How to take an adult "Amoxiclav 875 + 125", we will consider in this article.
The medication acts as a combined antibacterial agent that combines a bactericidal antibiotic, characterized by a wide spectrum of effectiveness from the category of semisynthetic penicillins. Next, let's talk about tablets "Amoxiclav 875 + 125". We also learn about the indications and dosage as part of the use of this medication.
Description of forms
In our article, we are considering one form of this drug. These are tablets "Amoksiklav 875 + 125". They contain 875 mg of antibiotic. In addition, there are 125 mg of clavulanic acid.
Structure
According to the instructions for use with Amoxiclav 875 + 125, this medicine contains antibiotic amoxicillin trihydrate and potassium salt, which is an enzyme inhibitor. They attribute it to the pharmacological category of penicillins.
The medicine contains amoxicillin and clavulanic acid. Auxiliary ingredients are silicon dioxide along with croscarmellose, magnesium stearate, talc, hypromellose, ethyl cellulose, polysorbate, titanium dioxide and triethyl citrate. Tablets are packaged in vials. Powder is also available in bottles. There is also a measuring spoon.
How to take an adult "Amoxiclav 875 + 125", not everyone knows.
pharmachologic effect
The combination of amoxicillin with clavulanic acid is unique in its own way. Amoxicillin and other penicillin antibiotics cause the death of pathogenic cells by binding to specific receptors. True, most of the bacteria during the period of use of the medicine learned to destroy the described antibiotic using the beta-lactamase enzyme.
How to take "Amoxiclav 875 + 125" for adults, it is important to find out in advance.
Clavulanic acid decreases the activity of the enzyme, due to which the drug has a wide spectrum of action. They even destroy bacterial strains that are resistant to amoxicillin. The medicine has a pronounced bacteriostatic effect on all varieties of streptococci (with the exception of methicillin-resistant strains), echinococcus, and listeria. Gram-negative bacteria like Bordetella, Brucella, Gardnerella, Klebsiella, Moraxella, Salmonella, Proteus, Shigella, Clostridium and others are sensitive to Amoxiclav.
Regardless of the combination with the use of food, the product can be well absorbed into the body, reaching a maximum concentration already in the first hour after use. It has a high distribution rate in the lungs, pleural, synovial fluids, tonsils, muscle and fatty tissues, sinuses and so on. In tissue, the highest concentration of Amoxiclav is observed one hour after ingestion.
It passes into breast milk in an insignificant amount. Amoxicillin undergoes partial destruction in the body, and clavulanic acid, in turn, is metabolized very intensively. The remedy is excreted by the kidneys. An insignificant conclusion is carried out by the lungs and intestines.
How to take Amoxiclav 875 + 125 for an adult, we will tell below. In the meantime, let's talk about the testimony.
Indications
The use of the presented antibiotic is prescribed for the treatment of various infectious diseases:
- Diseases like sinusitis (acute or chronic), inflammation of the middle ear, pharyngeal abscesses, bronchitis, tonsilopharyngitis, pneumonia and others.
- With pathology of the urinary tract, for example, with cystitis, pyelonephritis, urethritis and others.
- Against the background of gynecological infections, endometritis, septic abortion, salpingitis and others.
- With inflammation of the bile ducts (cholangitis or cholecystitis).
- In case of bone infections.
- With the development of infections of soft tissue and skin (we are talking about bites, phlegmon, wound infection).
- The occurrence of sexual pathologies (chancroid or gonorrhea).
- The presence of odontogenic infections in which pathogens enter the body through a cavity in the teeth.
So, we will find out how to take an adult "Amoxiclav 875 + 125".
Instruction manual
This medication is prescribed in different ways. The method of administration depends on the age of the patient, on his weight, the severity of the infection, and in addition, on the condition of the liver and kidneys. The optimal time for taking the drug is to start eating. How many days to take Amoxiclav 875 + 125? The course of this medicine lasts from 5 to 14 days, you can not use it longer.
How many times a day Amoxiclav 875 + 125 is taken? Tablets are drunk every eight hours, that is, 4 times a day.
If it is necessary to use the medicine for the treatment of patients with kidney diseases, urine creatinine content must be taken into account. Patients with liver problems need constant monitoring of their functions. This is confirmed by the instructions for use with Amoxiclav 875 + 125.
Contraindications
What are the contraindications for Amoxiclav 875 + 125?
As part of the administration of this medicine, a violation of liver function in the form of jaundice may occur if this drug has been used before and the patient has an increased sensitivity to its ingredients or to all penicillins in general. Patients who are allergic to cephalosporins, or in the case of pseudomembranous colitis, liver failure, or against a background of renal dysfunction, are prescribed a medication carefully. In people with mononucleosis who have previously been prescribed Ampicillin, a rash of erythematous nature may occur. In this situation, the antibiotic must be undone.
The dosage of Amoxiclav 875 + 125 is important to strictly observe in order to avoid the development of side effects.
Side effects
Usually, these easily pass and are normally tolerated by patients. Adverse reactions are more likely to occur in older people and those who use Amoxiclav for a long time. Most often, a side effect occurs during or after completion of therapy, but sometimes its development is observed several weeks after the end of the medication.
As for the digestive system, then, as a rule, people develop diarrhea along with nausea, vomiting and dyspepsia. Flatulence is less commonly noted along with gastritis, glossitis, discoloration of the tongue and enterocolitis. During or after the end of therapy with this medicine, pseudomembranous colitis may appear, which is a disease caused by a bacterium of the clostridium genus.
Against the background of the blood system, patients may experience anemia along with eosinophilia, a decrease in the number of platelets, white blood cells and agranulocytosis. The nervous system is able to respond to the use of the drug with headache, dizziness, agitation, insomnia, convulsions, hyperreactivity or inappropriate behavior.
Possible increase in liver function tests, including an asymptomatic increase in the activity of AsAT and the level of bilirubin in blood serum. The skin can respond to Amoxiclav by the appearance of a rash, urticaria, angioedema, erythema multiforme appears less often along with toxic epidermal necrolysis, exfoliative dermatitis, and so on. The appearance in the urine of blood along with interstitial nephritis may be noted. With prolonged use of the drug, fever, candidiasis of the oral cavity, and also vaginitis are possible.
How to use "Amoxiclav 875 + 125" with angina?
Use of the remedy for angina
Antibiotics in the presence of angina are prescribed only in the case of the development of moderate or high severity of this disease. "Amoxiclav" as an antibiotic is often prescribed for tonsillitis. Its use is indicated only when the bacterial form of infection with the presence of pathogenic microflora is confirmed, tested for sensitivity to the drug in question. In the treatment of angina in children, suspensions are used, and for adults, tablets are applicable. In difficult situations, use injections of the drug. It is important to remember that antibiotics should in no case be used for a long time, as this increases the resistance of pathogenic microflora to them.
Compatibility
It is important to adhere to the following rules:
- It is undesirable to simultaneously use "Amoxiclav" with drugs of indirect anticoagulants. This can cause an increase in prothrombin time.
- The interaction of Amoxiclav with Allopurinol causes risks of exanthema.
- Amoxiclav enhances the toxicity of metatrexate.
- You can not use this medication simultaneously with Amoxicillin and Rifampicin. These drugs are antagonists, their combined use weakens the antibacterial effect of both.
- It is forbidden to prescribe Amoxiclav with tetracyclines or together with macrolides (they act as bacteriostatic antibiotics).
- It is impossible to combine reception with sulfanilamides due to a decrease in the effectiveness of the use of this drug.
- It should be borne in mind that taking Amoxiclav reduces the effectiveness of any contraceptive in tablets.
Analogs of Amoxiclav 875 + 125
Which medication is better than Amoxiclav? Choosing antibiotics for the treatment of infection, one must be guided by the result of checking the pathogenic microflora for its sensitivity. There is no point in using a drug that does not kill bacteria. Therefore, the best is the antibiotic, to which the parasites that caused the patient's disease are sensitive.
Amoxiclav and Amoxicillin
Amoxiclav acts as a more effective means than this analogue, because many pathogenic microorganisms have developed immunity to this antibiotic, they have learned to destroy it, not allowing it to exhibit its bactericidal effect. But the presence of clavulanic acid in Amoxicillin also makes this antibiotic quite active.
Other analogues
What other analogues are there for Amoxiclav 875 + 125?
The drug "Augmentin" also acts as an analogue containing the same active ingredients. There is also a substitute called Flemoxin, which serves as a drug containing only amoxicillin. There is no clavulonic acid in it, and the medicine has a smaller spectrum of exposure, therefore, this tool is used only if the bacterial microflora is sensitive to it. The composition of Sumamed includes the antibiotic azithromycin, which has a wide range of effects. The choice must be made on the basis of a sensitivity test of pathogenic microflora. Adverse reactions are similar.
In addition to the aforementioned drugs, analogues include medicines in the form of Klavocin, Moksiklava, Amovikomba, Arleta, Baktoklava, Klamosara, Verklava, Medoklava, Liklava, Panclava , “Ranclava”, “Rapiclava”, “Toromentina”, “Flemoclav”, “Ecoclave”, and others.
Below are reviews about the "Amoxiclav 875 + 125". We learn what people think about this tool.
Reviews
Doctors in the reviews report that this medication is more effective in treating various diseases of the respiratory canals than its analogues. Usually, a course of five days is prescribed by specialists, after which it is necessary to take medications that restore the microflora. Doctors report that this drug works great for bacterial genital tract infection, rarely giving side effects.
Also, reviews of Amoxiclav 875 + 125 report that in parallel, doctors prescribe antifungal medications with probiotics to restore normal microflora. Injection use of the drug allows you to quickly eliminate the manifestation of diseases of the otolaryngological organs. The comments also note that the medication in question treats middle ear inflammation well.
Is Amoxiclav 875 + 125 effective in sinusitis?
How to take this medicine with different forms of sinusitis?
Before you go to the pharmacy after receiving the necessary prescription, you need to make sure that the person knows how to take Amoxiclav in the development of sinusitis. For example, this drug should be used only twenty or thirty minutes after eating. This is directly related to the fact that the digestive system is able to react negatively to the ingredients of the drug.
During therapy, you can not drink alcohol, as it affects the absorption into the blood of components from the intestinal tract. Impaired absorption can lead to serious complications, in particular, to liver pathology. In pharmacies, Amoxiclav is available only by prescription, since it is an antibiotic. The doctor must make sure that the patient does not have an allergic reaction so that he can prescribe this drug. Treatment of sinusitis with the drug in question in chronic and acute form is different:
- Against the background of an acute course, the course is from five to seven days.
- In the chronic type, from ten to fourteen.
Now we will find out how to take the described pharmaceutical agent against the background of the development of cystitis in people, since Amoxiclav 875 + 125 is also prescribed for cystitis.
Cystitis
According to the instructions, with cystitis, the drug is taken as follows:
- Pills must be dissolved in 250 milliliters of water, mixing thoroughly and taking according to the scheme.
- Before use, the powder should be diluted in one glass with water.
- They usually take pills before meals half an hour before eating it to reduce the risks of side effects.
- The drug is used for adults and for children from twelve years old, provided that the mass is more than forty kilograms. The maximum daily dosage is 1200 milligrams. It is necessary to use one tablet every twelve hours.
- In the presence of severe course, it is allowed to increase the dose to 1000 milligrams at a time. The maximum daily dosage is 2 grams. The intervals between doses are eight hours at a dose of 625 milligrams of the drug and 12 hours at 1000.
- The course of treatment for cystitis usually lasts seven days. When the course of the disease becomes severe, the course increases to fourteen days.
- In the event that the patient has severe kidney failure, then the one-time dosage of the drug should not be more than 625 milligrams.
Treatment of cystitis is carried out on an outpatient and inpatient basis. The described drug has a number of adverse reactions, therefore, at the time of therapy, control is carried out by a medical officer. Particular attention is given to the first intake of the drug in order to timely detect allergic reactions. Some patients with this drug may experience anaphylactic shock. For example, Amoxiclav was taken with cystitis by one patient, and within three hours after taking the pills she developed anaphylactic shock. Fortunately, the necessary medical measures were provided in a timely manner. Next, we find out how to take the medication in question in case of bronchitis in patients.
Assign "Amoxiclav 875 + 125" with bronchitis. Is it justified?
With bronchitis
Amoxiclav tablets are the most common form of medication. They are oval in shape and covered with a white shell. The presented remedy in the presence of bronchitis in adults, as well as in children who are over twelve years of age, is prescribed most often in tablet form. But at the same time, the weight of the child should be at least 40 kg. The method of use directly depends on the dosage of the active ingredient. Tablets are drunk before meals with a little water.
Powder for parenteral use is used subject to complex bronchitis or a life threat to the patient. It is prescribed for adults and children. The effect of this form of release is much faster than that of tablets. For adults, this powder is used for bronchitis by the following two methods:
- Through intravenous use. To do this, 600 milligrams of the drug is diluted in 10 milliliters of water for injection.
- To carry out a dropper, the drug is diluted similarly to the first method, but in addition 50 milliliters of the infusion solution are added to it.
For children, the dosage is calculated according to the following scheme:
- Babies under three months of age are prescribed 30 milligrams of the drug per 1 kg of body weight. The resulting dosage is divided into two doses per day.
- Children older than three months in the case of a mild form of the disease require 20 milligrams of antibiotic per 1 kg of body weight. In severe forms, it is necessary to prescribe 40 milligrams of the drug per 1 kg of weight. The resulting volume is divided into three doses per day with equal time intervals.
In the event that the disease requires more active therapy, the doctor may prescribe a parenteral form of antibiotic use. Recommended dosages in this case are as follows:
- Up to three years, 30 milligrams of the drug is prescribed per 1 kg of body weight twice a day.
- At the age of three to twelve years, 30 milligrams of the drug is usually prescribed per 1 kg of weight three times a day.
Dosage can be adjusted by the attending physician.
Amoxiclav is a new generation antibiotic that works against a wide range of pathogens. Its constituent amoxicillin and clavulanic acid in the aggregate effectively fight strains of infections that are sensitive to both of them. It has several forms of release with different dosages, which allows you to build the right balanced course of treatment.
We examined how to take Amoxiclav 875 + 125 for an adult and a child.