How to use Tivortin? Instructions for use of the drug are discussed below. In addition, the article provides information on how much such a tool costs, in what form it is produced, what helps, what analogues, contraindications and side effects it has.
Composition, release form, packaging
What are the forms of release of the drug "Tivortin"? Instructions for use indicate that this drug is made in the form of:
- Solution for infusion. Its active substance is arginine hydrochloride. As an additional component, the drug contains saline. The medicine is available in 100 ml vials placed in packs of cardboard.
- The drug "Tivortin" is a syrup for oral administration. The active element of this form is L-arginine aspartate. As auxiliary substances, methyl parahydroxybenzoate, sodium saccharin, flavoring, sorbitol, water and propyl parahydroxybenzoate are used. The medicine is packaged in 200 and 100 ml bottles, which are placed in cardboard packaging.
Pharmacological action of the drug
What is a medicine like Tivortin? The instruction for use states that the amino acid is the active element of this tool. It belongs to the group of conditionally irreplaceable. In the body, arginine is partially synthesized. However, its quantity is not enough to satisfy the daily human need for a given substance. In this regard, it is required that it constantly comes from outside, that is, with food.
Amino Acid Properties
What are the properties of the drug Tivortin? The instruction for use states that its active substance is a protector that takes an active part in the regulation of cell metabolism, and also affects the functioning of organs and tissues, provides them with protection if it is necessary to overcome a critical situation.
The drug in question acts as an antiasthenic, membrane stabilizing, antioxidant, detoxification, antihypoxic and cytoprotective agent. Participates in the formation of an energy substrate and helps maintain hormonal balance in the blood.
It should also be noted that under the influence of arginine, the amount of somatotropin, insulin, prolactin and glucagon in the blood increases.
It should also be said that arginine is involved in the following processes:
- proline amino acid and polyamine production;
- depolarization reactions of cell membranes;
- fibrinolysis and spermatogenesis.
The principle of action of the drug
How does the drug Tivortin (syrup, solution for infusion) work? It takes part in the processes of neutralizing ammonia, and also stimulates its excretion. In addition, the drug activates detoxification functions of the liver.
After taking the drug in question, its hepatoprotective effect is noted. The medicine reduces the activation and adhesion of leukocytes and platelets to the vascular endothelium.
The use of the drug Tivortin, the price of which is indicated below, causes a moderately pronounced anabolic effect, stimulates the activity of the thymus gland, corrects the acid-base balance and regulates the level of glucose in the blood.
Pharmacokinetics
How long does Tivortin take? Experts say that if an intravenous infusion is carried out at a rate of 30 drops per minute, then the maximum concentration of arginine in the body is observed after about 20 minutes.
If the drug is taken orally, then its active element is absorbed after a quarter of an hour.
It should be noted that arginine penetrates rather easily through the histohematological barrier. Its uniform distribution occurs in all organs and tissues. The drug is excreted mainly through the kidneys.
Indications for use
What deviations are prescribed Tivortin medication? Reviews of experts say that this drug has the following indications for use:
- coronary heart disease;
- state of asthenia and hypoxia;
- atherosclerosis of the vessels of the heart and brain;
- arterial hypertension;
- chronic and acute hepatitis (of different origin);
- peripheral vascular atherosclerosis;
- liver disease
- diabetic angiopathy;
- myocardiopathy;
- chronic heart failure;
- pulmonary hypertension;
- condition after myocardial infarction and acute disturbance of blood flow in the brain;
- hypercholesterolemia;
- interstitial pneumonia;
- obstructive pulmonary diseases that have a chronic course.
It should also be noted that this medication is very often used to correct immunity with reduced work of the thymus gland.
Contraindications
The drug in question cannot be used under the following conditions:
- intolerance to the components;
- renal and liver failure;
- hyperchloremic acidosis.
The drug is not used to treat children under the age of 3 years.
Dosage and administration
Solution for infusion "Tivortin" must be administered intravenously. The initial speed should be 10 drops per minute. 20 minutes after the start of the procedure, the speed can be increased to 30 drops.
The instructions for use indicate that the drug in question can be administered in a volume of 100 ml per day.
How should I use the oral form of the drug Tivortin (syrup)? The instruction says that such a medicine must be taken with food. Patients with atherosclerosis, coronary heart disease and diabetic angiopathy should be given 5 ml of the drug 3-8 times a day. As for patients after myocardial infarction, as well as with acute circulatory disturbance in the brain, hypercholesterolemia, arterial hypertension and lung diseases, he showed this drug in a dosage of 5 ml 3-6 times a day.
In the same dose, the medication is prescribed for people with hepatitis and other liver diseases.
Patients who have hypoxic and asthenic conditions, as well as patients with reduced immunity, are prescribed a drug in a volume of 5 ml 4-8 times a day.
The duration of treatment should be 8-15 days. A single dose of the oral form is not more than 25 ml.
Adverse reactions
Does the drug “Tivortin” have side effects (its analogues will be presented below)? When administered intravenously, the medicine can cause headaches, a burning sensation and heat in the body, as well as inflammatory processes at the injection sites. In addition, allergic reactions (for example, in the form of urticaria) may occur.
As for the oral administration of the drug, in rare cases there may be a feeling of slight discomfort in the stomach and intestines, as well as a feeling of nausea, which manifests itself immediately after using the solution. As a rule, such phenomena disappear on their own.
special instructions
Before using the tool in question, you need to know that:
- The drug "Tivortin" during pregnancy should be used only according to the indications and under the supervision of a doctor, since its active substance easily penetrates the placenta.
- The drug is prescribed with caution to patients who are diagnosed with kidney disease, and there are also some metabolic disturbances in the electrolytes.
- During treatment, it is necessary to eat a balanced diet, not to drink alcohol, relax, and also give up psychostimulants and smoking.
- If asthenia symptoms appear during therapy, then treatment should be stopped immediately.
Medication "Tivortin": price and analogues
There are many analogues of the drug Tivortin. The following drugs are considered the most effective and effective: Aminosol, Tivortin Aspartate, Neo, Aminol, Aminoven, Vazonat, Aminoplasmal, Nucleinate Cardio, Neocardil and Nuclex ".
Any of these medicines can be used instead of the aforementioned remedy. However, this should be done only after the approval of a specialist.
How much is the drug in the form of an infusion solution? The price for a bottle of 100 ml is approximately 250 Russian rubles. As for the Tivortin syrup, it can be purchased for 400 rubles.
Reviews about the drug
Reviews about a medication intended for oral administration are quite rare. However, in the comments that are available, patients claim that the syrup effectively eliminates all the unwanted symptoms that it is directed against. The most pronounced effect is observed when using the medication in complex therapy.
As for the solution for infusion, reviews about it indicate that this drug effectively lowers blood pressure, and also allows you to overcome other unpleasant signs of disease.
It should also be noted that negative reviews are often found, which contain information about the development of adverse reactions, in particular, arrhythmias and headaches.