With arrhythmias, cardiologists often prescribe lappaconitine hydrobromide. This tool helps to normalize the heart rate. The composition of the medicine includes a natural ingredient - the alkaloid of the plant aconite. This is a potent medicine. It has a powerful effect on the heart, blood vessels and central nervous system.
Composition and effect of the drug
The active ingredient in the drug is lappaconitine hydrobromide. The trade name is Allapinin. The medication is available in the form of round white tablets with a drug content of 25 mg.
The drug normalizes the heart rate, and also has a calming effect on the nervous system. And also this tool is a local anesthetic. The drug dilates blood vessels and blocks the contact of receptors with acetylcholine. This drug is not hypotensive, however, at very low pressure it is not prescribed.
The drug "Allapinin" begins to act approximately 1 hour after administration. The healing effect lasts 8 hours. Then the drug substance is excreted in the urine.
Indications
Instructions for use of lappaconitine hydrobromide recommends taking the drug for the following cardiac pathologies:
- paroxysmal (paroxysmal) tachycardia of the ventricular and supraventricular origin;
- extrasystole associated with extraordinary ventricular contraction;
- extrasystoles due to the appearance of additional impulses in the atrioventricular node and atria;
- flutter and atrial fibrillation.
With paroxysmal tachycardia, the medicine is prescribed if the patient does not suffer from organic heart diseases. It is allowed to take the drug for arrhythmias associated with overexcitation of the ventricles.
Contraindications
Taking lappaconitine hydrobromide is contraindicated in certain categories of patients. The drug should not be prescribed for the following pathologies:
- severe forms of arterial hypotension;
- complications and consequences of a heart attack (cardiogenic shock, cardiosclerosis);
- thickening of the walls of the left ventricle;
- heart failure;
- atrioventricular and sinoatrial blockade of the heart;
- blockade of the bundle of His;
- severe pathologies of the liver and kidneys;
- enzymatic disorders (malabsorption syndrome, intolerance to lactase, sucrose and fructose).
The medicine is not recommended to be taken before the age of 18 years. It is also undesirable to prescribe this drug to pregnant women. However, if it is necessary for health reasons, the cardiologist should evaluate the possible benefits of therapy for the mother and harm to the embryo. If treatment with the drug is carried out during lactation, then breastfeeding is stopped.
Unwanted effects
Lappaconitine hydrobromide can cause unwanted manifestations from various organs. The most common side effects are:
- headache, impaired coordination of movements, dizziness, double vision;
- deviations on the electrocardiogram;
- sinus tachycardia;
- increased arrhythmia;
- skin allergy.
If such symptoms occur, you should immediately contact a cardiologist. You may need a dosage adjustment or drug replacement.
Overdose symptoms
The recommended dosage must be carefully observed. Exceeding the permissible amount of antiarrhythmic drug leads to severe and dangerous disorders of the heart. In addition, blood pressure decreases sharply, the patient complains of visual impairment and dizziness. In such cases, it is necessary to do a gastric lavage and immediately call a doctor. In stationary conditions, symptomatic treatment is performed.
It is important to remember that an overdose often develops not only when the recommended number of tablets is exceeded, but also when "Allapinin" is taken with other drugs for arrhythmia.
How to take medicine
"Allapinin" is taken 1 tablet three times a day. If there is no therapeutic effect, then the frequency of administration is increased to 4 times a day. Use the drug at regular intervals. It is allowed to increase the daily dosage to 200-300 mg. The duration of the course of therapy is determined by the attending cardiologist.
special instructions
"Allapinin" is able to interact with other medicines. It is strictly forbidden to use this drug together with other medicines for arrhythmia. This can lead to exacerbation of tachycardia.
It is necessary to avoid the simultaneous appointment of "Allapinin" with drugs that activate liver enzymes. They can reduce the effectiveness of antiarrhythmic drugs.
During treatment with the drug, muscle relaxants are not recommended. Allapinin can dramatically increase their effect.
If the patient has a violation of water-electrolyte metabolism, then this deviation must be treated before the start of the course of therapy. While taking the medicine, you need to periodically check the metabolism of water and salts in the body.
If sinus tachycardia occurs during therapy, then "Bisoprolol", "Concor" or "Nebivolol" at the same time are prescribed in low doses.
During the course of treatment with "Allapinin" the use of alcohol is strictly prohibited. It is not recommended to drive a car and perform work requiring a quick reaction and a high concentration of attention. It must be remembered that the medicine has a sedative effect.
Storage, price and analogues
Tablets are stored at a temperature not exceeding +26 degrees. The medicine has a shelf life of 5 years.
The price of "Allapinin" in pharmacies is from 400 to 500 rubles (for 30 tablets). For some patients, the cost of the medicine seems high, and they are interested in cheaper drugs with similar effects.
The drugs "Alaritmin" and "Allaforte" have a similar composition. However, their cost is approximately equal to the price of Allapinin.
You can choose drugs with a similar effect on the body. They contain other active ingredients, but also have an antiarrhythmic effect. Such funds include:
- Etmozin.
- "Etatsizin".
- "Propanorm."
- "Rhythmorm."
Of the listed preparations, "Propanorm" is the cheapest analogue of lappaconitine hydrobromide, its price is from 250 to 400 rubles. Other analogues are more expensive.
Reviews of doctors and patients
Doctors often use Allapinin in their practice. Reviews of cardiologists and arrhythmologists about the drug are mostly positive. Experts believe this drug is an effective tool for the treatment of arrhythmic disorders. However, doctors note that it is necessary to prescribe this remedy with caution. In the early days of therapy, specialists try to use the minimum dosage. If the patient tolerates the drug well, then therapy is continued, and the amount of the drug is gradually increased.
However, not all patients tolerate Allapinin well. Reviews of cardiologists also report side effects of the tablets. Doctors say that it is impossible to predict in advance whether the patient will experience unwanted symptoms. Therefore, the dosage of the drug is recommended to be increased gradually. Cardiologists emphasize that this remedy cannot eliminate the cause of arrhythmia and make the prognosis of the disease more favorable. It only eliminates unpleasant symptoms. Doctors prescribe this drug if arrhythmia dramatically affects the performance and quality of life of patients.
Patient reviews about this medicine are contradictory. Many netizens note the effectiveness of the drug in the treatment of arrhythmia. But at the same time, most patients report unpleasant side effects. Many people do not tolerate this medicine. Most often there are complaints of neurological manifestations: headache, dizziness, blurred vision, double vision. This is due to the presence in the composition of the drug alkaloid poisonous plant aconite, which affects the central nervous system and vision. Especially often observed such manifestations in the elderly.
It is important to remember that such a drug for heart rhythm disturbances can not be taken independently. Only a doctor can choose the minimum effective dosage and take into account all contraindications. Self-medication in this case is unacceptable. "Allapinin" refers to complex drugs. The slightest excess of the recommended dose can lead to severe intoxication.