Why is Dicloberl (injections) needed? A comprehensive answer to the question will be given in the submitted article. In addition, we will tell you about how to use this drug, in what form it is produced, what is its composition, whether it has side effects and contraindications.
Drug Release Form
The peculiarity of this drug is that it is produced in completely different forms. In which, we will tell right now.
- The drug "Dicloberl 100". Instructions for use of this drug are enclosed in a cardboard box with the medicine. This medication is available in the form of tablets. They are enteric coated. In one cardboard pack can be 50 or 100 tablets with a volume of 50 mg.
- The drug "Dicloberl 75" (injections). Reviews of experts say that this form of the drug is the most effective, since the active substance immediately enters the bloodstream, bypassing the digestive system. The solution for intramuscular injection goes on sale in 3 ml ampoules (75 mg). In one cardboard pack is 5 ampoules.
- Medication "Dicloberl Retard." Instructions for use of this tool contain a lot of useful information. That is why before starting therapy, you should definitely familiarize yourself with it. The postfix "retard" indicates that the drug is available in the form of 100 mg capsules of prolonged action. In blisters can be 50, 20 or 10 capsules.
In what other form is the Dicloberl medication produced? Injections, tablets and capsules are not the only forms of the drug. After all, it can also be purchased in the form of 50 mg suppositories for rectal administration. The blister can contain both 5 and 10 candles.
Pharmacological characteristics of a medical product
What is the drug "Dicloberl" (injections)? Instructions for use states that it is a non-steroidal anti-inflammatory drug that is a derivative of phenylacetic acid. The active ingredient in this medication is diclofenac sodium.
The drug has pronounced anti-inflammatory properties. Such an effect on the human body is due to inhibition of prostaglandin synthesis.
The drug "Dicloberl" (injections and other forms) has analgesic, antipyretic and decongestant effects. It lowers the adhesive properties of platelets under the action of ADP and collagen.
Pharmacokinetics of a medical product
With the introduction of an injection solution, the maximum concentration of the drug in the blood is observed after about 10-20 minutes. When administered orally, diclofenac is completely absorbed from the intestine. In this case, the maximum concentration is observed after about 2-3 hours.
After the active element is absorbed from the intestine, a presystemic metabolism is immediately carried out. This happens due to the initial passage through the liver.
After using the suppository, the maximum concentration in the blood is observed after about half an hour.
About 30% of diclofenac is metabolized. The drug comes out through the intestines and kidneys. The half-life is approximately 120 minutes and does not depend on the work of the liver and kidneys.
Indications for the use of NSAIDs
In what cases are patients prescribed Dicloberl 75 (injections)? The instruction contains the following list of indications:
- primary dysmenorrhea;
- rheumatic diseases (e.g. rheumatism, rheumatoid arthritis or osteoarthritis);
- myalgia;
- spondylitis ankylosing;
- neuralgia;
- gout;
- pain in injuries of soft tissues or musculoskeletal system;
- dystrophic diseases of the joints.
Contraindications to the use of NSAIDs (non-steroidal drugs)
When should patients not be prescribed Dicloberl (injections)? Reviews of experts say that this medication has an extensive list of contraindications:
- age less than 15 years;
- an allergy to diclofenac, as well as other drugs belonging to the group of non-steroidal anti-inflammatory drugs;
- bronchial asthma;
- peptic ulcer of the duodenum and stomach;
- peptic ulcer;
- hematopoiesis;
- stomach or intestinal bleeding.
The drug "Dicloberl": instructions
The injections, reviews of which we will consider below, are used only for deep intramuscular injection (in the buttock). The daily dosage of the drug is 75 mg (i.e. 1 ampoule). The maximum volume of the drug per day is 150 mg.
If long-term therapy with the Dicloberl drug is necessary, then rectal or oral forms are prescribed to patients.
Dicloberl tablets are taken only by mouth. They do this exclusively during food consumption (in order to eliminate the irritating effect on the gastric mucosa), washing down with a small amount of liquid. Under no circumstances should tablets be chewed. The daily dosage of the drug is 50-150 mg. For convenience and safety, it is divided into 2-3 doses. The duration of therapy should be determined only by the attending physician.
Capsules "Dicloberl Retard" are prescribed once a day in a volume of 100 mg. If an increase in dosage is required, then tablets are used.
As for rectal suppositories "Dicloberl", they are administered after defecation deep into the rectum. The dosage of suppositories is determined only by a specialist and depends on the severity of the disease. As a rule, the daily volume of the drug is in the range of 50-150 mg. The indicated dosage must be divided into 2 or 3 doses.
Side effects after taking the drug
Can the Dicloberl drug (injections and other forms) adversely affect the human body? According to the attached instructions, this medication really has a number of side effects:
- Digestive tract: bloody vomiting, dyspepsia, melena, glossitis, bloody diarrhea, esophagitis, constipation, liver damage, decreased appetite, perforation and bleeding of an ulcer, exacerbation of gastric and intestinal diseases, pancreatitis, diarrhea, abdominal pain, gastrointestinal bleeding and nausea .
- Allergy: Lyell syndrome, skin rash, anaphylactic shock, bullous eruptions, Stevens-Johnson syndrome, itching, bronchospasm, burning sensation at the injection site, swelling of the larynx, tongue and face, sterile abscess at the injection site and necrosis of the subcutaneous fat.
- Central nervous system: visual impairment, dizziness, depression, headache, nightmares, insomnia, tremors, increased fatigue, a sense of fear, agitation, confusion, taste changes, stiff neck muscles, sensory disturbances, disorientation, changes in the perception of sounds and cramps.
- Blood system: agranulocytosis, thrombocytopenia, leukopenia and anemia.
- Heart and blood vessels: palpitations, chest pain, arterial hypertension, decreased blood pressure.
- Other: allergic vasculitis, deterioration in general condition with necrotizing fasciitis, pulmonitis .
Drug overdose
Exceeding doses of the drug can cause headaches, dizziness, loss of consciousness, vomiting, disorientation, myoclonic seizures in children, nausea, abdominal pain, gastrointestinal bleeding, impaired liver and kidney function. In case of an overdose, urgent symptomatic treatment is necessary.
Interaction with other medicines
Can I take other medicines at the same time as Dicloberl? The instruction (injections, tablets, capsules, suppositories - all of these forms of medication interact with other medicines almost identically) states that taking them while using digoxin, phenytoin and lithium preparations can increase the level of the latter in the blood.
When combined with diuretics, as well as drugs used for hypertension, their effectiveness is markedly reduced. By combining the drug with potassium-sparing diuretics, you can notice an increase in the concentration of potassium in the blood.
If you uncontrollably combine the medication with inhibitors of the angiotensin-converting factor, then you can easily provoke impaired renal function. By combining the drug with glucocorticosteroids and other non-steroidal anti-inflammatory drugs, the patient risks increasing the chance of developing adverse reactions from the digestive tract.
Taking the medication (one day) before or after methotrexate increases the concentration of the latter and enhances its toxic effects. When combining the drug with antiplatelet agents, monitoring by a specialist on the blood coagulation system is required.
In combination with cyclosporine, the negative effect of the latter is enhanced. As for funds with probenecid, they significantly slow down the excretion of diclofenac.
It cannot be said that there are isolated cases of an increase / decrease in blood glucose in patients diagnosed with diabetes mellitus, which necessitated a change in the dosage of antidiabetic drugs and insulin.
special instructions
For diseases of the digestive tract, heart and blood vessels, as well as autoimmune pathologies, induced porphyria, arterial hypertension, kidney diseases and individual intolerance to non-steroidal anti-inflammatory drugs, Dicloberl should be taken only under medical supervision. The same applies to the elderly, people who have undergone surgical intervention, as well as patients with respiratory diseases that are atopic in nature.
After intramuscular injection, the patient is better to be under medical supervision for at least 60 minutes.
The drug may affect a person's ability to drive vehicles and perform work with dangerous machinery.
If long-term therapy with Dicloberl is necessary, then the work of the kidneys and liver, as well as the level of glucose and the content of electrolytes in the blood, should be monitored.
Reviews about the drug
Now you know what the Dicloberl preparation is for (instruction). Injections, capsules, tablets and suppositories quite quickly and effectively eliminate pain syndromes. However, many patients complain that this medication negatively affects the gastrointestinal tract. That is why, with the slightest deviations of the digestive system, such a drug should in no case be included in drug therapy.