Choosing a dosage of Amoxiclav, the attending physician prescribing the drug. Certain recommendations in this regard are contained in the instructions applied by the manufacturer to the medicine. There are several forms of release (tablets, substance for injection, suspension). Each of them has its own dosage and consumption rules.
Attention to little things
Amoxiclav is one of the antimicrobial agents, therefore it can be used strictly under the supervision of a doctor. Self-medication can cause course inefficiency, provoke the appearance of superinfection and other complications. To take the drug showed the most pronounced result, you will have to use the medicine in the form recommended by the doctor for exactly as many days as the doctor will say, clearly observing the dosage and frequency of use. The doctor chooses the dosage of Amoxiclav based not only on the patient’s diagnosis, but also on the individual characteristics of the body. The role is played by age, weight, diagnosis, severity of the course of the disease.
Forms: what is what?
Before deciding on the dosage of Amoxiclav, it is worth paying attention to options sold in pharmacies. The drug is quite popular, it is produced by several pharmaceutical companies, so there are many forms of release.
Quite often, doctors recommend staying on combination tablets Amoxiclav 250 + 125. The first figure indicates the amount of amoxicillin in one tablet, the second indicates the content of clavulanic acid. It is impossible to tell in advance what dosage of Amoxiclav in this form the doctor will prescribe. As a rule, several tablets are used per day. The specific volumes depend on the diagnosis, the characteristics of the patient's body.
In addition to the main components, carmellose, cellulose are present in the tablets. The manufacturer in the attached documentation lists all the components of the tablets. They need to be carefully studied with increased sensitivity to the compounds used in pharmaceuticals.
Powders for minors
On sale is a powder medication for the preparation of a suspension. The medicine is intended primarily for minor patients. They proceed by choosing the dosage of Amoxiclav suspension 125 + 31.25, from the age of the child, the diagnosis. The first figure shows the content of the antimicrobial component, the second reflects how much acid is in the composition, which provides amoxicillin protection from active compounds produced by microorganisms.
The second option for the release of the drug for children is enhanced, that is, the concentration of active compounds is twice as high: 62.5 + 250 mg. For children, the dosage of Amoxiclav in this form must be agreed with the doctor. The doctor will tell you how to dilute the powder correctly in order to maintain proportions. Excessive consumption can cause a negative reaction of the body, so it is important to follow the established rules.
In addition to the basic compounds, Amoxiclav suspension also contains sodium citrate, saccharin and benzoate, cellulose and mannitol.
Intravenous use
For this application format, the doctor selects the dosage of Amoxiclav. As a rule, the drug is used in a hospital setting. There are two options for the release of a pharmaceutical product: 600 mg and twice the volume. The first contains 500 mg of the antimicrobial component, five times less of clavulanic acid. The reinforced form contains active compounds in a ratio of 1000 + 200.
Additional components in this form of release by the manufacturer are not used. The tool is intended for intravenous infusion. The procedure is recommended to be carried out under the supervision of the attending physician.
Enhanced Release Form
On sale there are, in addition to the usual, enhanced versions of Amoxiclav tablets. The dosage of the active ingredient per capsule is 500 + 125 or 875 + 125. The first figure reflects how much amoxicillin is in the composition, the second describes the content of the antibiotic stabilizing element that protects it from the influence of aggressive enzymes produced by pathological microbes. As part of the preparation, the antimicrobial compound is present in the form of a trihydrate, and the acid in the form of a potassium salt.
The manufacturer used additional substances in the manufacture of the medication. They do not have pharmacological activity, but they provide the drug with a long shelf life, simplify its administration, and increase overall effectiveness. Talc and cellulose, aromatic and coloring additives, silicon dioxide and aspartame, castor oil are used.
QuickTab
In this form of Amoxiclav tablets, the dosage of the active ingredients is 500 + 125 or 875 + 125. Amoxicillin accounts for a larger volume, a smaller figure reflects the amount of acid in the capsule of the drug. In addition to the main compounds, additional components were used. These are various coloring, aromatic compounds, talc, cellulose, silicon dioxide. The tool is strong enough, so it is important to use it under the supervision of a doctor. Incorrect use of the medication can provoke negative effects (like the incorrect use of Amoxiclav in any other form).
How to use?
For each of the forms of release there are own rules for use, dose selection. In tablet form, the medicine is intended for oral use. No need to chew the drug. The tablet is washed down with water. The dosage of Amoxiclav is chosen by the doctor, evaluating the condition of the patient, the response of the body. The duration of the course varies from 5 days to a two-week period. Amoxiclav tablets may be used by patients over six years of age. For children under the suspension.
The manufacturer recommends in the instructions for use of Amoxiclav the dosage for children based on the weight of the child: per kilogram - about 40 mg of the antimicrobial component. Obtained in such calculations, the volume is divided into three stages. The format of use is optimal for patients aged 6-12 years.
If the child's body weight is more than 40 kg, the same program for using the medication is suitable for him as an adult patient. In case of diseases assessed as mild, the average dosage of Amoxiclav for adults is three times a day on a 250 + 125 tablet. Between receptions take eight-hour breaks. An alternative course is twice a day with twelve-hour breaks per tablet 500 + 125.
If the disease is severe, the manufacturer recommended the following dosage of Amoxiclav for adults: three times with eight-hour breaks per tablet 500 + 125 or twice a day on a tablet 875 + 125. In the second option, the interval between use should be 12 hours. It is advisable to accurately withstand the specified time intervals, this determines the effectiveness of the course.
Double pills
Amoxiclav 2X is intended for oral use. Each capsule must be swallowed without violating the integrity of the shell. The drug is washed abundantly with water. The product is suitable strictly for adult patients. Use if severe infection is established, severe respiratory disease. Dosage - a tablet containing 1 g of the active ingredient, twice daily.
For a day for adults, the maximum amount of amoxicillin is estimated at 6 g. For clavulanic acid, the upper limit is 600 mg.
Special occasion
A dosage adjustment of Amoxiclav (250 mg and any other variant of the content of active components) is necessary if the patient has a renal failure. If creatinine clearance is estimated at 10 ml / min or less, it is necessary to reduce a single dose and lengthen the intervals between doses of the drug. If the patient suffers from anuria, tablets are used intermittently for up to 48 hours.
If creatinine clearance is estimated at 80 ml / min and above, the medication is prescribed with eight-hour intervals between doses. With an indicator of more than 50 ml / min, breaks of 8 hours should also be observed. At a value above 10 ml / min, it is recommended to use tablets at intervals of 12 hours between doses. If the clearance is 10 ml / min or less, the recommended temporary breaks are from 24 hours. The doctor selects a specific option based on the patient's reaction to the drug. The wrong frequency of doses, the dosage of Amoxiclav (250 + 125 or other forms of release) can cause an adverse reaction.
Suspension
Amoxiclav suspension for children is available. The dosage of 250 + 62.5 or 400 + 57 is chosen by the doctor. The doctor will tell you which of these two forms should be preferred, how to use the drug correctly. The powder is intended for the preparation of a solution taken orally. The dosage of Amoxiclav for children is not allowed to exceed the border recommended by the manufacturer. This may not be safe. Before use, you must carefully shake the bottle with the medicine, making sure that all the particles have moved away from the walls, bottom. 86 ml of pure liquid are poured in two portions. After the first, second addition, you need to mix the drug. Use it using a measuring spoon. It holds 5 ml.
The dosage for children of Amoxiclav 250 + 62.5, 400 + 57 is determined based on weight, diagnosis, age. Up to three months, the medication is used in a volume of up to 30 mg per kg of body weight. The volumes obtained in such calculations are divided into two uses. The instructions describing the dosage rules of Amoxiclav for children indicate that it is necessary to observe twelve-hour intervals between the use of the composition.
Nuances and rules
For children older than three months of age, but weighing less than 40 kg, the dosage of Amoxiclav suspension 250 + 62.5 or 400 + 57 is chosen, given that the optimal format is up to 25 mg of amoxicillin per kilogram of weight. The dose obtained in the calculations is divided into two doses, between which the twelve-hour intervals are maintained. An alternative dosage for Amoxiclav suspension for children is 20 mg per kg. This dose is divided into 3 doses, between which observe eight-hour intervals. This program is effective when the pathology is not too difficult.
If the infection is severe, the dosage of Amoxiclav suspension for children is calculated as 45 mg / kg. The resulting volume is divided into two doses. You can use the drug 3 times a day at intervals of 8 hours. Then on the day the dose is calculated as 40 mg / kg.
The manufacturer in the instructions to Amoxiclav writes about the dosage, indicating the upper possible restrictions. For children per day, the permitted dose is up to 45 mg / kg of amoxicillin. Clavulanic acid should be ingested no more than 10 mg / kg. In order not to make a mistake with the choice of volumes of the drug, it is better to first show the child to the doctor. The doctor will tell you exactly which release option is suitable, what the dosage of Amoxiclav should be (a suspension of 250 mg or another format).
Injections
One ampoule of Amoxiclav contains 30 mg of the drug, of which 25 mg is an antimicrobial compound, and the rest is in the stabilizing protective component. For injective use, the drug must be prepared: the contents of the ampoule are mixed with a special injection liquid. For 600 mg of the drug, 10 ml of liquid is needed, twice as much - at a double dose. The solution is injected into a vein. The duration of the procedure is up to 4 minutes.
If the doctor recommended an infusion into a vein, first the drug is dissolved in the above ratios, then the substance is injected into the infusion solution. For 600 mg of Amoxiclav, 50 ml is needed, for twice as much concentration - 100 ml of additional liquid. The duration of the procedure reaches 40 minutes.
After diluting the contents of the ampoule, administration begins within 20 minutes. If the procedure could not be started during this time, the medication is disposed of. The manufacturer indicates the inadmissibility of freezing the drug.
The doctor may recommend a dosage of Amoxiclav in tablets in the form of a powder for suspensions to children, but they rarely resort to injections. In this form of the drug is approved primarily for persons over the age of twelve, for patients whose body weight is 40 kg or more.
Rules and Features
As in the rules for the dosage of Amoxiclav suspension for children (250 mg and other release options), the instructions for the substance for injective use indicate the recommended time-outs between use. The manufacturer advises making an infusion every eight hours, using 1.2 g of the drug in one procedure.
In rare cases, Amoxiclav injections are allowed for children from the age of three. The recommended dose for this case is 30 mg per kilogram of body; eight-hour breaks are made between procedures.
Sometimes the doctor recommends which dosage for children to use Amoxiclav (125 mg of amoxicillin or another amount), making up a course of treatment for the newborn. An antibiotic can be used if a premature baby needs it. Between introductions take twelve-hour breaks. The dose is selected based on the weight, for each kg - 30 mg. It is hardly possible to achieve the desired effect, the injections are stopped, the antibiotic is prescribed orally (for example, a suspension, where the concentration of amoxicillin in milligrams is 125). The dosage of Amoxiclav is chosen by the pediatrician. The duration of the program reaches two weeks.
Operation Pending
Amoxiclav can be used if surgery is prescribed, and the risk of complications associated with pathological microorganisms is assessed as increased. In such a situation, the drug should be used for injective administration. Immediately before taking the painkiller, 1.2 g of the drug is administered once, if a short-term intervention is planned. If the duration of the operation is an hour or more, administration should be repeated after some time intervals. The maximum frequency is 4 times a day.
If the risk of septic complications is assessed as high, Amoxiclav should be used for intravenous administration after completion of the procedure. Over time, you can switch to the oral form. The manufacturer recommends resorting to this use case if signs of infection are detected during the operation of the patient.
Weak kidneys
If the failure of the functioning of this organ is established, it is necessary to carefully select the dosage for the introduction of the drug into the vein. Take into account creatinine clearance. If the indicator exceeds 30 ml / min, it is not necessary to change the dose relative to the standard, with parameters smaller, but more than 10 ml / min, first use 1.2 g of the drug, after 12 hours - half as much. The course is continued with the introduction of the drug in an amount of 600 mg. If creatinine clearance is estimated at 10 ml / min or less, the first dose is 1.2 g, all subsequent ones are half as much. Between the introductions make daily intervals.
If renal failure is established in a child in need of treatment, a dosage adjustment is necessary.
It was revealed that during hemodialysis up to 85% of the active components can be eliminated from the body. After such a procedure, Amoxiclav in the form of a substance for injection into a vein can be used. There is no need to select the course features if the patient is prescribed peritoneal dialysis, since this procedure does not affect the antibiotic content in the human body.
“Quicktab”: features of the reception
In this form, tablets are intended for pre-dissolution in water. The drug is prepared immediately before use. For one tablet, you need to take 100 ml of liquid or a little more. The prepared liquid is immediately drunk without residue. An alternative use is to chew the tablet thoroughly, then wash it down with a clean liquid without additives.
The Quicktub release form is recommended for patients over the age of twelve. Such tablets should be used if the patient's weight is at least 40 kg. On average, 2-3 tablets of a drug containing active ingredients in a proportion of 500 + 125 are prescribed per day. The specific dosage is determined by assessing the severity of the infectious process. Between receptions it is necessary to observe equal time intervals.
The manufacturer recommends using Amoxiclav Quicktab before a meal. If the disease is severe, you should stay on the release form 875 + 125. Tablets are consumed twice daily, with a 12-hour interval between doses. The duration of the course reaches two weeks. The doctor selects the specific duration based on the diagnosis, the body's response to therapy.
Pharmacology
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"Amoxiclav" is prescribed as a prophylactic medicine if septic negative consequences are expected, suppuration against the background of surgical intervention. The use of the drug is especially important if the procedure is performed on the cardiac, renal systems, and the pathways of bile. Amoxiclav is indicated for the prevention of complications in pelvic surgery.
You can use an antimicrobial agent as an element of the complex treatment of mixed infection, when anaerobic, gram-positive, gram-negative microscopic life forms are found in the patient's body. "Amoxiclav" is indicated for infection after surgery, pneumonia, abscesses, diseases of the biliary tract and ENT organs.
The tool has become widespread in the practice of orthopedists, for operations on the face, interventions affecting the jaw.
Negative consequences
Taking "Amoxiclav" can cause adverse reactions from the body. In most cases, such actions are short-term, easily tolerated by patients. More often occur if a person takes the drug at his discretion, without the consent of the doctor.
It is noted that up to three people out of a hundred patients suffered from nausea; violation of the chair bothered four out of every hundred. The incidence of dyspepsia is estimated at 1.6%.
All other side effects appear much less frequently than indicated. The manufacturer mentions that there is a risk of increased gas formation, weight loss and gastritis, and infectious and inflammatory processes in the oral cavity are possible. Sometimes, against the background of using the medication, the shade of the tongue changes. With therapy, or soon after its completion, there is a slight risk of pseudomembranous colitis. The cause of the disease is the effect of toxic compounds against the background of infection with clostridia.
It is known that Amoxiclav can provoke angioedema, skin rashes, erythema, dermatitis and necrolysis. The use of the drug carries a risk of anxiety, it can hurt and become dizzy. Perhaps a violation of the adequacy of behavioral reactions, seizure, increased activity. Some have disturbed sleep, confused consciousness. With the use of Amoxiclav, there is a risk of anemia, leuko-, thrombocytopenia, agranulocytosis.
Perhaps the appearance of blood elements in urine, candidiasis, fever. A long course can provoke candidiasis in the oral cavity. There is a risk of hepatitis, jaundice, but such side effects, as statistics show, are very rare. The first signs can be noticed already during the course or immediately after its completion, but in a small percentage of cases they come only a few weeks after the end of therapy.
Strongly impossible!
It is unacceptable to use Amoxiclav if the patient had: jaundice, hepatitis while taking antimicrobial drugs of the penicillin series.
It is known that hypersensitivity to the active compounds of Amoxiclav is possible. With these individual characteristics, the use of the drug is prohibited. The composition should not be used if too high a susceptibility of other drugs from the penicillin class is revealed.
There is no information on a possible teratogenic effect. If the doctor estimates the benefits of taking Amoxiclav during pregnancy significantly higher than the possible risks, he can prescribe this medication to the patient. In this case, the doctor explains what risks are associated with the use of the drug. When carrying a fetus, Amoxiclav prescribes lactation strictly according to indications in extreme cases, if there is no safer and more effective alternative.
Too much!
The manufacturer in the instructions indicates: the likelihood of taking an excessive amount of medicine is extremely small. If you use the medicine in a large dose, sleep disturbances and convulsions are possible. Some patients felt dizzy and aching, their condition became too agitated.
Effectiveness in case of overdose shows hemodialysis. The doctor prescribes drugs to stop the symptoms that arise in a particular case.