Colds today are familiar to almost every person. Probably everyone has a “favorite” remedy in their medicine cabinet to quickly lower their temperature, eliminate pain and fever. One of the most popular and effective drugs in this case is Panadol Extra. It is often used to relieve pain of various localization, reduce temperature and eliminate fever after vaccination. This medication belongs to NSAIDs, many use it to eliminate fever and temperature during the flu and SARS.
Description and description of the medication
Panadol Extra - combined drug, NSAIDs, analgesic and antipyretic. It comes in the form of tablets, one of which contains five hundred milligrams of paracetamol, as well as sixty-five milligrams of caffeine. As auxiliary components, the composition of Panadol Extra includes: sodium bicarbonate, sorbitol, citric acid, povidone and others.
These substances have an analgesic and antipyretic effect. Indications for use "Panadol Extra":
- Pain syndrome of varying intensity and localization.
- Pain after vaccination.
- Fever.
- High body temperature.
- SARS and the flu.
- Neuralgia, arthralgia.
- Algodismenorea (painful menstruation).
There are six strips in one package, each containing two tablets.
Drug action
Panadol Extra tablets reduce body temperature, relieve pain. The drug is presented in the form of effervescent tablets, soluble in water. Its constituents paracetamol and caffeine reduce the concentration of prostaglandins in the central nervous system, as they block the synthesis of cyclooxygenase. Paracetamol acts on the centers of pain and thermoregulation. But it does not have an anti-inflammatory effect. Caffeine also helps to eliminate depression, which accompanies pain, stimulates the central nervous system. It eliminates fatigue and drowsiness, increases performance.
Paracetamol is absorbed in the gastrointestinal tract in a short time, distributed evenly throughout the liquids. It is excreted by the kidneys together with urine in the form of metabolites after about three hours. Its maximum concentration in the blood is observed after two hours. Caffeine is also rapidly absorbed, most of it is excreted in the urine after about three hours.
Panadol tablets: instruction for use
Children under twelve years of age should not take the drug. The remaining patients need to take one or two tablets four times a day. Between receptions should pass at least four hours. The tablets are dissolved in pure water in the amount of one hundred grams. The maximum allowable dosage is eight tablets per day. It is unacceptable to take other drugs that have paracetamol or caffeine, and it is also not recommended to drink caffeinated drinks.
The duration of treatment should be established by the doctor in each case. Usually the medicine is not used for more than three days, otherwise a doctor’s consultation is required.
Usage restrictions
There are some contraindications for the use of the medication. Painkillers are not recommended for use in such situations:
- Increased susceptibility to the components of the drug.
- Pathologies of the kidneys or liver in a severe form.
- Hyperbilirubinemia.
- Blood disease.
- Anemia and leukopenia.
- Alcohol addiction.
- Excitation of the National Assembly.
- Sleep disorder.
- Epilepsy.
- Hypertension, leukopenia.
- Pathology of the heart and blood vessels.
- Severe atherosclerosis.
- Myocardial infarction.
- Tachycardia.
- Pancreatitis in acute form.
- Hyperthyroidism
- Severe diabetes mellitus.
- Glaucoma.
- Thrombosis, atherosclerosis.
- Hypertrophy of the prostate gland.
- Senile age (over sixty years).
- Children's age up to twelve years.
- The period of treatment with antidepressants and beta-blockers.
- Congenital fructose intolerance.
- Vasospasms.
- The period of gestation and breastfeeding.
Interaction with other medicines
These painkillers should not be consumed with alcoholic beverages. With the simultaneous use of "Cholestyramine", the effect of the drug will slow down. With the use of "Warfarin" increases the risk of bleeding. Barbiturates reduce the effectiveness of the drug. Anticonvulsants increase the toxic effects of paracetamol on the liver. When using diuretics with paracetamol, their effectiveness is reduced. The risk of developing a hypertensive crisis increases while using the drug and MAO blockers.
Caffeine enhances the effect of psychostimulating drugs, and also reduces the effectiveness of sleeping pills and sedatives, analgesics and anxiolytics. And also this substance while taking it with thyrotropic drugs increases their effectiveness.
Features of the use of the drug
If there are problems with the kidneys, as well as arthritis in the patient, additional specialist advice is required. The medication affects the results of laboratory blood tests on the concentration of glucose and uric acid.
If a person has severe infections, the likelihood of developing acidosis increases, which is accompanied by nausea and vomiting, decreased appetite, and shortness of breath. If these symptoms appear, you should immediately contact a medical institution.
With the simultaneous use of caffeinated drinks, the risk of sleep disturbances, tremors, and heart palpitations increases.
With prolonged persistence of negative symptoms, as well as persistent headache, it is recommended to consult a doctor to prescribe another medication.
When using the drug "Panadol Extra" during pregnancy, the risk of spontaneous miscarriage increases.
If dizziness occurs after taking the tablets, it is recommended that you refrain from driving cars or other mechanisms for a while.
Complications and consequences
Typically, the drug is well tolerated by all patients. But in some cases, side effects may occur. "Panadol Extra" causes such reactions:
- Nausea accompanied by vomiting.
- Pain in the abdomen or heart.
- Rashes on the skin and mucous membranes.
- Stevens-Johnson disease.
- Swelling, erythema.
- Lyell's Syndrome.
- Hypoglycemic coma.
- Anemia.
- Hematomas.
- Dyspnea.
- Thrombocytopenia.
- Arrhythmia.
- High blood pressure.
- Sleep disorder.
- Dizziness.
- Bronchospasm.
- Hepatonecrosis.
- Violation of the liver.
- Hyperactivity, anxiety.
- Disorder of the functionality of the digestive tract.
If any negative symptoms appear, treatment should be discontinued, and you should also consult your doctor.
Excessive Dosage
According to the instructions for the use of Panadol tablets, when using a large amount of the drug (more than ten grams), liver pathology develops. In people who have digestive disorders, HIV, epilepsy, alcoholism, an overdose occurs when taking five grams of the drug.
With an overdose during the day, the following symptoms develop:
- Nausea accompanied by vomiting.
- Pain in the abdomen.
- Pallor of the skin.
On the second day, liver pathology, acidosis develops. With severe intoxication, liver failure, encephalopathy, hypoglycemia, hemorrhages occur. Such events can be fatal.
Renal failure is manifested by severe pain in the lower back, hematuria. And pancreatitis, arrhythmia can also appear.
When using tablets in large doses, anemia, neutropenia, thrombocytopenia, pancytopenia, leukopenia, as well as a disorientation in space, renal colic, capillary necrosis develop for a long period.
If symptoms of an overdose appear, the victim must be taken to a medical facility. And also the patient needs to be given the sorbent as early as possible. After eight hours after poisoning, the effectiveness of the antidote decreases. If necessary, “Acetylcysteine” is administered to the victim. At home, with mild poisoning, which is not accompanied by vomiting, you can give a methionine tablet. And beta beta blockers are also allowed. Before taking the drugs, you need to rinse the stomach, if there are seizures, give “Diazepam". Therapy of intoxication is symptomatic.
Additional Information
Panadol Extra must be stored in a dry, dark place at an air temperature of up to twenty-five degrees Celsius. Shelf life is four years from the date of release of the drug. Children should not have access to medication.
Cost and purchase of the drug
This medication can be purchased in almost any pharmacy network in the country. You do not need a doctor's prescription to buy it, but you should not self-medicate. The cost of the medicine is about sixty seven rubles per package.
Analogs
There are several analogues of this drug. The most common are:
- Migrenol is a drug that has a similar composition and pharmacological effect. It well eliminates pain of varying intensity and localization, lowers the temperature in case of flu and acute respiratory viral infections, and eliminates body aches. Its cost is one hundred and seventy rubles per pack of eight tablets.
- "Solpadein" is a psychostimulant and analgesic. It has a similar pharmacological effect and composition. Produced by an Irish company. The price of the medicine is one hundred eighty rubles per pack of twenty-four tablets.
- Migrenium is a similar drug. Its cost is one hundred twenty-five rubles per pack of twenty tablets.
Reviews
About the drug "Panadol Extra" reviews are mostly positive. Many consumers note that the drug has a quick effect, helps to reduce body temperature in a short time and eliminate pain and body aches. It is often used to treat colds. In addition, most patients note that they did not notice any side effects when taking the medicine.
Many note the low cost of the medication. But there are people who say that you need to wait a long time until the tool begins to act.
Some patients, after reading the instructions, are afraid to use the medication, since it indicates a large number of contraindications and adverse reactions. But doctors say that with proper observance of all prescriptions and recommendations, negative symptoms are not observed. Doctors often prescribe medication for their patients to relieve pain. The effect of the drug is observed for a long time, which is a plus.
Doctors focus on the fact that there is no need to increase the dosage of the drug, since in this case the risk of developing negative consequences increases several times. It is unacceptable to engage in self-medication, it is best to contact the doctors when manifesting diseases, they will help you choose the most suitable remedy.