Iron is one of the constituent elements of human blood. It promotes the production of hemoglobin in the blood, which, in turn, saturates the tissues with oxygen. Also, this element is necessary for metabolic processes in the body, to maintain the immune system. Especially pregnant women need it. Iron is necessary for the normal development of the fetus. It is possible to compensate for its deficiency with the help of products, but this does not always work out, therefore medications are prescribed. One of these is Sorbifer. Side effects, indications, especially the reception will be considered further.
Operating principle
The combined preparation "Sorbifer" contains iron sulfate and ascorbic acid.
Iron plays a key role in the binding and transport of oxygen and carbon dioxide. Absorbed in the duodenum and proximal jejunum.
Vitamin C increases the absorption of iron in the stomach and intestines, and also participates in redox processes.
Hydrochloric acid in the stomach and vitamin C contribute to the absorption of iron.
The manufacturing technology of the drug provides continuous release of iron ions. For 6 hours, the slow release of the active substance prevents the dangerously high concentration of iron. This avoids irritation of the intestines and stomach.
Once in the intestines, iron binds to apoferitin. One part enters the bloodstream, and the other remains in the intestine in the form of feritin, which is excreted in the feces or enters the bloodstream after 1-2 days. In the blood, iron binds to apotransferin or passes into transferrin. In this form, it enters the organs through endocytosis in the plasma.
What is the composition of the drug
Sorbifer is available in the form of biconvex round tablets. Covered with a light yellow color. Engraving Z is applied on one side. They have a peculiar smell. Inside is gray.
One tablet contains:
- iron sulfate - 320 mg is equivalent to 100 mg of Fe;
- ascorbic acid - 60 mg.
Auxiliary components of the drug:
- magnesium stearate;
- povidone K-25;
- powder polyethylene;
- carbomer 934.
In the shell:
- hypromellose;
- titanium dioxide;
- macrogol 6000;
- iron oxide yellow;
- hard paraffin.
Tablets are packed in dark glass bottles of 30 or 50 pieces.
Further, we will familiarize ourselves not only with the indications and contraindications when taking the Sorbifer drug, we will also pay attention to side effects.
Who is assigned
To take a drug like Sorbifer, the following indications exist:
- iron deficiency;
- Iron-deficiency anemia.
Assign as a prophylactic:
- during pregnancy;
- during lactation;
- blood donors.
Pregnant women, if it is indicated to use "Sorbifer", the side effects of the drug should not be ignored. In case of any unusual symptoms during admission, you should consult a doctor.
Contraindications
The instruction for the drug contains a list of diseases in which it should not be prescribed. Pregnant women and everyone who is prescribed this medicine should especially pay attention to it to rule out these conditions. The list of contraindications includes:
- diabetes;
- diseases of the gastrointestinal tract;
- intestinal obstruction;
- anemia that is not associated with iron deficiency in the body;
- thrombosis;
- tendency to thrombosis;
- kidney disease
- high iron content in the body;
- the use of drugs containing iron;
- urolithiasis disease;
- violation of the removal of iron from the body;
- fructose intolerance;
- hypersensitivity to the components of the drug.
It is important to follow the instructions for the drug "Sorbifer", side effects in this case, there may be a minimum.
How to take the drug
For preventive purposes, Sorbifer is prescribed:
- Children over 12 years old: 1 tablet per day.
- Adults - 1 tablet per day.
In the case of treatment of iron deficiency anemia, the drug is taken:
- Children over 12 years old and adults: 1 tablet 2 times a day.
Pregnant women should use Sorbifer as follows:
- The first 6 months, 1 tablet per day.
- In the last trimester of pregnancy, 1 tablet 2 times a day.
During lactation appoint:
During treatment, the iron content in the blood plasma is monitored. The duration of therapy depends on this.
After the hemoglobin level in the blood is restored, it is recommended to take the drug for another 2 months.
In the treatment of iron deficiency anemia, taking the drug is necessary from 3 to 6 months.
Before taking Sorbifer, contraindications and side effects of the drug should be discussed with your doctor.
Application features
Having a baby, a woman should be especially careful when taking any medications. Therefore, it is necessary to familiarize yourself with the features of taking Sorbifer.
- Before treatment, it is necessary to determine the level of iron in blood serum and the ability of iron to combine in blood serum using a laboratory method.
- Ineffective in the treatment of another kind of anemia.
- Feces during treatment with the drug are painted in dark color.
- With oral administration of the drug, diseases of the gastrointestinal tract may worsen.
- With a course admission, it is necessary to monitor hemoglobin and serum iron in the blood.
- With urolithiasis, ascorbic acid per day should not exceed 1 g.
- With increased blood coagulation, high doses of the drug should not be used.
- Course long-term use requires monitoring of such indicators: blood pressure, kidney function, pancreas.
- With a deficiency of glucose-6-phosphate dehydrogenase, use the drug with caution.
- Do not drink tablets with alkaline mineral water. This reduces the absorption of the drug.
- Ascorbic acid, which is part of the preparation, can affect the following blood indices: glucose level, bilirubin, lactate dehydrogenase, transaminase activity.
When taking Sorbifer, side effects in women are more likely to occur if there are the following diseases:
- chronic diseases of the liver and kidneys;
- leukemia;
- bowel disease;
- inflammatory pathologies of the gastrointestinal tract;
- stomach ulcer and duodenal ulcer.
Interaction with other drugs
Often shows the drug "Sorbifer" side effects during pregnancy, if the doctor prescribes several drugs.
Do not use Sorbifer in conjunction with these medicines:
- Moxifloxacin;
- Ciprofloxacin;
- Levofloxacin;
- Norfloxacin;
- Ofloxacin.
The absorption of these medicines is significantly reduced.
It is necessary to observe an interval of at least 2 hours between taking Sorbifer and such drugs:
- Captopril;
- medicines containing zinc, calcium, magnesium;
- Clodronate
- Methyldopa;
- "Penicillamine";
- Risedronate
- "Tocopherol";
- thyroid hormones;
- Pancreatin
- "Tetracycline";
- glucocorticosteroids;
- Cimetidine.
Simultaneous administration with the Sorbifer drug reduces the effect of ascorbic acid:
- oral contraceptives;
- fruit and vegetable juices;
- alkaline mineral water.
The drug "Deferoxamine" together with ascorbic acid increases the toxicity of iron, especially in the heart muscle.
Side effects
It should be considered what side effects are possible when taking Sorbifer.
- Cardiovascular system: myocardial dystrophy, increased blood pressure.
- Gastrointestinal tract: constipation, diarrhea, nausea, pain in the stomach. With prolonged use, heartburn, irritation of the gastric mucosa are possible.
- Allergic reactions: itching, Quincke's edema. Redness of the skin.
- Endocrine system: impaired glycogen synthesis, hyperglycemia, glucosuria.
- Blood system: thrombocytosis, neutrophilic leukocytosis, erythrocytopenia, hyperprothrombinemia.
- Nervous system: headaches, insomnia, irritability.
It is also possible violation of the metabolism of zinc and copper in the body.
Often prescribed "Sorbifer Durules" during pregnancy. The doctor should warn the patient about side effects of the drug.
Overdose
You need to know the symptoms of an overdose of the drug:
- nausea;
- vomiting
- abdominal pain;
- diarrhea;
- drowsiness;
- bowel movements with blood;
- tachycardia;
- lowering blood pressure;
- dehydration;
- hyperglycemia.
There is a risk of perforation of the gastrointestinal tract.
In severe cases, for some period of time, the state of health may improve, but after 6-24 hours the situation worsens again. Seizures, liver and kidney failure, heart failure, coma are possible.
It is also possible after several weeks or months the development of cirrhosis and persistent narrowing of the pylorus.
An overdose of vitamin C can lead to hemolytic anemia and severe acidosis.
It is very important to know the symptoms of an overdose when taking Sorbifer Durules tablets. Side effects of the drug have similar symptoms, it is important to correctly assess the situation at an early stage. Timely assistance is very important.
Overdose Support
In case of an overdose, the following steps must be performed:
- Drink plenty of fluids to induce vomiting. You can use milk.
- Rinse the stomach with a solution of Desferoxamine 2 g / l.
- "Desferoxamine" 5 g + 50-100 ml of water is introduced into the stomach and left.
- An adult can drink Sorbitol.
- It is necessary to take an x-ray of the stomach after washing to identify the remaining tablets.
- In severe cases, maintenance therapy is prescribed and intravenously "Desferoxamine".
- With less severe intoxication, "Desferoxamine" is administered intramuscularly.
The patient should be constantly monitored. It is necessary to monitor the levels of iron in the blood serum.
Side effects during pregnancy
It is worth paying attention to the fact that most often the drug is prescribed for pregnant women. Therefore, we pay attention to the side effects that are recorded in pregnant women:
- rash;
- itching
- constipation;
- diarrhea;
- nausea;
- heartburn;
- headache;
- sleep disturbance.
If women took Sorbifer, side effects during pregnancy in reviews were written such as nausea, constipation.
As a rule, such deviations are very rare. After consulting a doctor and adjusting the dose, the symptoms go away.
It is worth noting that many women evaluated the increase in hemoglobin in the blood for a short period of time when taking Sorbifer. Side effects, in the reviews noted, while this did not appear. The effectiveness of the drug is confirmed not only during pregnancy, but also during lactation.
Reviews about the drug
"Sorbifer" is prescribed not only for pregnant women and during lactation, but also for people with iron deficiency anemia, both men and women.
Patients noted a minor side effect of Sorbifer in the reviews. This is a taste of metal with prolonged use. After cancellation or dose adjustment, everything is restored.
The reviews are mostly positive. The effectiveness of the drug is noted, some noted a rapid decrease in blood counts after discontinuation of the drug. But it is worth considering that the drug is recommended to be taken in maintenance doses after reaching normal levels for at least another 2 months. Non-compliance with this condition leads to such consequences.
Many noticed that with the course of taking the drug "Sorbifer" a side effect manifests itself in the form of heartburn. There are cases of nausea, constipation, digestive disorders.
Dose adjustment and compliance with the instructions can reduce the manifestation of side effects.
Some considered the high price a lack of drug.
In general, Sorbifer is safe for both older people and children over 12 years old. Before taking a consultation with a doctor. You should not prescribe a drug for yourself.