How much does a drug like Lamicon cost? The price of this medication will be presented in this article. Also in it you will find detailed instructions for the use of the drug, its contraindications, analogues, indications, adverse reactions, release form, composition and so on.
Composition, form and packaging of the medication
You can buy the drug in the following forms:
- Aerosol "Lamikon". The spray contains such an active substance as terbinafine. As additional components of this form, propylene glycol, cetostearyl ether of macrogol 20, benzoic acid, disodium edetate, water for injection and poloxamer 407. are used. The cutaneous preparation is available in bottles with a 25 g metering pump.
- Cream "Lamicon" (ointment). The instruction reports that terbinafine also acts as an active element of this form. Additional ingredients of this form are: mineral oil, sodium hydroxide, white soft paraffin, cetostearyl and phenylethyl alcohols, macrogol cetostearyl ether 20, propylene glycol, poloxamer 407 and purified water. The ointment goes on sale in tubes of 15 g.
- Oral drug "Lamicon". Tablets, the instruction of which is enclosed in a cardboard box, also contain such an active substance as terbinafine. As for the additional components, they include: corn starch, sodium starch glycolate, microcrystalline cellulose, anhydrous colloidal silicon dioxide, hydroxypropyl methyl cellulose and magnesium stearate. Tablets are contained in contour cells of 7 pieces.
Pharmacodynamics
The pharmacological group of the drug in question is antifungal. According to the instructions, the main substance of this agent is alilamine, which exhibits an active therapeutic effect on a large number of different strains of fungi.
The fungicidal properties of terbinafine (at normal concentration) apply to dermatophytes and molds, as well as some types of dimorphic fungi.
Depending on the species, with respect to yeast fungi, this medication can exhibit both fungicidal and fungistatic activity.
Operating principle
How does Lamicon Medication work? The instruction reports that this agent specifically inhibits the early stage of biosynthesis of sterols in the membranes of fungal cells. The result of this effect is intracellular cumulation of squalene, as well as ergosterol deficiency. This leads to the destruction of fungal cells.
The mechanism of action of the agent in question is directly related to the process of inhibition of such an enzyme as squalene epoxidase, which refers to the cytochrome P 450 system.
According to experts, the drug "Lamicon" has no effect on the effects of other drugs, as well as on hormonal metabolism.
Pharmacokinetics
How is the medicine "Lamicon" absorbed? The instruction states that with local or external application, the absorption of the active substance is less than 5% of the dose used. Therefore, its systemic exposure is negligible.
With external application, the drug immediately begins its action and remains highly effective for a short time (approximately 8-13 days).
Due to the preservation of the desired concentration of the drug in the stratum corneum of the epidermis, which was obtained during therapy, the fungicidal effect of the drug continues for a week after its withdrawal.
During oral administration of Lamicon, the active substance accumulates in the skin, nails and hair. The concentration of the drug in the tissues fully ensures its fungicidal properties.
The absorption of tablets is 70%, and their absolute bioavailability is 50%.
The drug taken in an amount of 250 mg causes the highest concentration in the blood after an hour and a half. The effective half-life is approximately 30 hours.
Food only slightly affects the bioavailability of the drug. With plasma proteins, the active substance binds to 99.5%. The medication penetrates through the dermis quite quickly and accumulates in the stratum corneum.
The allocation of "Lamicon" is carried out through the sebaceous glands. It is also found in hair, skin, and hair follicles. In the first weeks of therapy, the drug penetrates into the plates of the nails.
Terbinafine is metabolized rapidly with the participation of cytochrome P 450. After biological transformation, inactive metabolites of the drug are excreted through the kidneys.
With impaired liver and kidney function, the rate of terbinafine excretion is significantly slowed, which makes its concentration in plasma higher.
Indications for use
What are the local dosage forms of Lamicon prescribed from? Ointment, the instructions for use of which are described below, as well as a spray, have the following indications:
- fungal skin lesions that were caused by fungi of the genus Trichophyton, Microsporum and Epidermophyton (dermotophytosis of the feet, groin, trunk and other things);
- multicolored (or pityriasis) lichen, which arose due to exposure to Malassezia fungi;
- candidiasis of the skin, which was provoked by fungi of the genus Candida.
What is the purpose of using the oral form of the drug "Lamicon" (tablets)? The instruction reports the following indications:
- fungal infections of the skin, when their prevalence, concentration or severity are such that they must be treated precisely with the oral method (only a doctor determines);
- mycosis of the head and onychomycosis (damage to the plates of the nails).
It should be especially noted that Lamicon tablets are not used for the treatment of multicolored (or pityriasis) lichen.
Contraindications
What contraindications should you know before using Lamicon? The instruction reports that the only absolute prohibition on all forms of the medication in question is hypersensitivity to its substances.
As for the period of pregnancy, childhood and breastfeeding, they represent relative contraindications.
Ointment "Lamicon": instructions for use
Such forms of the drug as spray and ointment suggest their external use. Before using them for the treatment of fungal diseases, it is necessary to first clean and dry the affected areas of the skin.
Depending on the severity of the disease and the type of pathogen, the drug "Lamicon" (ointment) is applied twice a day. Aerosol is used with the same frequency.
The cream must be applied not only to the skin affected by the fungus, but also the areas adjacent to it. It is desirable to carry out this procedure with a thin layer, gradually rubbing the ointment into the integument.
If an infectious disease is accompanied by diaper rash (for example, under the mammary glands, in the inguinal region, between the buttocks or fingers), then the treated areas should be covered with a gauze bandage (all night).
Aerosol application
How should I use Lamicon spray? Reviews of experts report that it is used in sufficient quantity to moisturize by spraying on areas that are affected by fungi, as well as on healthy skin adjacent to them.
The duration of local therapy depends on the severity of the disease (up to two weeks).
Relief of the patient's condition is noted after a few days. For more effective therapy, you must strictly adhere to the instructions, do not skip the next application and do not stop treatment before the due date. Otherwise, there is a high risk of relapse.
How to take pills?
The pharmacological group to which the medication we are considering belongs to is indicated in the instructions. He also reports on how to take this remedy.
As a rule, Lamicon tablets are prescribed for children from 6 years old, as well as for adult patients. The administration of the oral drug is continued until all symptoms of the fungal disease completely disappear (depending on its nature and severity).
The total dosage of this medication for adults is 250 mg, and for children with a body weight of 20-40 kg - 125 mg. With a lot of weight, the child is also prescribed 250 mg of the drug.
The duration of therapy with trichophytosis and candidiasis of the skin is 2-4 weeks, and with dermatomycosis of the feet - 2-6 weeks.
Fungal diseases of the head are more common in children. As a rule, they respond to therapy if the drug is used in dosages recommended by the doctor for a month.
Treatment of onychomycosis takes 6 weeks for hand nails and 12 for foot nails. With reduced growth of the nail plates, therapy can be extended.
Adverse reactions
The local drug Lamicon, analogues of which are listed below, can cause manifestations such as peeling of the skin, burning, itching, pain, irritation, pigmentation, erythema, and crusting. Allergic reactions may also occur.
When taking tablets, the following undesirable effects are possible:
- neutropenia, agranulocytosis, Lyell syndrome, pancytopenia, Stevens-Johnson syndrome;
- thrombocytopenia, anaphylactoid reactions, taste disorders, symptoms of lupus erythematosus, headaches;
- photosensitization, paresthesia, hypesthesia, dyspepsia;
- dizziness, feeling of full stomach, diarrhea, loss of appetite;
- exacerbation of psoriasis, nausea, psoriasis-like rashes, abdominal pain, myalgia;
- urticaria, arthralgia, rash, generalized pustulosis, hair loss, increased liver enzymes;
- fatigue, hepatobiliary dysfunction, jaundice, hepatitis.
Analogs and cost of the drug
How much does Lamicon cost? The price of this drug depends on its form. Ointment and spray can be purchased for 180-220 rubles, and tablets for 370-400 rubles.
As for the analogues, among the more effective ones, it is possible to distinguish such agents as Amorolac, salicylic acid. "Mikoseptin", "Nitrofungin", "Mikolak", "Exoderil".
Reviews about the drug
Reviews of those who used the drug "Lamicon" are extremely positive. Patients report that the therapeutic effectiveness of this medication is observed only a few days after its active use. As a rule, by the end of the course of therapy, the fungal disease disappears altogether.
In severe cases, doctors recommend combining dosage forms (e.g. tablets and ointment, spray and tablets).
In addition to positive reports, negative reviews are found about Lamicon. Often they are associated with its inefficiency. However, experts argue that this is possible only in the treatment of mushrooms, insensitive to medication or its improper use. Therefore, before applying the ointment, tablets or spray, it is recommended to consult a doctor and establish the causative agent of the fungal disease.