Ofloxacin tablets are a popular antimicrobial drug with a pronounced effect. Belongs to the category of fluoroquinolones, belongs to antibiotics of a wide spectrum of influence. It is active in a relatively wide variety of pathological life forms. The tool is quite powerful, so it can cause side effects. The use of tablets is recommended strictly under the supervision of a doctor and at a dosage prescribed by a specialist. To prevent a negative response of the body, you must follow the established duration of the course. It is unacceptable to take an antibiotic at your own discretion.
general information
Instructions for use of Ofloxacin indicate that the drug is rapidly absorbed through the walls of the gastrointestinal tract, is evenly and in a short time distributed among the organs and tissues of the body, and is observed in biological fluids. Excretion is carried out mainly with urine, a small percentage - with the contents of the intestine. The maximum concentration in the circulatory system is recorded after a couple of hours from the moment the tablets were taken in food. Bioavailability is estimated at 96%. Hemodialysis allows you to remove only a third of the drug received in the body.
Instructions for use of Ofloxacin contains a list of components used by the manufacturer in the manufacture of the composition. One tablet contains 200-400 mg ofloxacin - an antimicrobial composition that provides the main effect of the drug. This compound affects the processes of DNA synthesis in a microbial cell, causing the death of microorganisms.
Ofloxacin tablets are presented on cardboard shelves by cardboard boxes containing blisters with doses of the medicine. Each capsule is made in a convex form on both sides, covered with a thin shell that is close to white, slightly rough. If you cut the tablet across, you can see two layers.
As auxiliary substances manufacturer used:
- cellulose;
- talc;
- silicon dioxide.
Carefully study the instructions for use of Ofloxacin with regard to the composition is necessary for people suffering from intolerance or hypersensitivity to any substances common in the pharmaceutical industry. A doctor who is prescribing for Ofloxacin should be warned of a possible allergic reaction.
Technical features
According to the instructions for use, Ofloxacin is one of the antimicrobial agents. The manufacturer focuses on the possibility of side effects with improper use of the composition, so it is recommended that you first seek qualified help. Only if the doctor considers Ofloxacin to be the appropriate drug for a specific patient, should he take it.
The active compound is one of fluorinated quinolones. Ofloxacin is a second-generation drug, characterized by its vast effect. Dosage must be selected, focusing on the diagnosis, degree of damage, localization of the focus. Course duration - a week.
Indications “Ofloxacin” mainly include infectious diseases:
- ear, throat, nose;
- soft tissue;
- integuments, bones, joints;
- urinary system;
- bile ducts;
- abdominal cavity;
- pelvic organs;
- reproductive system.
Ofloxacin is used for meningitis and pyelonephritis. Ofloxacin should not be used if bacterial enteritis is established.
The effect of Ofloxacin against pathological microorganisms provoking eye diseases is pronounced:
- blepharitis;
- conjunctivitis;
- keratitis;
- meibomite.
The drug is used for ulcers on the ocular cornea and infection with chlamydia. Ofloxacin injections are indicated for gonorrhea, chlamydia, and septicemia. With weakened immunity, the medication in various forms is taken as a prophylactic. You must first consult a doctor.
Limitations
Ofloxacin is not used if epilepsy is established, conditions in which the threshold for seizures decreases. The medication is not intended for minor patients and persons who have been identified:
- fluoroquinolone intolerance;
- glucose-6-phosphate dehydrogenase deficiency.
Ofloxacin is not intended for the treatment of pregnant women and breast-feeding mothers. Ofloxacin ointment is not used for children under one year of age. It is not an absolute contraindication for the use of Ofloxacin, but it requires increased caution in violation of the blood flow in the brain tissue, atherosclerosis. Medical control is necessary if Ofloxacin is prescribed for patients with chronic kidney failure or organic central nervous system disorders.
Application rules
Treatment with Ofloxacin in tablet form involves taking the drug orally during a meal. It is not necessary to violate the integrity of the shell, to chew the medicine - the tablet is swallowed whole. For better absorption, it is necessary to drink plenty of capsule with water.
The dosage of Ofloxacin should be chosen by the attending physician. The state of the kidneys, liver, the severity of the disease, the characteristics of the infectious agent, its level of sensitivity to the antimicrobial composition are evaluated. For an adult patient, the daily dose varies between 200-800 mg.
At a dose of up to 400 mg, the entire volume of the drug is used at a time. The manufacturer recommends drinking a pill in the morning. If a larger volume is written out, it is reasonable to divide it into two doses. The duration of therapy is from a week to one and a half.
Symptoms of the disease should disappear before the completion of the course of treatment. After stabilizing, the temperature drops, the tablets are used for food for another three days.
If gonorrhea is established, Ofloxacin is indicated to be used only once. Dosage - 400 mg.
Special occasion
According to reviews, Ofloxacin is sometimes prescribed for the treatment of children. This is practiced in situations where it is not possible to apply alternatives that are more reliable and safe for minors. The dosage for the day should be chosen by the doctor. The calculation is based on the weight of the patient: for every kilogram of weight - 7.5 mg of antibiotic. It is unacceptable to consume more than 15 mg per kilogram per day.
Infusion and external use
In some reviews of Ofloxacin, patients say that the drug was prescribed as an intravenous injection. This format is effective and shows a pronounced effect, but has strict limitations. A single administration is limited to 200 mg of the active compound. The duration of the procedure is from half an hour to an hour. As soon as the patient's condition stabilizes, the injections are replaced with tablets.
If infectious lesions of the urinary system are established, Ofloxacin is prescribed twice a day, 100 mg each. For diseases of the reproductive system, kidneys, the drug should be used once a day or twice, the dose is 100-200 mg. For pathologies of ENT organs, joints, skin, bone, soft tissues, septic infection, and damage to the abdominal cavity, the optimal use of Ofloxacin is 200 mg twice a day, and 400 mg in severe cases.
Ofloxacin ointment is indicated if infection with chlamydia of the organs of vision is detected. The drug is used daily up to five times, the duration of this course is up to 14 days. In other cases, Ofloxacin is used for eye diseases no more than three times daily. The tool in the amount of a centimeter strip is placed in the conjunctival sac.
Unpleasant consequences
In the instructions, the manufacturer indicates that the use of the drug can cause side effects. To reduce the likelihood of their occurrence, you must first consult with your doctor regarding the possibility of using Ofloxacin. What group of antibiotics does not provoke adverse reactions of the body? There are practically no such ones, so you should be careful when using any drugs. In general, as can be seen from the numerous responses of doctors and patients, if Ofloxacin is used according to indications, following the manufacturer's recommendations, unpleasant consequences are rather weak and are rarely observed.
Clinical trials have shown the possibility of side effects:
- sleep disturbances;
- the head hurts and is spinning;
- limbs go numb;
- anxiety;
- excitement;
- violation of the rhythm of the heartbeat;
- violation of the perception of colors, sounds, tastes, smells;
- anemia;
- leuko-, pancyto-, thrombocytopenia;
- pressure reduction;
- dermatitis;
- vasculitis;
- nephritis;
- allergic reactions.
In extremely rare cases, the administration of Ofloxacin provoked hallucinations and anaphylactic shock. Ofloxacin ointment can cause local unpleasant manifestations: dryness, burning, itching of the treated area, increased lacrimation, redness. Photophobia is possible. Ofloxacin and alcohol are categorically not combined. When drinking alcohol during the course of treatment, the risk of developing adverse reactions increases significantly.
Too much!
In clinical practice, cases of overdose are described. The patient is drawn to sleep, headache and dizziness, consciousness is confused. The patient is inhibited, tears, disorientation is possible. There is no specific antidote, gastric lavage and therapy are prescribed to eliminate the symptoms.
Ofloxacin: analogues
It is allowed to change the composition strictly in agreement with the attending physician. Wrong, poorly selected drug can provoke side effects, cause the development of superinfection, and also reduce the effectiveness of the therapeutic course to zero.
The most effective and well-known analogues of Ofloxacin:
If necessary, choose an alternative to Ofloxacin, you should first check with your doctor what exactly is suitable in this case. Much will depend on the diagnosis, the severity of the disease, background disorders of the internal systems and organs.
Pharmacology
Tablets, ointment, injections, and Ofloxacin drops are among the antibiotics with a wide spectrum of effectiveness. The active compound destabilizes the DNA chain, leading to the imminent death of pathological microorganisms. The bactericidal effect is rated as moderate. Ofloxacin is effective if infection occurs:
- atypical mycobacteria;
- beta-lactamases.
Resistance to Ofloxacin is shown:
- pepto-, peptostreptococci;
- nocardia;
- clostridia;
- fuso-, eubacteria;
- treponema.
In any form, Ofloxacin (drops, tablets, infusions, ointment) is not used if an acute form of tonsillitis is established. You can not use an antibiotic for pneumococcal provoked pneumonia.
Note!
Studies have shown that taking an antibiotic slows down the reaction rate, therefore, during the use of the composition, it is recommended to refrain from driving, working with high-precision mechanisms. If possible, tasks requiring increased concentration of attention should be avoided. It is preferable to completely abandon any form of activity associated with a health risk.
It is strictly forbidden to combine Ofloxacin and alcohol.
Passing the course of Ofloxacin, you should refuse to use hygienic tampons: they increase the likelihood of thrush.
With a high probability of porphyria, the use of Ofloxacin can provoke an attack. The drug can aggravate the condition of the patient with myasthenia gravis.
Under the influence of Ofloxacin, it is possible to obtain false negative results of a bacteriological test to establish tuberculosis.
In old age, individuals who simultaneously use glucocorticosteroids and Ofloxacin are at increased risk of tendon rupture.
Mother and child
Ofloxacin is not used during gestation. If you need treatment after birth, you will have to temporarily stop breastfeeding. For the treatment of children, Ofloxacin can be used only in the absence of an alternative.
Interaction
Tests have shown that Ofloxacin can be used with isotonic sodium solution, as well as solutions:
- glucose;
- fructose;
- Ringer’s.
The combination of the medication in question and heparin can provoke precipitation. A reduced antibiotic absorption rate is observed with antacids, which include:
- calcium;
- iron salts;
- magnesium;
- aluminum.
To prevent a decrease in effectiveness between doses of drugs should be kept at least two hours. With the simultaneous use of Ofloxacin and theophylline, the clearance of the second decreases by a quarter. To prevent negative reactions, a dosage reduction is necessary.
Larger than standard amounts of antibiotic in the blood plasma are observed with the simultaneous use of Ofloxacin and:
- "Methotrexate";
- "Cimeidine";
- "Furosemide";
- inhibiting the production of calcium drugs.
Ofloxacin increases the amount of glibenclamide in plasma. The combination of antibiotic and phytomenadione antagonists requires monitoring the quality of blood coagulability. The combination of an antimicrobial composition and non-steroidal drugs for stopping inflammatory processes based on methylxanthine, nitroimidazole increases the likelihood of a toxic effect on the nervous system. The risk of crystalluria, nephrotic effects is increased if Ofloxacin and urine-alkaline drugs are used at the same time.
Analogs: Phloxal
Under this name, ointments for the treatment of eye diseases are presented in pharmacies. 3 mg ofloxacin is accounted for one gram of the substance, the remaining volume is reserved for additional compounds:
- paraffin;
- wool fat;
- petroleum jelly.
The substance is homogeneous, without inclusions, lumps and crystals, painted in a light shade of yellow. The drug is packaged in an aluminum tube, which is placed together with the instructions for use in a cardboard box. The box indicates the name of the composition, the amount of active component in it, the amount of the drug, the rules of dispensing and storage conditions. Drops for the eyes are also available.
general information
"Phloxal" belongs to the category of antimicrobial compounds with a wide spectrum of action. This is an antibiotic from the fluoroquinolone group, designed specifically for the treatment of ophthalmic diseases. The composition is used topically; when it enters the cells affected by the virus, it inhibits the activity of the DNA gyrase of the pathological microorganism.
The most pronounced activity is observed during infection:
- Shigella
- neysseries;
- morganella;
- Klebsiella;
- mycoplasma;
- legionella;
- chlamydia
- salmonella;
- enterobacteria.
"Phloxal" shows the activity of a relatively limited spectrum of gram-positive pathological microscopic life forms, including some staphylococci, streptococci. Pseudomonads, some enterococci, streptococci are characterized by moderate antibiotic sensitivity.
You can use "Phloxal" for ophthalmic diseases provoked by beta-lactamase-generating microorganisms. Of anaerobic bacteria, the drug is effective only when infected with bacteroids of the genus urealyticus.
Indications
As tests have shown, when using drops, Phloxal ointment strictly according to the instructions, the antimicrobial composition accumulates in the tissues of the eye, without having a systemic effect on the body. The medication is recommended for use in inflammation, infectious eye lesions provoked by agents sensitive to ofloxacin:
- blepharitis;
- conjunctivitis;
- keratitis;
- ulcerative processes;
- chlamydia
- dacryocystitis.
The tool is effective not only as an element of treatment, but also as a preventative, if a person has undergone surgery on the organs of vision or trauma to this area.
rules
"Phloxal" is used daily for 14 days in a row with a frequency of two to four times a day. A drop is instilled under the lower eyelid of a sick eye. If the doctor recommended the use of “Phloxal” and other local means for the eye, between the approaches should observe time intervals of at least five minutes.
The use of "Phloxal" in the form of an ointment involves laying a strip of the drug under the lower eyelid. Frequency of use - up to three times daily. If infection with chlamydia is established, the frequency is increased to five times a day. The duration of the therapeutic course is up to 14 days.
You can combine both forms of the drug "Phloxal". With the simultaneous use of ointments and other topical drugs, it is “Phloxal” that should be applied last.
Contraindications and side effects
Phloxal may cause:
- redness of the eye;
- the allergic response of the body;
- burning, dryness, itching;
- fear of the light;
- active lacrimation.
The manufacturer categorically does not recommend the use of "Phloxal":
- during gestation;
- with breastfeeding;
- hypersensitivity to the substances used in the manufacture of the drug.
There is no official information about the negative effect of the drug on the fetus, but the manufacturer recommends not using drops and ointment in an “interesting” position, since to date the consequences are not exactly established.
Do not use contact lenses when undergoing antibiotic treatment. If necessary, vision correction is better to use glasses. In addition, it is recommended to use sunglasses throughout the treatment program, if possible, avoid prolonged exposure to high light conditions.