Urolithiasis, or urolithiasis, is a disease that manifests as the formation of stones or sand in the organs of the urinary system. This is a rather serious pathology requiring immediate treatment.
In severe forms, this disease requires surgical intervention. To avoid this, in the early stages of the disease, doctors recommend taking Uralit U. Instructions for the use of this medication, its features, release form and contraindications will be presented in this article.
Packaging, form, composition
The drug "Uralit" is made in the form of granules. It is intended for the preparation of an oral solution.
This medication contains hexakalium-hexanatrium-trihydrogen citrate complex. It is available in a cardboard box, where one can of medicinal substance is placed, as well as a measuring spoon, indicator paper and a control calendar.
The mechanism of action of the drug
What is a granulate like Uralit-U? Instructions for use informs that this medication is used to prevent the formation, as well as the dissolution of existing urinary stones.
The agent in question is a mixture of strong alkalis (salts), which are combined with acids (weaker).
When mixed with ordinary water, the granulate dissociates into ions, continuously supports the alkaline reaction of urine, and also regulates the pH (at the level of 6.2-7.5).
The indicated acidity allows uric acid salts to remain dissolved and not form stones. It is in this that the nephrolytic properties of this agent are manifested.
Pharmacokinetics
According to experts, the patient's response to the medication in question is dose-dependent. Alkalosis reduces the absorption of citrate in the tubules of the kidneys, and also increases its excretion. It should be noted that in this case, the excretion of calcium along with urine is reduced.
The medicine "Uralit" is almost completely absorbed from the digestive tract. Its bioavailability is about 100%. The whole drug is metabolized in the human body, and excreted in the urine.
During therapy with this agent, no changes in the gas or electrolyte composition of the blood occur.
Indications for use
Do you know what indications Uralit U can be prescribed for? Reviews of experts say that taking this drug for the treatment of certain diseases should only be done after consultation with a urologist.
According to the instructions, the drug in question is used to prevent the formation, as well as to dissolve existing calcium-containing and uric acid stones in case of urolithiasis, including the presence of stones in the bladder.
In late porphyria and uricosuria, this medication acts pathogenetically and alkalizes urine.
As a rule, this medicine is included in the treatment with cytotoxic drugs in order to prevent possible complications.
Contraindications
What diseases prohibits the use of granulate "Uralit-U"? The instruction for use states that this medication should in no case be prescribed for chronic or acute renal, as well as heart failure. In addition, the drug is not used for chronic urinary tract infections that were caused by urea-splitting microorganisms; with severe metabolic alkalosis, confirmed in laboratory conditions, and intolerance to the components of the drug.
It should also be noted that granulate "Uralit-U" is not prescribed if the patient needs to adhere to a strict salt-free diet (for example, with hypertension or kidney disease).
It should be noted that the safety of the drug in question and its effectiveness have not been studied in children under 12 years of age, as well as in nursing mothers and women in position. In this regard, this medication is not prescribed to them.
The drug "Uralit-U": instructions for use
Before using the drug in question for the treatment of urolithiasis, it should first be dissolved in a glass of ordinary water.
The dosage of this medication is selected individually, depending on the reaction of fresh urine. It is determined using indicator papers, which, together with the medicine, are placed in a cardboard box. This process is carried out before each intake of granulate. To do this, the indicator is soaked in urine and for two minutes it is compared with a color scale. This will allow you to determine the acidity in the range of 5.4-7.4.
In the treatment of late porphyria and cystine stones, it is necessary to use a special indicator with pH limits of 7.2-9.7.
The average dosage of this product is 4 scoops per day. In this case, one should drink in the morning, one in the afternoon and two in the evening.
It is imperative to maintain acidity within the required range:
- with urolithiasis or the so-called uricosuria - 6.2-6.8;
- in the presence of cystine stones - 7.5-8.5;
- with porphyria of the skin - 7.2-7.5;
- during therapy with cytostatics - exactly 7.0.
In the event that the pH values obtained are above normal, the dosage is reduced. An evening intake of the drug is made less by ½ a dosage spoon.
If the pH is lower, then the amount of medication is increased by the same volume.
Drug interaction
Is Uralit-U granulate allowed to be combined with other medicines? Reviews of experts report that far from all drugs, this tool can be combined.
According to the instructions, Uralit-U in combination with aluminum-containing preparations can enhance the absorption of aluminum ions in the blood. In this case, the interval between their intake should be at least two hours.
The course of therapy with this tool can be long, without interruptions or with them. The average duration of taking this drug is 1-6 months. However, only the doctor should determine the more accurate course of treatment.
Side effects
Now you know how to take Uralit-U. According to patient reviews, this tool is tolerated quite well. Although in rare cases, taking the oral solution can cause nausea, flatulence, vomiting, abdominal pain and diarrhea.
Typically, these adverse reactions go away on their own.
Medication Uralit-U: analogues and patient reviews
What can replace the drug in question? According to the chemical composition and therapeutic effect, the analogues of this agent are: “Fitolizin Plus”, “Cyston”, “Fitolit”, “Cital”, “Rendesmole”, “Uro-Gran”.
According to reviews, Uralit-U is a highly effective drug that copes quite well with the task. Many patients report that after a month of treatment, stones from the patient’s body are completely eliminated. However, it should be noted that this process is often accompanied by a laxative effect, which brings significant discomfort to the patient.