In what cases can the drug "Mazepam" be used? The price, indications and instructions for this medication are presented below.
Form, composition
"Mazepam" - round tablets, flat cylindrical. Their main substance is mezapam. As for the additional components, they are starch, lactose monohydrate and calcium stearate.
Drug action
What are Mazepam tablets? The instruction for use claims that this is an anxiolytic drug, or the so-called tranquilizer. This medication is a benzodiazepine derivative. It exhibits anxiolytic, antiepileptic and muscle relaxant properties, and also has a weakly pronounced timoleptic effect.
Hypnotic and sedative effect of this drug is observed to a lesser extent than standard benzodiazepine tranquilizers. In this regard, the medication in question belongs to a peculiar group of “daytime” tranquilizers.
This tool interacts with the receptors (benzodiazepine) of the limbic system, as well as with the activating ascending formation of the brain stem (brain). Thanks to him, the opening of chlorine channels occurs, which ultimately leads to an increase in the inhibitory effect of GABA in the central nervous system.
It should also be noted that the drug "Mazepam", the instructions for use of which are described below, helps to eliminate anxiety, psychoneurotic tension, feelings of fear, excessive fussiness and general motor excitement. In addition, it stabilizes the autonomic NS, restores emotional behavior and a critical assessment of one's own illness.
Kinetics
What pharmacokinetic parameters are characteristic for the Mazepam tranquilizer? The instruction for use claims that after ingestion, the tablets are rapidly absorbed in an amount of 50-75%. Their highest concentration in the blood is reached after two hours. Binding to plasma plasma proteins is 99.7%.
The metabolites of this drug are excreted through the kidneys and through the intestines within 20-175 hours.
Indications
Mazepam tablets, reviews of which you will find later, are used for irritability, neurosis, agitation, and nervous tension. Also, this tool is recommended for use in withdrawal symptoms in people who suffer from alcoholism, for the prevention of migraine and for menopausal syndrome.
In pediatrics, this drug is used for increased excitability of the child, mental lability and "school" neurosis.
Contraindications
The drug in question cannot be taken during pregnancy, myasthenia gravis, “night” apnea, intolerance to medazepam, pathologies of the renal system and liver, breastfeeding and various forms of dependence (drug, alcohol). In addition, this drug is contraindicated in cerebellar ataxia, organic pathology of the NS, intraocular hypertension, respiratory failure and spinal ataxia.
Tranquilizer "Mazepam": instructions for use
Mezapam tablets are taken three times a day, starting with a small dose of 5 mg. Gradually, the amount of this tool is brought to the level of 30 mg per day. In rare cases, it is permissible to take 40 mg of the drug per day.
For outpatient treatment, it is recommended that the following treatment regimen be observed: 5 mg of the drug in the morning and 10 mg in the evening. In a hospital setting, the maximum daily dosage of this drug can be increased to 60-70 mg.
The duration of therapy with this agent is 2 months (no more). After 30 days, the course can be repeated.
Side effects
The agent in question can cause the following effects:
- dyspeptic disorders, increased bilirubin, AST, ALT, dry mouth;
- heart palpitations, drop in blood pressure;
- stupor, disinhibition, headaches, anterograde amnesia, paresis of accommodation, depression, dizziness, dysarthria, loss of strength, loss of orientation, ataxia, aggressiveness, confusion;
- in people with COPD, when taking high doses of the drug, alveolar hypoventilation is noted;
- with obstruction of the respiratory tract and damage to the brain, inhibition of the respiratory center is observed.
Special recommendations
Taking Mezapam tablets can contribute to impaired attention and memory, as well as to a decrease in learning ability.
Together with this tool, the use of ethanol-containing drinks is unacceptable.
Gradual discontinuation of the drug is recommended in the treatment of withdrawal symptoms.
Long-term therapy can form a drug dependence on medozepam.
Price and reviews
The cost of the considered tranquilizer is about 150 rubles.
Patient reviews indicate a fairly good tolerability of this drug, subject to all the doctor’s prescriptions and dosage regimen. Although in isolated cases, this tool still contributes to the development of drug dependence, decreased potency, urinary retention, paradoxical reactions, allergic reactions, pain in the sternum and dysmenorrhea.