Hemostatic tablets "Tranexam" are actively used in medical practice in recent years. The tool belongs to the class of antifibrinolytic. And the main component that provides a pronounced effect is tranexamic acid. Consider how it works and when it is useful.
general information
The use of Tranexam tablets is indicated if there is a need to stop the activity of plasminogen and inhibit the reaction of the transformation of the substance into fibrinolysin. The drug in question is available not only in tablet form, but also in injectable solution. The drug has a systemic pronounced hemostatic effect. It is recommended to use the medication if the patient has bleeding, due to an increase in the concentration of fibrinolysis. This is often diagnosed with menorrhagia, observed with a pathological condition affecting platelets.
Tranexam tablets for bleeding are used if the patient's condition allows for the oral administration of medicines. One capsule contains a quarter of a gram of the active ingredient. The medicine is available in packages containing from 10 to 50 capsules. Each instance is coated, making it easier to use the composition.
Pharmacology
According to the instructions, Tranexam tablets with bleeding help stabilize the patient's condition. The activation of plasminogen is inhibited, the reaction is stopped, the product of which is plasmin. Taking the remedy for bleeding allows you to achieve both a systemic and local pronounced effect. The drug inhibits the activity of kinins, other peptides involved in the mechanism of formation of the inflammatory focus and allergic reaction. Thanks to this, the product belongs to the class of anti-allergic and effective in the treatment of inflammation.
The experiments showed that Tranexam has a pronounced analgesic effect. If the patient is prescribed opioid-type analgesics, the drug in question potentiates their activity.
Kinetics
According to the instructions for use, Tranexam tablets have a rather short absorption period. When using the composition in an amount of from two to eight tablets, the level of absorption does not exceed 50%. Achieving maximum concentration is possible three hours after the use of the composition. When using 500 mg of the drug, the highest content in the circulatory system is 5 μg / ml, for a gram and two - 8 and 15 units.
Approximately 3% of the active compound ingested comes into strong contact with profibrinolysin. As the manufacturer mentions in the instructions for the use of Tranex tablets, the active substance has the ability to evenly distribute in organic tissues. The exception is cerebrospinal fluid, in which the concentration of the drug is approximately ten times lower than in plasma.
The ability to penetrate the placenta and the barriers that protect the brain is revealed. In breast milk, the content of the drug was found to be approximately one hundred times lower than in blood plasma. The substance penetrates the seminal fluid, but does not correct the motility of germ cells.
A sufficient concentration to achieve the desired effect in the tissues of the body lasts up to 17 hours, in serum - no more than eight.
What is going on inside?
The manufacturer indicates in the accompanying documentation for Tranexam tablets 250 mg (the price in pharmacies is from 250 rubles) that a small percentage of the active compound is transformed when it is in the human body. It was possible to identify two products of such a reaction. The elimination half-life is estimated at three hours. The clearance in the kidneys corresponds to this indicator for blood serum - 7 l / h. Mostly elimination is carried out by the kidneys by filtration through the glomeruli of the organ. In the first 12 hours after the use of the composition, about 95% of the active compound received in the body is excreted unchanged.
It is noted that in case of a malfunction of the renal system, the risk of a cumulative effect increases, which imposes certain restrictions on the features of use and safety.
When will it help?
Prescribing the drug, the doctor will definitely tell you why Tranexam tablets help and how to use them so as not to harm yourself. The main indication for prescribing the composition is bleeding or an increased likelihood of such formation if fibrinolysis is activated, and the systemic effect covers the whole body. Often this kind of bleeding occurs during surgical intervention and shortly after it, as well as shortly after childbirth. Risks associated with manual removal of the placenta, bleeding that appeared during gestation.
"Tranexam" is prescribed for hemophilia, chorionic detachment. The drug is indicated for cancer, localized in the pancreas, prostate gland. The reason for the appointment is a complication of the course, affecting fibrinolysis. The medicine is used for purpura, leukemia, a number of liver diseases and the use of streptokinase.
From the instructions that describe why Tranexam tablets help most effectively, it follows that the drug can be used for angioedema due to hereditary factors. Sometimes the drug is prescribed as part of a comprehensive course of treatment for eczema, dermatitis, rash caused by medications or toxic compounds. The drug is indicated in the treatment of urticaria and a number of other allergic reactions.
Diagnoses and Benefits
The instruction explaining why Tranexam tablets are effective, recommends using the composition in case of local bleeding or increased likelihood of this. Sometimes medication is used if a tooth is removed, the uterine neck is conized, hematuria is treated. "Tranexam" is indicated if the prostate gland was operated on, if the focus of blood secretion is localized in the digestive tract, nasal cavity, and uterus.
According to the instructions for use, Tranexam tablets for bleeding are effective if this is due to pathological processes in the oral cavity. Also, the drug is prescribed if an inflammatory focus has formed in the pharynx, in the mouth. The medicine is used as part of the treatment of tonsillitis, pharyngitis, laryngitis. Its effectiveness has been proved as part of a comprehensive course of getting rid of stomatitis and aphthae.
When and how much?
By studying the instructions that describe in detail why Tranexam tablets show a pronounced effect, you can learn about the dosage rules and the frequency of use of the composition. The manufacturer recommends in some cases, first prescribe the patient a liquid form for injective administration, then transfer the patient to a tablet. For example, when operating the prostate gland, the bladder, it is necessary to inject the medicine into the vein during and after the intervention for three days, and then replace the injection with tablets. The drug is used every eight hours, the dosage is one gram, the duration is as long as signs of macrohematuria persist.
If the pathological condition includes blood coagulation problems, but the patient is shown a tooth extraction, it is also necessary to take Tranexam tablets effective for bleeding. The instructions for use recommended prior to the event to inject a vein into the vein in an amount of 10 mg per kilogram of mass, and after removal begin to take a tablet form. The duration of the course reaches eight days. The patient should consume 25 mg / kg. The daily dose is divided into 3-4 doses.
Condition and its correction
As can be seen from the reviews, Tranexam tablets are often prescribed to people who have local fibrinolysis. The drug is used up to three times a day. Dosage varies from gram to one and a half. With profuse bleeding in the uterus, the medicine is taken up to four times a day. Dose - up to one and a half grams. The duration of treatment reaches four days. If episodes of nosebleeds are repeated, Tranexam should be used with a weekly program, using three times a day per gram of composition.
If the uterine neck is conized, it is necessary to use the medicine in one and a half gram doses three times daily. The duration of the course reaches two weeks, to which the manufacturer draws attention to the instructions for the use of Tranexam tablets. Reviews indicate that the drug provides the desired effect. The persons to whom he was appointed soon noted an improvement, by the end of the second week the problem of bleeding was completely resolved.
If angioedema caused by hereditary factors is detected, the drug must be used daily up to three times a day. Dosage varies from gram to one and a half. The duration of the course is continuous. Interruptions are possible if the condition of the patient allows this.
Will it help?
The manufacturer assures that the medication is safe and effective if you follow the instructions accompanying the Tranexam tablet. Reviews about the drug contain information about undesirable side effects that bothered many patients, at the same time, the drug really reliably fights the main manifestations of the pathological condition, so its use is considered fully justified.
In no case should Tranexam be independently assigned to itself. As can be seen from the responses of lovers of self-medication, such an experience has always left a negative impression without any benefit to the body.
Side effects
In the accompanying instructions, the manufacturer indicates the possibility of anorexia while taking Tranexam tablets. The drug can provoke a disorder of the stool and heartburn, sometimes it causes vomiting. Some patients taking the drug noted that they were sick and dizzy, was drawn to a dream, the perception of the visual image and the ability to correctly determine colors were impaired. Occasionally, a medicine provokes thromboembolism, thrombosis.
The use of a medication is associated with a risk of soreness in the chest. There is a possibility of a violation of the frequency and speed of heart contractions. A decrease in pressure is possible, but this is more often observed with an injective use and is explained by an excessively high rate of infusion. Tranexam can cause allergies. Such a reaction manifests itself in rashes on the skin, itching, urticaria.
Is it possible or not?
It is strictly forbidden to take Tranexam tablets if increased susceptibility is established to any substance used in the manufacture of the medicine. Tranexam is not prescribed if hemorrhage is localized in the subarachnoid space.
Extremely accurately, only if possible, constantly monitor the patient’s condition, “Tranexam” is used against the background of thrombosis. Particular risks are associated with a heart attack, blood clots in the brain. The same relationship requires an increased risk of blood clots, complications of a similar nature. It is necessary to carefully combine Tranexam and heparin preparations, drugs that do not directly affect blood coagulation. Careful application is required: the presence of problems with the perception of colors, hematuria, renal failure. The latter is associated with the danger of a cumulative effect.
There is an increased risk of blood clots if Tranexam is used concurrently with hemostatic drugs, hemocoagulase.
Possible alternatives: “Tugina”
If it is not possible to purchase Tranexam, you should consult a doctor for the selection of an alternative option. Sometimes the doctor advises you to stay on the medicine "Tugina". There is a good effect of this remedy for bleeding and an increased likelihood of such formation. You can use the tool if angioedema is diagnosed from birth. The substance allows you to control the activity of plasmin, due to which the risk of complications, relapses is minimized.
The medicine "Tugina" is intended for intravenous administration. The dosage is selected based on body weight of 10 mg / kg. The highest concentration in blood serum is achievable only an hour after the procedure. After another hour, a third of the funds received is eliminated with urine. A day after the drug is ingested, more than 90% of the active compound is eliminated. A cumulative effect is observed in organic tissues. The ability to penetrate the blood-brain, placental barriers was revealed. In milk excreted by the mother glands, the substance is observed in a concentration of about 1% of the intrinsic plasma. No teratogenic effect. The volume of distribution is estimated at 9-12 liters, the ability to enter into strong ties with whey proteins is not more than 3%.
Application features
It was revealed that the “Tugin” medicine is stored in organic tissues in concentrations sufficient for a pronounced effect, at least 17 hours. For blood serum, this figure is eight hours. A small percentage of the active component is transformed, the clearance in the kidneys is 7 l / h, which is similar to plasma.
In gynecological practice, the drug "Tugina" is used for detachment, placenta previa, in the case of localization of the fetus outside the uterus and with bleeding after childbirth. Indications for administration are cesarean section, uterine rupture. The composition refers to the drugs recommended for miscarriage, helps to prolong pregnancy, prevent reproductive losses.
The drug in question is allowed to be used for menorrhagia, uterine conization, prostate surgery, bleeding, provoked by a device inside the uterus.