In the article, we consider the instructions and analogues for the drug "Trihexyphenidyl".
The prescribed drug can not always be easily purchased at the nearest pharmacy, or its cost is very high, while treatment is necessary. In such cases, you need to know about the available analogues that can replace the drug prescribed by your doctor.
Analogs "Trihexyphenidyl" should be selected by a doctor.
Indications
The drug is used:
- with parkinsonism (atherosclerotic, postencephalitis, idiopathic, as a result of a side effect of drugs, as monotherapy or in combination with levodopa);
- spastic paralysis caused by defects in the extrapyramidal system;
- Little's disease;
- Parkinson's disease.
So it is said in the instructions for use with Trihexyphenidil. Reviews and analogues will be considered below.
Instructions for use
The drug is antiparkinsonian and is available in tablet form. The use of "Trihexyphenidyl" is advisable for Parkinson's disease or Little's disease, as well as to reduce the effects of paresis, eliminate spastic paralysis and tremor.
It can be used in the treatment of extrapyramidal defects caused by the administration of drugs, including antipsychotics.
The medication produces an anticholinergic effect on the peripheral and central nervous system, promotes muscle relaxation, due to which trembling of the extremities is significantly reduced.
According to the instructions, "Trihexyphenidyl" has a weaker effect on rigidity and bradykinesia. Due to its ability to block choline, the drug reduces the production of sweat and saliva. It is characterized by signs of a local anesthetic.
The active substance is absorbed from the digestive tract with high speed, so it takes only an hour to take the pill until the effect occurs. Its action lasts 3-5 hours. If an injection was made, it begins to function after 5-10 minutes, its effect lasts up to twelve hours.
The drug passes through the blood-brain and placental barrier. It is excreted from the patient's body along with urine in the form of metabolites.
Dosage
The dosage is prescribed individually by the attending physician.
Initially, no more than one milligram per day is prescribed. To achieve the optimal therapeutic effect, the dosage should be increased every 3-5 days. It is divided into several doses (3-5) after a meal or throughout the day, according to medical advice.
The maximum amount for a single dose is ten milligrams. Patients after sixty years need special attention of specialists.
During prolonged use, it is necessary to control the pressure inside the eye. Over time, the intensity of undesirable effects decreases. The drug can cause addiction in the patient.
You can buy it for about 92 rubles (a pack of 50 tablets).
Analogs of Trihexyphenidyl
As an active ingredient, trihexyphenidyl is present in various drugs. Instructions for their use are completely similar to the original drug.
We list and describe the analogues of Trihexyphenidyl, among which are currently unavailable for purchase in Russia.
Foreign drugs
- Romanian drug Romparkin. It is produced in the form of white tablets. One tablet contains two milligrams of the active substance. The package contains five blisters, each containing ten tablets. With treatment, the initial dosage ranges from half to one milligram per day, it can increase over time to ten.
- Indian drug "Tryphin". Its dosage form is tablets, in each of which - 2 mg of the active substance. Treatment begins with one milligram per day, the dosage is gradually brought to a minimum effective. A maximum of 20 mg can be consumed per day. Break the reception should be 3-5 times a day.
- Canadian drug Apo-Trihex. It is produced in the form of tablets of 500, 100, 50 pieces per pack, 5 mg, as well as 500 or 50 pieces in a 2 mg vial. Reception begins with 1-2 milligrams, increases in 3-5 days, the dosage reaches 6-10 mg. The drug is taken 3-5 times during meals. Analogs and synonyms of "Trihexyphenidyl" can be purchased at any pharmacy.
- Italian or Indian drug "Trihexyphenidyl hydrochloride." It is made in the form of powder. Its minimum dosage is half a milligram per day. The dose increases over time to the minimum effective. At one time, you can use a maximum of 10 mg, during the day - no more than 20 mg. With hypersalivation, the drug is taken after a meal, and with a dry mouth - before a meal.
- German drug Parkopan. Available in the form of tablets containing 5 and 2 mg. Packing includes 100 pieces. The dose is selected individually by the attending physician, brought to the minimum effective. During the day, the body should enter for 3-4 applications.
- Another analog of Trihexyphenidyl is the German drug Akineton. Round white pills or injection. Tablets are sold in a cardboard pack of 2, 10 and 5 blisters, each of which includes ten pieces, or 2, 5 blisters containing 20 tablets. The active ingredient is biperiden. Patients are prescribed 1 mg several times a day, each day the dosage is increased by 2 mg. The maximum amount is 16 mg divided by 2-3 uses per day. Injections should be administered slowly intramuscularly or intravenously. 10-20 mg are divided into 2-3 procedures.
- Macedonian drug "Mendileks". Convex on both sides, round tablets, which contain 2 mg of the active ingredient - biperiden chloride. Cardboard packaging includes five blisters of ten tablets. The dose was originally two milligrams in two divided doses. For most patients, the optimal dosage is from 3 to 12 mg, divided into 3-4 doses. Treatment cannot be abruptly stopped, as there is a likelihood of withdrawal symptoms.
Russian analogues
Tablets "Cyclodolum". In each blister - 25 pieces, in a dense cardboard packaging - two blisters. It is used during or before ingestion. In the first dose, not more than 1 mg per day is prescribed. The dosage increases over time to 6-10 mg, 3-4 applications. In severe cases, an increase in dose to 12-16 mg is necessary. You can not drink more than 10 at a time and more than 16 mg per day.
Drug Comparison
Most of the analogues of “Trihexyphenidyl” contains trihexyphenidyl as the active substance, excluding only “Akineton” and “Mendileks” (biperidene chloride).
All drugs have the same effect - anti-Parkinsonian effect. By suppressing choline, drugs can act on the peripheral and central nervous system.
All analogues also have the same list of contraindications. They are strictly prohibited in the event of the presence of at least one of the items listed below:
- allergy to the active component;
- dementia
- with urinary retention;
- pulmonary edema;
- violations of the activity and disease of the gastrointestinal tract;
- risk of atrial fibrillation;
- pregnancy (especially the first trimester);
- age up to 12 years.
Side effects are also similar:
- nervous system: prolonged hallucinations, acute pain in the temples and head, disorientation;
- allergy: skin rash of various kinds and purulent mumps;
- effects due to anticholinergic effects: dry mouth, blurred vision, difficulty urinating, increased pressure inside the eye, impaired cardiac function (tachycardia).
If the drug is used for a long time, side effects get less expression.
Reviews
About "Trihexyphenidyl" speak well. Depending on the disease and its severity, the medicine is prescribed in certain dosages. People note that with Parkinson's disease, only the maximum allowable amounts are effective, in which side symptoms are frequent. For a number of patients, the drug is prescribed to eliminate side effects of antipsychotics. Often people complain that such a combination worsens their memory, causes dry mouth and constipation, but in general the medicine is effective.
We examined the drug "Trihexyphenidyl" instructions for use and analogues.