In our time, pathologies of the gastrointestinal tract are increasingly common. Symptoms of the disease not only cause discomfort and pain, but can also lead to serious complications. The patient appears pain in the epigastric region, heartburn, belching, digestive disorders. To get rid of the disease, you need to undergo an examination during the time and start treatment. Quite a common and popular drug to eliminate stomach problems is Nexium. Instructions for use, reviews - all information can be found in the article.
Release form
The drug is included in the group of ATPase inhibitors. Available in the form of pink tablets. The main substance in the composition of the drug is esomeprazole in a dosage of 20 and 40 mg. The auxiliary components are:
- crospovidone;
- glyceryl monostearate;
- iron dye oxide orange and red;
- magnesium stearate;
- microcrystalline cellulose;
- macrogol;
- titanium;
- talc.
The tablets are in aluminum blisters, 7 pieces each. The product is packaged in packs with a first opening control of 1, 2, 4 blisters in each. How to take "Nexium", the doctor will tell before starting the treatment process. Basic information will also be provided below.
Act
The main substance of the drug is considered an isomer of omeprozole, it reduces the effect of hydrochloric acid in the stomach by specifically inhibiting the proton pump in parietal cells. The maximum activity of the drug is observed sixty minutes after administration. Taking pills for a week at a dose of 20 mg, you can notice that the average hydrochloric acid in the gastric secretion is lowering - the corresponding taste is less and less felt in the mouth.
The therapeutic effect is achieved with inhibition of hydrochloric acid in almost 100% of patients after a two-month course. Also during treatment, when taken together with antibiotics, the patient successfully eradicates Helicobacter pylori bacillus, which provokes the development of an ulcer. Before starting treatment, instructions for use should be studied for the Nexium preparation. Analogs will have a similar effect on the body.
Pharmacokinetics
Esomeprazole is not acid resistant. Therefore, the tablets are coated with a special film that is immune to gastric juice. After use, the medicine is rapidly absorbed from the stomach. Its maximum activity is achieved within two hours. Almost 100% bound to plasma proteins. If you take food together with the medicine, then in the stomach the process of its absorption decreases and slows down. The main metabolites of the drug do not affect the secretion of the pancreas.
In the form of metabolites, the drug is excreted in the urine, and only a small part of it is excreted in the feces. In elderly patients, the metabolism does not change when taking the "Nexium". A cheap analogue, Esomeprazole, has similar pharmacokinetics.
Indications and contraindications
A medication can be prescribed for the following reasons:
- gastroesophageal reflux disease ;
- elimination of the causes of erosive reflux esophagitis;
- maintenance therapy in patients after ulcer healing in order to prevent exacerbation;
- treatment of ulcerative pathologies of the stomach and duodenum in combination with other drugs;
- preventive measures for the recurrence of peptic ulcer associated with the Helicobacter pylori bacterium;
- long medical process after gastric bleeding;
- ulcer healing associated with NSAIDs;
- pathological hypersecretion.
Contraindications:
- fructose intolerance, which is hereditary;
- sucrose and glucose deficiency;
- age up to 12 years;
- children's age after 12 years, except for patients with gastroesophageal reflux disease;
- complex reception together with Atazanavir and Nelfinavir;
- renal failure;
- hypersensitivity to the main substance - esomeprazole.
Before starting therapy, it is advisable to thoroughly study all the indications and contraindications that the Nexium medical device has. Russian analogs should also be used after consulting a doctor.
Dosage
Tablets are taken orally without chewing and drinking with a small amount of liquid. The medicine is covered with a special film that is resistant to gastric juice. The tablet cannot be crushed. For those patients who cannot swallow the drug whole, it is necessary to dissolve it in half a glass of water without gas and after a while drink. For prolonged use, people after suffering erosive esophagitis are prescribed 20 mg of the drug in order to avoid relapse. The medicine should be taken once a day.
In the treatment of
gastroesophageal reflux disease, adults and children with a body weight of more than 30 kg are prescribed a dose of 20 mg per day. If within a month the symptoms of the disease have not disappeared, then an additional examination is necessary. After recovery, you can drink pills as needed when symptoms occur. The dose in this case is 20 mg once a day. Those patients who take NSAIDs and belong to the risk group associated with gastric ulcer, only after consultation with a doctor, it is necessary to use the drug "Nexium". Analogs, reviews - all this information should be clarified before starting therapy.
With ulcerative pathologies associated with the Helicobacter pylori bacterium, the medicine is used as part of complex therapy at 20 mg per day. Additionally, amoxicillin (1 g) and clarithromycin (500 mg) are prescribed. Complex therapy is carried out for ten days.
For the purpose of acid-suppressing therapy for patients undergoing gastric bleeding, the drug is prescribed at a dose of 40 mg per day for one month.
Interaction with other medicines
The drug is not recommended to be taken at the same time with the following medicines:
- “Ketoconazole”;
- "Digoxin";
- Saksinavir
- Phenytoin;
- Voriconazole
- Warfarin.
If the patient takes one of these funds, then the doctor must inform you before using the Nexium medication. A cheap counterpart will have the same recommendations.
When using the drug in high doses, the patient may develop weakness, nausea and other symptoms of intoxication. There is no specific antidote to the medicine. Therefore, in this case, symptomatic and supportive therapy is prescribed. Dialysis is ineffective here, since the main substance of the drug is almost 100% bound to blood proteins.
Pregnancy and lactation
The use of Nexium during child bearing has been little studied. It can be prescribed only in exceptional cases, when the intended benefit for the expectant mother is greater than the risk to the fetus. According to the results of animal studies, there was no negative effect on the embryo, which could provoke deformity or underdevelopment. During breastfeeding, it is better to refrain from using the medicine. The drug passes into milk. If there is a need for therapy, it is advisable to abandon lactation.
If you take the medicine incorrectly, the following unpleasant symptoms may develop:
- the occurrence of allergic reactions, up to anaphylactic shock;
- dizziness;
- migraine;
- epigastric pain;
- muscle weakness;
- sleep disturbance;
- mastopathy
- impaired renal function.
If there are side effects, you should inform your doctor. How to take "Nexium" to avoid overdose, the doctor will be able to tell at the reception.
special instructions
The drug must be stored away from children, at a temperature not exceeding 30 degrees. The pharmacy is available on prescription. It is not recommended to appoint children under 12 years of age, with the exception of the need for therapy of gastroesophageal reflux disease. For patients with severe renal failure, the dose should not exceed 20 mg per day.
In the process of treatment, it is better to abandon driving vehicles and work related to concentration. Often dizziness occurs due to taking the tablets. Previously, the instruction for Nexium should be studied. Reviews show that side effects often develop in patients who neglect recommendations.
A cheap analogue is the Esomeprazole preparation
The medicine belongs to the group of antiulcer, is a proton pump inhibitor. Also, the active substance reduces the secretion of hydrochloric acid. A positive result is observed already an hour after taking 20 or 40 mg of the drug. If you take the medicine daily for five days, you can lower the level of hydrochloric acid by almost 80%.
The drug is unstable to an acidic environment. Therefore, the granules and tablets are coated with a special coating that may come in contact with gastric secretion. 98% of the drug binds to blood proteins. The drug Nexium has the same effect. The cheap analogue of Esomeprazole practically does not differ in composition.
Indications and contraindications
Esomeprazole may be prescribed in the following cases:
- treatment of erosive esophagitis;
- preventive measures for cured erosive reflux esophagitis;
- symptomatic treatment of GERD ;
- in combination with antibiotics to kill Helicobacter pylori, which causes stomach and duodenal ulcers.
Contraindications:
- hypersensitivity to the drug;
- pregnancy;
- lactation;
- severe renal failure;
- age to 16 years.
How to take the medicine?
Esomeprazole is administered orally. The dosage is established individually, taking into account the severity of the disease. Basically, it is 20 or 40 mg once a day. The tablet cannot be chewed and crushed. It is covered with a special membrane that helps the drug to be absorbed in the stomach. If it is not possible to swallow the medication as a whole, then it can be dissolved in a glass of still or boiled water and drink after 30 minutes.
With renal pathology, the drug is dosed at a rate of 20 mg per day. The reception algorithm of Nexium is identical. Cheaper analogues often have similar recommendations.
Side effects
If you take the drug incorrectly, the following unpleasant symptoms may develop:
- headache;
- dizziness;
- nausea;
- muscle weakness;
- sleep disturbance;
- allergic reactions;
- tremor and others
Reviews on the preparations "Nexium" and "Esomeprazole"
Most patients prefer to undergo treatment using these agents. The Russian counterpart has a more affordable price, which is about 30 rubles per package. But the imported original has a fairly high cost (about 800 rubles). According to patients, there is no significant difference in these drugs, so there is no need to overpay for Nexium. Instructions, analogues, their cost - it is desirable to study all this information before proceeding with treatment.
The described medicines are well tolerated, in a short time you can get rid of pain, which is due to the high content of hydrochloric acid in the gastric juice. They also help heal an ulcer and not cause repeated relapses. In combination with antibiotics, the patient gets rid of the Helicobacter pylori bacterium, which often leads to gastric and duodenal ulcers.
Only as prescribed by the doctor, you need to start treatment with Nexium. The cheap analogue of Esomeprazole also should not be used on its own.
The active ingredient is not addictive and withdrawal. The pill is convenient to take. They have a membrane that does not irritate the mucous membrane in the stomach and helps the drug to be rapidly absorbed. Each tablet (their color is pink) has a marking from the manufacturer, which protects the medicine from fake. Many gastroenterologists in their practice use the Nexium drug and its cheap analogue, the Esomkeprazole drug, for the treatment of stomach diseases of various etiologies. Experts note that the medications described above really show a good result of therapy.