“Vaidaza” is an antimetabolite, produced in the form of a lyophilisate (special powder) for suspension or already in the form of a ready-made suspension for subcutaneous administration. The active substance of this drug - azacitidine, getting into the body, displaces the enzymes responsible for the metabolic processes in cancer cells, and thereby stops their growth and disrupts viability.
Indications
The drug "Vaidaza", instructions for use of which will be proposed later in our article, is prescribed for adult patients suffering from:
- acute myeloid leukemia;
- myelodysplastic syndrome;
- chronic myelomonocytic leukemia.
As a rule, treatment with this agent is carried out under the condition of the impossibility of transplantation in patients with hematopoietic stem cells.
Why is the price of a generic drug “Vaidaza” lower than a branded product
It is no secret that many anticancer drugs have a high cost. This sometimes leads the patients to whom they were appointed to a difficult situation, because you have to buy more than one package.
In such cases, generics come to the rescue. These are drugs with an absolutely similar composition and also released according to the technology of the main branded product. The company that produces them buys a license, but does not spend money on their development, studying the effects of the drug and an advertising company, so the price of a generic is much lower than that of a branded drug.
So, the Indian company Natco Pharma launches XPREZA on the local market - a generic of the Vaidaza drug, which can be purchased on the website . Here, patients at affordable prices are offered a large number of hospital-grade drugs that can prolong and improve the quality of life for seriously ill patients.
Features of use and dosage of the drug
The drug "Vaidaza" is administered subcutaneously in the shoulder, thigh or abdomen. Moreover, the injection area must be alternated, and the place of each subsequent injection should be at a distance of more than 2.5 cm from the previous one.
Please note that the drug should not be injected into the area of seals, redness, hemorrhage or other damage.
It is recommended that you take anti-emetic drugs before injecting Vaidaza.
For all patients during the first course of therapy, regardless of blood counts, the initial dose is 75 mg / m² of the entire body surface and is administered for a week, every day. Then follows a break for 21 days, after which the cycle repeats.
As a rule, the patient needs 6 cycles. But treatment is continued until the effectiveness of therapy is visible, or until signs of progression of the pathology appear.
Preparation of injection
For the procedure, it is necessary to dissolve the contents of the bottle in water for injection (4 ml). Having received a concentration of 25 mg / 1 ml, the suspension should be shaken vigorously until it becomes homogeneous and becomes white. If you need to get a dose above 100 mg, you should take 2 bottles with Vaidaza.
Contraindications
In some cases, the appointment of the drug "Vaidaza" the instruction to which is provided in this article is not allowed. As a rule, this occurs in such patients:
- with common liver metastases;
- in childhood;
- with hypersensitivity to the main active substance of the drug or its other components;
- during pregnancy and lactation.
Carefully apply the named tool in patients with diseases of the heart, lungs, kidneys and liver.
Side effects
The most common side effects during therapy with the drug "Vaidaza", the instruction calls the following:
- nausea and vomiting;
- constipation or diarrhea;
- abdominal pain;
- anorexia;
- dizziness and headache;
- drowsiness, weakness;
- fever;
- anxiety, sleep disturbances;
- dyspnea;
- itching
- petechiae;
- arthralgia;
- nasopharyngitis;
- pneumonia;
- anorexia.