The medicine "Neoton" is included in the group of cardiological preparations and has a fairly wide range of indications for use. The tool is able to improve myocardial metabolism, intracellular energy transportation and microcirculation, slow down the destruction of ischemic cardiomyocytes and sarcolemma of myocytes. The drug is dispensed in pharmacies only if there is a prescription from a doctor.
Detailed instructions for Neoton will be discussed below.
Composition and form of release
The product is marketed in powder form for the preparation of an infusion solution.
The instructions for Neoton indicate that the active substance of the drug is phosphocreatine. It is this component that has antiarrhythmic and cardioprotective effects, as it is an energy resource of muscle cells.
Pharmacokinetics
Studies have shown that the maximum concentration of Neoton in the blood is observed 3 minutes after the infusion. Its active substance can accumulate in the muscles of the skeleton, myocardium and brain. In small amounts, it settles in the liver and lungs. "Neoton" is excreted through the kidneys.
Indications for use
When can a doctor prescribe a drug? The instructions for use of Neoton indicate that the drug is used to treat:
- acute myocardial infarction;
- myocardiosclerosis;
- chronic heart failure;
- encephalorpamia;
- acute cerebrovascular accident;
- intraoperative myocardial ischemia;
- cardiomyopathies.
The drug can also be used in sports practice to accelerate the body’s addiction to increased physical exertion and the prevention of physical stress syndrome.
Contraindications
Instructions for use "Neoton" states that the drug is not prescribed to patients:
- who are under 18 years old;
- with individual intolerance to the active substance of the drug;
- with chronic renal failure.
Contraindications include lactation. If necessary, the use of the drug will have to abandon breastfeeding. As for pregnancy, treatment with Neoton is allowed only in cases when it will bring benefits to the mother more than harm to the fetus.
Mode of application
With the help of a dropper, Neoton is administered intravenously into the patient's body. The required dosage depends on the type of disease.
For example, the instruction to "Neotonon" suggests that in acute myocardial infarction, a patient is injected with 2-4 grams of the drug. After that, 8-16 grams of the drug is dissolved in saline (200 ml) and administered by the drip infusion method for two hours. The next day, "Neoton" is administered 2 times 2-4 grams intravenously, on the third day - 2 applications of 2 grams. If such a need arises, therapy can be continued for up to six days.
In chronic heart failure, you need twice the use of the drug during the day for 1-2 grams intravenously. Therapy can last up to 10-14 days.
What does the instruction to Neoton say regarding the prevention of intraoperative myocardial ischemia? In this case, within three days before the operation and one to two days after it, the patient is administered 2 grams of the drug.
For the prevention of intraoperative limb ischemia, the drug is administered 2-4 grams before the operation (jet) and 8-10 grams during its operation (infusion).
The instructions for Neoton contain information regarding its use by athletes. The tool begins to be used 3-4 weeks before the start of the competition and continues for several more days after them. In this case, 1-2 grams of Neoton are dissolved in 0.05 liters of water and administered dropwise intravenously (within half an hour).
Despite the fact that the presence of chronic renal failure is a contraindication to the use of the drug, in some cases the doctor may still prescribe Neoton. But the dose of phosphocreatine should not exceed 4 grams.
More detailed information regarding dosages and the method of using the drug can be found in the official instructions.
Overdose and side effects
Cases of drug overdose have not been recorded.
With the rapid introduction of "Neoton" in patients there is a sharp decrease in blood pressure. In more rare cases, drug treatment becomes the cause of the development of allergic reactions.
Terms and conditions of storage
The instructions for the drug indicate that its shelf life is three years. It must be stored in a dry place, protected from direct sunlight and out of the reach of children. The air temperature should not exceed 30 degrees.
The drug is not allowed to freeze.
Interaction with other drugs and substances
The active substance of the drug is able to increase the effect of antiarrhythmic and antianginal drugs. In particular, we are talking about such medicines as Dobutamine, Norepinephrine, Epinephrine.
The product is compatible with water for injection, cardioplegic solution, 5% glucose solution.
The interaction of Neoton and alcohol has not yet been studied.
special instructions
Since the onset of signs of ischemia, the drug must be administered in the shortest possible time. This will ensure a favorable outcome of the disease.
The use of the drug in high doses (5-10 grams per day) leads to increased uptake of phosphates in the kidneys. This process, in turn, affects the secretion of hormones, calcium metabolism, purine metabolism, and kidney function. Therefore, long-term treatment with Neoton should in no case be carried out in high doses.
Reviews
What reviews about Neoton do patients leave? In most cases, they argue that the use of the drug eliminated the symptoms of the disease as soon as possible. True, experts say that this can be the merit not only of Neoton, since usually the medicine is not used independently, but as one of the components of complex therapy. But it is also not worth minimizing the merits of the drug.
Athletes also note the high effectiveness of the use of the product and say that significant physical activity was really much easier to carry.
As for the side effects, they appear only in the form of a decrease in blood pressure and rarely occur.
Analogs
This drug is not one of a kind. There are analogues of Neoton, which are similar to it in their pharmacological action. The most popular tools include:
- "Meldonium."
- Carditrim.
- "Riboxin."
- Kudesan.
- "Cardionate".
- "Antisten."
- Mildronate.
- Tincture of hawthorn.
- "Wazomag."
Before replacing Neoton with analogues, it is necessary to consult a doctor. Only a specialist can choose the most suitable drug in each of the individual cases.