Livial is an anti-climacteric. Available in the form of round-shaped tablets with beveled edges, milky. The active component is tibolone. Additional substances in the composition of Livial are:
- starch;
- lactose;
- food supplement E304;
- water;
- magnesium salt of stearic acid.
What are the properties of the drug
Is Livial a hormonal drug or not? It eliminates the lack of estrogen in women who are in the postmenopausal period, and alleviates the symptoms caused by a deficiency of these hormones in the body. In addition, the drug prevents bone loss after removal of the ovaries or the onset of menopause.
After oral administration, the absorption of tibolone occurs quickly and intensively. Since the component is rapidly metabolized, its concentration in the blood is very low.
Part of the accepted dosage is excreted with urine, but the main part is eliminated with feces. Eating does not have a significant effect on the degree of absorption. What reviews, price and instructions for the use of Livial exist?
When is the medicine prescribed?
According to the instructions for use, it is known that Livial is indicated for women during postmenopause:
- Eliminate signs of estrogen deficiency.
- As a preventive measure to prevent osteoporosis in women with an increased risk of onset.
Limitations
The drug is contraindicated in the following diseases:
- Breast cancer.
- Malignant estrogen-dependent tumors, including endometrial cancer.
- Endometrial hyperplasia in untreated condition.
- Vaginal bleeding of unknown origin.
- Thrombophilic conditions.
- Antithrombin deficiency.
- Arterial or venous thrombosis.
- Acute blockage of a blood vessel by a blood clot.
- Inflammation of a vein near a blood clot.
- Myocardial infarction.
- Hemorrhagic or ischemic cerebrovascular disorders, pulmonary thromboembolism.
- Attacks of sudden chest pain that appear due to an acute shortage of blood supply to the heart muscle.
- Transient ischemic attacks and other conditions preceding thrombosis.
- Cardiovascular failure in the stage of decompensation.
- Uncontrolled arterial hypertension.
- atrial fibrillation.
- Subacute bacterial endocarditis.
- Complicated lesions of the valvular apparatus of the heart.
- Severe injury.
- Severe liver disease or impaired liver function.
- Neoplasms of the liver.
- Liver failure.
- Limited damage to the bone capsule of the labyrinth of the inner ear, due to which there is ankylosis of the stapes and the associated conductive hearing loss.
- Hereditary disturbance of pigment metabolism with a high content of porphyrins in the blood and tissues and their increased excretion with urine and feces.
- Galactose intolerance.
- Glucose-galactose malabsorption.
- Lactase deficiency.
- Pregnancy
- Breastfeeding.
- The period since the last menstruation is less than 1 year.
- Confirmed hypersensitivity to the components of the drug.
With extreme caution, Livial is prescribed for:
- Systemic lupus erythematosus.
- Bronchial asthma.
- Benign tumor on the muscle layer of the uterus.
- A condition in which endometrial cells grow in atypical places.
- Diabetes mellitus.
- Hypertension.
- Gallstone disease.
- Liver disease.
- Increased blood cholesterol.
- Migraine.
- An increase in endometrial history.
- Epilepsy
"Livial": instructions for use, price
According to reviews, it is known that the cost of the drug varies from 2200 to 2900 rubles. It is not recommended to start using the Livial medication before twelve months from the time of the last menstruation.
If a woman has a bloody discharge when using another hormonal drug or without it, then before starting therapy, you need to make sure that there are no cancerous tumors in the genitals.
The medication is taken orally, swallowing them whole and drinking water. The concentration of the drug is 1 tablet per day, which must be consumed daily at the same time.
Substitutes
The following medicines perform analogs of Livial:
- "Angelique".
- "Welledien."
- "Femoston."
- "Climodien."
- "Ovestin."
- Klimonorm.
- Ladybone.
Before replacing Livial with an analog, it is necessary to consult a doctor to exclude contraindications. Next, the most popular generics will be discussed in more detail.
"Angelik"
A comprehensive anti-climacteric drug that is used as hormone replacement therapy for menopausal problems and as a preventive measure to prevent osteoporosis that occurs during postmenopause.
It is not recommended to use the drug to protect against unwanted pregnancy. If necessary, barrier contraceptives should be chosen. If there is a suspicion of pregnancy, the use of the drug should be stopped and resumed only after the "interesting position" is excluded. When asked what is better than Livial or Angelique, doctors give the answer that the drugs are the same and interchangeable.
In those situations where the representative of the beautiful half before using the medication did not use estrogen, or switches to it from another complex means, she can start using it at any time. Those women who before the "Angelica" took a complex cyclic medicine, you need to start using only after the bleeding ends after withdrawal.
This analogue of Livial is cheaper than the drug itself (1100-1900 rubles). One pack lasts twenty eight days. Use the medicine 1 tablet every day. After the end of one package, the next must be started without a break, on the next day.
"Angelik" must be taken as a whole, preferably at the same time. You can’t skip taking the medicine, but if this happens, you should take the missed tablet as soon as possible.
"Welledien"
The drug belongs to the group of drugs that are used for hormonal treatment to eliminate postmenopausal symptoms. The medication has estrogenic, as well as gestagenic and weak androgenic activity, normalizes the union of the structures of the pituitary and hypothalamus after the ovaries stop working, and provokes a decrease in the production of gonadotropic hormones.
According to the instructions, “Wellledien” slows down bone resorption in the postmenopausal period, mitigates symptoms of menopause such as flushing of the skin, excessive sweating, and migraine.
It has a positive effect on libido and mood. "Wellledien" has an activating effect on the mucous membrane of the vagina, not stimulating an increase in the cell layer through active division, during which organic tissues grow. The drug prevents the occurrence of osteoporosis, reduces the concentration of phosphates and calcium in the blood.
During therapy, constant monitoring of laboratory parameters in patients with hypercholesterolemia, as well as renal failure and diabetes mellitus, is needed. During therapy, a decrease in the content of total and free basic protein of blood serum (thyroxin-binding globulin) is likely.
Femoston
The drug is recommended for women with signs that provoke a deterioration in their quality of life. Particular care must be taken for patients from 65 years of age, since the experience of using "Femoston" at this age is limited.
Among the often encountered negative phenomena that appear when combining estradiol and dydrogesterone include tension and soreness in the mammary glands, pain in the abdomen. Femoston is an import analogue of Livial, the manufacturing country is the Netherlands.
Before starting treatment, a woman should undergo a general and gynecological examination, as well as a mammogram. In order to take into account the likely restrictions on admission and condition, the appointment of the drug should be based on information about the patient’s complete medical history. Based on the information received, the doctor must notify the woman of all the possible risks associated with hormonal treatment.
Klimodien
Hormonal anti-climacteric complex medication that contains estradiol valerate and gestagen. Estradiol valerate resumes estrogen levels after menopause and eliminates or weakens psychoemotional and autonomic menopause signs:
- hot flashes;
- heavy sweating;
- sleep loss
- increased irritability;
- headache.
This component eliminates the involution of the skin and mucous membranes. The use of the drug should begin no earlier than a year after the onset of menopause.
Ovestin
The drug is considered a substitute for female sex hormone, stabilizes the condition of the vaginal epithelium in menopausal and postmenopausal time, helps the regeneration of the physiological water-alkaline balance of the vaginal microflora, increases resistance to infectious processes. However, under the influence of the active substance, the level of cholesterol in the blood decreases, the amount of plasma increases in a small amount, as well as the cycle time of corticoids.
According to the instructions for use with Ovestin suppositories, it is known that, estriol, unlike other hormonal preparations, has a short action, remaining in the endometrial nuclei for a short time. When using this medication, there is no bleeding after withdrawal, the quantitative ratio of fibroglandular and connective tissue and fatty structures of the mammary gland does not increase, and endometrial proliferation does not occur.
When starting treatment, it is important to establish an individual and family history, and conduct a full examination of the pelvic organs and chest.
According to the instructions for the use of Ovestin suppositories, it is known that in the presence of vaginal infectious lesions, concomitant therapy is necessary. The drug does not adversely affect the ability to drive a car or perform work that requires an increased concentration of attention.
Klimonorm
Estradiol valeriat, which is part of the drug, helps make up for estrogen deficiency in women who have "come" menopause.
Levonogestrel helps prevent the appearance of hyperplasia and malignant neoplasms in the tissues of the endometrium. Estradiol stabilizes mental and emotional health, reduces the degree of menopause.
After use, Klimonorm is completely absorbed in the digestive system. The highest amounts of essential substances are observed in the blood approximately two to three hours after taking the pill. From the body, the medicine is eliminated with the help of the kidneys and intestines.
This medication is not recommended as a contraceptive. Before treatment, it is necessary to examine the condition of the mammary glands, as well as the liver, cholesterol and blood pressure.
Only a medical specialist after a preliminary study of certain parameters of the patient (woman's age, weight, the presence of pathologies and contraindications) will be able to prescribe Klimonorm.
Ladybone
The drug belongs to the number of anti-climacteric drugs. The composition includes tibolone - the active substance, as a result of oral use it is instantly exchanged, while three compounds are formed that determine the pharmacological characteristics of the drug. Livial or Ladybone, which is better?
The second drug helps make up for estrogen deficiency in women during postmenopause, while symptoms, including vasomotor disorders, as well as discomfort and dryness in the vagina, irritability, decreased libido, are alleviated.
According to the instructions for use with Ledibon, it is known that treatment with this medication prevents bone loss after removal of the ovaries or the onset of menopause.
The decision to start the Ledibon therapy course is determined on the basis of assessing the ratio of benefits and risk, all individual risk factors are taken into account, and women over sixty should also pay attention to the increased risk of strokes.
According to the instructions for use with Ledibon, it is known that for the treatment of postmenopausal symptoms, the drug is usually prescribed only for signs that have a detrimental effect on the quality of life.
All representatives of the fair half, without exception, need to evaluate well the benefits of treatment and risk at least once a year. Evidence of the risks associated with the use of tibolone in the treatment of premature menopause is limited.
Opinions
The responses of women about the majority of hormonal drugs tell us about the absence of pronounced negative reactions during treatment. Representatives of the beautiful half indicate that medicines, in particular, Ovestin, Ledibon, Angelik, really help to cope with unwanted psychoemotional reactions, eliminate irritability and irritability.
On forums with this topic, there are reviews of medical specialists who also confirm the increased effectiveness of hormonal drugs in eliminating the negative signs of the postmenopausal period. In general, the feedback about them is positive.
Reviews of the candles "Ovestin", which the representatives of the fair half leave, going to a thematic forum, as a rule, are positive. Its beneficial effect as a supporting agent during menopause is noted.
In addition, women narrate that these medicines help reduce the intensity of unpleasant symptoms of menopause, and help to eliminate a number of ailments.