“Ketoanalogs of amino acids” is a drug that helps restore protein-energy balance. Tablets are used for renal failure to reduce AMA and creatinine. The tool provides the body with irreplaceable organic compounds with a minimum intake of nitrogen.
What is the Keto Analogs of Amino Acids?
In pharmacology, there is a group that includes proteins and amino acids. The latter are structural elements of special tissue proteins. And some organic acids, such as glutamic, aspartic, glycine are neurotransmitters.
A healthy person needs 70 g of protein per day. In a number of pathological conditions, the daily requirement for enzymes increases. To maintain normal functioning, synthesized proteins and amino acids are used. Parenteral administration of proteins can cause anaphylactic reactions. To avoid undesirable effects, mixtures of individual amino acids are used. They provide complete artificial nutrition without the formation of antibodies in the body.
“Keto analogs of amino acids” is a combined preparation, which includes substitutes for organic compounds, the metabolites of which can be included in the synthesis of higher fatty acids. The drugs are used as a nutrient for the treatment of renal failure.
Structure
The dosage form of the drug “Ketoanalogs of amino acids” is film-coated tablets.
The composition of the substance is a complex of ten components necessary for the full functioning of the body. Active substances:
- α-keto analogue of isoleucine (67 mg). It cannot be produced in the body, and therefore must come from food.
- Leucine Alpha-Ketoanalog (101 mg). A deficiency in the body of leucine is often due to an increase in estrogen levels.
- Keto-phenylalanine calcium monohydrate (68 mg).
- Ketovalin calcium (86 mg). Together with isoleucine and leucine, valine serves as a source of muscle cell energy.
- Alpha-hydroxyanalogue methionine (59 mg). Methionine helps to lower blood cholesterol, improves liver function.
- Lysine monoacetate (105 mg).
- Threonine (53 mg). Amino acid is involved in the synthesis of collagen and elastin.
- Tryptophan (23 mg).
- Histidine (38 mg). A heterocyclic amino acid promotes tissue growth and regeneration.
- Tyrosine (30 mg). Amino acid promotes the production of melanin, improving adrenal function.
Medicinal effect and indications
The gradual extinction of renal function leads to disruption of the body. Treatment of the disease consists of symptomatic therapy and a special diet. The diet is a low-protein diet that includes amino acids.
“Keto analogs of amino acids” in tablets is prescribed for renal failure to provide the body with nutrients. The drug completely replenishes the body with components that are a source of energy even with a minimal intake of nitrogen.
The drug significantly slows the formation of urea and reduces the concentration of uremic toxins.
Keto analogs do not cause an increase in glomerular filtration in the remaining nephrons. Keto-containing additives have a positive effect on renal hyperphosphatemia: they reduce the creatine content in the blood, nephroprotective effect, prevent the onset of the last dangerous stage of the extinction of renal functions. Amino acids improve the course of fibrous generalized osteodystrophy.
The drug is prescribed for prevention and therapy in adults and children from 3 years of disorders of protein metabolism in severe renal impairment.
Method of application and dosage calculation
The Keto Analogs of Amino Acids tablets are taken orally with meals. It is believed that with this method, the absorption and metabolism of the components of the agent is significantly improved.
The drug is approved for use from three years. Dosage calculation depends on the patient’s body weight. Assign 1 tablet (0.1 g) per 5 kg of weight per day. Do not chew the tablet while taking it.
The drug is drunk until the glomerular filtration rate does not exceed 25 ml / min. In this case, patients should follow a diet low in protein: not more than 40 g per day for adults and 1.4-0.8 g of protein per 1 kg of weight for children.
During therapy, calcium in the blood is constantly monitored. With its increase, the dosage is reduced.
"Ketoanalogs of amino acids": analogues
The pharmaceutical industry produces a wide variety of drugs containing proteins and amino acids for parenteral nutrition. Despite their general purpose, they are prescribed for certain diseases, depending on the composition. Among these drugs, there are not many that are taken with renal failure. They are produced in different countries and have different names.
“Keto-analogues of amino acids” - trade names:
- "Ketosteril" - a drug used to treat renal and protein-energy deficiency. Manufacturer - German company Fresenius Kabi Deutschland GmbH;
- "Ketoaminol" - tablets prescribed to make up for the lack of amino acids with metabolic properties. Manufacturer Chinese pharmaceutical company "Nanjing Baijin Pharmaceutical";
- "Aminoven Infant" - a solution for parenteral nutrition.
The above drugs are most widely used in the treatment of extinction of renal function. Other drugs are prescribed in combination therapy from an insufficient amount of essential amino acids:
- "Aminosteril" - a solution for iv and drip. The drug is intended to make up for the lack of proteins;
- "Nephrotect" - a solution for iv injected to restore protein-energy balance in pathologies of the kidneys and ureter;
- "Nutriflex 70/180 lipid" is an emulsion designed to replenish nutrients when a normal meal is impossible or contraindicated.
Ketoaminol
The tool is a generic of the drug "Ketoanalogy amino acids." The drug is made in tablets, which are taken to prevent and treat pathological changes in protein metabolism caused by progressive fading of kidney function. "Ketoaminol" is prescribed in parallel with the diet, with low protein foods.
Dosage is calculated based on the patient’s weight of 0.1 g / kg per day. Unlike the Ketoanalogy Amino Acids tool, the drug is approved for use only after the patient is 18 years old. In addition to age, there are a number of contraindications:
- hypersensitivity to the substances that make up the tablets;
- amino acid metabolism disorders;
- increased serum calcium;
- prescribed with caution in patients with a hereditary predisposition to phenylketonuria.
Due to the lack of verification of the effect of the drug on the fetus, pregnant women should use the drug with extreme caution.
Ketosteril
The pharmacological effect of the Ketosteril preparation is similar to the medicinal effect of the Ketoanalogy amino acids. The process of replenishing the body with the necessary enzymes and organic acids occurs through transamination. The diet with the correctly selected content of carbohydrates (glucose), fats (lipids) and other things accelerates the processes. If the keto analog of aspartate is glutamate, then in order to accelerate the transamination reaction, the glucose content in the diet is slightly increased.
The drug improves protein metabolism, reduces the toxic effects of metabolic decay products, without increasing the level of glomerular filtration. “Ketosteril” breaks down urea, accelerates the utilization of nitrogen-containing metabolic products.
During therapy, monitor the concentration of calcium in the blood. To prevent hypercalcemia, the use of drugs that improve the absorption of calcium is excluded: “Ciprofloxacin”, quinolone derivatives, iron preparations.
"Aminoven Infant"
Means for parenteral nutrition "Aminoven Infant" can be called the generic "Ketoanalogov amino acids." The drug is used only for inpatient treatment, because it has a dosage form of a solution for injection of 6 and 10%.
Aminoven Infant contains the same amino acids as its Chinese counterpart. The drug is used for parenteral nutrition, administered intravenously or drip mainly in the central veins.
The dosage is selected individually, depending on age, characteristics of the body and therapeutic effect. "Aminoven Infant" is administered until the patient can not get enough nutrients with normal nutrition.
Reviews
Diseases in which drugs for parenteral nutrition are prescribed are very serious. Some patients are so exhausted that they hardly get out of bed. Therefore, there are few reviews on the “Ketoanalogs of amino acids”, they are most often left by relatives of patients.
Users say that they do not understand the analysis, but see that the health status of their loved ones has improved significantly after using the drugs. Doctors confirm that there is an effect, and it is not short-lived. True, some mothers say that children drink the pill with great reluctance, because the pills are hard and bitter. You have to persuade or trick for a long time so that the child drinks the medicine.
Those who have been prescribed and are on outpatient care write that pills are ideal for supporting the required amount of amino acids at home. There is no need to go “to the droppers” or to call a nurse at home.