about 2500 rubles.
Reviews about the drug
Reviews of patients about the drug in question are ambiguous. This drug helped someone very well, but someone complains about his inaction. In addition, there are quite a lot of reviews that “Fraxiparin” causes a large number of adverse reactions.
Experts do not recommend relying on the opinions of those who have already used this drug. The validity of the prescription of the medication, its effectiveness and the risks associated with it, can only be evaluated by an experienced specialist.
It should also be noted that there are no bad reviews about this tool during pregnancy.