In the article, we will consider the instructions for use in dentistry and reviews of allergy sufferers to the Septanest drug.
This medication is used when performing infiltration and conduction anesthesia. The medicine fully meets all quality standards. The medication is used for local anesthesia in dentistry, as well as for regional. Thanks to modern development techniques, this drug has a minimum of side and allergic manifestations.
Features of the composition
According to the instructions for use with Septanest, the composition includes the active components in the form of articaine hydrochloride and epinephrine hydrogenotartrate. Additional ingredients are sodium metabisulfite along with disodium edetate, hydroxide and water. The dosage form is a clear injection solution.
As indicated by the instructions to the Septanest, the shelf life of the drug is two years. Special measures and recommendations for the content of the medicine are as follows: in the original packaging, it can be kept at a temperature of twenty-five degrees, protecting from light and frost. Type of packaging: ampoules (cartridges) made of colorless glass.
Instructions for the use of Septanest during pregnancy will be presented below.
Pharmacological properties and excretion time
In accordance with the instructions, "Septanest" is classified as anesthetics. Artikain acts as a local amide type anesthetic that can prevent the spread of nerve impulses along nerve fibers. Adrenaline, which is added to the solution of articaine, as a rule, causes local vasoconstriction, thereby slowing down the absorption of the main ingredient into the blood, and accordingly, its concentration in the tissue increases. This helps create an operational bloodless field.
Anesthetic effectiveness comes quickly, within three minutes after administration. The analgesic effect lasts about sixty minutes. The anesthetic effect in the pulp is half as much. As part of the introduction of the drug into the oral mucosa, the active substance reaches its maximum concentration in half an hour.
The time for the removal of Septanest in dentistry is indicated in the instructions for use. The plasma half-life of articaine is kept within one hundred and ten minutes. A substance in the form of a metabolite is usually excreted by the kidneys, ten percent leaves unchanged with urine. Studies that have been conducted on animals have indicated the excellent tolerability of this drug. But similarly to other local anesthetics, in case of an overdose, some toxic reactions can occur.
Area of use and contraindications
What else does the instruction for the Septanest tell us?
The drug is used for local and regional decrease in sensitivity in maxillofacial and facial surgery, as well as in the field of dentistry. Most often it is used with the introduction of conduction, intraligamentary and infiltration anesthesia.
In the instructions for the use of contraindications "Septanest" in dentistry are also indicated.
They are:
- The presence of hypersensitivity to any of the ingredients of the drug.
- The occurrence of a conduction disorder of the cardiac system.
- The presence of incurable epilepsy.
- The development of high sensitivity to sulfur compounds (usually in patients with bronchial asthma).
- Against the background of paroxysmal tachycardia.
- With heart failure and glaucoma.
According to the instructions, adrenaline is contained in the Septanest, therefore caution and careful monitoring are required when patients have a history of arrhythmia along with coronary insufficiency or severe hypertension. In the event of hepatocellular insufficiency, hepatic metabolism of anesthetics is taken into account and a lower dose of the drug is required.
It should also be reduced in the presence of metabolic acidosis, hypoxia or hyperkalemia. It is undesirable to use the drug in question together with drugs like Guanethidine and other peripheral adrenergic blockers.
Instructions for the use of "Septanest" in dentistry
The drug is used to treat patients from the age of four years. For adults, the dosage can be adjusted depending on the duration and degree of intensity of the intervention. In the framework of standard conduction anesthesia, this drug is used in the amount of one ampoule. The general norm at one visit to the dentist, as a rule, does not exceed 7 milligrams of articaine per kilogram of patient weight.
In accordance with the instructions to the "Septanest" for children, the total dose should be 5 milligrams of articaine per 1 kg of weight. The optimal amount of medicine is calculated in the following way: the weight of the baby is multiplied by 1.33. The dosage for the elderly is reduced by half (that is, half as much as that of adults). Input method. This medication cannot be used intravascularly. Before injection, it is advisable to conduct an aspiration test. The injection speed should not exceed 1 milliliter per minute.
What can be learned from the instructions for the use of Septanest in dentistry during pregnancy?
Pregnancy Use
Animal experiments do not report teratogenic effects. Due to the lack of such in animals, toxic effects on the fetus of pregnant women are not expected. Some controlled clinical trials are underway, which prove that ingredients with teratogenic effects on the human fetus produce the same effect on animals. To date, however, there are no clinical trials that would unequivocally refute the toxic or teratogenic efficacy of atricain in pregnancy.
Therefore, "Septanest" with adrenaline according to the instructions during this period, if there is a need for surgical or dental procedures, it is recommended to use only in case of emergency. The components of this medication do not penetrate into breast milk in pharmacologically significant concentrations. Continued lactation is allowed after the weakening of the analgesic effect. It is important to note that this drug may cause the patient to lose concentration while driving a vehicle.
Cautions and subtleties of use
You must be aware that this drug contains adrenaline. In this regard, in exceptional cases, necrosis of local tissue in patients with diabetes and hypertension is not excluded. Due to the potential decrease in swallowing ability during anesthesia (we are talking about numbness in the mouth, face and mucous membranes, as well as the tongue), there are risks of aspiration. It is required to warn the patient that during the action of anesthesia it is impossible to have chewing gum or any food in the mouth.
This medication is not used in the area of infected or inflamed tissues, otherwise a local anesthetic may not be effective. The medication contains an active substance, whose presence can cause a positive reaction during the doping control of athletes.
In order to avoid the risks of allergic reactions to the ingredients of this drug, it is necessary to test for sensitivity (entering about ten percent of the dose, which is intended for local anesthesia). The drug must be administered extravasally and slowly, with parallel control of respiration. Increased monitoring is required in the treatment of patients undergoing anticoagulant therapy.
Side effects
Similar to the use of all other local anesthetics that are used in dental surgery, lipothymia (i.e., a brief loss of consciousness) can occur. The drug in question contains sulfites, which can cause or aggravate various allergic reactions. Undesirable manifestations can occur as a result of an intravascular accidental administration of the drug or against the background of its excessive absorption by vascularized or inflamed tissues.
According to the instructions for use and reviews of Septanest, predisposed patients may experience numerous negative manifestations from several systems of the body at once. But most often, a headache is recorded along with nervousness, drowsiness, nausea, tremor, agitation, anxiety, nystagmus and ringing in the ears.
The presence of such symptoms is the cause for hyperventilation. It is important to carefully monitor the patient's condition in order to prevent deterioration, as well as the development of seizures or the process of inhibition of the nervous system. The respiratory system can respond as follows: the appearance of tachypnea, apnea or bradypnea. The cardiovascular system makes itself felt by tachycardia, decreased pressure, collapse or severe cardiac arrhythmia. Such an abnormal heart rhythm can lead to organ arrest. Now let's talk about an overdose.
Overdose cases
In case of an overdose, patients may experience two types of toxic reactions:
- Immediately immediately after administration, for example, in case of improper intravenous use of the drug.
- Late reaction in connection with a local overdose of the drug.
Intoxication therapy against the background of the onset of the first symptoms requires immediate hyperventilation of the patient and place it strictly in a horizontal position. In the case of seizures, it is necessary to improve oxygenation and reduce symptoms by intravenous administration of benzodiazepine. With the development of severe complications, intubation is performed.
Inappropriate drug combinations
It is important to pay attention to the use of Septanest for the treatment of people taking other medications. Given the content of adrenaline in the composition of the drug in question, you should not take it with the drug "Guanethidine" and drugs of this type (we are talking about anti-glaucomatous medicines), since a significant increase in blood pressure is possible.
In the case of simultaneous administration of these drugs, extreme caution is necessary along with a dose reduction. With simultaneous use with halogenated volatile anesthetics, myocardial sensitization is quite possible. Precautions typically include lowering the dose of epinephrine to 0.1 milligrams per ten minutes for children or 0.3 milligrams per hour for adults.
Against the background of taking tricyclic antidepressants, there may be a risk of paroxysmal hypertension with the development of arrhythmia. Precautions in this case include lowering the dosage of epinephrine to less than 0.1 milligrams per ten minutes for children or 0.3 milligrams per hour for adults.
This is confirmed by the instructions for use for Septanest in dentistry.
special instructions
To avoid intravascular injection, aspiration tests should be performed. The volume of injection pressure should be consistent with tissue sensitivity. You can not give injections to the inflamed area. Eating with the use of this medication is possible only after a complete restoration of sensitivity.
In order to prevent infection (including viral hepatitis), it is necessary to use only sterile new syringes and needles within each intake of the solution from the vials. An open cartridge cannot be reused because there is a risk of hepatitis. Damaged cartridges must not be used. On the labels of refillable vials, the time of the first intake of the solution should be recorded. Open vials should be stored according to the instructions and fully apply them within two days.
The availability of the patient’s admission to driving or to engage in activities that may require a high motor and mental response is determined by the doctor.
Cost and analogues
The price of the described drug varies within two - two and a half thousand rubles. To date, analogues with the drug are drugs with a similar effect - Alfacain, Artikain, Brilocain, Primacain, Ubistesin, Ultracain, Cytocartin and others.
Next, consider the patient reviews of this medicine, which are often allergic.
Allergy Reviews
The manufacturer of the described drug reports that allergic reactions during its use occur in patients quite rarely. But among the messages, there are still complaints about the intolerance of the ingredients of the drug to some people.
Most often they are left by consumers who are prone to frequent allergies. It is noted that to prevent the occurrence of allergic manifestations, dentists check the patient's sensitivity to it before using the drug.
Complaints of side effects are rare among comments. Nevertheless, a possible headache, nervousness, drowsiness, nausea, agitation, anxiety, and tinnitus are reported.
We reviewed the instructions for use for Septanest in dentistry and reviews.