Why can such a medication as Lomflox be prescribed? Instructions for use, contraindications and indications for taking this medication will be presented in detail in this article. In addition, from it you will learn about in what form this drug is produced, what substances are included in its composition, how much it costs and whether it has analogues.
Drug packaging, its form, description and composition
In what form is a drug such as Lomflox produced? Instructions for use informs that this medication goes on sale only in the form of coated (film) oblong tablets (400 mg) of light brown color.
The active element of this tool is lomefloxacin (used in the form of hydrochloride). As for the additional components, they include lactose, purified talc, starch, crospovidone, polyvinylpyrrolidone, sodium lauryl sulfate, propylene glycol, magnesium stearate, sodium starch glycolate and colloidal silicon dioxide.
The following substances are included in the composition of the shell: methylene chloride, isopropanol, titanium dioxide and hydroxypropyl methylcellulose.
Lomflox tablets are in blisters (5 pieces each), which are placed in cardboard boxes.
How does the drug work?
What is the Lomflox medicine? Instructions for use indicate that this tool is an antimicrobial synthetic drug. It belongs to the preparations of the fluoroquinolone group and has a wide spectrum of bactericidal action.
The drug in question is capable of blocking the bacterial DNA gyrase, thereby forming a complex with its tetramer and disrupting DNA replication and transcription. As a result of such exposure, the death of a pathogenic cell occurs.
This medication is active against both gram-negative and gram-positive microorganisms and aerobes. In addition, the drug adversely affects chlamydia, mycobacterium tuberculosis (intracellular and extracellular), as well as some strains of uroplasm and mycoplasma.
In an acidic environment, the effectiveness of the drug is significantly reduced, and resistance develops very slowly.
The medication has a pronounced post-antibiotic effect.
It should be noted that streptococci and anaerobes are resistant to lomefloxacin.
Pharmacokinetics
How long does the Lomflox medicine (tablets) be absorbed? The instruction for use states that after taking the medicine inside, its active component is almost completely absorbed from the digestive tract.
When using 400 mg of the drug, its highest concentration in the blood is observed after 1.5-2 hours and is about 3.2-5.2 mg per liter. It should also be noted that when taking the drug at the indicated dosage, the concentration of lomefloxacin may exceed the BMD for most bacteria. At least for half a day.
The connection of the active substance with plasma proteins is approximately 10%. Lomefloxacin quickly penetrates into all body tissues. The concentration of the drug in biological fluids is 3-6 times higher than in plasma, especially in the tissues of the prostate gland, pulmonary macrophages and urine.
The half-life of the active element is about 7-9 hours. Approximately 70-80% of lomefloxacin is excreted during the day (unchanged) with urine.
In patients with impaired renal function, the half-life of the active element increases significantly.
Indications
What diseases are prescribed Lomflox medication? Instructions for use contain the following indications:
- respiratory diseases (infectious), and more precisely, their lower sections (including exacerbation of pneumonia and chronic bronchitis);
- infectious as well as inflammatory diseases that were caused by bacteria sensitive to lomefloxacin;
- otitis media;
- chronic and acute chlamydial, mixed and gonococcal infections;
- complicated and uncomplicated infections of the urinary and reproductive systems;
- infectious diseases of soft tissues and skin;
- infectious cholecystitis and enterocolitis;
- infections of joints and bones, including chronic osteomyelitis;
- pulmonary tuberculosis (including acutely progressive forms of the disease, drug resistance of bacteria, rifampicin intolerance, non-specific inflammatory processes associated with tuberculosis).
It should also be noted that the drug in question is often prescribed for the prevention of infectious complications during surgical transurethral interventions.
Contraindications
In the presence of any pathologies, in no case should you take Lomflox tablets? Instructions for use (the price of the drug is presented below) contains the following list of contraindications:
- the period of gestation and breastfeeding;
- epilepsy, cerebral atherosclerosis, as well as conditions accompanied by seizures;
- children's age up to 15 years;
- hypersensitivity of the patient to lomefloxacin, as well as other quinolones.
Medication "Lomflox": instructions for use
A description of this tool is always available in the attached instructions. In addition, the annotation to the drug informs patients about the dose in which it should be taken for one or another deviation.
Lomflox tablets must be taken orally (washed down with room temperature water). Its effectiveness does not depend on food intake. The usual dosage of this drug is 400 mg once daily.
With impaired kidney function, 400 mg of the drug is prescribed on the first day of treatment, and 200 mg (once a day) on the next day. Dosage and duration of therapy depend on the severity of the deviation and the sensitivity of the pathogen.
In the event that the patient is diagnosed with tuberculosis, Lomflox tablets must be combined with drugs such as Isoniazid, Pyrazinamide and Ethambutol.
It is highly undesirable to take lomefloxacin and rifampicin at the same time. This is due to the fact that these substances are competitive antagonists.
The risk of a photochemical reaction can be significantly reduced by taking Lomflox tablets in the evening.
Drug interaction
Can I take LOMFLOX medicine with other drugs? Instructions for use (analogues of the drug will be presented at the end of the article) states that this drug is able to increase the activity of oral anticoagulants, as well as increase the toxicity of NSAIDs.
Sucralfate and antacids slow down the absorption of the drug and reduce its bioavailability, forming chelate compounds. As for the simultaneous administration with probenecid, this helps inhibition of renal excretion.
Side effects
Can the drug Lomflox negatively affect the human body? Instructions for use (reviews, analogues are presented in this article) states that the drug in question has the following side effects:
- Vascular and heart: vasculitis and inhibition of the cardiopulmonary system.
- Respiratory system: pulmonary and laryngeal edema.
- Allergy: allergic reactions, photosensitivity, anaphylactic shock and Quincke's edema.
- Alimentary tract: colitis pseudomembranous and sore mouth.
- From the liver: the development of hepatitis.
- Urinary system: polyuria, interstitial nephritis, urinary retention, and renal failure.
- Muscles / skeleton: tendonitis, ligament rupture, arthralgia and myalgia.
- Nervous system (peripheral and central): anxiety, ataxia, confusion, convulsions, depression, tremors, sleep disorders, dizziness, mental disorders, headaches, hallucinations, visual disturbances, taste perversion, photophobia and diplopia.
- Skin: hyperpigmentation, exfoliative dermatitis, Stevens-Johnson syndrome and epidermal necrolysis.
- Metabolism: hypoglycemia.
- Blood: hemolytic anemia and thrombocytopenia.
special instructions
What features of the medicine should patients be aware of before taking Lomflox tablets? The description of the drug, the instructions are required to read, as well as the preliminary consultation of a specialist.
With a disease such as cirrhosis, dosage adjustment is not required. But this is only if the work of the kidneys is not impaired.
During drug therapy, exposure to UV rays should be avoided.
Antacids, as well as vitamins and other products that contain aluminum, magnesium and iron, should not be taken two hours before and within two hours after taking the medication in question.
Does the Lomflox drug affect the ability to drive a car and control various mechanisms? Instructions for use (the price of this drug is indicated in the section below) informs that this remedy can cause impaired attention and quite severe dizziness. In this regard, the question of the possibility of engaging in dangerous types of work should be decided only after assessing the patient's response to the medication.
Analogues of the drug "Lomflox", price, reviews
Instructions for using the tool in question were presented in this article (for informational purposes). As for the price, you can find out the exact cost only in pharmacies. As a rule, the average figure varies between 500 rubles (for 5 tablets).
What else does the instructions for use say about the Lomflox medication? Analogues of the drug are considered in it in detail. According to her, this medicine can be replaced by the following drugs: Xenaquin, Okatsin, Lomacin, Maksakvin, Lomefloxacin, Lofox, Lomefloxacin hydrochloride.
As for the reviews, for the most part they are positive. Patients note that Lomflox tablets fight infections quite effectively. However, it should be noted that some people taking this drug regularly complain of side effects.