Liver problems can hardly be considered a rarity. And in such cases, doctors recommend that patients take hepatoprotectors - drugs that protect liver cells. The list of such drugs is quite large, and “Phosphogliv Forte” capsules are considered effective.
Of course, people who are faced with the need to take this drug are interested in additional information. What properties does the medicine "Phosphogliv Forte" have? Instructions, reviews, analogues and cost are important data that should be studied before starting therapy.
What is the medicine? Features of the composition and form of release
Many people are faced with the need to take a drug such as Phosphogliv Forte. Instructions for use, analogues, contraindications, recommendations - this is extremely important information. But first, it’s worth familiarizing yourself with the general information.
This medicine is available in the form of hard orange gelatin capsules with a black cap. Inside contains a granular white powder (sometimes with a yellow tint) with a very specific smell. Capsules are packaged in blisters of 10 pieces. In the pharmacy you can buy a package consisting of 30, 50, 100 or 300 units.
This is a complex hepatoprotector, which immediately contains two active substances: phospholipids (73–79% of the total amount is phosphatidylcholine) and glycyrrhizic acid in the form of trisodium salt.
Of course, other compounds are also present in the powder, including calcium carbonate, talc, microcrystalline cellulose, colloidal silicon dioxide, and calcium stearate.
For the manufacture of the capsule, gelatin, titanium dioxide, and a yellow dye called "Yellow Sunset" are used, which, in fact, ensures the presence of an orange color. Black iron oxide is added to the material of the capsule “cap” as a dye.
How does the drug work?
In fact, this medicine has a lot of therapeutic properties. For example, phosphatidylcholine is used to build cell membranes. Thus, the drug provides a cytoprotective effect, as it restores the structure of the hepatocyte membranes.
In addition, this substance activates the liver, normalizes the metabolism of proteins and lipids, inhibits the formation of connective tissue elements, thereby reducing the risk of future fibrosis.
But glycyrrhizic acid has pronounced anti-inflammatory properties. In addition, this substance activates the synthesis of natural interferons in the body, which significantly increases the body's resistance to a particular infection. It has been proven that glycyrrhizic acid also slows down the process of reproduction of viruses (this property is especially valuable when it comes to treating viral hepatitis), not only in the liver, but also in other organs.
This component of the drug stabilizes cell membranes, enhances the effect of endogenous glucocorticoids. The substance has an antioxidant effect, relieves inflammation and allergic reactions if their appearance is not associated with an infection.
If skin lesions occur, then therapy using Phosphogliv prevents the further spread of the rash, inhibits the development of the inflammatory process, relieves swelling of the subcutaneous tissue, eliminates itching, burning and other unpleasant sensations.
Pharmacokinetics Information
According to the results of clinical trials, at least 90% of the phospholipids from the capsule are rapidly absorbed by the walls of the small intestine. Through a series of chemical reactions, phosphatidylcholine is converted into a polyunsaturated form. With lymph flow, this substance enters the bloodstream, where it binds to high density lipoproteins and enters the liver tissue. The maximum concentration is reached 6-24 hours after administration.
Phospholipids are excreted in the form of choline components (elimination half-life is 66 hours) and linoleic acid residues (about 32 hours). These substances leave the body with urine and feces.
Glycyrrhizic acid, penetrating the intestines, is susceptible to enzymes produced by beneficial microflora bacteria. As a result of these reactions, biologically active beta-glycyrrhetic acid is formed, which penetrates the systemic circulation. Here it binds to albumin proteins - almost the entire mass of metabolites penetrates directly into the liver. These substances leave the body along with bile, only a small amount enters the urine.
Capsules "Phosphogliv Forte": application
You already know what is part of the drug and what properties it has. But in what cases is it advisable to use the drug "Phosphogliv Forte"? Its use is shown in the following cases:
- acute and chronic forms of hepatitis;
- fatty degeneration of the liver (hepatoses of various origin);
- liver damage, including those associated with the ingestion of toxins, the use of certain drugs, the use of alcohol;
- cirrhosis of the liver;
- various types of intoxication of the body;
- psoriasis;
- eczema;
- neurodermatitis.
It should be noted immediately that only a doctor can prescribe this drug. The fact is that the drug is rarely used for monotherapy - in most cases it is included in the treatment regimen as an adjuvant. Only a specialist can choose the right dose and make a schedule for taking medications.
Instructions and dosage
How to take the drug "Phosphogliv Forte"? Instructions for use contain only general data and are intended for reference. In the process of treating a particular liver disease, it is important to adhere to all the doctor's recommendations.
Children over 12 years old and adult patients, as a rule, take 1-2 capsules three times a day. You need to drink them with food, washed down with a small amount of liquid. By the way, to date, there is no evidence of overdose symptoms.
How long does the Phosphogliv Forte therapy last? Capsules are usually taken for three months, although in some cases, treatment can be extended up to six months.
To date, there is no data on the interaction of this hepatoprotector with certain drugs. However, it is important that you tell your doctor about all the drugs you take.
Can I drink pills during pregnancy?
The drug "Phosphogliv Forte" is contraindicated in pregnancy. The fact is that during therapy, the activity of the immune system increases, which increases the likelihood of miscarriages and other complications.
Nevertheless, if a woman has chronic forms of hepatosis and hepatitis, then the doctor may decide to conduct therapy using hepatoprotectors. In such cases, the patient should be constantly under the supervision of doctors and regularly take tests.
Should I use the drug for hepatitis C?
According to statistics, this drug is widely used as part of complex therapy for hepatitis C. This drug helps to normalize liver activity. It is also proved that during therapy, the rate of development of fibrosis is significantly reduced. In addition, the drug normalizes the activity of liver enzymes, improves the general well-being of patients, and protects the functional liver cells from destruction.
As a rule, patients take this drug before starting antiviral therapy, although in some cases the course of taking hepatoprotectors can last more than a year. Of course, the drug can in no case be used as a substitute for antiviral agents (only they are effective for hepatitis C).
Hepatoprotectors and alcohol
Alcohol and the substances contained in capsules are not antagonists. Nevertheless, drinks containing ethanol adversely affect the functioning of the liver, activating inflammatory and dystrophic processes in this organ. That is why the use of alcoholic beverages is prohibited for any liver disease.
Contraindication Information
This tool is considered safe and is widely used in modern medicine. On the other hand, not every patient can use the “Phosphogliv Forte” capsules. The instruction contains information about contraindications.
- The medicine is not prescribed if the patient has allergic sensitivity to the constituent components, therefore, before starting therapy, it is imperative to study the composition of the drug.
- Contraindications include pregnancy. The active substances of the drug partially penetrate into breast milk. If the need for treatment during lactation still exists, then feeding the baby for a while should be stopped.
- The drug (in any form) is not indicated for patients under 12 years of age.
- Also, the drug is not prescribed for patients with antiphospholipid syndrome.
The drug should be used with caution for the treatment of arterial and portal hypertension. In this case, constant monitoring of blood pressure is necessary. It is better if the patient is under the supervision of a doctor.
Are adverse reactions possible?
Is Phosphogliv Forte capsule therapy always safe? The instruction contains information that in some cases, therapy is associated with the appearance of some complications.
- In some patients, the capsules cause various allergic reactions, which include the appearance of rashes and redness on the skin (this can be accompanied by burning and itching), inflammation of the mucous membrane of the eyes. Sometimes there are problems with nasal breathing and coughing - these symptoms are associated with swelling of the mucous membranes.
- Perhaps the appearance of disorders of the heart and blood vessels. Sometimes after taking blood pressure rises (this is a short-term phenomenon). Some patients develop peripheral edema.
- Various digestive disorders are occasionally observed. People complain of nausea, loss of appetite, frequent belching, increased flatulence in the intestines, discomfort, and sometimes abdominal pain.
Nevertheless, in modern medical practice, the drug "Phosphogliv Forte" is widely used. Reviews of doctors, as well as the results of clinical trials, confirm that side effects are extremely rare. If, against the background of therapy, you still notice a deterioration in well-being, jumps in blood pressure or other disorders, then you should immediately inform your doctor about this.
How much is the drug?
Many people today are looking for information on the drug Phosphogliv Forte. Instructions for use, reviews, indications, possible complications are important issues. But no less interesting is the information about the cost.
How much does Phosphogliv Forte medicine cost? The cost of a package consisting of 50 capsules ranges from 950 to 1100 rubles. It is worthwhile to understand that sometimes, to complete the full course of therapy, one box of medication will not be enough.
How to replace the drug "Phosphogliv Forte"? Analogs in the modern market
You already know how the drug affects the human body. Of course, today many people are faced with the need to take the medicine Phosphogliv Forte. But what if the drug does not suit you for one reason or another?
Of course, analogues exist, and their list is quite impressive. The list of hepatoprotectors include Essential, Essel Forte and Essliver Forte. Sometimes doctors recommend taking the capsules Livorin Forte, Rezalyut Pro, Fosfontsiale and Lipostabil. Silymar, Maksar, Glutargin and Karsil tablets have approximately the same pharmacological properties. Of course, it’s not worth it to use such drugs on your own. Only the attending physician, acquainted with the medical history, can draw up the most effective and safe treatment regimen for the patient.
What do the doctor's say? Reviews of specialists and patients
What do experts and patients say about the Phosphogliv Forte drug? Reviews about the application are positive. Doctors note that taking capsules against a background of various liver lesions really helps to normalize the work of the body - this is confirmed by laboratory tests, since biochemical parameters (activity of liver enzymes, bilirubin concentration) are normalized. The medicine also helps to improve the patient's condition with viral forms of hepatitis.
Patients also confirm that the drug helps relieve symptoms that occur against a background of liver diseases. After several days, nausea disappears, digestion processes normalize, pain and discomfort go away.
Also, the medicine significantly improves the condition of people suffering from chronic skin diseases. It's no secret that psoriasis, various forms of neurodermatitis and eczema to one degree or another are associated with impaired liver function. That is why hepatoprotectors are included in the treatment regimen of these diseases. Patients note that rashes and spots on the skin disappear much faster during treatment with Phosphogliv.
The undoubted advantages include a relatively affordable cost, since many analogues will cost a more round amount. Cases of adverse reactions are recorded, but are extremely rare, therefore this medicine is considered to be safe. In addition, therapy has not so many contraindications.