"Analgin": instructions for use, release forms, analogues, reviews

The article discusses the instructions for use with "Analgin" in tablets and ampoules.

It is a non-steroidal anti-inflammatory drug (NSAID). It is part of the pyrazolone group, has an antipyretic and analgesic effect. The tool is able to reduce the formation of endoperoxide, bradykinin, free radicals. The drug does not affect the exchange of water and electrolytes, it does not affect the mucous membrane of the esophagus. The effectiveness of the drug decreases with the stimulation of inflammatory receptors.

Pharmacological forms, composition

According to the instructions for use with "Analgin", the components that make up the composition may vary depending on its pharmacological form. Manufacturers produce the drug in several pharmacological forms - in the form of suppositories intended for rectal administration, in the form of tablets and an injection solution.

Instructions for use with "Analgin" for injections will be presented below.

The main active ingredient in Analgin is sodium metamizole. In the injection solution and in tablets it contains 500 mg. Suppositories may have a dosage of 100 mg and 250 mg.

As additional components in the manufacture of the tabletted “Analgin”, calcium stearate, powdered sugar, potato starch, and talc are used. An additional component in the solution is water, in suppositories - solid fat.

Drug exposure

As indicated by the instructions for use, "Analgin" is able to suppress the activity of the COX enzyme, which is involved in the synthesis of prostaglandins, and inhibit the peroxidation of lipid compounds. Under its influence, the pain impulses transmitted through the Gaulle and Burdach beams are blocked, the threshold of excitability of the pain centers located in the thalamus and the intensity of heat transfer increase. The medication relieves pain, with hyperthermia lowers body temperature, has an antispasmodic effect by relaxing the muscles of the bile ducts.

"Analgin" is a non-narcotic analgesic synthesized over a century ago. Unlike antibiotics, the drug is not able to slow down the growth and reproduction of pathological bacteria. Its main task is to block the transmission of pain signals entering the brain. It is the mechanism of action of the drug that differs from opioid (narcotic) analgesics, which act directly on the brain.

Instructions for use with Analgin tablets are very detailed.

Indications for use

The medication is recommended for use in order to stop the pain of a diverse etymology. The drug is prescribed in the presence of the following ailments:

1. Peritonitis, pancreatitis.
2. Shingles.
3. Pneumothorax.
4. Tumors, injuries, burns.
5. Inflammation processes.
6. Dispersive aortic aneurysm.
7. Thrombosis of the great vessels.
8. Myocardial infarction.
9. Pleurisy, pneumonia.
10. Neuralgia of various nature.
11. Colic: renal, intestinal, hepatic.
12. Toothache.
13. Menstrual pain.
14. Myocarditis.
15. Lumbago, sciatica.
16. Headache.

In accordance with the instructions for use with "Analgin", the tablet or injection form can be used for arthralgia, rheumatism, chorea, a febrile symptom that occurs after an insect bite, or for diseases of a purulent, infectious, or urological nature. The use of a medication is recommended if the usual therapy does not resolve the chronic or acute pain syndrome.

The pharmacological form shown for use depends on many factors. A tablet drug is prescribed most often, since it is easy to use, and compliance with its use does not require much effort.

As indicated by the instructions for use, tablets "Analgin" from headaches help quickly.

The injection form is indicated if the use of the drug is enterally unacceptable, there is severe pain after surgery, there is a need for a rapid decrease in temperature, osteochondrosis or arthritis is being treated.

Instructions for use for injection "Analgin" confirms this.

Use of medication

The use of “Analgin”, as well as the dosage regimen, directly depends on the nature of the disease, the body’s reactions to the active component, the causes of the development of pain, undesirable reactions, and the strength of pain. The optimal dose is the minimum amount of medication that allows you to control pain and fever. The most commonly used oral form is Analgin. With parenteral administration, allergic reactions often occur. If an overdose occurs, the patient should undergo a gastric lavage using a probe, to ensure the intake of enterosorbents, saline laxatives, drugs that force diuresis.

According to the instructions for use for "Analgin" in ampoules, if necessary, the dosage is selected individually by the doctor. It depends on the severity of the pain syndrome, the reaction of the body to the main component, the weight of the patient and his age. Large doses of injectable "Analgin" are not recommended. The required amount of solution is calculated so that its minimum amount allows you to stop pain.

Instructions for use with "Analgin" for injections reports that if the patient's body weight is more than 53 kg, a single dose can be 500-1000 mg. That is, for one injection, 1-2 ml of solution is used. If there is such a need, then up to 5 ml of the drug can be used. The maximum allowable amount for use during the day is 10 ml of solution. The introduction of intramuscularly or intravenously is carried out if it is necessary to quickly remove pain. So it is said in the instructions for use for "Analgin."

The infusion solution is prepared using solvents such as sodium chloride (at a concentration of 0.9%), Bieffe sodium lactate solution, glucose solution (at a concentration of 5%). Potentially, “Analgin” is incompatible with individual medicines, and therefore it is unacceptable to mix it with other drugs in the same syringe or in the infusion system.

Are Analgin tablets effective at temperature? The instructions for use and patient reviews say that helps, and very quickly.

Adult patients with a body weight exceeding 53 kg are shown taking tablets “Analgin” in the amount of 0.5-2 tablets. They should be washed down with water in large quantities (more than 200 ml). If the indicated dosage does not stop the pain, then repeated doses of no more than two tablets are permissible, no more than three times a day. The maximum number of tablets that can be taken per day is 8. If the patient has toothache, it is recommended to use half the tablet. If the pain does not disappear, you should take the second half of the pill. Before taking the drug, it is important to brush your teeth and rinse your mouth with soda solution.

Quite often, patients are prescribed “Analgin-quinine”, which contains not only metamizole sodium, but also 50 mg of quinine (in one tablet). Quinine in the composition of the drug allows you to fight malaria pathogens - unicellular parasites of the genus Plasmodium. Quite often, this form of “Analgin” is used in gynecology after abortion and childbirth. It is allowed to use the medication from 12 years old. At the age of 14 years, three times a day are indicated for one tablet. In the future, a single dosage is doubled. Per day, no more than six tablets are allowed.

The quinine contained in the preparation suppresses the thermoregulatory center located in the hypothalamus. As an antipyretic, Analgin-quinine can be used for three days, and as an analgesic for five days. The course of treatment can be increased if there is evidence and approval of a doctor. The medication acts quickly, depending on the severity and nature of the pain, the onset of the therapeutic effect takes 20-120 minutes. This is confirmed by the instructions for use. Analogs of "Analgin" will be presented at the end of the article.

The drug in the form of suppositories is intended for the treatment of children. At the age of 2-3 years, the rectal administration of half of the suppository is indicated, at the age of 4-5 years - one suppository, at the age of 5-7 years - two suppositories per day. The dosage of the suppository in these cases should be 0.1 grams. Children 7-14 years of age are shown the use of suppositories with a dosage of 0.25 grams. They should be administered up to three times a day. The duration of use should be determined by the pediatrician.

According to the instructions for use, "Analgin" at a temperature helps pretty quickly, but it should be used with caution.

Special instructions for use

Due to the fact that in patients with impaired renal function and in old age, metamizole sodium metabolites are excreted from the body more slowly, they need a dose adjustment downwards. If there is no way to reduce the dose used "Analgin", you should reduce the duration of its administration.

With a long course of treatment with Analgin, patients are advised to periodically conduct a blood test in order to count the number of leukocytes.

Caution is necessary when prescribing "Analgin" to patients with low blood pressure. This is due to the fact that while taking the medicine there is a risk of hypotension. The maximum dosage in the treatment of such patients should be no more than 1 gram per day. If the patient has gastrointestinal diseases, they should prefer Analgin Ultra, the main difference of which is the presence of the membrane.

The drug is not recommended for use in pregnant women, in particular, in the first trimester and in the last month and a half. A similar limitation is associated with the ability of metamizole to affect fetal development. The active substance is absorbed quickly and can be excreted in breast milk, respectively, the use of the drug is limited in lactating women. If there is an urgent need, Analgin can be used by pregnant women, but only after the doctor approves the appointment and the benefits and likely risks are compared.

In accordance with the instructions for use, tablets "Analgin" for children is not recommended because of the high content of metamizole in them. Suitable in this case is the use of candles. Such therapy is allowed from the age of two.

Interaction with other medicines

With the parallel use of caffeine, codeine, barbiturates, H2 antihistamines, the effect of metamizole is enhanced. Propranol is able to slow down the inactivation of metamizole.

Combinations with sarcolysin and tiamazole can cause leukopenia. Concurrent use with sedatives and tranquilizers enhances the analgesic effect of Analgin.

Metamizole metabolism is impaired, and its toxicity increases if taken in conjunction with oral contraceptives, tricyclic antidepressants, allopurin.

While taking metamizole, the activity of hypoglycemic drugs intended for oral use, indirect anticoagulants, and indomethacin increases. The plasma concentration of cyclosporine is also reduced.

Side effects of "Analgin"

In accordance with the instructions for use with "Analgin" in ampoules and tablets, following the use of the drug, the following undesirable effects may develop due to the effects of metamizole sodium:

1. Interstitial nephritis.
2. Hypersensitivity.
3. Hemorrhage.
4. Hypothermia.
5. Hypotension.
6. Hypotension.
7. Thrombocytopenia.
8. Granulocytopenia.
9. Agranulocytosis.

Contraindications

What else does the instructions for use with Analgin for adults and children tell us?

The tablet form is contraindicated in children under ten years of age, in the form of candles - up to two years. Injection form is not prescribed for children under 3 months of age, or if the child weighs less than 5 kilograms.

Instructions for use with tablets "Analgin" for adults and children should be strictly observed.

Do not use any form:

1. During pregnancy.
2. During lactation.
3. In the presence of acute surgical pathologies.
4. With arterial hypotension.
5. With alternating porphyria in an acute state.
6. With hemolytic anemia, which has a congenital form against a background of a lack of cytosolic enzyme.
7. With pathological changes in the hematopoietic system, with bone marrow depression.
8. With intolerance to any NSAIDs, including simple analgesics.
9. With aspirin bronchial asthma.
10. With individual hypersensitivity to metamizole and any other component that is part of the drug.

Analogs

At present, there are a lot of analogues of “Analgin” in composition and therapeutic effect. The most popular are:

1. Tetralgin. Available in tablet form. It allows you to stop the pain symptoms that occur with myalgia, algodismenorrhea, neuralgia, toothache, arthralgia. Contraindications to the use of Tetralgin are: intracranial hypertension, head injury, alcoholism, arrhythmia, bronchospasm.
2. "Spazmalgon." Produced by the manufacturer in tablet form and in injection. It has the effect of anesthetic and antispasmodic. Contraindicated before the age of 6 years, in the first and third trimester of pregnancy, with anrioventricular block, intestinal obstruction, tachycardia, angina pectoris.
3. "Revalgin." May have a tablet and injection form. It is characterized by analgesic and antispasmodic non-narcotic effects. Contraindicated during lactation, with atony of the urinary and gall bladders, angle-closure glaucoma, acute liver porphyria.
4. Pentabufen. It has only a tablet form. Allows you to eliminate the pain of various etymologies. Long-term use of the drug provokes the following undesirable effects: itching, rash, leukopenia, anemia, vomiting, nausea.
5. "Baralgin." Like Analgin, it is available in the form of tablets, injection solution and suppositories. Effective for pain and cramping. Contraindicated in renal and hepatic insufficiency, pain with an unclear location, pregnancy and hypertension.

If there is a need to replace "Analgin", you should consult a doctor who will determine the feasibility of replacing and advise an analogue, as well as the scheme for its use.

Cost

"Analgin" is produced by many pharmaceutical companies, on which its cost depends. So, the average price for “Analgin” in the form of candles is 150 rubles. The tablet "Analgin" will cost about 20-30 rubles, and the injection - 30 rubles.

Thus, "Analgin" is more than an affordable pain reliever.

Reviews about "Analgin"

"Analgin" is a universal and time-tested analgesic, which is available to all categories of patients. The medication is highly effective for pain of various origins. Successfully relieves toothache, headache, arthralgic, rheumatoid and neurological pain.

Nevertheless, reviews about the drug left by patients are often controversial. Some note the positive qualities of the drug, its availability, effectiveness, speed of exposure. Other patients report a large number of contraindications and often developing unwanted effects. That is why "Analgin" is banned for use in many developed countries.

Most often, patients agree that it is possible to take “Analgin” in adulthood, but in no case should they be abused. And for the purpose of treating children, it is better to purchase a similar, but safer drug.

We reviewed the drug "Analgin" instructions for use for children and adults.