Drugs with proteolytic activity are used to treat various diseases. Their therapeutic effectiveness is associated with the ability of the medication to act on collagen cartilage, break down necrotic tissues, thin the viscous secretion, exudate and blood clots. It should also be noted that such medicines are actively used for scleroderma, joint contractures, hematomas, ankylosing spondylitis, etc. In addition, the said agents improve the absorption of injection solutions, local anesthetics and radiocontrast substances.
The most prominent representative of such drugs is Lidase. Reviews on the effectiveness of this medication will be described at the end of the article. Also in it you will find information about the form in which the medication is produced, whether it has contraindications, etc.
The composition and form of the drug
The medication in question is made using the testes of cattle (cattle). The basis of this drug is the enzyme hyaluronidase, as well as additional substances.
Currently, this tool is available in several forms:
- powder intended for external use;
- Lidase solution, or rather lyophilisate for its preparation; It can be used both for injection and for local application;
- lyophilisate intended for solution preparation (for local and external use).
It is impossible not to say that some doctors prescribe suppositories with Lidase to their patients. However, it should be borne in mind that such suppositories are not available on an industrial scale. They can be ordered at the pharmacy according to a special medical prescription.
Pharmacology
All of these forms of medicine in pharmacies in Moscow can be purchased without a medical prescription (with the exception of candles). But before you buy such a drug, you should understand why it is prescribed and how it works.
According to the instructions, this is an enzyme medication isolated from the testes of cattle (cattle). It is able to break down such an element of the intermediate substance of connective tissues as hyaluronic acid. By the way, the latter is a mucopolysaccharide. It consists of glucuronic acid and acetylglucosamine. These components are cementitious substances of connective tissue. The medication under consideration is able to reduce its viscosity, increase vascular and tissue permeability, and also facilitate the movement of fluid in interstitial spaces. In addition, Lidase injections reduce tissue swelling, soften and flatten scars, increase the volume of articular movements, reduce contracture and prevent their formation.
The duration of action of this drug with intradermal administration is 2 days.
Indications for the use of the drug
The drug "Lidase" can be used to treat many diseases, as well as eliminate specific symptoms. According to the instructions, this medication is prescribed for:
- joint stiffness;
- scars of various origins (postoperative, traumatic or burn);
- osteoarthrosis;
- protracted ulcers;
- chronic tenosynovitis;
- skin diseases, including scleroderma;
- joint contracture that occurs after inflammation or injury;
- hydrocephalus;
- ankylosing spondylitis;
- diseases that affect the lumbar spine;
- retinopathy;
- myocardial infarction;
- hyphema;
- inflammation of the upper respiratory tract, which is accompanied by obstruction;
- neuritis, plexitis;
- soft tissue hematoma (on the surface);
- hemophthalmia.
Contraindications
After purchasing the medicine in pharmacies in Moscow or other cities of Russia, you should definitely read the instructions. According to her, an enzyme preparation is not recommended for use with:
- inflammatory and infectious diseases of an acute nature;
- hypersensitivity to constituent ingredients;
- previous hemorrhage;
- at a minor age.
- acute intercurrent diseases .
For the implementation of inhalation procedures, "Lidase" is contraindicated in patients with:
- malignant tumor;
- regular hemoptysis;
- incessant bleeding;
- respiratory failure;
- tuberculosis of any form;
- pulmonary hemorrhage;
- vitreous hemorrhage .
Mode of application
How should I enter the drug "Lidase"? Customer feedback will not provide an answer to the question. For him you need to see a doctor.
In the treatment of scars, the drug is administered subcutaneously or intramuscularly. In the first case, an injection is made right under the scar, and in the second - as close to the affected area as possible.
The dosage of this medicine is 1 ml once a day for 20 days.
With ophthalmic diseases, treatment is carried out by electrophoresis, as well as by instillation of a 0.1 percent solution in the eyes. In this case, Lidase is combined with an antibiotic.
For tuberculosis and respiratory diseases, the drug is recommended to be used in the form of injections or inhalations.
In gynecological practice, "Lidase" is used in the form of candles and injections. Suppositories (1 piece) are injected into the vagina once a day every 2 days. The course of therapy is 10 introductions.
If necessary, use dressings use a special solution of "Lidase". How to breed this medication? It is diluted with boiled water, as well as 10 ml of a 9 percent sterile sodium chloride solution. These components are mixed in a container, where a bandage is subsequently placed. After that, it is applied to the affected area, and waxed paper is placed on top and fixed with a bandage.
Side effects
Can the drug "Lidase" cause side effects? Customer reviews quite often contain information that the medication in question is well tolerated, including with a high sensitivity of the patient and a complex form of the disease.
In very rare cases, this remedy can contribute to the development of an allergic reaction, which manifests itself in the form of skin lesions.
Reviews about the drug
What do they say about the drug "Lidase"? Feedback on the effectiveness of this medicine can be left by any consumer. Most often, this medication is prescribed in the form of injections. At the same time, patients often complain that during the first few procedures the injections bring rather unpleasant sensations and even noticeable pain. However, these symptoms go away in the future.
According to experts, in gynecological practice injections "Lidaza" help save women from many diseases in this area. In this regard, despite the doubts of patients, this drug is often prescribed and has a very effective effect in the treatment of many diseases.