Eleflox is a member of the fluoroquinolone group . The drug has an antimicrobial effect. The main component of the drug is levofloxacin. Eleflox solution and tablets are indicated for skin infections, infectious processes in soft tissues, septicemia, community-acquired pneumonia, prostatitis of bacterial etiology, acute sinusitis and other diseases of an infectious nature.
The composition and release form of the drug "Eleflox"
The drug is made in two dosage forms - tablets (packs of 5 and 10 pcs.), Solution for intravenous administration (bottle of 100 ml). The solution contains 5 mg / ml of active ingredient. Tablets may contain 250 or 500 mg of the main component.
The composition of the tablets includes some excipients: polysorbate 80, magnesium stearate, crospovidone, hypromellose, MCC (Avicel PH 101, 102).
The Eleflox antibiotic in the form of tablets is coated, for the formation of which iron oxide (yellow, red), macrogol, and titanium dioxide are used. The solution as auxiliary components contains sodium hydroxide, water for injection, hydrochloric acid and anhydrous dextrose.
Pharmacological action of the drug "Eleflox"
The active component inhibits the synthesis of bacterial DNA. Morphological changes occur, affecting the cytoplasm, membranes, cell wall of microorganisms and causing their death. These processes provide bactericidal and antimicrobial effects. Some anaerobes and aerobes (gram-positive, gram-negative), and other microorganisms are sensitive to the drug.
With the oral administration of the Eleflox medication, the composition of this agent is rapidly absorbed into the gastrointestinal tract almost completely. At a dosage of 500 mg of active substance, bioavailability is almost 100 percent, plasma binding is on average 35 percent. The medicine penetrates well into some tissues and organs. A small part of it is oxidized, deacetylated in the liver. Basically, the kidneys are involved in removing the drug from the body.
Indications for use of the drug "Eleflox"
"Eleflox", analogues are used for skin lesions, prostatitis, diseases that affect the respiratory tract, the organs that make up the urinary system. The medication is used as an additional tool in the treatment of tuberculosis, the form of which is defined as stable.
The drug treats infectious and inflammatory diseases that arise as a result of the negative effects of microorganisms that are sensitive to levofloxacin. "Eleflox" instructions for use allows you to assign in cases where it is identified:
- prostatitis of bacterial etiology;
- acute sinusitis;
- intra-abdominal infection;
- exacerbated chronic bronchitis;
- infectious processes in the urinary tract with or without complications;
- infections affecting the skin and soft tissues;
- community-acquired pneumonia;
- diseases in which ENT organs are affected;
- septicemia;
- bacteremia;
- drug-resistant tuberculosis (the appointment of "Eleflox" is carried out using complex therapy).
Contraindications to taking the drug "Eleflox"
There are a number of contraindications for the drug. "Eleflox" instructions for use does not allow use in epilepsy, convulsive syndrome, bearing a child and during lactation. The medicine is not prescribed for patients whose age is less than 18 years. Contraindications include tendon lesions resulting from quinolone therapy, and an increased sensitivity of the body to the components of the drug. Therefore, before use, you should carefully study the composition of the drug and consult with a specialist.
During therapy, special attention is required to the patient with impaired renal function, glucose-6-phosphate dehydrogenase deficiency. During treatment, elderly patients also need medical supervision.
The use of the drug "Eleflox"
Eleflox, analogues are recommended to be used between meals or in front of them (30 minutes before meals). Tablets can be taken exclusively in its entirety with a sufficient amount of warm water.
Basically, at the initial stage of treatment, every day, the drug is taken orally in compliance with an interval of 1-2 hours. The dose depends on the disease, its severity and sensitivity to the medicine of the causative agent of the disease.
Typically, with creatinine clearance exceeding 50 ml / min, the following treatment regimens are used:
- complicated chronic bronchitis - dose per day - 250-500 mg, a course lasting from one week to ten days;
- acute sinusitis - the medicine "Eleflox" (500 mg) is taken every day for ten days or two weeks;
- community-acquired pneumonia - the use of 1000 mg of the drug per day for 2 doses for 1-2 weeks;
- complicated infection affecting the urinary tract - the daily dose corresponds to 250 mg of the drug, the duration of the course is a little more than a week, if necessary, the treatment is extended;
- pathologies in which the urinary tract is affected and there are no complications - for about 4 days, 250 mg of the drug is taken;
- Prostatitis caused by bacteria - long-term treatment is required, sometimes within 28 days with 500 mg of Eleflox every day;
- sinusitis - treatment is performed with tablets in a daily dose of 500 mg;
- intra-abdominal infection - the dose for daily use is 500 mg, the duration of the course with complex treatment is 1-2 weeks;
- diseases in which the skin and soft tissues are affected - need therapy with a double dose of 250 mg or 500 mg of the drug daily for no more than two weeks;
- tuberculosis resistant to other drugs - for complex treatment, it is necessary to take 500 mg of the drug every day (it can be taken 2 times) for three months.
For patients with kidney disease with certain values of CC (ml / min) "Eleflox" instructions for use can be taken as follows:
- KK 50-20 - first take 250 mg, later - 125-250 mg (it is possible to divide into several doses);
- KK 10-19 - first take 500 mg per day, with further treatment - 125 mg in 12-48 hours;
- QC below 10 - everyone does the same as in the previous case, but the medicine is used not once every 12-48 hours, but once every 1-2 days.
A dropper made from the Eleflox solution is placed for at least an hour. Further treatment depends on the condition of the patient. It is possible to switch to taking the tablets in the dosage in which the dropper was placed. In cases where the human body was subject to peritoneal dialysis and hemodialysis, the introduction of additional doses of the drug is not required.
The treatment of elderly patients who have liver problems is performed for 48-72 hours or longer, until the symptoms disappear, the pathogens are completely eradicated.
If the next dose of the drug was missed, the next dose is administered or taken as soon as possible, then the established treatment regimen is followed.
Side effects of the drug "Eleflox"
"Levofloxacin" ("Eleflox") can provoke the development of side effects. Among the possible adverse reactions of the body - the appearance of dysbiosis, toxic hepatitis, enterocolitis, dyspepsia. Muscle pain, abdominal pain, headache, loose stools, cramps, tremors, and temperature may be present. With a negative reaction of the body to the drug, increased activity may be noted in liver enzymes. If a side effect such as pseudomembranous colitis is detected, further treatment becomes impossible.
Taking the drug is sometimes accompanied by discoordination when making movements, the presence of emotional lability, depression and sleep problems. In some cases, impaired consciousness, smell and taste are noticed. The list of adverse reactions includes arthralgia, thrombocytopenia. Agranulocytosis, paresthesia may well develop. The patient may have leukopenia, eosinophilia.
As for other side effects during the treatment with Eleflox, the instructions for use include asthenic syndrome, hypoglycemia, fever, acute porphyria, increased appetite, tachycardia, arrhythmia and a significant decrease in blood pressure (there is a possibility of collapse).
Allergic reactions sometimes occur, burning and itching of the skin, trembling in the limbs. Secondary infection is possible. The appearance of photosensitization, neuropathy is not ruled out. The detection of any side effects is an occasion to consult a doctor.
Overdose of Eleflox
Since there is no antidote, an overdose requires symptomatic therapy. Among the effective methods to eliminate this condition are peritoneal dialysis, hemodialysis.
special instructions
Patients who left reviews after treatment with the Eleflox agent report cautious use of the drug in certain cases. Some patients require compulsory medical supervision.
With the disappearance of high body temperature, therapy should continue for another 2-3 days. Treatment of severe pneumonia requires the use of several drugs, otherwise the desired result may be absent.
During the course of therapy, it is worthwhile to exclude exposure to sunlight, artificial ultraviolet radiation due to the risk of photosensitization.
There are other nuances that need attention. Any changes in well-being should be reported to the doctor.
The combination of the drug "Eleflox" with other means
Interacting with some medicines, "Eleflox" enhances their effect or weakens. The same thing can happen with the action of the drug itself. If necessary, treatment with other drugs during the treatment with "Elefloxom" should be borne in mind that they may be incompatible. Any changes regarding medication should be discussed with your healthcare provider.
The cost of Eleflox
Depending on the dosage form of the Eleflox preparation, the price is approximately 760-940 rubles. for tablets in a dosage of 500 mg (No. 10). About 345-450 rub. there is a solution for intravenous administration (100 ml).
Reviews about the drug "Eleflox"
Basically, patients positively evaluate the drug. In their opinion, "Eleflox" is effective and can cure many diseases of infectious etiology.
The drug is often prescribed to patients if it is necessary to fight several pathogens at once.
Reviews left after treatment with Eleflox indicate the presence of rare cases of negative reactions of the body. Side effects are often mild and completely disappear when therapy is completed.
Analogues of the drug "Eleflox"
Medicines, the effect of which is similar to what "Eleflox" has on the body, exist in large numbers. One can distinguish such drugs as “Maklevo”, “Leobeg”, “Lebel”. It is known about the possibility of using “Lefoksin”, “Levofloxacin”, “Glevo”, “Ivacin” as substitutes. These funds are the most common and are used, if necessary, to select an analogue to the Eleflox drug. The price of analogues is lower, the effect of their use is similar.
"Eleflox" refers to serious medicines and can cause a lot of side effects. Before use, it is important to carefully study the instructions. Its use for treatment should be carried out only after the appointment of a doctor who will track changes in the body.