The drug "Grandaxin" refers to tranquilizers with a pronounced psycho-vegetative effect. The medicine is widely in demand in medical practice, since it can have a beneficial effect in the fight against depression, oppressed mental states. A similar effect has its analogues. "Grandaxinum" is easy enough to replace with another drug. But is it safe?
Pharmacological effects
The drug is a tranquilizer. It belongs to the group of benzodiazepine derivatives. Like its analogues, "Grandaxinum" has an anxiolytic effect on the body. This effect is not accompanied by muscle relaxant, sedative, anticonvulsant effects.
This tool is an excellent psycho-vegetative regulator that relieves the patient of various forms of disorders. It has a moderate stimulating activity.
The absence of a muscle relaxant effect allows doctors to prescribe sedative "Grandaxinum" to patients suffering from myasthenia and myopathy.
In addition, the drug practically does not provoke mental or physical dependence in patients. It does not have a withdrawal syndrome.
The composition of the drug
The drug is available in tablet form. The pill is round and flat, white (sometimes it can be a little grayish).
The active substance of this agent is tofisopam. In addition to it, the medicine has a number of auxiliary components:
- stearic acid;
- gelatin;
- potato starch;
- microcrystalline cellulose;
- magnesium stearate;
- talc;
- lactose monohydrate.
Indications for appointment
The medicine is in great demand with neurosis-like conditions, neurosis. The instruction provides the following indications for the Grandaxin preparation:
- Reactive depression, accompanied by moderately psychopathological symptoms.
- PMS, menopausal syndrome.
- Neuroses and similar conditions.
- Cardialgia
- Disorder of mental adaptation.
- Syndrome of alcohol withdrawal.
- Myopathy, myasthenia gravis, neurogenic muscle atrophy, and some other conditions accompanied by neurotic symptoms (for the treatment of patients who are anxiolytic, which have pronounced muscle relaxant properties, are contraindicated).
The drug “Grandaxin” has a rather favorable effect on the human body. The medicine is able to eliminate the unpleasant symptoms that often accompany neurosis:
- apathy
- emotional stress;
- anxiety (moderate);
- obsessive states;
- autonomic disorders;
- decreased activity.
Dosage of medication
Reception "Grandaxinum" is appointed exclusively by the doctor individually for each patient. After all, it is extremely important to take into account not only the pathology of the patient, but also his general condition.
Instructions for taking the medicine provide the following recommendations:
- Adults are prescribed 1-2 pills from 1 to 3 times a day.
- If the product is used irregularly, then it is allowed to use 1-2 tablets.
- The daily maximum dose can reach 300 mg. This is equivalent to 6 tablets.
- Elderly people and patients suffering from renal failure should reduce the dosage by 2 times.
Contraindications
Due to individual characteristics or pathologies, this remedy may not be suitable for some people. Manufacturers claim that the medicine is contraindicated in the following phenomena:
- decompensated respiratory failure ;
- lactation;
- hypersensitivity to the components of the drug;
- when the patient uses the medicines “Cyclosporin”, “Tacrolimus”, “Sirolimus”;
- in the first trimester of pregnancy;
- in the patient's condition, which is accompanied by severe aggressiveness, deep depression, psychomotor agitation;
- sleep apnea syndrome;
- lactase deficiency;
- galactose intolerance;
- malabsorption syndrome.
With increased caution, the doctor may prescribe medication to patients suffering from such diseases:
- epilepsy;
- respiratory failure (acute);
- angle-closure glaucoma;
- organic brain damage.
Feasible side effects
The drug "Grandaxinum" can provoke undesirable manifestations in a patient. As a rule, such reactions are observed in the elderly or patients suffering from impaired renal function, liver. It is noted that side effects can also occur in people with a delayed mental development. If such unpleasant reactions occur, the doctor will select no less effective analogues.
Grandaxin can cause the following side effects:
- Flatulence, constipation, nausea, a feeling of dry mouth, decreased appetite, sometimes even cholestatic jaundice.
- Muscle tension, pain in them.
- Allergic reactions - skin itching, exanthema.
- Disturbed sleep, headache, psychomotor agitation, confusion, excessive irritability.
- Depressed breathing.
Important notes
An excellent tranquilizer that can relieve the patient of unpleasant symptoms is the drug “Grandaxin”. Reviews of doctors fully confirm its effectiveness. However, at the same time, doctors recommend using this remedy extremely carefully. Since along with the contraindications and side effects described above, a number of features should be taken into account.
So, the drug “Grandaxin” is able to enhance the effect on the body of the following funds:
- antidepressants;
- general anesthesia;
- sedatives;
- sleeping pills;
- analgesics;
- histamine H1 receptor blockers;
- antipsychotic medications.
Antiepileptic drugs, ethanol, nicotine, barbiturates can enhance the metabolism of the active substance of the drug “Grandaxin”. Thus, there is a decrease in the concentration of the drug in the blood, and a weakening of its effect on the body is caused. In people suffering from epilepsy, this medication can increase convulsive readiness.
In addition, the drug is not recommended for use in case of chronic psychosis, phobias. Since the drug can provoke an increase in the risk of aggressive behavior in the patient and attempted suicide. That is why doctors never prescribe Grandaxin tablets for depression, accompanied by anxiety, in the form of monotherapy.
Doctors opinion
Most doctors use the drug "Grandaxinum" in their practice. Doctors' reviews based on observations of the patient's condition confirm a beneficial effect on the body.
In addition, the great advantage of this tool, according to doctors, is the amazing ability of the drug not to cause dependence and muscle relaxant action.
The tool perfectly eliminates emotional stress, anxiety, apathy. And in modern life, overwhelmed by stresses, this is quite relevant. In addition, the medicine helps women to cope with PMS, menopause. However, it can be combined with hormone replacement therapy.
Patient opinion
Patients using this medicine respond positively about it. After all, the remedy really allows you to cope with many unpleasant symptoms. It returns to the patient a lost sense of calm, normalizes well-being, eliminates panic attacks. The medicine with VSD and osteochondrosis helps quite effectively.
At the same time, the search for effective analogues of the drug “Grandaxin” (the price of which is palpable for the budget) often begins precisely because of the cost of the drug.
There are very few negative opinions about the drug. And basically they indicate the occurrence of side effects.
Cost of medicine
This is an important issue that interests patients who are prescribed Grandaxin tablets. The price of the medicine, of course, may vary slightly. Therefore, we give the average data:
- tablets (50 mg) No. 60 - 610 rubles;
- pills (50 mg) No. 20 - 301 rubles.
The main analogues
If necessary, replace the original product, select the drug only with a doctor. If we talk about effective analogues, Grandaxin can be replaced with one of several drugs.
Among them:
- Gidazepam;
- Apaurin;
- Alprazolam;
- Tazepam
- "Relanium";
- "Diamidazepam";
- Afobazol;
- Nozepam
- "Neurol";
- Seduxen
- "Relanium";
- Zolomax;
- Alzolam
- "Phenazepam";
- Chlozepide
- Rudotel.
It is not possible to consider all substitutes for the drug “Grandaxin”. Analogs, the price of some of them will be presented below, should appoint, do not forget about it, only a doctor.
Grandaxinum or Afobazolum?
Very often, the original tool is replaced with this particular analogue. A fair question arises: "Which is better - Afobazol or Grandaksin?". There is no definite answer.
Both drugs are tranquilizers synthesized based on benzodiazepine. Their indications for use are almost identical. These drugs have a fairly similar effect. In addition, the first and second medicine have proven themselves perfectly.
However, they have differences. Both patients and doctors, analyzing which is better - “Afobazol” or “Grandaksin”, notice that the first remedy has fewer side effects. In addition, it does not have many contraindications.
It would seem that the conclusion suggests itself. However, there is another significant nuance. This is the price of Afobazol medicine - 314 rubles. The cost of the drug is practically no different from the Grandaxin tablets.
An effective analogue is the drug "Phenibut"
This remedy is a potent sedative. It is a highly effective sedative. It helps patients cope with anxiety before surgery or other, no less responsible, events.
The drug "Phenibut" has a rather unpleasant side effect - it is drowsiness. If we compare it with Grandaxin tablets, which have a stimulating effect, then its effect on the body is in many ways the opposite.
Thus, the drug "Phenibut" is in demand for nervous excitability, which is accompanied by insomnia. In addition, it should be borne in mind that with apathy, the medicine is not used.
The cost of the drug depends on the manufacturer. In addition, it plays a role in which pharmacy this product will be purchased. On average, for packaging number 20 will have to pay 185 rubles.
Conclusion
Before looking for an analogue for Grandaksin, be sure to replace it with a truly effective and safe remedy. Since the original medicine stands out very favorably among other tranquilizers. After all, it has a number of advantages.