A large number of people suffer from pathologies of the gastrointestinal tract. This is due to errors in nutrition, non-observance of food intake and many other reasons. Very often among diseases of the stomach and intestines, ulcer problems occur, which, if left untreated, can lead to serious complications. Currently, there are many drugs that help get rid of such diseases. One of them is Ulsepan. Instructions for use, analogues of the drug will be considered in the article.
The form of release of the drug and its composition
This drug is available in two forms:
- Tablets.
- Lyophilized powder for solution for injection.
"Ulsepan" (tablets) composition has the following:
- Pantoprazole (40 mg) is included as the active ingredient.
- Among the additional components are calcium carbonate, mannitol, crospovidone, povidone, sucrose stearate, calcium stearate.
- The tablets are coated on top with a coating that includes white opadri, Acryl-Eze yellow, talc, titanium dioxide, silicon dioxide, sodium bicarbonate, yellow iron oxide , sodium lauryl sulfate.
One bottle of Ulsepana contains the active ingredient pantoprazole in an amount of 40 mg and sodium hydroxide as an auxiliary component.
Pharmacological effects on the body
What properties does Ulsepan have? Instructions for use states that this drug belongs to the group of antiulcer drugs. It is a proton pump inhibitor. After taking the drug, the active active substance accumulates in the tubules of the parietal cells and blocks the last phase of the production of hydrochloric acid. This leads to a decrease in its secretion in the gastric juice.
It was also revealed in the course of numerous studies that Ulsepan has antibacterial activity against the bacterium Helicobacter pylori and helps other drugs fight it.
After ingestion, “Ulsepan” (tablets) is rapidly absorbed, the instruction reports that after a couple of hours the maximum concentration in plasma is reached. It should be noted that the absorption of pantoprazole does not depend on food intake.
In what cases is the reception of "Ulsepan"
If you wonder about what Ulsepan pills come from, the following pathologies can be mentioned, in which the doctor prescribes them:
- Gastric and duodenal ulcer. These pathologies are currently not uncommon.
- Zollinger-Ellison Syndrome.
- Reflux esophagitis of varying severity.
- Helicobacter eradication in patients with an ulcer that was caused by this particular bacterium in combination with the use of antibacterial drugs.
For any pathology of the gastrointestinal tract, you should not self-medicate. Therapy should be prescribed only by a doctor.
Contraindications to the use of "Ulsepan"
There are not many conditions in which taking this medicine is prohibited, but you still need to know them. If you are going to take the drug "Ulsepan", the instructions for use recommend that you refrain from this in the following cases:
- Hypersensitivity to the components of the drug.
- Cirrhosis of the liver or hepatitis, which are accompanied by a severe form of liver failure.
- You can not take the drug together with Atazanavir.
- Severe renal impairment.
It is worth discussing with your doctor the presence of contraindications before starting treatment with this drug.
Therapy regimen and dosage
If you have not asked the doctor how to take Ulsepan, the instructions for use contain detailed information. For any pathologies, the tablets are taken orally, they are not required to be chewed, only it is necessary to drink plenty of water. Dosage may vary depending on a particular disease:
- If there is an ulcer in the stomach or in the duodenum, the drug is taken 1-2 tablets per day. The course of such therapy is from 2 weeks to a month with an exacerbation of peptic ulcer, and a stomach ulcer requires a longer intake - 1-2 months.
- If there are erosive and ulcerative lesions of the gastrointestinal tract as a result of taking NSAIDs, then Ulsepan is prescribed 1-2 tablets per day for 1-2 months.
- In the presence of reflux esophagitis, the drug is taken one tablet for 2 months, if there are no improvements, then the course of therapy can be extended.
- If the diagnosis of Zollinger-Ellison syndrome is made, then the dosage of the drug is selected in each case individually, taking into account the clinical manifestations. The initial dosage is usually one tablet 2 times a day. The dose may increase to 6 tablets per day, and the duration of such treatment is more than a year.
- To eradicate Helicobacter, take the drug 1 tablet twice a day along with antibacterial agents.
During the course of therapy, it is always necessary to monitor the reaction of the body to taking the medicine, and if the adverse effects occur, immediately inform the doctor.
Injection treatment
When is Ulsepan Solution prescribed? The instruction intravenously recommends introducing it only if oral administration is not possible. Dosage will also depend on the pathology:
- For the treatment of erosive reflux esophagitis , a dosage of 40 mg of the active substance is recommended once a day for a week or a little more. The lyophilized powder in the vial must be diluted with 10 ml of saline solution - a primary solution is obtained, which is combined with 100 ml of sodium chloride or 5% glucose solution to obtain a concentration of 0.4 mg / ml. The solution should be used immediately after preparation.
- In the presence of Zollinger-Ellison syndrome, the dosage may be 80 mg twice a day. The preparation scheme is the same as in the previous case.
Unwanted effects of Ulsepan therapy
Those patients who took Ulsepan tablets often leave positive reviews, but note that there may rarely be such manifestations:
- Dizziness and headache.
- Skin rashes or itching.
- Fatigue, drowsiness.
- Trouble sleeping.
- Dry mouth.
- Increased activity of liver enzymes.
It is rare to observe:
- Visual disturbances (blurry, veil before the eyes).
- Urticaria.
- Myalgia, arthralgia.
- Fever.
- Hypersensitivity to the components of the drug.
- Increased bilirubin content.
- Depressed state, apathy.
Very rarely occur:
- Leukopenia and thrombocytopenia.
- Disorientation.
If we talk about side effects after intravenous administration of the drug, then, in addition to the above, soreness at the injection site can be observed.
If undesirable manifestations occur during treatment, then it is necessary to inform the doctor about them in order to adjust the dosage or, if necessary, completely cancel the therapy with this drug.
Treatment with Ulsepan during pregnancy
Taking this medication during the period of gestation is extremely undesirable. Therapy is only possible if the benefit to the mother outweighs the potential risk to the developing child.
Considering that the active ingredient of Ulsepana passes into breast milk, you should stop breast-feeding or delay the duration of therapy while taking the medicine.
How Ulsepan interacts with other medicines
Before starting therapy using this medication, it is necessary to find out how it is combined with other drugs. If the doctor has prescribed Ulsepan, the instructions for use recommend that you do not combine it with drugs whose bioavailability depends on the acidity of the medium, it will reduce their effectiveness.
“Ulsepan”, unlike other drugs of this group, can be safely used in patients:
- Who suffer from cardiovascular disease and take Digoxin, Nifedipine, or Metoprolol.
- You can safely be treated with this drug for those who drink antibacterial agents. They will complement each other perfectly.
- Without fear, you can continue therapy with hormonal drugs.
- Ulsepan is well combined with NSAIDs, for example, Diclofenac, Naproxen, Piroxicam.
- If you take Levothyroxine or Glibenclamide, nothing bad will happen either.
- Reception of "Diazepam" is not a contraindication to therapy "Ulsepan."
- Antiepileptic therapy goes well with taking this medication.
- Combined "Ulsepan" with anticoagulants.
From the above information, we can conclude that “Ulsepan” is quite compatible with other drugs, which is very good, especially for those patients who suffer from many chronic pathologies and are forced to constantly take a bunch of drugs.
Some nuances in therapy
What other information does the instruction about Ulsepan contain (patient reviews are presented below)? She reports that it is necessary to undergo a full examination to exclude tumors in the digestive tract, since the use of the drug can mask the symptoms and the diagnosis will be made too late.
If treatment is prescribed to patients with problems in the liver, then during the course of therapy it is necessary to monitor the activity of enzymes in the plasma, if it increases, then therapy must be canceled.
Also, in the presence of severe abnormalities in the functioning of the liver and kidneys, do not take Ulsepan together with antibiotics. The active substance of this drug is able to reduce the absorption of vitamin B12, this must be considered if you are taking it. This is especially true for those patients who have a deficiency of this vitamin.
A long course of therapy with Ulsepan requires constant monitoring of the patient.
Analogs of Ulsepana
Currently, there are a fairly large number of drugs that contain the same active substance:
- Zovanta.
- "Control".
- "Nolpaza."
- Pantaz.
- Pantasan.
- Pantocar.
- "Panum" and others.
Analogs should be selected only by a doctor.
Patient reviews about the drug
Taking any drug entails both positive and negative opinions of patients. If you have been prescribed the drug "Ulsepan", instructions for use, reviews are the information that you need to study before starting treatment.
We can say that after a course of therapy with this drug, most patients have good impressions. Many note a decrease in the manifestation of the symptoms of the disease. If the drug was prescribed for gastritis, then bouts of pain visited a person less and less, digestion and general condition improved.
Among all the side effects that are indicated in the instructions, almost none occurred. Even co-administration with other drugs was well tolerated.
For some patients, the doctor prescribed Ulsepan for chronic gastritis, which was accompanied by frequent heartburn. Patients note that the medicine helped quite efficiently, a special lightness appeared in the stomach, seizures became less frequent, and overall well-being improved significantly.
Any medicine, no matter how well your friends and neighbors speak about it, should be prescribed only by a doctor. Everyone has a different organism and may not perceive the drug at all, and not everyone has the same disease.
Only after a full examination can you start therapy, then a positive result will not be long in coming.
So, we examined the drug "Ulsepan". Instructions for use, analogues, reviews are now known to you. We hope you find this information useful.