Do you know why doctors prescribe a drug like Tiocetam? Instructions for the use of this tool, as well as its release form, composition and indications will be presented in this article. We will tell you about the pharmacological characteristics of the drug, whether it has contraindications and side effects.
Forms of release of the drug and its composition
Currently, in pharmacies you can buy two different forms of the drug "Tiocetam". Instructions for use states that such a drug is available in the form of a solution and tablets (for intravenous and intramuscular administration, as well as for oral administration, respectively).
The active substance of the solution are thiotriazolin and piracetam. This form of the drug is sold in ampoules (10 and 5 ml each), which are placed in blister packs and cardboard packs.
As for the tablets, thiotriazolin and piracetam are also their active ingredients. On sale, they come in cardboard packaging of 60 pieces.
Pharmacological characteristics
What properties does the medicine “Tiocetam” have? Instructions for use informs that this tool belongs to the group of cerebroactive. It is able to exhibit antioxidant, anti-ischemic and nootropic properties.
The therapeutic effect of the drug is due to the mutually potentizing effect of piracetam and thiotriazolin. The first element is the cyclic derivative of GABA. This substance belongs to nootropic drugs. It acts directly on the brain, improving attention and consciousness, learning and memory. In this case, the drug does not have any psycho-stimulating and sedative effects.
At the neuronal level, a substance such as piracetam greatly facilitates synaptic transmission. It affects the activity and density of postsynaptic receptors. It should be especially noted that the hemorheological properties of piracetam are directly related to its effect on platelets, red blood cells and blood vessels.
As for thiotriazolin, it is able to react with lipid radicals and reactive oxygen species. This process occurs due to the pronounced reducing properties of the thiol group.
It should also be said that thiotriazolin prevents the formation of reactive oxygen species. This process is carried out by reactivation of antiradical enzymes such as catalase, superoxide dismutase and glutathione peroxidase.
From the foregoing, we can safely conclude that the drug "Tiocetam" (injections and tablets) improves cognitive as well as integrative brain activity, promotes learning and eliminates amnesia. In addition, the medication increases the performance of both long-term and short-term memory.
Indications
Why is “Tiocetam" necessary? Instructions for use contain the following indications:
- cerebral ischemia (chronic);
- ischemic stroke (recovery period);
- non- cognitive cognitive impairment ;
- diabetic encephalopathy.
Contraindications
Does a medication such as Tiocetam have contraindications? The instruction says that this drug can not be used with:
- hypersensitivity to thiotriazolin or piracetam, as well as to other substances of a medical device;
- Huntington's chorea ;
- severe renal failure of a chronic nature;
- acute cerebrovascular accident (i.e. hemorrhagic stroke) ;
- psychomotor agitation;
- pregnancy and lactation;
- hereditary lactose intolerance, lactase deficiency;
- sucrose deficiency and fructose intolerance;
- glucose-galactose malabsorption;
- in childhood.
Reception with caution
In the presence of any abnormalities, with such caution is prescribed such a medication as "Tiocetam"? The instruction says that this drug is able to affect platelet aggregation. In this regard, it should be used carefully by patients with surgical interventions, as well as with impaired hemostasis and with severe bleeding.
Also, the use of the medication in question should be controlled by a doctor in case of chronic renal failure, in old age, with cardiovascular pathologies (in this group of patients, adverse reactions are most often noted).
The drug "Tiocetam": instructions for use (injections)
If it is impossible to take the medication inside, it is administered intramuscularly or intravenously.
With ischemic stroke (during the recovery period), as well as chronic circulatory disorders in the brain, the drug is prescribed 20-30 ml. Previously, it is diluted in a 0.9% solution (100-150 ml) of sodium chloride, and then administered intravenously (dropwise) once a day.
The course of this treatment should be at least 15 days. After that, they switch to the tablet form of the drug.
How should a solution of “Tiocetam” be used for diabetic encephalopathy? Instructions for use (injections should be prescribed only by the attending physician) states that in this case, the drug must be used in a volume of 5 ml (intramuscularly) once a day for 10 days. After this course, you can safely switch to the tablet form.
Medication "Tiocetam": instructions for use (tablets)
Tablets should be taken orally half an hour before a meal.
For ischemic stroke (during the recovery period), as well as for chronic circulatory disorders of the brain, the patient is given 2 tablets three times a day. Such treatment is carried out for 25-30 days. If necessary, the course can be extended up to 4 months.
For the treatment of diabetic encephalopathy, the patient is also prescribed 2 tablets three times a day. However, in this case, the treatment is carried out for 45 days.
The last dose of the drug must be taken no later than 5 pm. This will prevent sleep disturbance.
Overdose
What symptoms occur when the drug “Tiocetam” is taken incorrectly (the price of the medicine is indicated below)? If you do not follow the doctor’s instructions, then the patient may experience dose-related side effects. As a treatment, you should cancel the medicine, induce vomiting, rinse the stomach (when taking tablets) and use symptomatic therapy.
Side effects
There are a large number of undesirable effects that may occur after using a medication such as Thiocetam. Instructions for use (the price of this drug is quite high) contains the following list of adverse reactions:
- Nervous system: motor disinhibition, anxiety, irritability, hallucinations, drowsiness, tinnitus, depression, insomnia, headaches, ataxia, dizziness, exacerbation of the course of epilepsy, mental agitation, confusion, asthenia, and imbalance.
- Alimentary tract: dry mouth, nausea, bloating, vomiting, abdominal pain and diarrhea.
- Heart and blood vessels: hypertension, tachycardia, pain in the region of the heart, arrhythmia, coronary insufficiency (in the elderly).
- Allergy: angioedema, hypersensitivity, dermatitis, anaphylactic reactions, itching, fever, urticaria.
- Respiratory: attacks of suffocation and shortness of breath.
- Hearing organs: vertigo.
- Metabolism: weight gain.
Drug interaction
Injections and tablets "Tiocetam" is forbidden to prescribe with drugs that have an acidic pH value.
Due to the presence of piracetam in the drug, the effect of antianginal drugs and antidepressants is enhanced.
With simultaneous use with thyroid hormones, there is a possibility of confusion, sleep disturbance and irritability.
Metabolic interactions with other drugs are unlikely.
Joint administration of the drug with alcohol does not affect the level of concentration of piracetam in the blood.
special instructions
With long-term treatment of the elderly, continuous monitoring of the kidneys is recommended. If necessary, then carry out dose adjustment.
During therapy with the drug “Tiocetam” one should refrain from driving a car, as well as from engaging in dangerous types of work that require quick psychomotor reactions and an increased concentration of attention.
Storage conditions
The product in question must be stored in a place protected from light (sunlight) and out of the reach of children. The storage temperature of the drug is 15-24 ° C. Shelf life is two years.
Medication cost
How much is the drug "Tiocetam"? The price of this tool may be different, depending on the margin of the pharmacy network, as well as on the form of release of the drug. The average cost of this medication is 460 Russian rubles.
Many patients who have been prescribed such a drug consider this to be an overpriced one. Given that the medication should be taken for a long period (from several weeks to several months), treatment is quite expensive.