In the article, we consider the instructions for use of the Ofloxin preparation, as well as reviews and analogues.
The medication is an antimicrobial agent, has a wide range of effects and belongs to the group of fluoroquinolones. Able to act on DNA gyrase, providing over-spirilization. Under the action of the active substance, the DNA chains of bacteria are destabilized, resulting in the death of the microorganism.
Pharmacological forms
According to the instructions for use with Ofloxin, it is available in tablet form. The tablet has a biconvex shape and white color. There are no impurities or an odor. The pill also has a shell, on one side there is a risk, on the other there is an engraving indicating the dosage of the drug.
The drug is packaged in contour blisters with cells that are placed in a cardboard package.
Structure
As indicated by the instructions for use with Ofloxin 200 mg, the main active ingredient in the drug is ofloxacin.
A drug with such a dosage contains, respectively, 200 mg ofloxacin. There is also a medicine with a dosage of 400 mg - it contains 400 mg ofloxacin.
As auxiliary components are used: talc, povidone, crospovidone, lactose monohydrate, magnesium stearate, poloxamer, corn starch. The shell is made of talc, titanium dioxide, macrogol, hypromellose.
In accordance with the instructions for use, Ofloksin is able to exert antibacterial (bactericidal) effects.
Indications for use
Most often, Ofloxin is used in the following cases:
- Prevention of infectious diseases in patients suffering from neutropenia.
- As an element of complex therapy for patients with tuberculosis.
- In order to prevent complications of an infectious nature developing as a result of surgical intervention.
- With infectious eye lesions (keratitis, meibomites, dacryocystitis, blepharitis, bacterial corneal ulcers, conjunctivitis).
- For infections that accompany AIDS.
- With chlamydia.
- Meningitis. Infectious genital infections with a severe course (prostatitis, gonorrhea, epididymitis, colpitis, orchitis).
- With infectious lesions of organs located in the pelvis (prostatitis, parametritis, cervicitis, salpingitis, endometritis).
- With urethritis, cystitis and other infections affecting the urinary tract.
- With pyelonephritis and other kidney diseases of an infectious etiology.
- With infectious lesions of the gastrointestinal tract and pathways that remove bile.
- Infectious lesions of the skin and soft tissues.
- Infectious lesions of the joints and bones.
- With laryngitis, pharyngitis, sinusitis, otitis media and other diseases of ENT organs with an infectious genesis.
- With pneumonia, abscesses in the lungs, bronchiectasis and other infectious lesions of the respiratory system with a severe course.
Contraindications
Instructions for use with Ofloxin and specialists do not recommend its use in the following physiological or pathological conditions:
- The lactation period.
- Pregnancy.
- Hypersensitivity to the main or any additional component of the drug.
- Age to 18 years.
- Decreased seizure threshold due to inflammation in the central nervous system, head injury, stroke.
- Epilepsy (also with a history of epilepsy).
- With a lack of glucose-6-phosphate dehydrogenase.
Caution must be exercised in the administration of Ofloxin to patients suffering from vascular atherosclerosis in the brain, as well as to those who have circulatory disorders. In the treatment of patients with chronic insufficiency of the kidneys and liver, it is recommended to choose a drug that has a similar therapeutic effect, but less dangerous.
Negative impact
What else can you learn from the instructions for use with Ofloxin? Against the background of the use of the drug, the following negative effects may develop:
- From the gastrointestinal tract can develop: pseudomembranous enterocolitis, cholestatic jaundice, hyperbilirubinemia, increased activity of liver transaminases, abdominal pain, vomiting, flatulence, diarrhea, nausea.
- From the side of the central nervous system: increased intracranial pressure, hallucinations, confusion, depression, phobia, increased irritability, anxiety, psychotic reactions, nightmares, intense dreams, paresthesia of the extremities, numbness of the limbs, convulsions, tremors, insecurity of movements, dizziness, headaches.
- Sense organs: imbalance, smell, hearing, taste, diplopia, impaired color perception.
- CCC: collapse, vasculitis, tachycardia.
- The system of bones and muscles: tendon rupture, tendosynovitis, arthralgia, myalgia, tendonitis.
- Urine excretion system: increased urea, hypercreatininemia, impaired renal function, acute interstitial nephritis.
- Allergic manifestations: anaphylactic shock, erythema multiforme, photosensitization, Quincke's edema, Lyell's syndrome, bronchospasm, fever, Stevens-Johnson syndrome, eosinophilia, allergic nephritis, allergic pneumonitis, urticaria, rash, itching.
- Skin reactions: vasculitis, papular rash, bullous hemorrhagic dermatitis, petechiae.
- Other reactions: vaginitis, hypoglycemia, superinfection, dysbiosis.
Use of medication
“Ofloxin” has a wide range of effects, and therefore the dosage should be selected for each patient individually, taking into account the disease and the severity of its course.
According to the instructions for use with Ofloxin 200 mg, it is recommended that adult patients take 1 tablet 2 times a day. You can also use once a day 400 mg. Per day, no more than 800 mg is allowed. The duration of therapy is determined taking into account the sensitivity of the pathogen that provoked the disease, and more often up to 10 days. Experts advise taking the medicine in the morning, at least 30 minutes before breakfast. Tablets must be washed down with water.
It is important to remember that the drug should be agreed with the doctor.
Overdose
According to the instructions for use with Ofloxin tablets, the following symptoms develop when an overdose occurs:
- Dizziness.
- Drowsiness.
- Profuse vomiting.
- Inhibition.
- Disorientation.
- Confusion.
With the development of these symptoms, it is necessary to rinse the stomach and prescribe symptomatic therapy drugs to the patient.
The dosage of Ofloxin tablets according to the instructions for use should be strictly observed.
Interaction with other medicines
When taking Ofloxin together with products enriched with iron salts, magnesium, aluminum, calcium, its therapeutic effect is reduced. This is due to the fact that these substances are capable of forming insoluble complexes. It is necessary to observe a two-hour interval between taking such products and medication.
Against the background of the use of ofloxacin, theophylline clearance decreases by a quarter, and therefore it is recommended to reduce the dose of drugs based on this substance.
With simultaneous use with drugs that block tubular secretion, the concentration of ofloxacin in the body increases significantly.
Ofloxacin also affects the concentration of glibenclamide.
The parallel use of Ofloxin and vitamin K antagonists is contraindicated. A similar combination of drugs negatively affects the blood coagulation system.
When used in conjunction with nitroimidazole, methixanthin, neurotoxic effects may develop.
When taking “Ofloxin” with drugs that can alkalinize urine, the risk of crystalluria and nephrotoxic effect increases.
Ofloxin analogues are not described in the instructions for use.
Analogs
Currently, there are more than 20 drugs, the effect of which is similar to Ofloxin. Some of them are less expensive, others are less dangerous, but also less effective.
If necessary, Ofloxin can be replaced by one of the following analogues: Phloxal, Uniflox, Dancil, Glaufos, Vero Ofloxacin, Loflox, Oflocid, Ofloxacin, Zanocin.
It is important to remember that the feasibility of replacing should be determined by the doctor, since each of the analogues has a number of specific contraindications and side effects.
Cost
In Russian pharmacies, the average cost of Ofloxin with a dosage of 200 mg is 165 rubles.
This information is not in the instructions for use. “Ofloxin 400 mg” will cost about 298 rubles. The price at various drugstores can vary, as it depends on the pricing policy of the pharmacy, the region where the drug is distributed, and its manufacturer.
Reviews
There are a lot of reviews about the drug, however, their nature is contradictory. So, some patients recommend the drug, indicating its effectiveness and availability, others report that they did not get a tangible therapeutic effect, but taking the drug provoked many negative reactions in them. Quite often there is information that when taking Ofloxin, patients suffer from lethargy, drowsiness, thrush, loss of appetite, hallucinations, abdominal pain.
That is why it is worth remembering that taking the drug should be coordinated with a doctor who will first exclude possible contraindications and will select a dosage in such a way as to minimize the risk of negative phenomena.
We reviewed the instructions for use of Ofloxin and reviews about the drug.