Why is the Proflosin medication prescribed? Instructions for use of this medication, its side effects, contraindications and indications will be described in detail in this article. In addition, we will tell you about whether this drug has analogues, how much it costs and what patients say about it.
Release form and composition
In what form is Proflosin sold? Instructions for use inform that this drug is available in the form of modified release capsules. The medication in question contains such an active element as tamsulosin hydrochloride. It also has auxiliary substances in the form of triethyl citrate, microcrystalline cellulose, talc, as well as a copolymer of ethyl acrylate and methacrylic acid.
Pharmacological characteristics
How does the drug "Proflosin"? The instructions for use indicate that the active substance of the agent in question is able to competitively and selectively block α1A-adrenergic receptors (postsynaptic), which are located in the smooth muscles of the neck of the bladder, prostate and prostatic glands of the urethra. Such an effect leads to a decrease in the tone of smooth muscles, which helps to improve the outflow of urine.
It cannot be said that α-adrenoreceptor blockers reduce blood pressure due to a decrease in vascular resistance (peripheral).
Pharmacokinetic properties
How long is the drug Proflosin absorbed? Instructions for use say that after taking the capsules inside, tamsulosin is absorbed quite quickly from the digestive tract. However, its absorption slows down a bit after eating. With a single dose of the drug in a dosage of 0.4 mg, the highest concentration of the drug in the blood is reached after about six hours.
Communication with proteins is about 99.7%. As for the volume of distribution, this agent is relatively small (approximately 0.2 l / kg).
According to experts, tamsulosin does not undergo a “first pass” through the liver and is metabolized slowly with the formation of inactive metabolites. Most of this substance is unchanged in the blood.
Tamsulosin, including its metabolites, is excreted mainly with urine. About 9% of the drug is excreted unchanged by the kidneys. The half-life of the substance is about 10 hours.
Indications
Do you know the purpose for which doctors prescribe a drug such as Proflosin to patients? Analogs and the mentioned tool itself must be taken only for the treatment of prostatic hyperplasia (benign), as well as for the treatment of dysuric disorders.
Contraindications
Under what conditions should you not take Proflosin capsules? Reviews of experts say that this drug can not be used for hypersensitivity to tamsulosin or other substances, liver failure (in severe form), as well as orthostatic hypotension (including a history).
In addition, the medication in question should be taken with caution in patients with chronic renal failure and arterial hypotension.
Dosage and Administration
"Proflosin" is a medicine for oral administration. As a rule, it is prescribed in the amount of the 1st capsule once a day after the 1st meal or breakfast.
The drug must be swallowed whole (in no case chewed), washed down with warm water. In this case, the capsule cannot be broken or divided into parts. Otherwise, this may affect the release rate of the active component. The duration of use of the drug is not limited.
Overdose
What consequences await the patient if Proflosin was taken in an increased dose? To date, cases of overdose when using this medication have not been observed. However, experts warn that there is a possibility of a sharp decrease in blood pressure and the occurrence of tachycardia. Such events may require special events. To restore pressure and heart rate, the patient should take a horizontal position. Hemodialysis in this case is impractical, since the active substance of the drug has a high affinity for blood proteins.
In order to prevent further absorption of tamsulosin, it is necessary to rinse the stomach, as well as give the patient activated charcoal or an osmotic laxative.
Interaction with other medicines
How does Proflosin affect other medications? According to experts, tamsulosin does not interact with Enalapril, Atenolol, Theophylline and Nifedipine.
With simultaneous use with "Cimetidine" there is a slight increase in the concentration of the active component of the agent in the blood plasma, and with "Furosemide", on the contrary, its decrease. Such phenomena do not require dose adjustment of the medication, since its concentration remains within the normal range.
The drugs "Warfarin" and "Diclofenac" can significantly increase the rate of elimination of tamsulosin.
The simultaneous administration of tamsulosin with other ai-adrenoreceptor blockers can cause a decrease in blood pressure.
Side effects
Does a drug like Proflosin have side effects? The instruction (analogues of the medicine are presented below) states that this medication can really adversely affect the human body.
Consider the side effects of the drug in more detail:
- Heart and blood vessels: orthostatic hypotension and tachycardia.
- Nervous system: dizziness, fainting, and headache.
- Alimentary tract: constipation, nausea, diarrhea and vomiting.
- Reproductive system: priapism and violation of ejaculation.
- Integuments and subcutaneous tissues: rash, urticaria, pruritus and angioedema.
- Others: the development of narrow pupil syndrome during surgery to remove cataracts, rhinitis and asthenia.
special instructions
What should the patient be informed about before prescribing the drug in question? According to the instructions, this medication is prescribed only to the stronger sex.
At the first symptoms of orthostatic hypotension, the patient must be given a sitting or lying position.
Before starting treatment, the presence of diseases, as well as conditions that can cause symptoms similar to signs of prostatic hyperplasia (benign), should be excluded.
Before therapy, as well as during it, a rectal examination (finger) should be performed regularly.
With the development of angioedema, treatment should be stopped immediately. Repeated prescription of the drug is contraindicated.
During surgery to eliminate cataracts while using Proflosin, a narrow pupil syndrome may develop. This probability should be taken into account by the surgeon.
When taking the medication in question, special care must be taken when driving, as well as engaging in hazardous activities that require an increased concentration of attention.
The drug "Proflosin": analogues and the cost of the drug
Do you know how much the drug in question is worth? In pharmacies, 30 capsules can be purchased for 420-450 Russian rubles. If you have been prescribed a longer course of treatment, then 100 capsules will be required. Such an amount of medicine costs about 1200 rubles.
What medications can I replace with Proflosin? Its analogues are the following drugs: Tamsulosin, Bazetam, Tamsulosin retard, Focusin, Hyperprost, Tulosin, Glansin, Taniz-K, Omnik, Taniz ERAS, Omsulosin, Tamsulon-FS, Revocarin, Tamsulosin hydrochloride, Sonizin, Tamselin, Tamsulosin-Teva.
The mentioned medicines have different features. In this regard, they should be used only as directed by the doctor.
Reviews about the drug
What do patients say about a drug like Proflosin? Reviews of patients are only positive. According to the men who took the mentioned capsules, this medication effectively treats benign prostatic hyperplasia and dysuric disorders in general. However, many patients are confused by the high cost of this drug. Given that it should be taken for several months, the treatment is very expensive.