Crohn's disease is an intestinal pathology that is prone to progression. The inflammatory process spreads transmurally and is characterized by various complications of the local and systemic form. The disease affects the entire thickness of the intestinal wall, narrows its lumen, form infiltrates, abscesses and ulcers. To stop the process of the disease, the patient is prescribed anti-inflammatory drugs.
Such effective medicines to eliminate the symptoms of Crohn’s disease and ulcerative colitis (ULC) include the medical products Sulfasalazin-EN and Sulfasalazin. Medications are also prescribed for rheumatoid arthritis to relieve pain and inflammation. Like many drugs, they have their contraindications and side effects. What does the drug “Sulfasalazin-EN” consist of, what is the difference from “Sulfasalazin”? All information can be found in the article.
Release form and clinical group of the drug "Sulfasalazin-EN"
The medicine has anti-inflammatory properties and is used to treat Crohn's disease and UC. It is produced in tablet form, light brown in color. Unlike Sulfasalazin, Sulfasalazin-EN tablets are coated with a special coating that dissolves only in the intestines. The main substance in the composition of the drug is sulfasalazine in a dosage of 500 mg. The product is packaged in blisters of 10 capsules.
Act
A drug is used to eliminate the symptoms of Crohn's disease and UC. Sulfasalazine is released to aminosalicylic acid, which has an anti-inflammatory effect at the site of erosion. Also, sulfapyridine is formed, which has antimicrobial activity and inhibits the functions of gonococci, streptococci and Escherichia coli.
When ingested, the tablets are almost not absorbed in the intestine. Here they break down under the influence of intestinal microflora and form sulfapyridine by 75% and aminosalicylic acid by 25%. For three days, the substances are mainly excreted by the kidneys and only in a meager percentage ratio - feces. Such an effect on the patient’s body is provided by the sulfasalazin-EN agent. Unlike Sulfasalazine, reviews about the drug - all this information is worth exploring before starting treatment.
When is the medicine used?
The medicine is prescribed for the following pathologies:
- NAC;
- Crohn's disease;
- rheumatoid arthritis.
It is forbidden to take medication in such cases:
- kidney and liver disease;
- anemia;
- porphyria;
- pregnancy;
- lactation;
- hypersensitivity to the substances that make up the drug.
Before starting the treatment process, it is carefully necessary to study all contraindications for taking the Sulfasalazin-EN medicine. Unlike Sulfasalazine, special instructions - all information is important. The drug can be used after consultation with a specialist.
What dosage is the treatment prescribed for?
After examining, examining and clarifying the diagnosis, the doctor prescribes a remedy for the treatment of Crohn’s disease and UC (ulcerative colitis). The medicine is taken according to a special scheme:
- the first day - 500 mg three or four times;
- the second day - 1 gram every six hours;
- all other days, the medicine is taken at 2 or 1.5 g.
After improvement, the patient is left with a dose to maintain for a few more months. The norm of the drug is 500 mg several times a day. Correction of treatment can only be performed by a specialist.
For children after 5 and up to 7 years of age, the medication is prescribed 250-500 mg several times a day. After 7 years of age, the dosage will be 500 mg up to 6 times a day.
With rheumatoid arthritis in adults, the medicine is also dosed according to a certain algorithm:
- first week - 1 tablet at a dose of 500 mg once a day;
- second week - 500 mg twice a day;
- third week - 500 mg three times.
The course of treatment is up to six months or more, depending on the severity of the disease and the individual characteristics of the body.
The daily norm should not be more than 3 g for the drug "Sulfasalazin-EN". The instruction describes the difference from Sulfasalazine in sufficient detail. This also applies to the scheme of receiving funds.
For children with rheumatoid arthritis, the medicine is prescribed at the rate of 50 mg per 1 kg of body weight per day, divided into two or three uniform doses. For patients after 16 years, the maximum allowable dose is 2 g. The medicine is prescribed orally after a meal. It should be washed down with a large amount of liquid and not chewed.
Neglect of dosage recommendations can lead to the development of the following unpleasant symptoms:
- weakness
- abdominal pain;
- dizziness;
The patient is prescribed symptomatic treatment, gastric lavage. It is important to control urination.
The drug “Sulfasalazin-EN” should be taken according to the instructions. Differences from Sulfasalazine (properties, release form) are not significant. However, it is worth asking the doctor in what form it is better to take the medicine.
The drug "Sulfasalazine"
The medicinal product belongs to the group of anti-inflammatory drugs, is prescribed for the treatment of Crohn’s disease and UC. It is produced in tablet form of yellow-brown color. The composition of the drug includes sulfasalazine (500 mg).
The drug has anti-inflammatory and antimicrobial effects. It also has an immunosuppressive and anti-rheumatic effect. The main substance of the tablets, sulfasalazine, has a positive effect on the intestines due to two active components. These are sulfapyridinone and aminosalicylic acid. It has a bacteriostatic effect against diplococci, staphylococci and Escherichia coli drug "Sulfasalazin-EN." Unlike Sulfasalazine, a description of the active ingredient - all information is presented in the instructions.
Indications and contraindications
The medicine is prescribed for such pathologies:
- NAC;
- Crohn's disease;
- various forms of rheumatoid arthritis.
Contraindications:
- severe pathology of the kidneys and liver;
- blood diseases;
- age up to 5 years;
- hypersensitivity to the components.
Has an insignificant drug "Sulfasalazine - EN" difference from "Sulfasalazine." Instructions for use describe similar indications and contraindications. What medication to use in a particular case, a specialist will tell.
Dosage
On the first day of treatment for adults, the medicine is prescribed at a dose of 500 mg 4 times, then on the second day - 1 g 4 times, in the future the drug is taken from 1.5 to 2 g per day. The course of treatment depends on the severity of the process and the individual characteristics of the body.
Overdose can lead to the development of the following symptoms:
- migraine;
- cramps
- insomnia;
- epigastric pain;
- vomiting
- diarrhea;
- allergy.
Sulfasalazin-EN has not such pronounced side effects. The difference from Sulfasalazine is that the medication is coated.
If any of the described drugs was not purchased at the pharmacy, the specialist will select a quality substitute.
The drug "Salofalk"
The drug has an anti-inflammatory property and is prescribed for Crohn's disease and UC. Available in the form of yellow tablets. The composition of the drug includes mesalazine in a dose of 250 and 500 and 1 g. The tool has an anti-inflammatory, antioxidant effect on the intestinal wall
Indications:
Contraindications:
- blood diseases;
- preschool children;
- hypersensitivity to the components.
At the beginning of the treatment process, you should carefully study all the features of the drug "Salofalk" and "Sulfasalazin-EN." The difference from Sulfasalazine in use is not significant. Drugs are taken according to a similar pattern.
Dosage
Patients are prescribed 500 mg three times a day. In severe cases, the dose may increase to 3 g per day. The drug is taken for three months.
The medicine "Sulfasalazin-EN". Difference from Sulfasalazine: patient reviews
Two identical in composition of the drug. The only difference is that Sulfalazin-EN is coated with a coating that is soluble only in the intestine, unlike Sulfasalazine tablets, which are coated with a film. Also, the first medicine causes more allergic reactions, which manifest themselves in the form of a rash and itching on the skin. If you believe the reviews of patients, the drug "Sulfasalazine" is in great demand.
Specialists note that both drugs can lead to the development of side effects. There is nausea, vomiting, and pain in the stomach. Moreover, it has an insignificant means "Sulfasalazin-EN" difference from "Sulfasalazine." Photos of medicines are also similar.
Experts note that this group of drugs does not help everyone equally. These funds are not reliable enough for the defeat of peripheral joints. To avoid the development of urolithiasis, it is advisable to drink tablets with a large amount of mineral water, drink plenty of fluids during the day. What is the difference between Sulfasalazin-EN and Sulfasalazine? The analogue (the drug "Salofalk"), although it is prescribed for similar pathologies, but has much more discrepancies. This is due to the difference in composition.
Total
If the patient has problems with the stomach, then it is better for him to take "Sulfasalazin-EN", which will not dissolve in the stomach, but only in the intestine. In a small part of patients, in the early stages of taking funds of this group, fever, skin rashes can occur, which disappear on their own after several days of therapy.
Doses of drugs are selected individually, depending on intestinal damage and the stage of development of the disease. During the period of exacerbation, the dosage of the drug reaches maximum values, then, to improve the condition, it decreases slightly. If a patient has significant side effects when taking drugs, this should be reported to the attending physician. According to patients, there is no significant difference between the drugs. The difference from “Sulfasalazine” of the drug “Sulfasalazin-EN” is only that the drug dissolves in the stomach and can cause pain in the epigastric region.
If you regularly take pills according to the specified scheme, you can stop the process of bone destruction with rheumatoid arthritis. The medicine can be prescribed for adults and children after 5 years. Do not exceed the dosage so as not to cause side effects that are fraught with serious complications from other organs and systems. It is also better to drink tablets immediately after eating and drink them with alkaline solutions, such as mineral water. After one month of treatment, an improvement will be observed. The medicine is prescribed for a long period, but does not cause addiction and withdrawal syndrome. Sulfasalazin-EN and Sulfasalazine are available at the pharmacy with a prescription.