Proserinum (injections) is a synthetic drug, the main active ingredient in which is neostigmine methyl sulfate.
This drug has a pronounced anticholinesterase activity, and therefore, after its use, the transmission of excitation from the nerve to the skeletal muscle improves, all cholinergic effects are enhanced in the internal organs and eye, it also increases gastrointestinal motility, increases the tone of the bronchi, bladder and endocrine gland secretion.
The drug "Proserin" is available not only in the form of a solution for injection, but also in the form of tablets, granules, from which a suspension is prepared for oral administration (for children).
Indications for use
The specified drug is used in the presence of myasthenia gravis, paralysis and paresis, with impaired motor activity after a brain injury, neuritis, after encephalitis, poliomyelitis and tuberculous meningitis.
It is also used when it is necessary to treat atrophy of the optic nerve, to reduce intraocular pressure, which increases with glaucoma, and if necessary, narrowing the pupil. With these diseases, the drug is used in the form of eye drops.
Prozerin (injections) is used to stimulate labor and also has an analgesic effect. Often, the drug is used in therapy, where it is used to treat atony of the stomach, bladder and intestines, and is taken orally.
The drug "Prozerin" injections, like other forms of the specified medicinal product, is used exclusively as prescribed by the doctor, and its independent use is prohibited.
If the drug is used orally, then its dose for an adult is from one hundredth to fifteen hundredths of a gram and is taken up to 3 times a day. For children under the age of ten - one thousandth of a gram for each subsequent year, but not more than 0.01 g per day.
The drug Prozerin (injections) can be administered either subcutaneously or intramuscularly in an amount of 1 ml of a 0.05% solution, but children are given one tenth of a ml for each year, but not more than 0.75 milliliters, everything is done in one or two times. The total duration of the course of treatment depends on the severity of the disease and can be from 15 to 40 days, and in some cases longer.
If a weak labor activity is noted, then the drug "Proserin" (ampoules) must be used for subcutaneous injection and at the same time, the Atropine drug is administered. This is done only once at the first dose or injection. Also, the drug is taken orally in an amount of 0.003 g every 40 minutes up to 6 times, and injections are made with a 0.05% solution 2 times every hour for 1.0 ml.
For an adult, the maximum daily dose of the drug is 0.05 g, and a single dose should not exceed fifteen hundredths of a gram. As for injections, the maximum dose per day is 0.006 g, a single dose is not more than two thousandths of a gram.
Possible side effects
After using this drug, bradycardia, diarrhea, nausea, decreased blood pressure, increased bronchial secretion, general weakness and allergic reactions may appear.
If a person has diarrhea and abdominal pain, as well as heavy sweat, this indicates the toxic effect of Prozerin. In such cases, the drug Atropine is administered subcutaneously.
You can not use the medicine in the presence of epilepsy, increased muscle tone, bronchial asthma, angina pectoris, atherosclerosis and intolerance to this drug.
The drug "Proserine": reviews
People who suffer from myasthenia respond well about this drug, since it is with its help that constant maintenance therapy is carried out.
Patients ’attitude to Prozerin is ambiguous, while some make regular injections, others resort to its use only in rare cases, and some do not tolerate it. As a side effect, many patients report the appearance of both dry mouth and profuse salivation and cramps.