According to the instructions for use, Domperidone is a drug in tablets, which has an antiemetic property. The medicine belongs to the pharmacological group of antiemetics and central dopamine receptor blockers.
Composition and packaging
The composition of the medicine contains the main ingredients and auxiliary. The first is domperidone. It is presented in an amount of 10 mg.
The list of excipients consists of the following elements:
- magnesium stearate;
- pregelatinized starch;
- microcrystalline cellulose;
- talc;
- silicon dioxide colloidal;
- polyethylene glycol;
- polyvinyl alcohol;
- titanium dioxide.
The tablets have a round biconvex shape. The top of the tablet is covered with a film that prevents premature dissolution of the substance.
A blister pack with 10 tablets is used as a container. 1–5 blisters are put in a cardboard bundle.
Pharmacodynamics
This medicine has several properties:
- blocks central and peripheral dopamine receptors;
- increases motor and evacuation activity of the stomach;
- blocks the inhibitory property of dopamine on the motility of the gastrointestinal tract.
The result of such work of the medicine is the elimination of nausea, the suppression of the vomiting process, the blocking of hiccups. Along with this, prolactin index increases in blood serum.
Pharmacokinetics
Drug absorption occurs rapidly. The maximum plasma concentration is observed 30-60 minutes after oral administration.
Instructions for use "Domperidone" states: about 30% of the active substance is excreted in the urine, and almost 66% in the feces. After a single dose, the elimination period is 7–9 hours.
Indications for admission
Instructions for use of Domperidone tablets indicate several pathological conditions in which Domperidone will be effective.
- Hiccups.
- Atony of the digestive tract (weakening tone). This category also includes postoperative atony.
- Nausea and bouts of vomiting. The causes of this pathology may be different. These include toxemia, various diseases, taking certain drugs, conducting endoscopic diagnostic procedures.
- Esophagitis, gastroesophageal reflux, delayed gastric emptying. Symptoms of these diseases are: flatulence, a feeling of fullness and bloating, heartburn, belching, in which pieces of eaten food get into the oral cavity.
Instructions for use "Domperidone": dosage
The tablets are taken orally. This should be done before meals (15-20 minutes).
The dosage for adult patients and children over 5 years old reaches 10 mg (1 tablet).
The frequency of use may be 3-4 times a day. If necessary, the evening dose can be taken before bedtime.
With regular attacks of nausea and vomiting, a single dose is increased to 20 mg. The maximum volume of the drug per day is 80 mg.
Self-medication is strictly not recommended. His selection and daily rate should be addressed by the attending physician.
Side effects
The instructions for use of the drug "Domperidone" described several side effects. They occur infrequently and can be single or in complex.
The gastrointestinal tract in some cases responds with transient intestinal spasms.
With increased sensitivity of the patient to the composition of the drug, urticaria, redness of the skin and itching occur.
From the nervous system, isolated cases of extrapyramidal disorders were noted.
If at least one of the above symptoms has been noticed, you should refuse to take the medicine and consult a doctor to correct therapy.
Contraindications
Despite the high effectiveness of the drug, it is not suitable for every patient, therefore, before prescribing, you should familiarize yourself with the contraindications:
- The presence of increased sensitivity to the components of the composition.
- Mechanical bowel obstruction.
- Suspicion of bleeding localized in the organs of the gastrointestinal tract.
- Children's age up to 5 years. According to the instructions for use of Domperidone for children over 5 years of age, the medication is also contraindicated if the child’s body weight is less than 20 kg.
- Prolactinoma.
- Perforation of the intestines or stomach.
Patients with impaired liver and kidney function
Despite the recommended dosage in the instructions for use of Domperidone, in the presence of renal or hepatic insufficiency, the amount of the drug and the frequency of administration are selected individually. During treatment, the doctor must monitor the condition of the patient and, if necessary, prescribe intermediate tests.
During pregnancy and lactation
Women during pregnancy are not recommended to prescribe this drug. This is explained by the lack of sufficient data on the effect of the active substance on the fetus.
When breastfeeding, women are also forbidden to take Domperidone. The fact is that in breast milk, the concentration of the active substance is 10-50% of the amount that is present in blood plasma. In infants receiving this drug during breastfeeding, there is a tendency to the development of pathologies of the cardiovascular system.
The effect of the drug on the ability to drive a car
During the course of therapy using this medication, special care should be taken to drive a car and operate machinery.
Overdose
The maximum daily dose of Domperidone is considered to be 80 mg. In adult patients, excess rates are rare. Basically, these pathological conditions occur in children. Overdose can be identified by the following symptoms:
- agitation;
- extrapyramidal disorders;
- the occurrence of convulsive seizures;
- altered consciousness.
There is no specific antidote for this substance, therefore symptomatic treatment is indicated. First of all, you should rinse your stomach and take activated charcoal.
Interaction with some other medicines
Judging by the reviews and instructions for use, Domperidone is often used as an adjunct to complex medicine, therefore compatibility is an important characteristic of this drug.
The combined use with macrolides, antifungal drugs of the azole series, the antidepressant Nefazadone, and HIV protease inhibitors increases the concentration of domperidone.
Sodium bicarbonate and Cimetidine affect the bioavailability of the active substance.
Antacids and M-anticholinergic drugs are completely neutralized.
When combined with Ketoconazole, a dose adjustment of Domperidone is required, since in this case the concentration of this substance increases almost 3 times.
The medicine is suitable for combination with Digoxin, Paracetamol, antipsychotics and dopaminergic receptor agonists. No changes in concentration were detected in these cases.
Pharmacy leave conditions and storage features
This medicine may be dispensed in pharmacies without a doctor’s prescription.
Storage Requirements:
- lack of direct sunlight;
- temperature conditions are not higher than +25 degrees.
Analogs
According to the instructions for use of Domperidone, there are several analogues to this medicine. They may be similar in composition or effect. This list includes: “Domet”, “Motilak”, “Passenger”, “Motinorm” and others.
It is not worth it to replace Domperidone with these medicines on your own, since the dosage and contraindications for these medicines are different. Before taking, be sure to consult a doctor.
Reviews
Patients note in the reviews about the Domperidone tablets instructions for use, detailed in detail and reduction after several applications of pain in the stomach. As well as eliminating nausea and regular bouts of vomiting. In addition, the tablets are small and easy to swallow.
As for the opinion of doctors, they note the high effectiveness of the drug, the possibility of use in many diseases and a small number of side effects.