Hypertension is very common in the world. This is a rather insidious disease, which in the initial stages is difficult to identify. Therefore, after 40 years, it is worth regularly monitoring performance indicators. If the results are too high, then you need to see a therapist. The sooner you start treatment, the faster you can defeat the disease.
Modern drugs are highly effective. This is a group of adrenergic blockers. Tablets very gently reduce pressure and do not harm the body. The drug "Lokren" is very popular with therapists today. Instructions for use, analogues, the correct dosage - all this information will be presented below.
Composition and form of release of the drug
Lokren tablets are white, slightly convex, on one side there is a marking with the inscription EK20. With such a titer, the medicine can easily be distinguished from a fake. The tablets are coated with a thin coating. The main component in the composition of the tablets is betaxolol hydrochloride in a dose of 20 mg. Auxiliary components of the drug are lactose monohydrate, microscopic cellulose, sodium carboxyl methyl starch.
The shell in the composition has hypromellose, macrogol, titanium dioxide. Pills are available in blisters, 14 pieces each. Any analogue of Lokren will have a similar composition and indications for use.
The effect of the drug on the body
Tablets belong to the group of beta-blockers. They are considered selective first row blockers. Betaxolol, which is part of the drug, has a cardioselective beta-adrenergic blocking effect, is characterized by the absence of agonistic activity, and serves as a weak membrane stabilizer. Thanks to this medicine, the heart rate decreases during rest and physical activity. The main effect is a decrease in blood pressure in a calm state and during exercise.
When using the medicine, tachycardia passes, the load on the heart decreases, peripheral blood circulation normalizes. The antihypertensive effect of betaxolol with prolonged use does not decrease. When ingested one dose of the tablet, a therapeutic effect occurs within three hours and lasts for a day. A stable result can be achieved with a long course of treatment. Such actions have the Lokren tablets on the body. Analogues of the drug also normalize arterial parameters when used correctly.
Pharmacokinetics
When ingested, the drug dissolves very quickly and is 100% absorbed from the stomach. The maximum effect in plasma is achieved after two hours. The medicine binds to blood proteins by 50%. Betaxolol in the liver forms inactive metabolites. Almost 80% of the active component is excreted by the kidneys in the form of metabolites. 20% leaves the body unchanged.
Quickly enough, it is possible to achieve a positive therapeutic effect if the Lokren tablets are taken correctly. Instructions for use contain all the necessary information.
Indications and contraindications
Arterial hypertension is considered the reason for the appointment of the drug. The tool can be taken both independently and in combination with other medicines to reduce blood pressure. Tablets are prescribed for the prevention of angina attacks.
Severe forms of bronchial asthma and chronic bronchitis, acute heart failure are considered contraindications to treatment with the drug. You can not take the medicine with severe phenomena of bradycardia, severe forms of Raynaud's disease and impaired peripheral circulation. There are age restrictions. The medication is not prescribed for minors.
It is not recommended to drink tablets for renal and liver failure. During pregnancy and lactation, the product can be used only if the potential benefit to the mother exceeds the possible harm to the baby.
Before starting treatment, you should carefully study the instructions for the use of Lokren. Reviews of specialists show that side effects most often occur in those patients who do not adhere to the recommendations.
Dosage
The drug should be washed down with plenty of fluids. The medicine cannot be chewed. It is necessary to start treatment with half a tablet (10 mg). If in two weeks a positive therapeutic effect does not occur, it is necessary to increase the dosage. The maximum daily norm cannot exceed 40 mg.
Many doctors do not recommend their patients drink more than one tablet per day. With a poor decrease in pressure, one more hypotensive drug should be added to the treatment. Patients with severe renal failure should start taking the medicine with a dose of 5 mg. Gradually, the daily norm increases. Must be studied before using the tool "Lokren" instructions for use.
Overdose
With an overdose of tablets, dizziness, a strong decrease in pressure, cyanosis of the fingers and nails, bradycardia, and fainting can be observed. Symptoms such as bronchospasm and heart failure also develop.
Treatment for an overdose is gastric lavage. It is recommended to give the patient an adsorbent to drink and connect infusion therapy. With a pronounced decrease in pressure, you need to drip “Dopamine” and enter “Atropine”. It is worth adding cardiac glycosides and antispasmodics. In a severe case, the introduction of blood substitutes and plasma is indicated. Any analogue of Lokren should be taken, adhering to the dosage prescribed by the doctor.
Side effects
During treatment with the drug, an allergic reaction may begin. It manifests itself in the form of a rash on the skin and itching. There are also reactions from the nervous system, which are manifested by dizziness, headache, asthenia, insomnia, nightmares, paresthesia. Side effects include decreased vision and decreased intracranial pressure. While taking the pills, abdominal pain, nausea, and vomiting are often observed. Blood counts and leukopenia may develop. In men, taking medication often causes impotence. With caution, tablets should be prescribed in old age.
It should be stored at room temperature in a dark place inaccessible to babies, the drug "Lokren". Analogs are used under the same conditions.
The analogue of Lokren in Russia is Betaxolol.
How to choose a quality substitute for a medicine? What if the pharmacy did not have Lokren funds? Analogues of the drug can always be recommended by a doctor. Betaxolol is popular. It is a cardioselective beta-blocker that is used to lower blood pressure and angina attacks. After ingestion, it is completely split in the stomach. The maximum effect is achieved in plasma within three hours. The medicine is excreted by the kidneys in the form of metabolites that form in the liver.
The drug perfectly reduces intraocular pressure, if you use a solution in the form of drops for the eyes.
The medicine is used once a day in a dosage of 20 mg. The medication can be taken independently or as part of complex therapy. It is not recommended to take the drug during pregnancy and lactation. The medicine in rare cases causes side effects in the form of a rash and burning sensation on the skin. Dizziness and nausea can also be observed, as with the use of Lokren tablets. Russian analogs have the same indications and contraindications.
The drug "Betak"
The medicine belongs to the first row beta-blockers. White pills. Each dose contains 20 mg of betaxolol hydrochloride. The medication can only be prescribed by a doctor. The medicine helps to normalize blood pressure, reduce heart rate at rest and during physical exertion, normalizes peripheral blood circulation and reduces angina attacks.
It is not recommended to prescribe a medicine for pathologies of the kidneys and liver. During pregnancy and feeding, taking the drug is prohibited. The tool can cause an allergic reaction and small deviations in the functioning of the nervous, digestive systems. With caution, it is necessary to appoint people in old age and with increased sensitivity to the components of the tablets. This analogue of Lokren may well replace the imported original.
Reviews
Experts respond positively to beta-blockers. In a short period, you can normalize blood pressure and reduce left ventricular hypertrophy. The listed drugs are well tolerated by patients and do not affect the functioning of other organs and systems. Any analogue of Lokren will show a positive effect if it is used in accordance with the instructions.