The drug with the trade name "De-Nol" is recognized as an effective gastroprotective agent. Doctors also prescribe this remedy for various pathologies of the stomach. De-Nol tablets have antiseptic, astringent, anti-ulcer and anti-inflammatory effects.
Indications
Painful sensations in the epigastric zone, indigestion, belching, heartburn - this is just a short list of warning signs with which a person turns to a gastroenterologist or therapist. After all the necessary diagnostic measures have been taken, the doctor draws up the most effective treatment regimen, which often includes the use of De-Nol tablets.
The medication is not an antibiotic. Nevertheless, based on the information specified in the instructions for use, De-Nol helps rid the body of pyloric helicobacteria, the causative agent of functional dyspepsia and gastritis. The active substance of the drug penetrates directly to the location of pathogenic microorganisms, after which it destroys them in a short time. The drug also improves the course of many ailments that affect the gastrointestinal tract.
Indications for De Nol:
- Gastritis, gastroduodenitis (both acute and chronic).
- Damage to the duodenum, perforation of the walls of the stomach of any severity, including peptic form.
- IBS.
- Functional dyspepsia.
- The defeat of the mucous membrane of the digestive organ, which is a consequence of taking hormonal and non-steroidal anti-inflammatory drugs.
- GERD is a chronic pathology, the course of which is accompanied by the penetration of the contents of the stomach back into the esophagus.
- Iron deficiency anemia that persists for a long time. However, the cause of its appearance has not been established.
Also, the indication for De-Nol is the prevention of relapse after surgery in the stomach, performed to treat ulcers or remove malignant neoplasms. In addition, the drug is recommended for people with close relatives who suffer from cancer of the digestive system.
Release form, composition
The drug "De-Nol" is sold in cardboard boxes. Each of them contains 7 or 14 blisters of 8 tablets. The manufacturer clarifies that a slight ammonia odor may be present in the package.
The tablets are round and biconvex. Each is coated. The color of the tablets is light cream. The manufacturer thought out a system of protection against fakes. On each tablet, graphical embossing of gbr 152 can be seen on both sides. In addition, they are marked with a square in the form of gaps in the lines of the sides and slightly smoothed corners.
The instructions for use of "De-Nol" indicate that the active component of the drug is tricalcium bismuth decitrate. In one tablet, it is contained in an amount of 304 mg. In addition, the composition is represented by the following auxiliary components: corn starch, magnesium stearate, hypromellose, potassium polyacrylate, povidone K30.
The active substance when interacting with water forms a colloid, which, in turn, is able to penetrate the mucous layer enveloping the walls of the stomach. There it breaks up into compounds, forming a protective film.
Bismuth tripotassium decitrate has the following positive effects:
- Increases the resistance of the digestive organ mucosa to adverse factors.
- Destroys pathogens. The active substance destroys their shell, interferes with the activity and fixation of bacteria to the organ wall.
- Promotes the speedy recovery of the mucosa.
- Reduces the activity of gastric juice.
The advantages of the drug include the fact that its action does not violate the digestive process. Even with prolonged treatment, pathogens do not develop resistance to the drug.
Instructions for use
De-Nol is prescribed only by the attending physician, which takes into account the results of the diagnosis. At the same time, there should be no drugs in the treatment regimen containing bismuth.
What matters is how to take De Nol - before meals or after meals. In order for the active substance to benefit, it must penetrate the walls of the stomach. If even a small amount of food will be in the body at this time, bismuth tripotassium decimate will mix with it and leave the body naturally. As a result, the body will not even have a minimal positive effect. That is why the drug must be taken strictly on an empty stomach. For the next 30 minutes it is forbidden to drink and eat any food.
Based on the instructions for use, De-Nol is recommended to be taken according to the following scheme:
- Children under 12 years old and adults. The daily dose of the active substance is 480 mg. During the day you need to drink 4 tablets. They can be divided into both 2 and 4 doses.
- Persons 8-12 years old. The daily dosage is 240 mg. It is necessary to take 1 tablet twice a day.
- Children 4-8 years old. The pediatrician calculates the daily dosage individually. For 1 kg of a child’s body weight, 8 mg of the active substance should be accounted for.
The tablets must be swallowed whole. It is unacceptable to chew them, break them up or grind them in any other way. When taking the drug, it is necessary to ensure that a sufficient amount of fluid is delivered to the stomach. It is recommended to drink tablets with clean still water. At the same time, it is forbidden to consume milk, nectars, vegetable and fruit juices.
The duration of De-Nol treatment is from 3 weeks to 2 months. This period is explained by the fact that even after getting rid of pathogenic microorganisms in the stomach, a high activity of inflammatory processes remains. The exact duration of treatment is indicated by the doctor when prescribing "De-Nola". The course in this case depends on the existing disease, its severity. The individual health characteristics of the patient are also taken into account.
Contraindications
“De-Nol” is not recommended for persons suffering from the following ailments:
- impaired renal function;
- severe adverse reactions of an allergic nature;
- individual intolerance to the components of the drug.
The drug is prohibited for women during pregnancy and lactation. This is due to the likely negative effect on the fetus and the penetration of the active substance into breast milk. Bismuth is a heavy metal, therefore, if there is a vital need for it, it is necessary to stop breastfeeding for the duration of treatment.
In addition, the age of children under 4 years is a contraindication to De-Nol. It is also not prescribed if the patient has recently taken preparations containing bismuth in order to treat other pathologies.
Side effects
Most often, against the background of taking the drug in patients, the following conditions appear:
- nausea;
- flatulence;
- frequent urges to commit an act of defecation or, conversely, constipation;
- impaired appetite;
- the presence in the oral cavity of a metallic taste;
- feces acquire a different shade (from dark brown to black).
The presence of the above side effects of "De-Nola" is not a reason to consult a doctor. Their occurrence is due to the adaptation period. These conditions pass without any intervention, their presence does not mean that the course of treatment must be interrupted.
Less commonly, patients experience allergic reactions. As a rule, they appear in the form of itching and rashes on the skin. The decision as to whether treatment should be continued should be made by the physician. Isolated cases of the occurrence of anaphylactic shock as a side effect of De-Nol have been recorded.
The duration of treatment with the drug should be no more than 2 months. This period can be increased by a doctor, but only if there is a vital need. This is due to the fact that with prolonged treatment, the risk of developing the following diseases significantly increases:
- nephropathy;
- arthralgia;
- gingivitis;
- pseudomembranous colitis;
- encephalopathy.
The trigger factor for the occurrence of these pathologies is the accumulation of bismuth in the central nervous system.
With strict adherence to the prescribed treatment regimen, the risk of complications is minimal. They disappear on their own after completing the medication. As a rule, serious complications are extremely rare. In most cases, they are the result of an unjustified increase in dosage or duration of treatment. When they appear, you need to see a doctor.
Overdose
Judging by the reviews, De-Nol is well tolerated by patients. A threat to health is taking the drug in a dosage 10 times higher than the standard. In such cases, renal failure develops.
Deterioration of well-being can occur against the background of prolonged treatment, in which a large amount of bismuth has accumulated in the tissues of the central nervous system. In this situation, symptomatic therapy is indicated. At the same time, the De-Nol treatment course is completed.
In acute poisoning, you must call an ambulance. Prior to the arrival of doctors, it is recommended to rinse the affected stomach, give it sorbents and saline laxatives. In severe cases, the patient is hospitalized. In the hospital, the patient is prescribed hemodialysis and taking medications that restore the normal functioning of the kidneys.
Compatibility with other medicines and alcohol
It so happens that the patient simultaneously with "De-Nol" takes other drugs designed to get rid of gastrointestinal pathologies.
In this case, it is necessary to take into account their compatibility:
- Proton pump inhibitors. These include: Omez, Omeprazole, Nolpaza, Pantan, Ulsepan, Pariet, Rabiet, Ontime, Epicurus, Lantsid, Helikol, etc. Not less than half an hour must elapse between taking any of these drugs and using De-Nol.
- Antacids. The most common drugs: "Gastracid", "Fosfalugel", "Maalox", "Rennie", "Vicalin". Agents containing bismuth and antacids are incompatible. Between their receptions should pass at least half an hour.
In addition, De-Nol and alcohol are incompatible. With any type of treatment, it is not recommended to use alcohol-containing drinks, especially for people with certain diseases of the stomach. Alcohol irritates the walls of the organ, preventing the penetration of the active substance into them. Also, the drug is often prescribed simultaneously with antibiotics. If you take alcohol and De-Nol at the same time, the toxic effect on the liver will increase significantly.
Analogs
Currently, there are several drugs on the pharmaceutical market whose active ingredient is bismuth tripotassium dicitrate.
The most famous analogues of "De-Nola" are the following drugs:
- Ulkavis. Contains 303 mg of active substance. It is an antiulcer and anti-inflammatory drug that inhibits the vital activity of the Helicobacter pylori bacteria. The drug must be taken 4 times a day for half an hour before a meal. Dosage for children - 1 tablet twice a day. The following side effects may occur while taking the drug: nausea, vomiting, frequent urge to defecate, allergic reactions. Ulkavis is most often recommended by doctors as an analogue of De-Nola.
- "Novobismol". An antiseptic and antiulcer drug, the dosage regimen of which is also identical to the De-Nola dosing regimen. The manufacturer notes that against the background of Novobismol’s treatment, not only feces, but also the tongue may darken. The duration of treatment should also not exceed 8 weeks.
- Escape. Antiulcer and gastroprotective agent with bactericidal activity against Helicobacter pylori. It has the same indications and limitations as De Nol. The regimen is also identical to the latter.
The “Venter" drug has a similar effect. Its active substance is sucralt. Unlike products containing bismuth, this drug has the ability to bind fatty acids much better. However, the active substance does not have any effect on the Helicobacter pylori bacterium.
Reviews
In most patients, their health improves within a few days after the start of the drug. Judging by the reviews, De-Nol eliminates unpleasant symptoms associated with the development of gastritis, peptic ulcer and other pathologies of the gastrointestinal tract in a short time.
Doctors prescribe this drug to their patients most often. This is due to its high degree of effectiveness. In most cases, upon re-examination, specialists identify significant improvements in patients.
Finally
Currently, diseases of the digestive system are diagnosed very often. To combat them, doctors in most cases prescribe De-Nol. This is a modern drug, the active substance of which penetrates the walls of the stomach and forms a protective layer that prevents the effects of negative factors on the organ. In addition, it contributes to the speedy restoration of its mucous membrane.
According to the instructions for use, "De-Nol" must be taken 4 times a day (or twice a day, but 2 tablets at once). The main contraindications are: pregnancy, lactation and children under 4 years old. Based on the information in the instructions for use, the drug has a number of side effects, the risk of which is minimal with exact adherence to the dosage regimen and dosage regimen.