Diseases of the cardiovascular system are one of the most frequent in the world, in addition, mortality from them is quite high. A large number of cardiological ailments are accompanied by discomfort and pain. This forces modern pharmacology to develop drugs that can improve the quality of life of patients, prevent the development of problems and normalize heart function. “Deprenorm” and “Deprenorm MV” in a dosage of 35 mg with a prolonged action are drugs that relieve pain in the heart due to the ability to normalize metabolism in the heart muscle.
Indications for admission
The medicine "Deprenorm MV 35 mg" is recommended for the following health problems:
- Ischemia of the heart, ischemic cardiomyopathy.
- Vascular pathologies of vision, hearing, vestibular apparatus.
- Vascular dizziness, Meniere's disease, tinnitus.
In the treatment of ischemic ailments, "Deprenorm MV 35 mg" is used in combination with other drugs.
Therapeutic effect
"Deprenorm MV 35 mg" contains the active ingredient trimetazidine. By the principle of exposure, it is similar to a medication such as Preductal. It has antianginal, antihypoxic, cytoprotective, metabolic effects. About such a medicine as "Deprenorm MV 35 mg", reviews of doctors are more often positive. Experts speak of him as an effective and fast-acting medicine. The expected effect is observed on average two weeks after the start of therapy.
The pharmacological effect of the drug is to improve the metabolism and function of cardiomyocytes and brain neurons. It reduces the degree of myocardial damage, enhances aerobic glycolysis and inhibits the oxidation of fatty acids. As a result, the energy potential increases, oxidative decarboxylation and rationalization of oxygen consumption are activated. Thanks to the drug, normal myocardial contractility is maintained, the depletion of ATP and creatine phosphate in the cells is prevented.
If the patient suffers from acidosis, the drug helps to normalize the state of the ion channels of the membranes and the content of potassium ions inside the cells, does not allow the accumulation of calcium and sodium in cardiomyocytes. Reduces acidosis and phosphate levels in cells.
If the goal is to eliminate angina pectoris, then thanks to trimetazidine, the coronary reserve increases, which slows down the development of ischemia, which is caused by physical activity. This effect has been observed since the beginning of the third week of treatment.
Simply put, trimetazidine, which is in this drug, has a supporting effect on the heart, favorably affects the brain and nervous system, as it protects nerve cells, normalizes their respiration and energy supply. At the same time, the myocardium retains the ability to normal contraction, as a result, the patient is less likely to experience angina attacks, blood pressure differences become less pronounced.
Therapy with this drug allows you to reduce the dose of nitrates that the patient takes. Tinnitus disappears, indicators of vestibular tests improve, hearing becomes sharper. Dizziness is less common. Increases stamina and ability to physical activity. If the patient suffered from vascular eye disease, his condition of the retina improves.
Those who constantly take Deprenorm MV 35 mg have generally positive reviews about the drug: they note that overall there has been a noticeable improvement.
From the gastrointestinal tract, the drug is completely absorbed, the half-life is about 6 hours, excreted by the kidneys.
Release forms and rules of application
The drug relates primarily to antianginal. It is available in the form of two-layer round tablets, coated with a pink shell.
There are two types of medication: Deprenorm and Deprenorm MV (with a modified release). The first is available in a dosage of 20 mg. The second is in a dosage of 35 mg. There is also a release form of 70 mg, but it is not convenient for everyone, since you have to divide the tablet into two doses, in contrast to the already prepared single dose - “Deprenorm MV 35 mg”. The instruction recommends a standard daily dose of 70 mg, which must be taken with meals in two divided doses (the optimal time is breakfast and dinner).
Sometimes the dose of the drug can be changed to 70 mg once, that is, two tablets in one dose.
The duration of treatment is determined individually depending on the patient's disease, its duration and general condition. Tablets "Deprenorm MV 35 mg" have a prolonged effect.
The medication is only prescribed by prescription, since it is forbidden to use it without medical supervision. It is especially important to take it as required by the treatment with the drug "Deprenorm MV 35" instruction. Reviews about this drug practically do not report a negative effect on the patient’s condition, there are no overdose problems, there are practically no side effects, but nevertheless, like any other strong cardiological medicine, Deprenorm should be drunk with caution.
Contraindications
It is necessary to take into account some conditions of the body when taking a drug such as Deprenorm MV 35 mg. The instructions for use do not recommend the use of the drug if the patient has serious impairment of liver function and kidney pathology, including renal failure, in which the CC is less than 1 ml / min.
You can not carry out therapy if the patient is pregnant or breastfeeding. The medicine negatively affects the fetus and even leads to malformations. When breastfeeding, the drug enters the baby’s body with mother’s milk and also has a negative effect on it. "Deprenorm MV" is not prescribed at the age of under 18 years, because the effectiveness and safety of this medicine for children and adolescents (as well as for the fetus) has not been established.
The treatment with the drug in question is undesirable if the patient is more than 75 years old. If it is necessary to take this particular drug, it must be used with extreme caution.
Deprenorm is not recommended if the patient has sensitivity to its components.
The drug can not be used as a remedy for the relief of angina attacks. If the patient develops an attack, the cardiologist should change the principle of therapy.
It is worth noting that the reception of "Deprenorm" does not interfere with driving a car and performing work that requires special attention, since it does not have a sedative effect, but should be taken with caution, as it sometimes provokes dizziness.
Side effects
Few drugs do not cause side effects, especially for potent drugs, such as Deprenorm.
Trimetazidine can occasionally cause reactions from the digestive system - gastralgia, nausea, and vomiting. With individual intolerance, it is able to provoke allergic skin itching. Patients may complain of headache, palpitations.
Also, trimetazidine is able, although extremely rare, to cause symptoms of parkinsonism or to strengthen them. Therefore, patients, especially the elderly, should be regularly observed by a cardiologist. In the case of motor disorders (tremors, increased tone, instability in the Romberg position and others), the drug is completely canceled, the symptoms disappear within four months. If they persist, a neurologist consultation is required.
However, those who drink tablets containing trimetazidine, as recommended by the "Deprenorm MV 35" instruction, often leave positive reviews. Patients talk about mild side effects or their absence. In most situations, adverse reactions are eliminated by reducing the dose of the drug. In any case, if unusual symptoms appear, the patient should immediately inform the attending physician about them.
Overdose
As for the excess dose of "Deprenorm", it should be noted that there is currently no information about cases of overdose of the drug. Nevertheless, it is highly discouraged to take in volumes exceeding those indicated.
Interaction with other means
There is no information on the interaction of the drug "Deprenorm MV" with others. But in any case, you must consider taking other drugs and be sure to inform your doctor about what you are already taking if he prescribes Deprenorm MV 35 mg. Instructions for the use of other medicines may contain information about the interaction with agents for the treatment of coronary heart disease. Be sure to study such information, since when taking two or more drugs, the effect of them may weaken or intensify. In the first case, there will not be the expected result from taking the drug, in the second, an overdose is possible up to poisoning.
Synonyms and analogues
If the drug "Deprenorm MV" for some reason does not suit the patient, you can easily pick up analogues with the same active substance. The medication is antianginal. It also helps get rid of vegetovascular dystonia and coronary heart disease. Based on the reason why Deprenorm MV therapy is carried out, the analogue can be selected from medications based on trimetazidine. Only a doctor should prescribe a replacement. He will tell you what information is reported on this subject attached to the drug "Deprenorm MV 35" instructions, reviews.
Analogs are represented by the following means:
- "Angias Retard."
- "Vero-Trimetazidine."
- “Medarum 20” and “Medarum MV”.
- "Preductal" and "Preductal MV".
- "Trimektal" and "Trimektal MV".
- "Trimetazidine" and "Trimetazidine MV";
You can also pay attention to Angital, Antisten, Rimekor, Tridukard, Trimet, Preductal, Trimetazide, as well as Trimetazide produced by FPO Ferrain, Biocom.
Usually they have the same dosage and are taken in the same way as Deprenorm MV. They generally have the same contraindications and the incidence of side effects. They are also prescribed either as an independent drug, if there is enough of it for a given disease, or they are used in complex treatment in combination with other medicines. All products containing trimetazidine are recommended by a doctor, are purchased by prescription and cannot be taken uncontrollably. Please note that it is very important to consider the reviews of only those patients who take this medicine strictly according to the rules.
The group of drugs taken with vegetovascular dystonia also includes Cortexin, Cardio-Omega, Doppelherz VIP, Ginkgo-biloba. The drugs prescribed for cardiac ischemia include Benzaflavin, Atenolan, Atorvastatin.
Reviews of doctors about the "Deprenorm"
If the cardiologist prescribed the patient trimetazidine, then he will be interested not only in the instructions supplied with the Deprenorm MV 35 tool. Reviews are often crucial, especially if they are left by doctors about the effectiveness and feasibility of taking this drug, both independently and in complex treatment.
Unfortunately, cardiologists have no unequivocal attitude towards Deprenorm. Some of them believe that he can not significantly affect the patient's condition. But most of them still quite often prescribe "Deprenorm MV 35 mg." The instruction reviews of doctors in general confirms: the action declared in it is proved by the results that are obtained as a result of taking the drug by patients.
Both of them have arguments and evidence of their point of view, so it is worthwhile to find out the opinion of patients who took this drug.
Patient Reviews
Many patients are supporters of this drug. They take it and feel an improvement. If you do everything as recommended by the tool "Deprenorm MV 35", reviews about it will be positive.
Patients who added the drug to the usual treatment regimen noted that angina pectoris occurs less and less, pain and shortness of breath are less disturbing, and even visual acuity improves.
But there are consumers who consider the placebo effect those actions that give "Deprenorm MV 35 mg." Patient reviews suggest that as a result of auto-suggestion there is a temporary improvement, but in fact there is no proven effectiveness.
Nevertheless, most patients believe that it makes sense to take this drug. In addition to the lasting effect, reduction of pain and overall improvement in well-being, he has rare side effects, affordable price, he does not have any noticeable negative effect on his health condition, but only if concomitant diseases allow him to be treated with Deprenorm.
It is advised to pay special attention to contraindications: many patients began to take Deprenorm, not taking into account the state of health. As a result, instead of improvements, they showed side effects, they began to complain more about health. The withdrawal of the drug and the choice of another method of therapy normalized the condition, but in this case the problem is not in the medicine itself, but in the fact that the patient ignored contraindications to it.
Patients without contraindications, taking this drug, note that with regular admission, blood circulation improves, pressure normalizes. After a long period of discomfort, they generally feel healthy. Many, after they began to be treated with this tool, noticed that they began to walk easier, shortness of breath disappeared, the heartbeat was smooth and calm. Some begin to climb stairs without stops and respite, to engage in physical exercises.
Of the significant advantages of this drug, patients note that you can drink it constantly, without interruption, for an arbitrarily long time. At the same time, the need for other medicines (for example, nitroglycerin) is reduced, and even in a stressful situation, the heart continues to work without interruptions and pains. It is especially noted that upon transition or inclusion in the Deprenorm therapy, the effect of the treatment is more noticeable and significant.