Currently, there are a huge number of drugs that cope well with bacterial infections. Microorganisms quickly mutate and create resistant strains, so new drugs are constantly appearing in the fight against pathogens. One such remedy is Iksim Lupine. Instructions for use, composition and reviews will be discussed later.
What is the drug?
"Iksim Lupine" (cefixime) is a semi-synthetic antibiotic belonging to the third generation cephalosporin group. It has a bactericidal effect due to disruptions in the cell wall of pathogenic microorganisms. The drug “Iksim Lupine”, the manual confirms, has a broad antimicrobial effect on all types of bacteria belonging to the group of aerobic and anaerobic gram-positive and negative, including Pseudomonas aeruginosa.
The drug is resistant to beta-lactamases, and is also highly active against such bacteria: Haemophilus parainfluenzae, Escherichia coli, Neisseria gonorrhoeae, Moraxella catarrhalis, Citrobacter spp., Pasteurella multocida, Proteus vulgaris, Proteus mirabilis, Stremones pyr. agalactiae, Shigella spp., Klebsiella pneumonia and many others.
The following bacteria species are resistant to the main component of this agent: most of the strains of Staphylococcus, including methicillin-resistant, Bacteroides fragilis, Enterobacter spp.
When taking the medicine, the bioavailability of the active component is up to 50% and this does not depend on when the food was taken. But the maximum concentration of cefixime in serum is achieved much faster if you take the drug before meals, and not during. The binding of cefixime with plasma protein compounds, mainly with albumin, is about 65%. Half of the received dose of the drug is excreted in the urine during the day, while its appearance does not change, 10% of the drug comes out with bile.
The composition of the antibiotic
" Iksim Lupine," the instruction says about this, is available in the form of a powder intended for the preparation of a suspension, which is subsequently recommended for oral administration. The powder, like the suspension obtained, has a white or slightly yellow color with a pleasant fruity odor. Available in bottles of polyethylene of 25 grams or in a bottle of 50 g in a cardboard box, the kit comes with a special measuring cup for the correct dosage.
5 ml of powder already diluted with water contains:
- the main substance is cefixime, presented as a trihydrate - 120.39 mg;
- additional components: colloidal silicon dioxide, sodium benzoate, sucrose, xanthan gum, as well as strawberry flavoring.
When is Ixim Lupine recommended?
Suspension "Iksim Lupine", the instruction reports, it is recommended for patients with infectious and inflammatory diseases that were caused by bacteria sensitive to the drug:
- upper and lower respiratory tract: tonsillitis, pharyngitis, sinusitis, bronchitis;
- otitis media;
- infections of the genitourinary system of an uncomplicated nature;
- intestinal infections in the acute phase;
- pelvic inflammatory diseases in women;
- gonorrhea of the neck of the genital organ of a woman and the urogenital canal of uncomplicated nature.
How to take and prepare a suspension?
Suspension "Iksim Lupine", the instruction warns about this, is recommended for use by adults and adolescents over 12 years old, but only to those with a body weight of more than 50 kg.
The dose per day should not exceed 400 mg in one dose or 200 mg in two doses.
With an uncomplicated form of gonorrhea of the neck of the female genital organ and channel for urination, it is recommended to take 400 mg once a day.
Drinking "Iksim Lupine", instructions for children confirms that a child under 12 years old can, the dose is calculated in this way:
- from 6 months to a year old - from 2.5 and not more than 4 ml;
- children two and under four years old - 5 ml;
- starting from five to 10 years, the dose is from 6 ml and not more than 10;
- up to 12 years, the dose is calculated as follows: 8 mg suspension per 1 kg of the child’s weight, if taken once, and 4 mg per 1 kg twice a day.
The course of therapy is from a week to 10 days, with pathologies that were caused by Streptococcus pyogenes bacteria, it is necessary to take a suspension for at least 10 days.
If the patient has impaired renal function, then the dose is selected individually, focusing on the serum creatinine index:
- if creatinine is within 20 and not more than 60 ml / min, then the dose is reduced by 25% per day;
- if the indicators are below 20 ml / min, then the dose is halved.
How to prepare the suspension "Iksim Lupine"? The instruction will tell you in detail how not to make a mistake with the amount of water.
And it all starts with the fact that the bottle with the powder is well shaken. After that, half the right amount of purified water is added to it, the boiled cooled one can be used, tightly closed and mixed well, so that a yellowish liquid without lumps is obtained. After adding water to the desired mark, it is indicated on the label of the bottle. Shake the bottle thoroughly and let stand for several minutes.
Before using the suspension, the vial is thoroughly shaken.
After the suspension is prepared, it can not be stored for more than two weeks.
Undesirable manifestations of taking "Ixim Lupine"
No matter how good and effective the Ixim Lupine medicine is, the instructions for use warns that side effects may appear. You need to be prepared for such manifestations:
- allergic reactions manifest in the form of urticaria, rash, pruritus, and polymorphic erythema;
- in the digestive system can be observed pain in the peritoneum, vomiting, nausea, dysbiosis, cholestasis, stomatitis;
- the nervous system responds with headache, dizziness and tinnitus;
- the genitourinary system can respond to medication with vaginitis and candidiasis;
- The genitourinary system responds with interstitial nephritis, but such manifestations are rare;
- the hematopoietic system can respond to suspension with manifestations of eosinophilia, leukopenia, neutropenia, thrombocytopenia, hemolytic anemia;
- laboratory tests can show a high level of liver transaminase activity, alkaline phosphatase, hyperbilirubinemia, high urea nitrogen, hypercreatininemia, an increase in prothrombin time.
Overdose
Exceeding the dose of the drug "Iksim Lupine", instructions for use for children and adults warns about this, leads to increased side effects. In this case, there is no antidote for the rapid withdrawal of the drug from the body. It is recommended to rinse the stomach immediately, and then seek help from specialists.
They, in turn, will prescribe maintenance therapy, which includes taking antihistamines, glucocorticoids, infusion of infusion funds, as well as connecting to an artificial lung ventilation device. In case of an overdose, hemo or peritoneal dialysis will not yield results.
Reception "Iksim Lupina" during the bearing of the baby and breastfeeding
During pregnancy, it is recommended to take the drug only if there is no other way out for the expectant mother and other means do not give the desired effect. But first you need to consult with a gynecologist, and then already begin treatment with the drug "Iksim Lupine." Instructions, the price of the drug is available to everyone, warns of risk to the fetus.
Admission during breastfeeding is possible, but only if you temporarily transfer the baby to artificial nutrition.
Special instructions for use
Patients who have previously experienced allergic reactions are advised to take Ixim Lupine with caution. Price, instructions for use are available to everyone, in the insert all undesirable manifestations are precisely described. During therapy, a false positive reaction of Coombs and urine to glucose is possible.
Taking the drug does not affect car driving.
Interaction with other medicines
The active substance "Iksim Lupine" - cefixime significantly enhances the effect of taking coagulants of indirect action, and also reduces the prothrombin index.
Increases the amount of carbamazepine in blood plasma.
" Iksim Lupine" instructions, reviews also confirm this, warns that if you take the drug simultaneously with tubular secretion blockers, they slow down the release of cefixime through the kidneys, which can provoke a high level of toxicity in the body.
Antacids, which contain magnesium or aluminum hydroxide, significantly reduce the absorption rate of the drug.
Analogs of "Iksim Lupine"
If for some reason it is impossible to take the Iksim Lupine antibiotic, then you can choose another similar remedy in which the active substance will be the same. Today, pharmacists offer such analogues:
- "Pantsef."
- Cephoral Solutab.
- Suprax.
- Zefspan.
The doctor should select an analog in each individual case.
"Iksim Lupine": instructions for use, price, reviews
Many patients who have been prescribed the antibiotic “Iksim Lupine” respond positively about it. The product tastes very good. Children take it with great pleasure, and the effect of taking it is noticeable already on the third day after the start of therapy.
The drug is allowed to be taken even by babies from 6 months, which can not be said about other drugs that are recommended for combating pathogenic organisms. The cost of a bottle of suspension in 100 mg is 490 rubles.
Undesirable manifestations occur, but only in isolated cases, and if you do not violate the dosage, then the drug is well tolerated. You can avoid complications and negative consequences if you take any medication only after consulting a doctor.